Journal
JOURNAL OF ANTIBIOTICS
Volume 64, Issue 7, Pages 509-513Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2011.41
Keywords
furaquinocins; gene cluster; regulatory gene; Streptomyces
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [21580104] Funding Source: KAKEN
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Two novel furaquinocin (FQ) analogues, I (1) and J (2), were isolated from Streptomyces reveromyceticus SN-593 strain NRM2. Their structures were elucidated by MS and NMR analyses. Similar to the previously described FQ D (3), both 1 and 2 possessed a dihydrofuran ring fused to a polyketide naphthoquinone skeleton. The main difference between 1, 2 and 3 was the type of residue attached to C-13; these were a carboxyl, a carboxamide and a methyl residue, respectively. The Journal of Antibiotics (2011) 64, 509-513; doi: 10.1038/ja.2011.41; published online 25 May 2011
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