Article
Pharmacology & Pharmacy
Bin He, Wenkan Zhang, Jiaming He
Summary: The study demonstrated that fraxinellone (FRA) isolated from the D. dasycarpus plant inhibited the proliferation and migration of osteosarcoma cells, induced cell apoptosis, and increased autophagy flux. The pro-apoptotic effect of FRA was achieved through excessive autophagy flux, providing new ideas for future osteosarcoma treatment and offering theoretical support for the anti-cancer mechanism of FRA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Dilara Ataseven, Aysegul Ozturk, Mustafa Ozkaraca, Ziad Joha
Summary: Several studies have shown an inverse association between serum lycopene levels and the risk of cancers, prompting further research using animal models and cell cultures. This study aimed to evaluate the anti-proliferative and pro-apoptotic effects of lycopene on colon cancer HT-29 cells. Lycopene at doses of 10 and 20 µM significantly inhibited the growth of HT-29 cells and promoted apoptosis. These findings suggest that lycopene has potential as a therapeutic agent for colon cancer.
Article
Chemistry, Medicinal
Marta Jedrzejczyk, Natalia Stepczynska, Greta Klejborowska, Malgorzata Podsiad, Joanna Stefanska, Dietmar Steverding, Adam Huczynski
Summary: This study presents the synthesis and biological evaluation of eleven derivatives of the natural polyether ionophore monensin A, modified at the C-26 position. These derivatives showed varying degrees of antimicrobial and antiparasitic activity. One phenyl urethane derivative exhibited the most promising antibacterial activity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Pharmacology & Pharmacy
Dominika Czerwonka, Magdalena Mielczarek-Puta, Michal Antoszczak, Aleksandra Cioch, Marta Struga, Adam Huczynski
Summary: In developed countries, cancer is the second leading cause of death, with colon and prostate cancer being among the most frequently diagnosed types of neoplastic diseases. The search for new treatment strategies against these types of cancer is of great interest. Salinomycin (SAL) has emerged as a promising anticancer drug candidate for various tumor cells, showing improved activity against colon and prostate cancer cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Ewa Forma, Magdalena Brys
Summary: Propolis, a natural material produced by honey bees from various botanical sources, has therapeutic activities such as antibacterial, antifungal, and anti-inflammatory effects, with potential benefits in inhibiting cancer cell proliferation and metastasis. Research suggests that propolis can also stimulate apoptosis, influence the tumor microenvironment, and potentially reduce the side effects of chemotherapy and radiotherapy.
Article
Oncology
Jianwen Ye, Lei Qi, Jialu Liang, Ke Zong, Wentao Liu, Renfeng Li, Ruo Feng, Wenlong Zhai
Summary: Lenvatinib exerts its anticancer effects on gallbladder cancer by inhibiting cell proliferation, colony formation ability, migration, inducing apoptosis, and reducing drug resistance, mainly through the downregulation of p-AKT expression.
Article
Biochemistry & Molecular Biology
Jeyce Kelle Ferreira de Andrade, Alexandre Jose da Silva Goes, Vanessa Xavier Barbosa, Mariza Severina de Lima Silva, Mariana Aragao Matos Donato, Christina Alves Peixoto, Gardenia Carmen Gadelha Militao, Teresinha Goncalves da Silva
Summary: Thiosemicarbazones derived from beta-lapachone showed potent cytotoxic effects on leukemia cells, with BV3 being the most selective compound, exhibiting high toxicity to tumor cells and low toxicity to normal cells. These compounds have the potential to be promising candidates for anticancer drugs.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Plant Sciences
Hailan Bao, Qi Muge
Summary: Myristicin can inhibit cell proliferation, induce apoptosis, prevent cell migration and invasion, suppress epithelial-mesenchymal transition, and exert therapeutic effects on hepatic carcinoma by suppressing the PI3K/Akt/mTOR signaling pathway.
PHARMACEUTICAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiaoshuo Dai, Xiaoyan Zhang, Wei Chen, Yihuan Chen, Qiushuang Zhang, Saijun Mo, Jing Lu
Summary: This article comprehensively summarizes the latest progress and research findings on the anticancer activities of dihydroartemisinin (DHA), focusing on its molecular mechanisms and pharmacological effects. It also discusses new methods to improve DHA's bioavailability and its synergistic anti-tumor effects with other clinical drugs. Additionally, it highlights the need for further research on the anticancer effects of DHA to provide strong theoretical support for its use as an anticancer drug.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alice De Palo, Dijana Draca, Maria Grazia Murrali, Stefano Zacchini, Guido Pampaloni, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Fabio Marchetti
Summary: Piano-stool iridium complexes based on the pentamethylcyclopentadienyl ligand have been extensively studied as potential anticancer drugs, with two complexes showing significant antiproliferative activity on multiple cancer cell lines. These complexes do not affect the viability of primary mouse peritoneal cells and exert their tumoricidal effects through a combination of effects on cellular proliferation, apoptosis, and senescence triggered by mitochondrial failure and reactive oxygen and nitrogen species production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
AhmadReza Rezaeian, Fatemeh Khatami, Saeed Heidari Keshel, Mohammad Reza Akbari, Akram Mirzaei, Keykavos Gholami, Reza Mohammadi Farsani, Seyed Mohammad Kazem Aghamir
Summary: This study demonstrates that MSC-exosomes have certain anti-tumor effects on prostate, bladder, and kidney cancer cells. These effects are mainly achieved by inducing apoptosis and inhibiting cancer cell proliferation.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Cristian Urla, Matias Julian Stagno, Joerg Fuchs, Steven W. Warmann, Evi Schmid
Summary: This study provides the first evidence that zerumbone has strong inhibitory and apoptotic effects on pediatric rhabdomyosarcoma cell lines, and also reduces cell migration and downregulates the hedgehog pathway.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biology
Shouqiang Zhang, Hui Ren, Hanting Sun, Songhua Cao
Summary: The study investigated the in vitro anticancer effects of dieckol on human osteosarcoma cells, showing that dieckol could effectively inhibit cell viability and promote apoptosis by blocking the PI3K/AKT/mTOR signaling pathway. This suggests that dieckol may be a promising candidate for osteosarcoma management in the future.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Organic
Shenghui Wang, Yongfeng Guan, Xiujuan Liu, Xinying Yuan, Guangxi Yu, Yinru Li, Yanbing Zhang, Jian Song, Wen Li, Saiyang Zhang
Summary: A series of novel quinoline-indole derivatives were designed and synthesized, among which compound 9b exhibited potent inhibitory activity against various cancer cell lines. Mechanism studies showed that compound 9b exerted its anticancer effects through inducing apoptosis, down-regulating apoptosis-related proteins, and arresting cells at G2/M phase.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Gulay Ozkan, Deniz Gunal-Koroglu, Ayse Karadag, Esra Capanoglu, Susana M. Cardoso, Basem Al-Omari, Daniela Calina, Javad Sharifi-Rad, William C. Cho
Summary: This comprehensive review examines the anticancer mechanisms of lycopene through in vivo and in vitro research, highlighting the experimental conditions. Relevant scientific pharmacological articles were collected from multiple databases, investigating the molecular action and cellular effects of lycopene in various tumors. The anticancer potential of lycopene is attributed to its singlet-oxygen quencher characteristics, stimulation of detoxifying enzymes, initiation of apoptosis, inhibition of cell proliferation and cycle progression, as well as modulation of gap junctional communication, growth factors, and signal transduction pathways. Factors such as dose, drug delivery systems, cancer type, tumor size, and treatment time are crucial in determining the anticancer properties of lycopene.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Anna Markowska, Michal Antoszczak, Janina Markowska, Adam Huczynski
Summary: Vitamin E, a powerful antioxidant, protects fatty acids from oxidation and has potential anticancer effects by reducing cancer stem cell activity. It is also involved in protection against mutagenic effects, anti-angiogenic activity, and inhibition of invasion and metastasis of neoplastic cells.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Chemistry, Medicinal
Marta Jedrzejczyk, Natalia Stepczynska, Greta Klejborowska, Malgorzata Podsiad, Joanna Stefanska, Dietmar Steverding, Adam Huczynski
Summary: This study presents the synthesis and biological evaluation of eleven derivatives of the natural polyether ionophore monensin A, modified at the C-26 position. These derivatives showed varying degrees of antimicrobial and antiparasitic activity. One phenyl urethane derivative exhibited the most promising antibacterial activity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Nutrition & Dietetics
Anna Markowska, Michal Antoszczak, Janina Markowska, Adam Huczynski
Summary: The effectiveness of vitamin C in fighting cancer has been widely discussed and researched. High concentrations of vitamin C have been shown to selectively destroy cancer cells, and intravenous administration of high doses of vitamin C may improve patients' quality of life. The use of vitamin C may contribute to reducing chemotherapy-related side effects.
Article
Biotechnology & Applied Microbiology
Dominika Czerwonka, Malgorzata Podsiad, Joanna Stefanska, Michal Antoszczak, Adam Huczynski
Summary: Chemical modification of natural polyether ionophore salinomycin has been found to be a promising strategy to generate semisynthetic analogs with improved biological activity profiles. Particularly, regioselective O-acylation of the C20-epi-hydroxyl has resulted in promising antibacterial active agents with excellent inhibitory activity against planktonic staphylococci and potential in preventing the formation of bacterial biofilms. These non-genotoxic salinomycin derivatives represent attractive candidates for further antimicrobial drug development.
JOURNAL OF ANTIBIOTICS
(2022)
Article
Chemistry, Multidisciplinary
Michal Antoszczak, Sebastian Muller, Tatiana Caneque, Ludovic Colombeau, Nelson Dusetti, Patricia Santofimia-Castano, Christine Gaillet, Alain Puisieux, Juan Lucio Iovanna, Raphael Rodriguez
Summary: Persisting cancer cells are resistant to therapy and can adopt a drug-tolerant state through epithelial-mesenchymal plasticity. This study synthesized complex small molecule chimeras that accumulate in lysosomes and induce ferroptosis in drug-tolerant pancreatic cancer cells. The findings pave the way for the development of new cancer medicines targeting active ferroptosis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Nutrition & Dietetics
Anna Markowska, Michal Antoszczak, Janina Markowska, Adam Huczynski
Summary: The main function of vitamin K in the human body includes its involvement in the blood clotting cascade and its anticancer effects. Epidemiological studies have shown that reduced intake of vitamin K may increase the risk of geriatric diseases and cancer. Recent research has also indicated that vitamin K has potential in fighting against female malignancies.
Review
Biochemistry & Molecular Biology
Anna Markowska, Michal Antoszczak, Janina Markowska, Adam Huczynski
Summary: Hyaluronic acid (HA), a significant component of the extracellular matrix, plays a crucial role in cell localization and proliferation. However, high levels of HA are associated with negative prognosis in cancer patients due to the correlation with multidrug resistance, metastasis, and cancer progression. This review summarizes the relationship between HA and the CD44 receptor, as well as other components of the HA signaling pathway, and explores their potential as prognostic biomarkers and targets for targeted therapy in gynecological cancers.
Article
Chemistry, Medicinal
Michas Antoszczak, Kieran Gadsby-Davis, Dietmar Steverding, Adam Huczy
Summary: Salinomycin (SAL) is a natural compound with a broad spectrum of biological effects. In this study, novel urea and thiourea analogs of C20-epi-aminosalinomycin were synthesized and evaluated for their trypanocidal and cytotoxic activities. Among the tested compounds, 4b and 4d showed the most potent antitrypanosomal activity and were capable of inducing faster cell swelling in bloodstream-form trypanosomes compared to the reference compound SAL. These findings suggest that C20-epi-aminosalinomycin derivatives have the potential to be developed into improved trypanocidal drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Nutrition & Dietetics
Anna Markowska, Michal Antoszczak, Janina Markowska, Adam Huczynski
Summary: Endometriosis is a chronic disease that affects about 10% of women of reproductive age, causing pain and infertility. Treatment includes medication and surgical removal of lesions, but recurrence rates remain high. This review article focuses on the potential benefits of polyphenols, vitamins, and micronutrients in fighting endometriosis. Although studies have shown promising results in animal models, more well-designed studies are needed to evaluate the effects of dietary factors on women with endometriosis.
Review
Nutrition & Dietetics
Anna Markowska, Michal Antoszczak, Karol Kacprzak, Janina Markowska, Adam Huczynski
Summary: Fisetin is a natural compound with a broad spectrum of pharmacological properties, showing anticancer effects on female malignancies. However, large-scale clinical trials are needed to evaluate its chemotherapeutic efficacy.
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Dominika Czerwonka, Sebastian Mueller, Tatiana Caneque, Ludovic Colombeau, Adam Huczynski, Michal Antoszczak, Raphael Rodriguez
Summary: A library of novel salinomycin derivatives was synthesized and evaluated for their biological activity against breast cancer stem cells and non-stem cells. The results showed that these newly synthesized compounds exhibited high activity and demonstrated higher selectivity for cancer stem cells.
ACS ORGANIC & INORGANIC AU
(2022)
