Article
Agriculture, Dairy & Animal Science
Eduard Molinero, Ramona N. Pena, Joan Estany, Roger Ros-Freixedes
Summary: In this study, a missense polymorphism in the AGPAT5 gene was found to be significantly associated with fat content and composition traits in pigs. The variant showed positive effects on intramuscular fat content and fatty acid composition. The impact of the variant on fat content was more pronounced in fatter pigs and it interacts with other genes that affect overall fatness.
Article
Agriculture, Dairy & Animal Science
Cai Ma, Yi Sun, Jiying Wang, Li Kang, Yunliang Jiang
Summary: This study revealed the expression and polymorphism of GPAT3 in its promoter region in Laiwu pigs, which is consistent with changes in intramuscular fat content. The expression level of GPAT3 was found to be higher in Laiwu pigs, and a SNP at -1526 site may contribute to IMF deposition by affecting its expression in pigs.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Microbiology
Xin Li, Mengyu Li, Jinyi Han, Chuang Liu, Xuelei Han, Kejun Wang, Ruimin Qiao, Xiu-Ling Li, Xin-Jian Li
Summary: The study revealed significant differences in microbial beta diversity between low-BF and high-BF pigs, with certain bacteria being differentially enriched in each group. Specific bacteria such as Oscillospira, Peptococcus, and Bulleidia were positively correlated with BF, while Sutterella and Bifidobacterium were negatively correlated. Functional analysis indicated pathway abundance differences in cell motility and glycan biosynthesis in the microbiota of the H-BF group.
JOURNAL OF MICROBIOLOGY
(2022)
Article
Horticulture
Elizabeth Straley, Jen Colcol Marzu, Michael J. Havey
Summary: This study successfully validated onion resistance to Fusarium basal rot through genetic analysis and selective breeding. Quantitative trait loci (QTLs) regulating resistance were identified, and genomic regions associated with resistance on chromosomes 2 and 4 were validated. A QTL that decreased resistance was also discovered.
Article
Genetics & Heredity
Barbara Silva-Vignato, Aline Silva Mello Cesar, Juliana Afonso, Gabriel Costa Monteiro Moreira, Mirele Daiana Poleti, Juliana Petrini, Ingrid Soares Garcia, Luan Gaspar Clemente, Gerson Barreto Mourao, Luciana Correia de Almeida Regitano, Luiz Lehmann Coutinho
Summary: Understanding the architecture of gene expression is important for studying complex traits in cattle, such as intramuscular fat content and backfat thickness. This study aimed to identify gene expression regulatory polymorphisms associated with these traits in Nellore cattle. Using RNA-Seq data and a high-density SNP panel, SNP calling and GWAS were performed to identify relevant QTL. Additionally, eQTL analysis revealed cis and trans-eQTL associated with these traits and identified potential deleterious SNPs. Transcription factors involved in lipid metabolism-related pathways were also found. This study contributes to our understanding of the genetic architecture underlying important traits in cattle.
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Applied
Xinhua Hou, Run Zhang, Man Yang, Naiqi Niu, Junchao Wu, Ze Shu, Pengfei Zhang, Lijun Shi, Fuping Zhao, Ligang Wang, Lixian Wang, Longchao Zhang
Summary: Chinese indigenous pig breeds have higher intramuscular fat content and better meat quality. This study investigated the differential metabolites and lipids in the skeletal muscle of Laiwu and Yorkshire pigs, revealing their association with intramuscular fat content and meat flavor. The results showed that the Laiwu pig had a faster lipid droplet formation and contained more triglyceride, reflecting its higher intramuscular fat content.
Article
Genetics & Heredity
Dan Hao, Xiao Wang, Yu Yang, Hong Chen, Bo Thomsen, Lars-Erik Holm
Summary: In this study, SNPs in bovine miRNAs were detected using whole-genome re-sequencing data from 1632 cattle. A total of 1109 SNPs in the precursor region, 334 SNPs in the mature region, and 130 SNPs in the seed region were identified. Most SNPs were in Hardy-Weinberg equilibrium and SNPs in the seed region altered the repertoire of target genes, which were enriched in different pathways or functional annotations.
Article
Veterinary Sciences
Xinglong Gong, Min Zheng, Jian Zhang, Yourong Ye, Mengqi Duan, Yangzom Chamba, Zhongbin Wang, Peng Shang
Summary: Fat deposition traits play a crucial role in pig production and breeding. This study analyzed the differential expression of mRNA levels in dorsal adipose tissue of Tibetan and York pigs at different growth stages and identified key genes involved in regulating fat deposition in pigs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Pan Xu, Desen Li, Zhongping Wu, Ligang Ni, Jiaxing Liu, Ying Tang, Tongshun Yu, Jun Ren, Xuting Zhao, Min Huang
Summary: This study sequenced the genome of Sujiang pigs and identified genes associated with growth and fatness traits through genome-wide association study and meta-analysis. The findings provide insights into the genetic architecture of porcine traits and potential markers for selective breeding in Sujiang pigs.
Article
Biochemistry & Molecular Biology
Yueyun Ding, Yinhui Hou, Zijing Ling, Qiong Chen, Tao Xu, Lifei Liu, Na Yu, Wenliang Ni, Xiaoling Ding, Xiaodong Zhang, Xianrui Zheng, Wenbin Bao, Zongjun Yin
Summary: This study assessed the whole transcriptome expression profiles of pigs' Longissimus dorsi muscle with high and low IMF content to identify genes involved in porcine IMF adipogenesis. The findings revealed the involvement of non-coding RNAs in fatty acid metabolic processes, lipid metabolism, and fat cell differentiation. The study also constructed competing endogenous RNAs (ceRNA) regulatory networks, highlighting the roles of lncRNAs, circRNAs, and miRNAs in IMF deposition. These findings provide potential regulators and molecular regulatory networks for future research on IMF traits in pigs, which can aid in improving pork quality through marker-assisted selection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Hao Li, Cineng Xu, Fanming Meng, Zekai Yao, Zhenfei Fan, Yingshan Yang, Xianglun Meng, Yuexin Zhan, Ying Sun, Fucai Ma, Jifei Yang, Ming Yang, Jie Yang, Zhenfang Wu, Gengyuan Cai, Enqin Zheng
Summary: This study analyzed the scoring results of flesh color and intramuscular fat in different time periods, revealing their genetic structure and identifying related genes and genetic loci, which is of great importance for improving pig meat quality traits.
Article
Agriculture, Dairy & Animal Science
Hao Liu, Xing Zhang, Yaning Hu, Xingbo Zhao
Summary: This study reveals an association between mtDNA polymorphisms and backfat thickness (BFT) in pigs. The 48 polymorphic sites in mtDNA generated 22 haplotypes, which clustered into 4 haplogroups. HG1 showed a lower BFT value compared to other haplogroups, and H4 in HG1 exhibited the lowest BFT of all analyzed haplotypes.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Genetics & Heredity
Peng Zhou, Chang Yin, Yuwei Wang, Zongjun Yin, Yang Liu
Summary: This study investigated the genetic factors contributing to growth efficiency and lean meat percentages in Large White pigs. By analyzing three distinct pig populations, several candidate genes, such as CNTN1 and MC4R, were identified as potentially influential for growth. Additionally, other genes, namely, PDZRN4, LIPM, and ANKRD22, were found to play a partial role in fat growth. These findings provide valuable insights into the genetic basis of important traits in Large White pigs, which can inform breeding strategies for improved production efficiency and meat quality.
Article
Agriculture, Dairy & Animal Science
Zhiwang Zhang, Tingli Pan, Yu Sun, Siqi Liu, Ziyi Song, Haojie Zhang, Yixing Li, Lei Zhou
Summary: The study showed that calcium addition promotes intramuscular fat accumulation by inhibiting fatty acid oxidation, providing a new approach for increasing intramuscular fat content and improving meat quality.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Zhong Xu, Junjing Wu, Jiawei Zhou, Yu Zhang, Mu Qiao, Hua Sun, Zipeng Li, Lianghua Li, Nanqi Chen, Favour Oluwapelumi Oyelami, Xianwen Peng, Shuqi Mei
Summary: This study used ATAC-seq and RNA-seq analysis to examine the accessible chromatin and gene expression in Xidu black pigs, identifying key genes and regulatory pathways associated with meat quality and fat deposition.
FRONTIERS IN NUTRITION
(2022)