Article
Agriculture, Dairy & Animal Science
B. Li, P. M. VanRaden, D. J. Null, J. R. O'Connell, J. B. Cole
Summary: This study aimed to identify potential quantitative trait loci (QTL) for 27 production, fitness, and conformation traits of Guernsey cattle through genome-wide association analyses, with a major QTL detected on BTA19 and the MYH10 gene within this region highly associated with milk production and body conformation traits. After fine mapping, only one significant SNP was found on BTA19 for most traits, with multiple independent significant SNPs identified for protein yield, dairy form, and stature. The haplotype hosting the major QTL on BTA19 was traced back to a US Guernsey born in 1954, indicating a long-term influence on the population.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Engineering, Environmental
Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Yung Hyun Choi, Sang Rul Park, Chang-Min Lee, Gi-Young Kim
Summary: This study reveals that BPA inhibits osteoblast differentiation and bone formation by activating ROR alpha, potentially causing bone-resorptive diseases such as osteoporosis.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Xiaoqian Yu, Xiaoqi Bian, Hongmei Zhang, Shanshan Yang, Daxin Cui, Zhiguang Su
Summary: Liraglutide has been shown to improve hepatic steatosis in clinical practice, and this study reveals that the ameliorating effect may be dependent on the activity of RORa. Through experiments with mouse models and hepatocyte models, it was found that RORa plays a key role in the effect of liraglutide on hepatic lipid deposition.
Article
Pharmacology & Pharmacy
Silvia G. Inderbinen, Manuel Kley, Michael Zogg, Manuel Sellner, Andre Fischer, Jacek Kedzierski, Stephanie Boudon, Anton M. Jetten, Martin Smiesko, Alex Odermatt
Summary: ROR gamma t is a key protein that regulates immune responses, and impaired function may contribute to inflammatory and autoimmune diseases and promote skin cancer. Certain chemicals commonly used in cosmetics and body care products have been found to activate ROR gamma t and potentially worsen skin diseases. Further research is needed to assess the concentrations of these compounds in tissues and target cells, and their significance in activating ROR gamma t.
Article
Agriculture, Dairy & Animal Science
Ki Yong Chung, Jongkyoo Kim, Bradley J. Johnson
Summary: The study aimed to investigate the impact of all-trans retinoic acid (ATRA) on the regulation of adipogenesis-related genes in bovine intramuscular (IM) and subcutaneous (SC) adipose cells during differentiation. Results indicated that increasing levels of ATRA might block adipogenic differentiation via transcriptional regulation of PPAR gamma. The expression of PPAR gamma was decreased with the addition of ATRA in bovine IM cells and tended to be downregulated in high levels of ATRA treatment in SC cells.
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Estela Fernandez-Alegre, Estibaliz Lacalle, Cristina Soriano-Ubeda, Jose Ramiro Gonzalez-Montana, Juan Carlos Dominguez, Adriana Casao, Felipe Martinez-Pastor
Summary: Melatonin plays an important role in reproduction through its antioxidant, hormonal, and paracrine actions. The membrane receptors MT1/MT2 have been found on spermatozoa from bull and red deer, with different functions. MT1 is related to sperm viability preservation in bull, while MT2 could modulate cell functionality to prevent excess ROS produced by mitochondria. In red deer, the resistance to melatonin and receptor activation may be due to the high circulating melatonin levels during the breeding season, but the receptors could still be involved in mitochondrial protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Perrine Pegorier, Morgane Bertignac, Viviane Nguefack Ngoune, Geraldine Folch, Joumana Jabado-Michaloud, Veronique Giudicelli, Patrice Duroux, Marie-Paule Lefranc, Sofia Kossida
Summary: The adaptive immune response allows vertebrates to recognize and remember specific pathogens, generate immunity, and mount stronger attacks each time the pathogen is encountered; T cell receptors are antigen receptors of the adaptive immune response, with αβ and γδ two groups with similarities but also differences in gene loci.
Article
Food Science & Technology
Felipe C. Maciel, Otavio R. Machado Neto, Marcio S. Duarte, Min Du, Josiane Fonseca Lage, Priscilla D. Teixeira, Cyntia L. Martins, Edmilson H. R. Domingues, Luiz A. Fogaca, Marcio M. Ladeira
Summary: The study found that administering vitamin A to cattle at birth can increase intramuscular fat content and upregulate the expression of certain genes related to fat metabolism, potentially enhancing carcass marbling without affecting animal performance.
Article
Food Science & Technology
Xiaoxiao Yu, Yannan Ma, Yanhui Luo, Gaojian Tang, Zongyou Jiang, Jiashan Zhang, Boping Ye, Zhongzuo Huang, Yicheng Luo, Min Du, Bo Wang
Summary: Vitamin A promotes beef marbling fat development by increasing intramuscular adipose progenitors without affecting overall fatness. Retinoic acid enhances capillary development and adipogenesis of stromal vascular cells, but inhibits lipid accumulation during terminal adipogenesis.
Article
Physiology
Kaidi Jin, Qianqian Jin, Zhongqiang Cai, Baoyu Huang, Lei Wei, Meiwei Zhang, Wen Guo, Yaqiong Liu, Xiaotong Wang
Summary: Recent studies reveal that retinoic acid receptors have a higher expression level in mollusks, potentially playing a role in development and metabolism. After injection with retinoic acid, both receptors showed elevated expression levels, indicating a potential regulatory mechanism in mollusks. Additionally, the receptors can interact to form a heterodimer complex, suggesting a conserved function in signaling pathways.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Aneet Kour, Sitangsu Mohan Deb, Nilesh Nayee, Varinder Singh Raina, Vandana Yadav, Saket Kumar Niranjan
Summary: This study identified potential genetic variants and QTLs associated with clinical mastitis in Bos indicus breed, Sahiwal. By analyzing estimated breeding values and genome-wide SNPs, a total of 25 SNPs and 16 QTLs were found, with several novel QTLs identified. Important candidate genes for clinical mastitis were also highlighted, offering potential regions for future fine mapping and downstream analysis.
Article
Chemistry, Medicinal
Zheming Ruan, Peter K. Park, Donna Wei, Ashok Purandare, Honghe Wan, Daniel O'Malley, Sylwia Stachura, Heidi Perez, Cullen L. Cavallaro, Carolyn A. Weigelt, John S. Sack, Max Ruzanov, Javed Khan, Murali Gururajan, Jessica J. Wong, Yanling Huang, Melissa Yarde, Zhuyin Li, Cliff Chen, Huadong Sun, Virna Borowski, Jenny H. Xie, Monique Anthony, Michele Agler, Brian E. Fink, Lalgudi S. Harikrishnan
Summary: The discovery of a series of substituted diarylether compounds as agonists of retinoic acid related orphan receptor gamma t (RORγ t) is described. While potent and selective compound 22 with improved pharmacokinetic properties was identified, no evidence of efficacy was observed in an animal tumor model.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Cell Biology
Jia Duan, Qiufeng Liu, Qingning Yuan, Yujie Ji, Shengnan Zhu, Yangxia Tan, Xinheng He, Youwei Xu, Jingjing Shi, Xi Cheng, Hualiang Jiang, H. Eric Xu, Yi Jiang
Summary: This study reports the cryo-electron microscopy structure of GPR35 coupled with G(13) and bound to the anti-allergic drug lodoxamide. The structure reveals a novel divalent cation coordination site and a unique ionic regulatory mode of GPR35, providing insights into its ligand binding promiscuity. Structural comparison with other G protein subtypes-coupled GPCRs highlights significant movements in the G alpha(13) subunit and the GPR35 TM6 helix.
Article
Gastroenterology & Hepatology
Vu L. Ngo, Zhenda Shi, Baoming Jiang, Andrew T. Gewirtz
Summary: Prevention of RV infection by gut-resident SFB is mediated by the generation of RA, which activates RAR signaling and enhances enterocyte migration to impede RV infection.
Article
Agriculture, Dairy & Animal Science
Zhi Cao, Maodou Xu, Shangzong Qi, Xinlei Xu, Wei Liu, Linyu Liu, Qiang Bao, Yang Zhang, Qi Xu, Wenming Zhao, Guohong Chen
Summary: This study investigated the lipid composition and metabolic pathways of goose meat, revealing changes in intramuscular fat deposition and lipid composition with age. Glyceride molecules showed significant changes and played a pivotal role in intramuscular fat deposition. Pathway analysis identified glycerophospholipid and glyceride metabolism as the most significant pathways associated with lipid changes during goose growth.
Meeting Abstract
Agriculture, Dairy & Animal Science
Q. Nguyen, R. L. Tellam, J. Kijas, W. Barendse, B. P. Dalrymple
JOURNAL OF ANIMAL SCIENCE
(2016)
Article
Agriculture, Dairy & Animal Science
W. Barendse
ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 5
(2017)
Article
Agriculture, Dairy & Animal Science
M. R. S. Fortes, K. Kemper, S. Sasazaki, A. Reverter, J. E. Pryce, W. Barendse, R. Bunch, R. McCulloch, B. Harrison, S. Bolormaa, Y. D. Zhang, R. J. Hawken, M. E. Goddard, S. A. Lehnert
Article
Fisheries
Melony J. Sellars, Leanne Dierens, Sean McWilliam, Bryce Little, Brian Murphy, Greg J. Coman, William Barendse, John Henshall
AQUACULTURE RESEARCH
(2014)
Article
Genetics & Heredity
Russell E. Lyons, Nguyen To Loan, Leanne Dierens, Marina R. S. Fortes, Matthew Kelly, Sean S. McWilliam, Yutao Li, Rowan J. Bunch, Blair E. Harrison, William Barendse, Sigrid A. Lehnert, Stephen S. Moore
Article
Agriculture, Dairy & Animal Science
Y. Ramayo-Caldas, M. R. S. Fortes, N. J. Hudson, L. R. Porto-Neto, S. Bolormaa, W. Barendse, M. Kelly, S. S. Moore, M. E. Goddard, S. A. Lehnert, A. Reverter
JOURNAL OF ANIMAL SCIENCE
(2014)
Article
Biochemistry & Molecular Biology
Anders Goncalves da Silva, William Barendse, James W. Kijas, Wes C. Barris, Sean McWilliam, Rowan J. Bunch, Russell McCullough, Blair Harrison, A. Rus Hoelzel, Phillip R. England
MOLECULAR ECOLOGY RESOURCES
(2015)
Article
Multidisciplinary Sciences
Michael P. Heaton, Theodore S. Kalbfleisch, Dustin T. Petrik, Barry Simpson, James W. Kijas, Michael L. Clawson, Carol G. Chitko-McKown, Gregory P. Harhay, Kreg A. Leymaster
Article
Multidisciplinary Sciences
Michael P. Heaton, Kreg A. Leymaster, Theodore S. Kalbfleisch, James W. Kijas, Shannon M. Clarke, John McEwan, Jillian F. Maddox, Veronica Basnayake, Dustin T. Petrik, Barry Simpson, Timothy P. L. Smith, Carol G. Chitko-McKown
Article
Multidisciplinary Sciences
Maria-Ines Fariello, Bertrand Servin, Gwenola Tosser-Klopp, Rachel Rupp, Carole Moreno, Magali San Cristobal, Simon Boitard
Article
Multidisciplinary Sciences
Laercio R. Porto-Neto, Antonio Reverter, Kishore C. Prayaga, Eva K. F. Chan, David J. Johnston, Rachel J. Hawken, Geoffry Fordyce, Jose Fernando Garcia, Tad S. Sonstegard, Sunduimijid Bolormaa, Michael E. Goddard, Heather M. Burrow, John M. Henshall, Sigrid A. Lehnert, William Barendse
Article
Agriculture, Dairy & Animal Science
William Barendse
ANIMAL PRODUCTION SCIENCE
(2014)
Article
Genetics & Heredity
Sunduimijid Bolormaa, Jennie E. Pryce, Antonio Reverter, Yuandan Zhang, William Barendse, Kathryn Kemper, Bruce Tier, Keith Savin, Ben J. Hayes, Michael E. Goddard
Article
Agriculture, Dairy & Animal Science
Laercio R. Porto-Neto, William Barendse, John M. Henshall, Sean M. McWilliam, Sigrid A. Lehnert, Antonio Reverter
GENETICS SELECTION EVOLUTION
(2015)
Article
Agriculture, Dairy & Animal Science
Sunduimijid Bolormaa, Jennie E. Pryce, Yuandan Zhang, Antonio Reverter, William Barendse, Ben J. Hayes, Michael E. Goddard
GENETICS SELECTION EVOLUTION
(2015)