Review
Biochemistry & Molecular Biology
Barbara Gierlikowska, Albert Stachura, Wojciech Gierlikowski, Urszula Demkow
Summary: This article provides an overview of the importance of neutrophils in sepsis, explains the dependence between cytokines and their activation, and summarizes the impact of cytokines on phagocytosis and NET formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sahil Gupta, Hajera Amatullah, James N. Tsoporis, Kuiru Wei, Ana Paula Teixeira Monteiro, Amin M. Ektesabi, Amir K. Varkouhi, Chirag M. Vaswani, Amanda Formosa, Alexandre T. Fabro, Sri Nagarjun Batchu, Chris Fjell, James A. Russell, Keith R. Walley, Andrew Advani, Thomas G. Parker, John C. Marshall, Patricia R. M. Rocco, Gregory D. Fairn, Tak Wah Mak, Claudia C. dos Santos
Summary: The ability to effectively clear infection is crucial for host survival. DJ-1 deficiency in bone marrow macrophages (BMM) promotes an increase in L3C-associated phagocytosis during bacterial infection, but not lipopolysaccharide infection. DJ-1 deficiency facilitates the complexing of Rubicon with Beclin-1 and UVRAG, leading to the assembly of autophagolysosomes decorated with LC3 molecules during intact bacterial infection.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Immunology
Minji Kim, In Jun Yeo, Dong Ju Son, Heepom Lee, Jaesuk Yun, Sang-Bae Han, Jin Tae Hong
Summary: This study investigated the effect of K284 on liver injury during sepsis. The results showed that K284 could alleviate septic liver damage and reduce inflammation. It was found that K284 could decrease the expression of M2 polarization markers and CXCL3, thereby reducing liver injury. Therefore, K284 may be a suitable treatment for sepsis-related hepatic injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Shaowei Jiang, Yang Wang, Liang Chen, Honghua Mu, Connor Meaney, Yiwen Fan, Janesh Pillay, Hairong Wang, Jincheng Zhang, Shuming Pan, Chengjin Gao
Summary: This study investigates the associations among serum levels of PAI-1, PAI-1 gene polymorphisms, immunological indicators, and clinical outcomes in septic patients. The results suggest that genetic polymorphisms of PAI-1 can affect serum levels of PAI-1, which in turn may influence mortality by affecting neutrophil activity.
CHINESE MEDICAL JOURNAL
(2023)
Review
Immunology
Yi Wang, Cheng-long Zhu, Peng Li, Qiang Liu, Hui-ru Li, Chang-meng Yu, Xiao-ming Deng, Jia-feng Wang
Summary: Sepsis is a life-threatening dysfunction caused by an uncontrolled host response to infection, leading to respiratory dysfunction and acute respiratory distress syndrome (ARDS). Neutrophils, the first line of defense against infection, play a major role in sepsis. However, studies have shown that despite high levels of chemokines at the site of infection, neutrophils cannot migrate properly and instead accumulate in the lungs, causing tissue damage and ARDS. Dysregulation of chemokine receptors, particularly G protein-coupled receptors (GPCRs), is implicated in impaired neutrophil migration. This review summarizes the signaling pathways and mechanisms by which GPCR dysfunction in sepsis leads to impaired neutrophil chemotaxis and proposes potential targets for intervention to improve neutrophil chemotaxis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hui-Wen Yang, Chih-Yuan Lin, Feng-Zhi Lin, Pei-Ling Yu, Shih-Ming Huang, Yao-Chang Chen, Chien-Sung Tsai, Hsiang-Yu Yang
Summary: The study found that ITI-214 improves intracellular Ca2+ regulation, resulting in a positive inotropic effect and suppression of arrhythmic events in Sirt1-deficient ventricular myocytes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Mi Hyun Seo, Dae Won Kim, Yeon Sook Kim, Suk Keun Lee
Summary: This study investigated the effect of different concentrations of PTX on RAW 264.7 cells and found that low dose PTX enhanced proliferation, differentiation, and inflammation, while attenuating ER stress and fibrosis, whereas high dose PTX had the opposite effect.
Article
Immunology
Dadong Liu, Min Xiao, Jing Zhou, Peng Wang, Jingwen Peng, Wenjian Mao, Yuepeng Hu, Yuxiu Liu, Jiangtao Yin, Lu Ke, Weiqin Li
Summary: CXCR4hi neutrophils, a subset of neutrophils with high CXCR4 expression, play an important role in sepsis-induced acute lung injury (ALI). PFKFB3, a key glycolysis gene, is upregulated in CXCR4hi neutrophils and promotes sepsis-induced ALI by enhancing neutrophil extracellular trap (NET) formation. PFKFB3-mediated glycolytic metabolism is involved in the regulation of NET formation in CXCR4hi neutrophils.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Katsuyuki Umebashi, Masayoshi Yamamoto, Akinori Tokito, Ku Sudou, Yoko Takenoshita, Michihisa Jougasaki
Summary: This study demonstrated that IL-33 induces MCP-1 expression in HUVECs through the JNK and p38 MAPK pathways, and simvastatin can inhibit MCP-1 production by selectively suppressing JNK. Simvastatin may inhibit the progression of IL-33-induced inflammation by suppressing JNK to prevent MCP-1 production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yali Sun, Xianfei Ding, Yuqing Cui, Hongyi Li, Dong Wang, Huoyan Liang, Shaohua Liu, Xiaojuan Zhang, Haixu Wang, Tongwen Sun
Summary: This study demonstrates that the administration of Sivelestat in septic rats can improve survival, gut microbiota composition, and associated metabolites, providing new options for sepsis treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Yuan Ma, Yue Zhang, Rui Li, Shuwei Deng, Qiushi Qin, Chongping Ran, Yu Hao, Jianping Zhang, Liuluan Zhu
Summary: Taurine, with its anti-inflammatory and antioxidant effects, protects neutrophils and monocytes by reducing the expression of inflammatory cytokines and limiting the formation of reactive oxygen species. Additionally, taurine improves tissue injuries and mortality rates, showing promise as a therapeutic strategy for sepsis.
CELLULAR IMMUNOLOGY
(2022)
Article
Immunology
Kai Yang, Bin Wu, Wu Wei, Cuiyu Li, Lu Li, Zhukai Cong, Qian Xiang
Summary: This study investigated the effects of curdione, an active ingredient of Curcuma zedoary, on sepsis-induced lung injury. The results showed that curdione can alleviate tissue pathological changes, reduce inflammatory factors and protein concentrations, decrease oxidative stress responses, inhibit platelet activation, and reduce neutrophil infiltration and NET formation. Curdione has great therapeutic potential in sepsis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Feifei Du, Avin Hawez, Zhiyi Ding, Yongzhi Wang, Carl-Fredrik Ronnow, Milladur Rahman, Henrik Thorlacius
Summary: This study investigates the role of a protein called Mid1 in abdominal sepsis. The results show that Mid1 expression is increased in endothelial cells in septic mice and can be further increased by TNF-alpha stimulation in vitro. Knockdown of Mid1 using siRNA reduces the upregulation of ICAM-1 and the adhesion of neutrophils to endothelial cells. In vivo, silencing Mid1 decreases leukocyte adhesion in septic lungs and also reduces the expression of ICAM-1. The study also suggests that Mid1 may target a protein called PP2Ac in endothelial cells. Targeting the Mid1-PP2Ac axis could be a potential strategy to reduce lung inflammation in abdominal sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Arezou Khosrojerdi, Sara Soudi, Ahmad Zavaran Hosseini, Sahar Ghaffari Khaligh, Seyed Mahmoud Hashemi
Summary: The study demonstrated a dose-dependent effect of imipenem on inflammatory responses in sepsis mice. Treatment with a low dose (25 mg/kg) of imipenem resulted in decreased bacterial load, endotoxin level, and inflammatory cytokine production, improved pathology, and increased survival rate in sepsis mice compared to other groups.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kritsanawan Sae-khow, Awirut Charoensappakit, Direkrit Chiewchengchol, Asada Leelahavanichkul
Summary: Vitamin C plays an important role in neutrophil function and has been studied in the treatment of sepsis. High-dose intravenous vitamin C (HDIVC) has been shown to improve neutrophil activity and microbial control, but long-term administration may have negative effects. Further studies are needed to determine the proper use of vitamin C in sepsis treatment.