Review
Pharmacology & Pharmacy
Nick J. Spencer, Damien J. Keating
Summary: This article discusses the recent findings regarding the functional role of endogenous 5-HT in enterochromaffin cells and enteric neurons in gut motility and other major homeostatic pathways. The advancements in recording techniques and access to genetically modified animals have led to significant changes in our understanding of the role of gut-derived 5-HT. Experimental data suggests that the major patterns of GI motility and transit still occur even without endogenous 5-HT, and 5-HT3 receptor antagonists are more potent in inhibiting GI motility in segments lacking endogenous 5-HT.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Minjie Wan, Zhanchuan Ma, Jiawen Han, Min Rao, Feng Hu, Pujun Gao, Xiaocong Wang
Summary: The 5-HT/5-HT7R signaling pathway helps to constrain inflammation through functional Bregs in ulcerative colitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Electrochemistry
Martin Perez-Estebanez, William Cheuquepan, Jose V. Cuevas-Vicario, Sheila Hernandez, Aranzazu Heras, Alvaro Colina
Summary: Time Resolved Raman spectroelectrochemistry (TR-Raman-SEC) was used for the first time to obtain two different Raman spectra of one single analyte in the same experiment, by combining electrochemical surface enhanced Raman scattering (EC-SERS) and electrochemical surface oxidation enhanced Raman scattering (EC-SOERS). This double detection method provides a broad insight into the interaction between analyte and substrate surface.
ELECTROCHIMICA ACTA
(2021)
Article
Medicine, Research & Experimental
I Erkizia-Santamaria, R. Alles-Pascual, I Horrillo, J. J. Meana, J. E. Ortega
Summary: The study found that psilocin showed similar affinities for 5HT2AR, 5HT2CR, and 5HT1AR in both human and mice brain. Psilocybin induced a dose-dependent head-twitch response (HTR) and affected body temperature, which were both mediated by 5HT2AR, 5HT2CR, and 5HT1AR. These findings provide key insights into the mechanism of action of psilocybin and its therapeutic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Jiaqi Jin, Fan Xu, Yi Zhang, Jing Guan, Xiurui Liang, Yuxin Zhang, Ansheng Yuan, Runkun Liu, Jihua Fu
Summary: This study investigated the relationship between RIRI and the activation of the renal 5-HT degradation system, revealing that inhibiting 5-HT2AR and 5-HT synthases can alleviate RIRI-induced damage, highlighting the involvement of 5-HT2AR in this process.
Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Gui Yang, Gaohui Wu, Wenkai Yao, Li Guan, Xiaorui Geng, Jiangqi Liu, Zhiqiang Liu, Liteng Yang, Qinmiao Huang, Xianhai Zeng, Pingchang Yang
Summary: This study reveals that patients with perennial allergic rhinitis have higher concentrations of 5-HT in their serum. 5-HT can enhance the expression of IL-6 and IL-21 in dendritic cells, leading to the conversion of Tregs to Th17 cells.
CLINICAL IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sahika Guner, Tamila Akhayeva, Charles D. Nichols, Hakan Gurdal
Summary: The interaction between serotonin receptors and epidermal growth factor receptors (EGFR) was investigated in this study, with a focus on their role in vascular constriction. It was found that EGFR, Src, and PI3K play a role in serotonin-induced vasoconstriction, especially in the mesenteric artery. The upstream mediators of EGFR transactivation by serotonin were identified as Ca2+/CaM, Src, and PI3K, with Erk1/2 and Akt activation playing a partial role. Furthermore, different subtypes of serotonin receptors (5-HT2A and 5-HT1B) have varying effects on EGFR transactivation through Src and/or PI3K, with 5-HT2A having a greater impact than 5-HT1B receptors.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bernd Frerker, Felix Bock, Marie-Louise Cappel, Stephan Kriesen, Gunther Klautke, Guido Hildebrandt, Katrin Manda
Summary: In this study, the enhanced effects of oxaliplatin and irinotecan, alone and in combination with 5-FU, when treated with ionizing radiation were tested. Comparison of the two combination therapies showed no superiority of either regimen. Our results support the use of FOLFIRI as a radiosensitizer for metastatic colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Haiying Zhao, Shunxin Chen, Kaizhao Hu, Zhifei Zhang, Xiaoru Yan, Huijie Gao, Wei Du, Huiling Zheng
Summary: The study revealed that 5-HTP reduced GMEC apoptosis by activating the ERK1/2 signaling pathway. Additionally, both 5-HTP and ERK1/2 positively regulated Bcl-3 expression.
Article
Pharmacology & Pharmacy
Yu-Xin Zhang, Chen Li, Xiu-Rui Liang, Jia-Qi Jin, Yi Zhang, Fan Xu, Jing Guan, Ying-Ying Ma, Xiao-Nan Ma, Run-Kun Liu, Ji-Hua Fu
Summary: 5-hydroxytryptamine (5-HT) is involved in the pathological processes of several liver diseases, particularly acute liver injury induced by carbon tetrachloride (CCl4). The study showed that the expression of 5-HT2A receptor, 5-HT synthetase, and MAO-A in hepatocytes is upregulated by CCl4, leading to increased degradation of mitochondrial 5-HT and overproduction of reactive oxygen species (ROS). This may contribute to the development of acute liver injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Qiyi You, Qijun Li, Liyuan Lv, Zhihua Lin, Yinghui Dong, Hanhan Yao
Summary: Serotonin is a crucial substance in the gastrointestinal and central nervous systems, and its functions are regulated by binding to 5-HT receptors. This study identified and analyzed seven 5-HTR genes in Sinonovacula constricta, providing insights into their expression patterns and potential influences.
Article
Psychiatry
Jan Terock, Antoine Weihs, Alexander Teumer, Johanna Klinger-Koenig, Deborah Janowitz, Hans J. Grabe
Summary: Previous studies have suggested a connection between childhood trauma, serotonergic neurotransmission, and alexithymia. The study found that childhood trauma and the rs6295 polymorphism have a significant interaction effect on alexithymia in male subjects.
PSYCHIATRY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yi Jiang, Jie Zhou, Bai-Lin Song, Yan Wang, Dong-Lin Zhang, Zheng-Tian Zhang, Lai-Fu Li, Ying-Juan Liu
Summary: Social animals self-organize into dominance hierarchies, influenced by the serotonin system in the amygdala. This study explores the role of different 5-HT receptor subtypes in social rank determination and reveals their involvement in the formation and modulation of social hierarchy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Rashid Giniatullin
Summary: 5-hydroxytryptamine (5-HT) is considered a key mediator in migraine, but the role of 5-HT3 receptors in pain transmission remains controversial. The applicability of currently available 5-HT3 antagonists in migraine treatment is not clearly supported by clinical data.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)