Article
Neurosciences
Jie Chen, Sumei Liu, Xueqin Wang, Jufang Huang, Jade Phillips, Daqing Ma, Wen Ouyang, Jianbin Tong
Summary: The study investigates the impact of anesthesia and surgery on the connectivity and cognition of the medial prefrontal cortex-hippocampus in aged rats. HDAC6 overexpression is found to be associated with impaired connectivity and cognition. Local HDAC6 knockdown and systemic HDAC6 inhibition can improve learning and memory impairment in aged rats.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Immunology
Changliang Liu, Jiahui Wu, Ming Li, Rui Gao, Xueying Zhang, Shixin Ye-Lehmann, Jiangning Song, Tao Zhu, Chan Chen
Summary: This study found that elevated Smad7 in the hippocampal CA1 region can enhance neuroinflammation and apoptosis, leading to learning and memory impairment after surgery. Therefore, Smad7 may be a potential therapeutic target for the treatment of memory impairment after anesthesia surgery.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Qi Zhou, Zilei Zheng, Xupeng Wang, Wei Li, Luqi Wang, Chunping Yin, Qi Zhang, Qiujun Wang
Summary: Postoperative cognitive dysfunction (POCD) is a common complication of anesthesia or surgery, which can be induced by sevoflurane inhibiting the cholinergic pathway. Transauricular vagus nerve stimulation (taVNS) has been shown to have neuroprotective effects in rats with POCD, but the mechanisms related to the cholinergic system have not been fully revealed. In this study, sevoflurane-exposed rats showed cognitive impairment, which was attenuated by taVNS treatment. TaVNS treatment activated the cholinergic system, reduced apoptosis and necroptosis in the hippocampus, and decreased microglial activation caused by sevoflurane. However, blocking the cholinergic system inhibited the neuroprotection and anti-inflammation effects of taVNS in the hippocampus. Overall, taVNS may alleviate sevoflurane-induced hippocampal neuronal apoptosis, necroptosis, and microglial activation by activating the cholinergic system.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Junhua Li, Guiyun Wu, Wen Song, Yafang Liu, Zhixiao Han, Zhiwen Shen, Yujuan Li
Summary: The study indicated that melatonin improved propofol-induced memory impairment in aged rats. Melatonin mitigated mitochondrial dysfunction and decreased apoptotic cell counts in the regions of HIP and PFC. Moreover, prophylactic melatonin treatment reversed the propofol-induced inactivation of PKA/CREB/BDNF signaling and synaptic dysfunction.
NEUROTOXICITY RESEARCH
(2021)
Article
Rehabilitation
Matthew J. Miller, Rashelle M. Hoffman, Laura A. Swink, Deborah E. Barnes, Cory L. Christiansen
Summary: This study compared characteristics between middle-aged and older prosthesis users with and without cognitive impairment, and found that cognitive impairment is associated with differences in perceived physical function. Even after controlling for physiological and mental health differences, cognitive impairment remains related to worse perceived physical function.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Chemistry, Medicinal
Qing Li, Xianjie Zhang, Siyuan Li, Wen Li, Yunpeng Teng, Yukai Zhou, Hongfei Xiong
Summary: The study aimed to investigate the protective effects of Carnosol on postoperative cognitive dysfunction induced by Sevoflurane (SEV) in aged rats and explore the underlying mechanisms involving neuroinflammation, microglial activation, and neuronal apoptosis regulation.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Behavioral Sciences
Jin-Meng Lv, Li-Min Zhang, Jie-Xia Wang, Jing -Jing Shao, Xin-Gui Guo, Lu-Ying Wang, Li-Qing Kang, Wei-Chao Zheng, Yue Xin, Rong-Xin Song, Wei Guo, Dong-Xue Zhang
Summary: In this study, elderly rats exposed to abdominal surgery exhibited cognitive dysfunction and emotional changes, which may be associated with neuronal degeneration and reduced phosphorylated P38MAPK.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Behavioral Sciences
Lifeng Wang, Guanfa Peng, Li Chen, Mingling Guo, Bingyu Wang, Yunmeng Zhang, Jianshun Zhou, Maolin Zhong, Junming Ye
Summary: This study found that Icariin (ICA) has neuroprotective effects in a postoperative cognitive dysfunction (POCD) rat model, and these effects may be associated with the inhibition of hippocampal neuroinflammation. Therefore, ICA could be a potential therapeutic target and method for treating POCD.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Qi Tang, Qiang Guo, Ke Li, Fan Fei
Summary: This study found that VRT-043198 can improve PND in aged mice after abdominal exploratory laparotomy by restoring the expression of NGF and BDNF.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Biochemistry & Molecular Biology
Lidan Liu, Xin Zhang, Cong Wang, Xiuying Wu, Bo Long
Summary: This study aimed to investigate the effects of hypercholesterolemia on sevoflurane-induced cognitive impairment in aged rats. The results showed that hypercholesterolemia aggravated the cognitive impairment induced by sevoflurane, possibly by inducing neuroinflammation and apoptosis.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chunping Yin, Qi Zhang, Juan Zhao, Yanan Li, Jiaxu Yu, Wei Li, Qiujun Wang
Summary: Postoperative cognitive dysfunction (POCD) is a common complication in the aged population. Necroptosis inhibitor Nec-1 can alleviate POCD. This study found that Nec-1 can relieve sevoflurane-induced POCD by reducing calcium overload and necroptosis activity.
NEUROCHEMICAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Ji Heon Lee, Ye Jin Jeon, Hyeon Chang Kim, Sun Jae Jung
Summary: The study aimed to investigate the influence of inflammation on the association between CVH and cognition. It was found that in the middle-aged Korean population, CVH is not significantly associated with cognitive decline.
EPIDEMIOLOGY AND HEALTH
(2021)
Article
Pharmacology & Pharmacy
Chunguang Hao, Xiaguang Duan, Xiaoyan Yang, Zaiqing Huang, Fang Li, Jianping Yang
Summary: This study found that inhalation anesthesia may lead to postoperative cognitive dysfunction in some patients. Through experiments on aged rats, it was found that sevoflurane inhalation can cause changes in cognitive function, as well as down-regulation of RGS2 expression in the hippocampus, increased neuronal apoptosis, and decreased expression of NGF and BDNF. Therefore, sevoflurane inhalation may be one of the important factors leading to cognitive dysfunction.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Neurosciences
Stephanie M. Muscat, Nicholas P. Deems, Michael J. Butler, Emmanuel A. Scaria, Menaz N. Bettes, Sean P. Cleary, Ross H. Bockbrader, Steven F. Maier, Ruth M. Barrientos
Summary: This study highlights the importance of addressing perioperative neurocognitive disorders (PNDs) and provides evidence that blocking toll-like receptor 4 (TLR4) activation can mitigate the cognitive impairment caused by morphine treatment. These findings offer a promising therapeutic target for preventing or treating PNDs.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Stephanie M. Muscat, Nicholas P. Deems, Heather D'Angelo, Meagan M. Kitt, Peter M. Grace, Nathan D. Andersen, Shaelyn N. Silverman, Kenner C. Rice, Linda R. Watkins, Steven F. Maier, Ruth M. Barrientos
Summary: Postoperative cognitive dysfunction (POCD) is a collection of cognitive impairments experienced by individuals following surgery, with persistent POCD most commonly affecting older individuals. In a study on aged rats, it was found that postsurgical treatment with morphine led to long-term memory impairments through a neuroinflammatory mechanism rather than pain modulation. Central blockade of IL-1b signaling completely prevented the memory impairment in rats, suggesting a potential target for future treatment discoveries.
NEUROBIOLOGY OF AGING
(2021)