Journal
JOURNAL OF ANTIBIOTICS
Volume 65, Issue 7, Pages 355-359Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2012.30
Keywords
Actinomadura; polyketide; spirotetronate
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Nomimicin (1), a new spirotetronate-class polyketide, was isolated from the culture broth of an actinomycete of the genus Actinomadura. Its structure was established by spectroscopic methods, and the absolute configuration was determined by a combination of NOESY experiment, J-based configuration analysis and the modified Mosher method. Nomimicin (1) showed antimicrobial activity against Micrococcus luteus, Candida albincans and Kluyveromyces fragilis. The Journal of Antibiotics (2012) 65, 355-359; doi: 10.1038/ja.2012.30; published online 25 April 2012
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