Journal
JOURNAL OF ANTIBIOTICS
Volume 64, Issue 4, Pages 303-307Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2011.16
Keywords
antitrypanosome; endophytic actinomycete; spoxazomicins; Streptosporangium oxazolinicum
Funding
- Drugs for Neglected Diseases initiative (DNDi)
- Quality Assurance Framework of Higher Education from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
- Institute for Fermentation, Osaka (IFO), Japan
- All Kitasato Project Study (AKPS)
- Grants-in-Aid for Scientific Research [21580129] Funding Source: KAKEN
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Three novel antitrypanosomal alkaloids, named spoxazomicins A-C, were isolated by silica gel column chromatography and HPLC from the culture broth of a new endophytic actinomycete species, Streptosporangium oxazolinicum K07-0460(T). The structures of the spoxazomicins were elucidated by NMR and X-ray crystal analyses and shown to be new types of pyochelin family antibiotic. Spoxazomicin A showed potent and selective antitrypanosomal activity with an IC50 value of 0.11 mu g ml(-1) in vitro without cytotoxicity against MRC-5 cells (IC50=27.8 mu g ml(-1)). The Journal of Antibiotics (2011) 64, 303-307; doi: 10.1038/ja.2011.16; published online 9 March 2011
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