Article
Chemistry, Multidisciplinary
Matz Liebel, Franco V. A. Camargo, Giulio Cerullo, Niek F. van Hulst
Summary: Scientists have successfully addressed the challenge in the field of nanoscale imaging by combining concepts of ultrafast spectroscopy, wide-field nanoscopy, and digital holography. They have introduced an ultrafast holographic transient microscope for wide-field transient nanoscale imaging and demonstrated time-resolved spectroscopy of gold nanoparticles.
Article
Chemistry, Multidisciplinary
Lu-Xuan Wang, Miao Zhang, Chao Sun, Li-Xin Yin, Bin Kang, Jing-Juan Xu, Hong-Yuan Chen
Summary: Single-nanoparticle electrochemistry allows for studying electrochemical behaviors beyond the ensemble system. By directly tracking ion migration dynamics, it was found that the dynamics of electric double layer (EDL) formation deviates from the classical prediction under nanoscale and transient conditions. A new theoretical model was proposed to describe the transient dynamics of EDL formation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Optics
Xinli Jiang, Zhongjiang Chen, Da Xing
Summary: In this paper, a patterned competition method based on saturable transient absorption effect is introduced to achieve super-resolution imaging in PAM by breaking the diffraction limit. The technique enables the observation of microstructures of dark materials in a way that defies the diffraction limit, expanding the application range of PAM and opening up a new pathway for super-resolution imaging.
OPTICS AND LASERS IN ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Zhaoshuai Gao, Pei Wu, Lixin Yin, Bin Kang, Hong-Yuan Chen, Jing-Juan Xu
Summary: This study utilized the nonlinear plasmonic scattering response to achieve single-wavelength super-resolution imaging, successfully implementing this method on a custom-built system to achieve higher resolution than traditional methods.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Matz Liebel, Franco V. A. Camargo, Giulio Cerullo, Niek F. van Hulst
Summary: This study demonstrates the suitability of the ultrafast holographic transient (UHT) microscope for tracking dynamically moving non-fluorescent nanoparticles in scattering environments. The authors show that UHT microscopy can accurately distinguish different types of nanoparticles and localize single particles in 3D. The combination of these concepts allows for simultaneous tracking of multiple particles and recording of their phototransient signals.
Article
Multidisciplinary Sciences
Yeseul Kim, Jun Lim
Summary: This article introduces a spectroscopic X-ray nano-imaging technique based on Zernike phase contrast, which can improve the detection sensitivity and contrast at the nanoscale, suitable for battery research and imaging.
SCIENTIFIC REPORTS
(2022)
Article
Nanoscience & Nanotechnology
Yu-Chien Huang, Te-Hsin Chen, Jz-Yuan Juo, Shi-Wei Chu, Chia-Lung Hsieh
Summary: A study demonstrated optical widefield interferometric photothermal microscopy for visualizing and quantifying heat generation of single nanoparticles with high sensitivity; the photothermal signal of small metallic nanoparticles was determined by the amount of dissipated heat, independent of particle size; for larger nanoparticles, the strong scattered light of the particle enhanced the photothermal signal by interfering with the scattered field of the thermal lens.
Review
Pharmacology & Pharmacy
Chengying Zhang, Zhiqi Tian, Rui Chen, Fiona Rowan, Kangqiang Qiu, Yujie Sun, Jun-Lin Guan, Jiajie Diao
Summary: Optical microscopes have advanced modern biomedicine and super-resolution microscopy (SRM) has become popular in the life sciences, especially in living cell imaging. SRM has been used to study drug delivery and kinetics at the subcellular level, providing insights into drug mechanisms and efficacy assessment. This paper reviews recent advances in SRM and its applications in assessing subcellular drug dynamics.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Physical
Weiqing Yang, Zhihong Wei, Yan Nie, Yuxi Tian
Summary: Since its first optical detection in 1989, single-molecule spectroscopy has rapidly developed and been widely applied. However, the low photon emission efficiency of majority of matter limits the applications of photoluminescence-based optical methods. Efforts have been made to directly image nonfluorescent matter using different methods based on light-matter absorption or scattering. In this review, we discuss five popular methods, including dark-field microscopy (DFM), surface plasmon resonance microscopy (SPRM), surface enhanced Raman microscopy (SERM), interferometric scattering microscopy (iSCAT), and photothermal microscopy (PTM), for imaging nonfluorescent particles/molecules. We summarize the principles, applications, advantages, and disadvantages of each method and discuss further development and applications.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Analytical
Jun-Hao Wan, Chen Qian, Gang Wu, Xian-Wei Liu
Summary: Label-free imaging of nanoscale targets with intrinsic properties is crucial for unveiling the underlying mechanisms of chemistry, physics, and life science. Plasmonic imaging techniques provide real-time imaging and insights into nanoscale detection and nanocatalysis. In this study, a high-resolution plasmonic imaging method is presented, demonstrating its capability to image various nanomaterials and accurately track the interfacial dynamics of nanoparticles. With the simplicity and capacity for label-free and real-time imaging, this approach serves as a promising platform for characterizing nanomaterials at the single-particle level.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Romain Rouxel, Michele Diego, Paolo Maioli, Noelle Lascoux, Fabien Vialla, Francesco Rossella, Francesco Banfi, Fabrice Vallee, Natalia Del Fatti, Aurelien Crut
Summary: When a metal nanoparticle absorbs light, it undergoes a series of relaxation processes that lead to transient modifications in its optical response. By using time-resolved spectroscopy experiments, it was shown that the transient optical response could be attributed to internal thermalization processes within the nanoparticle, and the effects of electron and ionic lattice heating were quantitatively studied. The study demonstrated the possibility of selectively probing electronic or lattice dynamics by choosing specific probe wavelengths, and showed that the timedependent spectral shape of transient extinction cross-section changes was successively dominated by electron and lattice heating effects.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Multidisciplinary
Lu-Xuan Wang, Sheng-Lan Huang, Pei Wu, Xiao-Rui Liu, Chao Sun, Bin Kang, Hong-Yuan Chen, Jing-Juan Xu
Summary: This study investigates the transport kinetics of different ions within nanochannels and finds that the ion transport in short nanochannels deviates significantly from the classical model. The results suggest that the formation of electrical double layer becomes the rate-determining step in short nanopores/nanochannels and affects the apparent ion transport kinetics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
He Gao, Pei Wu, Pei Song, Bin Kang, Jing-Juan Xu, Hong-Yuan Chen
Summary: Plasmonic nanoparticles like gold and silver have potential as nanoprobes for biological sensing and imaging, with a demand for small gold nanoparticles (Au NPs) comparable in size to quantum dots and fluorescent proteins. Very small nanoparticles below the Rayleigh limit are difficult to visualize using light scattering with a dark-field microscope, and while a photothermal microscope can detect them, its imaging speed is too slow for live cell processes. The absorption modulated scattering microscopy (AMSM) method allows for imaging sub-10 nm Au NPs within a cellular medium, offering sensitivity similar to photothermal microscopy but with a much faster imaging speed suitable for dynamic tracking of small nanoparticles in living cells.
Review
Chemistry, Multidisciplinary
Yanzi Xu, Ruohan Xu, Zhi Wang, Yu Zhou, Qifei Shen, Wenchen Ji, Dongfeng Dang, Lingjie Meng, Ben Zhong Tang
Summary: Recent progress on STED fluorophores for super-resolution imaging is outlined, including inorganic fluorophores, fluorescent proteins, organic luminescent materials, aggregation-induced emission (AIE) luminogens, and fluorescent nanoparticles. Characteristics of these aforementioned STED fluorophores are also included and compared to provide a deep understanding of the relationship between the properties in luminescent materials and their performance in STED imaging.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Samuel J. Francis, Marco D. Torelli, Nicholas A. Nunn, Gowthami M. Arepally, Olga A. Shenderova
Summary: Thrombosis is a major health issue in the United States and there is a lack of understanding about its causes, progression, and response to anticoagulant therapy. This study demonstrates the use of fluorescent nanodiamond (FND) as a label for blood clots, which offers advantages over organic fluorophores, such as reduced photodegradation. The addition of tissue plasminogen activator (tPa) allows visualization of clot lysis, which is important for studying the resolution of deep vein thrombosis and pulmonary embolism.
Editorial Material
Chemistry, Physical
Joan-Emma Shea, T. Daniel Crawford, Martin Zanni, Gregory Hartland, William Aumiller
JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
Editorial Material
Chemistry, Physical
Joan-Emma Shea, T. Daniel Crawford, Martin Zanni, Gregory Hartland, William Aumiller
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Biographical-Item
Chemistry, Physical
Nicholas Kotov, Gregory Hartland
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Editorial Material
Chemistry, Physical
Joan-Emma Shea, T. Daniel Crawford, Martin Zanni, Gregory Hartland, William Auniller
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Physical
Jishnudas Chakkamalayath, Gregory V. Hartland, Prashant V. Kamat
Summary: Lead-free halide double perovskites offer an environmentally friendly alternative for optoelectronic solar cell devices. Metal ion exchange can be used to synthesize such double perovskites. The metal ion exchange process is reversible, and under light stimulation, the double perovskite can release gold. These results provide insights into the dynamic nature of gold within the perovskite lattice under both chemical and light stimuli.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Editorial Material
Chemistry, Physical
Joan-Emma Shea, T. Daniel Crawford, Martin T. Zanni, Gregory Hartland, William Aumiller
JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Editorial Material
Chemistry, Physical
Joan-Emma Shea, T. Daniel Crawford, Martin T. Zanni, Gregory V. Hartland, William Aumiller
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Editorial Material
Chemistry, Physical
Joan-Emma Shea, T. Daniel Crawford, Martin T. Zanni, Gregory V. Hartland, William Aumiller
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Editorial Material
Chemistry, Physical
Joan-Emma Shea, T. Daniel Crawford, Martin T. Zanni, Gregory V. Hartland, William Aumiller
JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Editorial Material
Chemistry, Physical
Joan-Emma Shea, T. Daniel Crawford, Martin T. Zanni, Gregory V. Hartland, William Aumiller
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Editorial Material
Chemistry, Physical
Joan-Emma Shea, T. Daniel Crawford, Martin T. Zanni, Gregory V. Hartland, William Aumiller
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Optics
Janak Bhandari, Brendan s. Brown, John a. Huffman, Gregory Hartland
Summary: Micron-sized dye-doped polymer beads were imaged using transmitted/reflected light microscopy and photothermal heterodyne imaging (PHI) measurements. The images showed distinct ring patterns attributed to diffraction effects and/or internal reflections within the beads. The ring pattern disappeared when an incoherent light source was used. In an organic medium, heat transfer changed the refractive index of the environment, resulting in a ring pattern external to the beads in the PHI images.
Article
Chemistry, Physical
Wei-Yi Chiang, Autumn Bruncz, Behnaz Ostovar, Emily K. Searles, Sadie Brasel, Gregory Hartland, Stephan Link
Summary: We conducted a study on the pump wavelength-dependent electron-phonon relaxation in colloidal solutions of isolated gold nanospheres and nanorods. The electron-phonon relaxation time was found to be independent of pump wavelength and the plasmon bleach recovery dynamics described the cooling process of hot thermalized electrons with the lattice. A nonlinear trend in the electron-phonon relaxation time was observed when the nanorods were excited at the longitudinal mode with linearly polarized excitation.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Nanoscience & Nanotechnology
Kirill Kniazev, Evgenii Zaitsev, Shubin Zhang, Yang Ding, Loc Ngo, Zhuoming Zhang, Gregory V. Hartland, Masaru Kuno
Summary: Label-free, bond-selective imaging has new opportunities in chemistry, biology, and material science. However, issues such as low sensitivity, low spatial and temporal resolution hinder its application in studying spatially-congested specimens. In this paper, a widefield infrared photothermal heterodyne imaging technique (wIR-PHI) is introduced, which overcomes these issues and enables high-resolution imaging with hyperspectral capabilities and high sensitivity. The technique has potential for kinetic imaging and spectroscopic studies in important chemical, biological, and material processes in the future. Rating: 9/10.
Article
Chemistry, Multidisciplinary
Cameron Wright, Gregory V. Hartland
Summary: The fundamental and n = 3 overtones of Au nanoplate thickness vibrations were studied using transient absorption microscopy. It was found that the frequencies of the n = 3 overtone are lower than 3 times the frequency of the fundamental. This anharmonicity was explained by a continuum mechanics model that includes organic layers on top of the nanoplate and between the nanoplate and the glass substrate. The results suggest that engineering layers of soft material around metal nanostructures can be used to control the vibrational lifetimes.
