Article
Nutrition & Dietetics
Joana Erica Lima Rocha, Mariely Mendes Furtado, Renato Sampaio Mello Neto, Ana Victoria da Silva Mendes, Ana Karolinne da Silva Brito, Jose Otavio Carvalho Sena de Almeida, Emerson Iuri Rodrigues Queiroz, Jose Vinicius de Sousa Franca, Maisa Guimaraes Silva Primo, Ana Lina de Carvalho Cunha Sales, Andreanne Gomes Vasconcelos, Wanessa Felix Cabral, Selma Aparecida Souza Kuckelhaus, Jose Roberto de Souza de Almeida Leite, Ana Karina Marques Fortes Lustosa, Massimo Lucarini, Alessandra Durazzo, Daniel Dias Rufino Arcanjo, Maria do Carmo de Carvalho e Martins
Summary: This study evaluated the effects of fish oil supplementation on rats with hypercholesterolemia induced by a high cholesterol diet. It found that fish oil supplementation can reduce plasma and hepatic triglyceride concentrations and alleviate liver damage.
Article
Environmental Sciences
Javad Seyedi, Mohammad Behzadi Tayemeh, Milad Esmaeilbeigi, Hamid Salari Joo, Elnaz Keshtkar Langeroudi, Ashkan Banan, Seyed Ali Johari, Mohammad Javad Jami
Summary: This research evaluated the antioxidant capability of quercetin against silver nanoparticles toxicity towards the lipid contents of ovarian, nervous, and hepatic systems as well as skeletal muscles. The findings suggest that unsaturated acyl chains, particularly HUFAs, in the liver tissue and oocyte cell are highly susceptible to peroxidation or degeneration by AgNPs. The alteration in HUFAs and PUFAs of the liver and oocyte could impact on maternal and offspring health and consequently alter long-term population dynamics of aquatic animals.
ENVIRONMENTAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mosaad A. Abdel-Wahhab, Aziza A. El-Nekeety, Hagar E. Mohammed, Tamer M. El-Messery, Mohamed H. Roby, Sekena H. Abdel-Aziem, Nabila S. Hassan
Summary: Fish oil has beneficial effects on human health, but faces challenges such as organoleptic properties of food and susceptibility to oxidation. Titanium dioxide NPs are widely used in pharmaceutical and food applications, but may cause oxidative damage to living organisms. Encapsulated mullet fish oil (EMFO) shows a strong antioxidant role against oxidative damage and genotoxicity of TiO2-NPs.
Article
Food Science & Technology
Zahra Hossein Zadeh, Ebrahim H. Najdegerami, Mehdi Niko, Vahid Nejati, Hassan Ahmadi Gavlighi
Summary: This study found that GT oligosaccharides have an impact on the weight and liver weight of NAFLD-induced rats. In addition, the use of GT oligosaccharides significantly reduced oxidative stress, liver injury, and hyperglycemia in NAFLD-induced rats, and upregulated the expression of autophagy genes.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Brenda Barcena, Aurora Salamanca, Cristina Pintado, Lorena Mazuecos, Margarita Villar, Eduardo Molto, Elena Bonzon-Kulichenko, Jesus Vazquez, Antonio Andres, Nilda Gallardo
Summary: Aging is a universal and irreversible process that results in loss of adaptability. Prolonged fasting has a significant impact on lipid peroxidation in the liver of old rats, associated with downregulation of antioxidant genes and alterations in RNA splicing at the nuclear proteome level.
Article
Food Science & Technology
Vinicius Tejada Nunes, Itamar Luis Goncalves, Patricia Martinez Oliveira, Denise Lima Feksa, Silvia Muller de Moura Sarmento, Genifer Erminda Schreiner, Clovis Klock, Charline Casanova Petry, Jacqueline da Costa Escobar Piccoli, Vanusa Manfredini, Cristiane Casagrande Denardin
Summary: This study examined the effects of pummelo extract on NAFLD rats, specifically looking at biochemical, inflammatory, antioxidant, and histological changes. The results showed significant improvement in lipid profile, liver and kidney function, inflammation, and oxidative stress markers in the group administered pummelo extract. The study suggests that pummelo extract could be beneficial in preventing the development of NAFLD.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Lidia V. Kravchenko, Ilya V. Aksenov, Nikolay S. Nikitin, Galina V. Guseva, Ludmila I. Avrenyeva, Nikita V. Trusov, Anastasia S. Balakina, Victor A. Tutelyan
Summary: The study shows that alpha-lipoic acid can reduce visceral adipose tissue/body weight ratio, increase liver antioxidant enzyme activity, and prevent lipid accumulation in the liver. However, under a high-calorie choline-deficient diet, alpha-lipoic acid exacerbates oxidative stress and lipid accumulation in the liver.
Article
Nutrition & Dietetics
Wei Jiang, Fu-Rong Li, Huan-Huan Yang, Guo-Chong Chen, Yong-Fei Hua
Summary: Regular use of fish oil supplements was found to significantly lower the risk of liver cancer, including both HCC and ICC. Higher intake of oily fish was also associated with a lower risk of HCC.
FRONTIERS IN NUTRITION
(2021)
Article
Environmental Sciences
Shimaa S. Khaled, Mohammed A. Abdel-Gabbar, Hanan Soliman, Noha A. Ahmed, El-Shaymaa El-Nahass, Osama M. Ahmed
Summary: This study aimed to evaluate the preventive effects of naringin, naringenin, and their combination on liver injury induced by Taxol in Wistar rats. Treatment with naringin and/or naringenin reduced the abnormal levels of liver function markers and improved liver histological changes in Taxol-treated rats. The treatments also decreased hepatic lipid peroxidation and increased antioxidant enzyme activities. The naringin and naringenin mixture appeared to be more effective in improving organ function and structural integrity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xianyang Chen, Wangting Song, Yige Song, Hongli Cao, Xiao Xu, Shujia Li, Yanmin Fu, Teng Xue, Chunguang Ding, Feng Lin, Yuan Shi, Jiujun Li
Summary: In this study, continuous intake of Acer truncatum Bunge seed oil (ASO) for 30 days was found to reduce brain damage and improve cognitive ability in rats with hypoxic-ischemic encephalopathy (HIE). Lipidomic analysis showed that HIE rats had decreased unsaturated fatty acids and increased lysophospholipids in the brain, while ASO treatment increased phospholipids, plasmalogens, and unsaturated fatty acids, and decreased lysophospholipids and oxidized glycerophospholipids in both serum and the brain. Enrichment analysis revealed that ASO intake mainly affected sphingolipid metabolism, fat digestion and absorption, glycerolipid metabolism, and glycerophospholipid metabolic pathways. Cognitive improvement after ASO administration was attributed to increased essential phospholipids and omega 3/6/9 fatty acids, coupled with decreased oxidized glycerophospholipids in HIE rats. These findings suggest that ASO has the potential to be developed as an effective food supplement for newborns with ischemic hypoxia.
Article
Food Science & Technology
Ivonne Peugnet-Gonzalez, Sandra Luz Martinez-Hernandez, Manuel Enrique Avila-Blanco, David Alejandro Hernandez-Marin, Jose Roberto Macias-Perez, Liseth Rubi Aldaba-Muruato, Teodulo Quezada-Tristan, Joaquin Sosa-Ramirez, Gloria Stephanie Villa-Jaimes, Javier Ventura-Juarez, Martin Munoz-Ortega, David Ibarra-Martinez
Summary: The study found that watercress extract can prevent liver fibrosis induced by CCl4 through its antioxidant and hepatoprotective effects. Watercress extract can improve steatosis and fibrosis, increase IL-10 expression, and regulate the expression of fibrogenic markers.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Shahid Karim, Batoul Madani, Abdulhadi S. Burzangi, Mohammed Alsieni, Mohammed A. Bazuhair, Maha Jamal, Hussam Daghistani, Mohammed O. Barasheed, Huda Alkreathy, Mohammad Ahmed Khan, Lateef M. Khan
Summary: Human colon microbiota produces a metabolite called urolithin A (URO A) with antioxidant, anti-inflammatory, and anti-apoptotic activities. This study investigates the protective effects of URO A against doxorubicin-induced liver injury in Wistar rats. The results show that URO A supplementation reduces liver damage by reducing oxidative stress, inflammation, and apoptosis.
Article
Chemistry, Medicinal
Seerat Mehdi, Fiaz-ud-Din Ahmad, Arslan Hussain Lodhi, Umair Khurshid, Ahmed Awais Khalid, Sheikh Safeena Sidiq, Liaqat Hussain, Mirza Shaharyar Baig
Summary: The study found that p-coumaric acid has anti-inflammatory and antioxidant potential against liver injury. It can regulate immune responses, liver function enzymes, lipid profile, oxidative stress, and pro-inflammatory markers to improve LPS/D-GalN-induced liver injury.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jessica Rosso Motta, Ivo Emilio da Cruz Jung, Veronica Farina Azzolin, Cibele Ferreira Teixeira, Luiza Elizabete Braun, Daniel Augusto De Oliveira Nerys, Marco Aurelio Echart Motano, Marta Maria Medeiros Frescura Duarte, Ednea Aguiar Maia-Ribeiro, Ivana Beatrice Manica da Cruz, Fernanda Barbisan
Summary: The study suggests that inadequate omega-3 levels in the brain may increase the risk of neuropsychiatric disorders, while avocado oil as a dietary supplement may attenuate the oxidative stress and apoptosis induced by chronic cortisol exposure.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Branko Ravic, Jasmina Debeljak-Martacic, Biljana Pokimica, Nevena Vidovic, Slavica Rankovic, Marija Glibetic, Predrag Stepanovic, Tamara Popovic
Summary: The study aimed to investigate the potential benefits of a fish-based diet on police dogs undergoing intensive training. The results showed that the diet enriched with marine fish improved the biochemical profiles and oxidative status of the dogs.
Review
Pharmacology & Pharmacy
Einar S. Bjoernsson, Vesna Vucic, Guido Stirnimann, Mercedes Robles-Diaz
Summary: Corticosteroid therapy has shown beneficial effects in moderate/severe drug-induced liver injuries (DILI) and drug-induced autoimmune hepatitis (DI-AIH), but not in drug-induced fulminant acute liver failure (ALF). The majority of patients with CPIs-induced liver injury responded to corticosteroids, although spontaneous recovery is common without treatment. Randomized controlled trials are needed to properly assess the role of corticosteroids in DILI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Veterinary Sciences
Svetlana Nedic, Miloje Duric, Slobodanka Vakanjac, Sveta Arsic, Sreten Nedic, Marko Samardzija, Suncica Borozan
Summary: The aim of this study was to investigate the biochemical components and antioxidant protection parameters in boar seminal plasma (SP) and their relationship with semen quality. The study found that good quality semen had higher levels of ionized calcium, total cholesterol, lactate dehydrogenase activity, thiol groups, paraoxonase 1, and total antioxidant capacity, while poor quality semen had higher phosphorus concentrations and alkaline phosphatase activity. Various correlations were observed between these parameters and sperm motility and morphology. Elevated levels of paraoxonase 1 and total antioxidant capacity in SP were found to be potential biomarkers of boar semen quality. The association between paraoxonase 1 activity and boar semen quality has not been previously reported.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Andrea Pirkovic, Aleksandra Vilotic, Suncica Borozan, Mirjana Nacka-Aleksic, Zanka Bojic-Trbojevic, Milica Jovanovic Krivokuca, Maurizio Battino, Francesca Giampieri, Dragana Dekanski
Summary: The bioactive compound oleuropein derived from olives was evaluated for its effects on damage induced by hydrogen peroxide in human trophoblast cells in vitro. The study found that oleuropein had cytoprotective effects by improving antioxidant status, preventing protein and lipid damage, and reducing iNOS levels.
Article
Biochemistry & Molecular Biology
Rajna Minic, Aleksandra Arsic, Milica Kojadinovic, Aleksa Palibrk, Brizita Djordjevic, Zorica Stevic
Summary: The study identified significant differences in fatty acid composition in erythrocytes of ALS patients compared to healthy volunteers, suggesting metabolic disturbances in ALS. There were correlations between fatty acid levels and ALS disease assessment scores, as well as disease duration, providing important insights for potential interventions.
JOURNAL OF MEDICAL BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Vesna Vucic, Danijela Ristic-Medic, Aleksandra Arsic, Snjezana Petrovic, Marija Paunovic, Nadja Vasiljevic, Jasminka Z. Z. Ilich
Summary: Osteosarcopenic adiposity (OSA) syndrome, characterized by the deterioration of bone, muscle, and adipose tissue, remains poorly understood despite extensive research. This study aimed to evaluate the impact of dietary intake/nutritional status and physical activity on OSA through a review of human studies. After screening articles published in English and conducted on healthy individuals aged ≥18 years, a total of 23 studies were included. The findings suggest that higher intake of protein, calcium, potassium, and vitamins D and C, as well as a diet rich in fruits and low-fat dairy foods, may have a positive influence on OSA. Meanwhile, higher serum levels of vitamin D were associated with better OSA outcomes, while higher ferritin levels were linked to poorer outcomes. Resistance training was also found to be a beneficial intervention for older women with OSA.
Article
Biochemistry & Molecular Biology
Marija Paunovic, Jelena Kotur-Stevuljevic, Aleksandra Arsic, Maja Milosevic, Vanja Todorovic, Azra Guzonjic, Vesna Vucic, Snjezana Petrovic
Summary: A Western-style diet high in fat and simple sugars is a major risk factor for chronic diseases and metabolic syndrome. Consuming polyphenol-rich juices can help prevent oxidative stress caused by a high-fat high-fructose diet. These juices have shown to reduce oxidative stress parameters and provide protection mechanisms.
Article
Biochemistry & Molecular Biology
Radisa Prodanovic, Sreten Nedic, Ivan Vujanac, Jovan Bojkovski, Svetlana Nedic, Ljubomir Jovanovic, Danijela Kirovski, Suncica Borozan
Summary: Cows in the peripartal period experience changes in thyroid hormones and are vulnerable to lipomobilization and oxidative stress. The addition of chestnut tannins in the diet may improve feed efficiency and prevent oxidative stress-related health issues. This study examined the effects of chestnut tannin supplementation during the close-up period on thyroid status and the interaction between thyroid hormones and oxidative stress biomarkers in prepartum dairy cows.
Article
Pharmacology & Pharmacy
Sasa R. Ivanovic, Nevena Borozan, Dejana Cupic MIladinovic, Irena Zivkovic, Suncica Borozan
Summary: This study aims to investigate the correlation between cholinesterase activity and oxidative stress parameters in the liver and diaphragm during prolonged use of diazinon. Wistar rats were treated with diazinon for different periods of time and the activity of cholinesterase and oxidative stress parameters were examined. The results showed significant changes in cholinesterase activity and oxidative stress parameters in the liver and diaphragm during the cholinergic crisis and outside the crisis.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Oncology
Romana Masnikosa, David Piric, Julia Maria Post, Zorica Cvetkovic, Snjezana Petrovic, Marija Paunovic, Vesna Vucic, Laura Bindila
Summary: DLBCL is the most common hematological malignancy worldwide. In our study, we observed differential lipid profiles in treatment-naive female patients with DLBCL and disease-free controls. We suggest here S1P, SM 36:1, SM 34:1, and PI 34:1 as DLBCL lipid signatures for further validation in larger DLBCL cohorts.
Article
Chemistry, Medicinal
Goran Bokan, Tanja Glamocanin, Zoran Mavija, Bojana Vidovic, Ana Stojanovic, Einar S. Bjornsson, Vesna Vucic
Summary: Herb-induced liver injury (HILI) caused by ashwagandha supplements is an important concern, as there have been reported cases of liver injury and even liver transplantation associated with its use. This paper reviews all reported cases and presents two new cases of ashwagandha hepatotoxicity. The findings show a probable relationship between ashwagandha and liver injury, emphasizing the need for caution when consuming ashwagandha supplements.
Article
Chemistry, Multidisciplinary
Katarina M. Rajkovic, Milica Drobac, Petar Milic, Vesna Vucic, Aleksandra Arsic, Mirijana Peric, Milena Radunovic, Sanja Jeremic, Jelena Arsenijevic
Summary: This study aimed to characterize the chemical composition of black walnut nut and green husk extracts and evaluate their antimicrobial activities. The results showed that both nut and green husk extracts contained biologically active compounds with potential antifungal properties.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Katarina M. Rajkovic, Milica Drobac, Petar Milic, Vesna Vucic, Aleksandra Arsic, Mirijana Peric, Milena Radunovic, Sanja Jeremic, Jelena Arsenijevic
Summary: The study found that ellagic acid is the main compound in black walnut, and the ethanol extracts of black walnut have antimicrobial activity against Candida albicans.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2023)
Article
Medicine, General & Internal
Danijela Ristic-Medic, Snjezana Petrovic, Marija Takic, Vesna Vucic, Aleksandra Arsic, Slavica Raden, Marija Glibetic
Summary: This study aimed to investigate the effects of a lipid-lowering diet on key fatty acid ratios and omega-3 index in moderately hyperlipidemic subjects. The results showed that the lipid-lowering diet resulted in decreased key fatty acid ratios, increased omega-3 levels, and improved insulin sensitivity.
ACTA CLINICA CROATICA
(2022)
