Chemical biology of inflammatory cytokine signaling

Digitoxin elicits anti-inflammatory and vasoprotective properties in endothelial cells: Therapeutic implications for the treatment of atherosclerosis?

(2009) Joanna Jagielska et al.   ATHEROSCLEROSIS

Gambogic acid covalently modifies IκB kinase-β subunit to mediate suppression of lipopolysaccharide-induced activation of NF-κB in macrophages

(2009) Umamaheshwari D. Palempalli et al.   BIOCHEMICAL JOURNAL

Odoroside A and ouabain inhibit Na+/K+-ATPase and prevent NF-κB-inducible protein expression by blocking Na+-dependent amino acid transport

(2009) Yohei Takada et al.   BIOCHEMICAL PHARMACOLOGY

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors

(2009) John Liddle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Peperomins as anti-inflammatory agents that inhibit the NF-κB signaling pathway

(2009) Chieko Tsutsui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-thiol Conjugation

(2009) Hiroshi Kamiyama et al.   JOURNAL OF ANTIBIOTICS

Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β)

(2009) John A. Christopher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Tight-Binding Inhibitory Factor- B Kinase (IKK-2) Inhibitors Demonstrate Target-Specific Anti-Inflammatory Activities in Cellular Assays and following Oral and Local Delivery in an in Vivo Model of Airway Inflammation

(2009) C. D. Sommers et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Novel, Highly Selective, Tight Binding I B Kinase-2 (IKK-2) Inhibitor: A Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the Nuclear Factor- B Pathway in Arthritis-Relevant Cells and Animal Models

(2009) G. Mbalaviele et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ubiquitylation in innate and adaptive immunity

(2009) Vijay G. Bhoj et al.   NATURE

Epoxyquinol B, a Naturally Occurring Pentaketide Dimer, Inhibits NF-κB Signaling by Crosslinking TAK1

(2008) Hiroshi KAMIYAMA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Modification of the cysteine residues in I B  kinase and NF- B (p65) by xanthohumol leads to suppression of NF- B-regulated gene products and potentiation of apoptosis in leukemia cells

(2008) K. B. Harikumar et al.   BLOOD

Berberine Modifies Cysteine 179 of I B  Kinase, Suppresses Nuclear Factor- B-Regulated Antiapoptotic Gene Products, and Potentiates Apoptosis

(2008) M. K. Pandey et al.   CANCER RESEARCH

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates TNF-α-mediated activation of NF-κB and caspase-8

(2008) Hirotsugu Ogura et al.   EXPERIMENTAL CELL RESEARCH

The IκB kinase complex: master regulator of NF-κB signaling

(2008) Laura A. Solt et al.   IMMUNOLOGIC RESEARCH

ERK and p38 MAP kinase are involved in downregulation of cell surface TNF receptor 1 induced by acetoxycycloheximide

(2008) Hirotsugu Ogura et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Caspase-8 Mediates Mitochondrial Release of Pro-apoptotic Proteins in a Manner Independent of Its Proteolytic Activity in Apoptosis Induced by the Protein Synthesis Inhibitor Acetoxycycloheximide in Human Leukemia Jurkat Cells

(2008) Kimiko Kadohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of NF-κB Components by Covalent Binding of (−)-Dehydroxymethylepoxyquinomicin to Specific Cysteine Residues

(2008) Mizuki Yamamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioactive Triterpene Saponins from the Roots ofPhytolacca americana

(2008) Liyan Wang et al.   JOURNAL OF NATURAL PRODUCTS

p38 Mitogen-Activated Protein Kinase-Dependent Tumor Necrosis Factor- -Converting Enzyme Is Important for Liver Injury in Hepatotoxic Interaction between Lipopolysaccharide and Ranitidine

(2008) X. Deng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Novel therapeutic applications of cardiac glycosides

(2008) Ioannis Prassas et al.   NATURE REVIEWS DRUG DISCOVERY

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY