Isoflurane anesthetic hypersensitivity and progressive respiratory depression in a mouse model with isolated mitochondrial complex I deficiency

Fatal breathing dysfunction in a mouse model of Leigh syndrome

(2012) Albert Quintana et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered Anesthetic Sensitivity of Mice Lacking Ndufs4, a Subunit of Mitochondrial Complex I

(2012) Albert Quintana et al.   PLoS One

Isoflurane Selectively Inhibits Distal Mitochondrial Complex I in Caenorhabditis Elegans

(2011) Ernst-Bernhard Kayser et al.   ANESTHESIA AND ANALGESIA

Isoflurane Differentially Modulates Mitochondrial Reactive Oxygen Species Production via Forward versus Reverse Electron Transport Flow

(2011) Naoyuki Hirata et al.   ANESTHESIOLOGY

General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain

(2011) Victoria Sanchez et al.   ANESTHESIOLOGY

Bioenergetic homeostasis decides neuroprotection or neurotoxicity induced by volatile anesthetics: A uniform mechanism of dual effects

(2011) Jun Zhang et al.   MEDICAL HYPOTHESES

Pharmacological targeting of mitochondrial complex I deficiency: The cellular level and beyond

(2011) Peggy Roestenberg et al.   MITOCHONDRION

Identification and characterization of anesthetic targets by mouse molecular genetics approaches

(2010) Berthold Drexler et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Metabolic manipulators: a well founded strategy to combat mitochondrial dysfunction

(2010) Saskia Koene et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Mouse models for nuclear DNA-encoded mitochondrial complex I deficiency

(2010) Saskia Koene et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease

(2009) F. Distelmaier et al.   BRAIN

Is a New Paradigm Needed to Explain How Inhaled Anesthetics Produce Immobility?

(2008) Edmond I Eger et al.   ANESTHESIA AND ANALGESIA

Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy

(2008) Shane E. Kruse et al.   Cell Metabolism

Neuromuscular and mitochondrial disorders: what is relevant to the anaesthesiologist?

(2008) Jacques J Driessen   Current Opinion in Anesthesiology

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

(2008) Nicholas P. Franks   NATURE REVIEWS NEUROSCIENCE