Article
Genetics & Heredity
Byung Woo Yoon, Hyun-Tae Shin, Je Hyun Seo
Summary: This study provides insights into the genetic differences in prostate cancer incidence among different ethnicities, using data on single-nucleotide polymorphisms associated with prostate cancer. The study reveals that the polygenic risk score, as well as certain genes such as AR, CDKN1B, and MAD1L1, are associated with ethnic differences in prostate cancer.
Article
Biology
Atsushi Zoda, Shinichiro Ogawa, Rino Kagawa, Hayato Tsukahara, Rui Obinata, Manami Urakawa, Yoshio Oono
Summary: We evaluated the performance of single-step genomic prediction for breeding values of superovulatory response traits in Japanese Black donor cows. Records of 25,332 embryos and oocytes and genotype information on 36,426 SNPs were collected. The estimated heritabilities and genetic correlations differed when using pedigree information versus a combination of pedigree and SNP marker genotype information. Using the single-step genomic prediction showed potential for improving the rate of genetic improvement, but it is important to maintain genetic diversity during selection.
Article
Genetics & Heredity
Byung-Woo Yoon, Hyun-Tae Shin, Jehyun Seo
Summary: This study provides insights into the genetic causes of differences in vitamin D concentrations among individuals of diverse ancestries. The analysis reveals distinct genetic patterns among different populations, with the genetic risk score for vitamin D concentration highest in Europeans followed by East Asians and Africans. The study suggests that genetic factors play a more significant role in vitamin D concentration differences than latitude effects.
Article
Biology
M. Z. Trujano-Chavez, J. E. Valerio-Hernandez, R. Lopez-Ordaz, A. Ruiz-Flores
Summary: The research compared the effect of different minor allele frequency thresholds during the quality control process of genotypes on the prediction of genomic values, and found that in small populations, a minor allele frequency between 0.0 and 0.05 does not significantly impact genomic value prediction. Additionally, the prediction ability model remained consistent throughout the study.
REVISTA BIO CIENCIAS
(2021)
Article
Chemistry, Analytical
Qidi He, Ou Hu, Meng Chen, Zhixian Liang, Lushan Liang, Zuanguang Chen
Summary: A novel AS-PCR method for multiple SNP genotyping in a single run was proposed, which showed high sensitivity and low cost. It is suitable for genotyping multiple genes and has great potential for wide applications in personalized health management.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemical Research Methods
Ying Li, Xiao-Ou Zhang, Yan Liu, Aiping Lu
Summary: ASB-analyzer is a user-friendly tool for detecting, characterizing, and visualizing ASB SNPs. It is implemented in Python, R, and bash shell and packaged in the Conda environment. It is available as an open-source tool on GitHub at https://github.com/Liying1996/ASBanalyzer.
BMC BIOINFORMATICS
(2023)
Article
Biotechnology & Applied Microbiology
Sarah R. Oikemus, Edith L. Pfister, Ellen Sapp, Kathryn O. Chase, Lori A. Kennington, Edward Hudgens, Rachael Miller, Lihua Julie Zhu, Akanksh Chaudhary, Eric O. Mick, Miguel Sena-Esteves, Scot A. Wolfe, Marian DiFiglia, Neil Aronin, Michael H. Brodsky
Summary: Huntington's disease is a neurodegenerative disease caused by a trinucleotide repeat expansion in the huntingtin gene. Inactivation of the mutant allele using CRISPR-Cas9 gene editing offers a potential therapeutic approach, and targeting a protein coding sequence containing a single nucleotide polymorphism allows for allele-specific inactivation. This study successfully demonstrated allele-selective reduction of mutant huntingtin protein in a mouse model of the disease.
HUMAN GENE THERAPY
(2022)
Article
Genetics & Heredity
Hyun-Tae Shin, Byung Woo Yoon, Je Hyun Seo
Summary: Differences in allele frequencies associated with intraocular pressure related SNPs between Koreans and other ethnicities were observed, which may explain the high prevalence of open-angle glaucoma with normal intraocular pressure predominantly in Koreans and East Asians.
BMC MEDICAL GENOMICS
(2021)
Article
Plant Sciences
Frank Maulana, Ramasamy Perumal, Desalegn D. Serba, Tesfaye Tesso
Summary: This study assessed the efficacy of using genomic information of parental genotypes to predict the performance of grain sorghum hybrids. The results suggest that genomic prediction could be an effective tool for predicting the performance of sorghum hybrids based on parental genotypes.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Matthew C. Fitzpatrick, Vikram E. Chhatre, Raju Y. Soolanayakanahally, Stephen R. Keller
Summary: The study evaluates the ability of genomic offsets derived from Gradient Forests to predict organismal responses to environmental change and explores the use of GF for identifying candidate SNPs. Results suggest that genetic offsets serve as a first order estimate of expected maladaptation of populations to rapid environmental change, and GF may have some promise as a method for identifying candidate SNPs. Additionally, populations with larger predicted genetic offsets performed worse in common garden experiments, indicating the potential utility of genetic offsets in predicting performance under changing environmental conditions.
MOLECULAR ECOLOGY RESOURCES
(2021)
Article
Endocrinology & Metabolism
Polina Popova, Alexandra A. Klyushina, Lyudmila B. Vasilyeva, Alexandra S. Tkachuk, Elena A. Vasukova, Anna D. Anopova, Evgenii A. Pustozerov, Inga Gorelova, Ekaterina N. Kravchuk, O. Li, Tatiana M. Pervunina, Anna A. Kostareva, Elena N. Grineva
Summary: Among 11 SNPs associated with T2D and/or GDM in other populations, significant association with GDM was confirmed for two variants in MTNR1B in Russian women. However, the value of these variants in identifying GDM cases was limited.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Yumeng Tian, Ping Li
Summary: This article reviews the research progress in the use of genetic risk score (GRS) in diabetes mellitus in recent years and discusses future prospects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Sho Okamura, Yuko Onohara, Hidenori Ochi, Takehito Tokuyama, Naoya Hironobe, Yosaku Okubo, Yoshihiro Ikeuchi, Shunsuke Miyauchi, Kazuaki Chayama, Yasuki Kihara, Yukiko Nakano
Summary: This study found that a mutation in the GJA1 gene is associated with rapid ventricular rate and may serve as a new genetic marker for atrial fibrillation tachycardia. Through genotyping of 311 patients with persistent AF and replication in 146 patients, the significant impact of GJA1 SNP on HR during AF was confirmed.
SCIENTIFIC REPORTS
(2021)
Article
Agronomy
Lorena G. Batista, Victor H. Mello, Anete P. Souza, Gabriel R. A. Margarido
Summary: Including allele dosage can improve genomic selection in highly polyploid species under higher frequency of different heterozygous genotypic classes and high dominance degree levels, as shown by leveraging allele dosage information to enhance accuracy of selection models beyond autotetraploids.
THEORETICAL AND APPLIED GENETICS
(2022)
Article
Health Care Sciences & Services
Yu-Ting Hsiao, Feng-Chih Shen, Shao-Wen Weng, Pei-Wen Wang, Yung-Jen Chen, Jong-Jer Lee
Summary: This study identified genetic determinants of increased risk of diabetic retinopathy (DR) in individuals with type 2 diabetes mellitus (T2DM), focusing on FTO (rs8050136) and PSMD6 (rs831571) genetic variations. By combining genetic and nongenetic risk factors, the predictive model showed improved accuracy in predicting DR risk, especially in patients with poor glycemic control or severe microalbuminuria.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Agronomy
Bilal Ashraf, Vahid Edriss, Deniz Akdemir, Enrique Autrique, David Bonnett, Jose Crossa, Luc Janss, Ravi Singh, Jean-Luc Jannink
Article
Multidisciplinary Sciences
Nanna Hellum Nielsen, Ahmed Jahoor, Due Jensen, Jihad Orabi, Fabio Cericola, Vahid Edriss, Just Jensen
Article
Agronomy
Nana Vagndorf, Nanna Hellum Nielsen, Vahid Edriss, Jeppe Reitan Andersen, Jihad Orabi, Lise Nistrup Jorgensen, Ahmed Jahoor
Article
Multidisciplinary Sciences
Hsin-Yuan Tsai, Fabio Cericola, Vahid Edriss, Jeppe Reitan Andersen, Jihad Orabiid, Jens Due Jensen, Ahmed Jahoor, Luc Janss, Just Jensen
Article
Agronomy
Vahid Edriss, Yanxin Gao, Xuecai Zhang, MacDonald Bright Jumbo, Dan Makumbi, Michael Scott Olsen, Jose Crossa, Kevin C. Packard, Jean-Luc Jannink
Article
Agriculture, Dairy & Animal Science
Vahid Edriss, Bernt Guldbrandtsen, Mogens S. Lund, Guosheng Su
ARCHIV FUR TIERZUCHT-ARCHIVES OF ANIMAL BREEDING
(2013)
Article
Agriculture, Dairy & Animal Science
Vahid Edriss, Rohan L. Fernando, Guosheng Su, Mogens S. Lund, Bernt Guldbrandtsen
GENETICS SELECTION EVOLUTION
(2013)
Article
Agriculture, Dairy & Animal Science
Mohammad Ali Edriss, Vahid Edriss, Hamid Reza Rahmani
ARCHIV FUR TIERZUCHT-ARCHIVES OF ANIMAL BREEDING
(2009)