Article
Cell Biology
Shubhadeep Roychoudhury, Anandan Das, Manesh Kumar Panner Selvam, Saptaparna Chakraborty, Petr Slama, Suresh C. Sikka, Kavindra Kumar Kesari
Summary: This study analyzed the research trend in radiotherapy associated with male infertility over the past 20 years. The results showed a positive growth in research on the impact of radiotherapy on male infertility, primarily focusing on its effects on semen parameters and fertility preservation techniques. However, there is limited research on the influence of radiotherapy on male reproductive hormones and omics-related research in male reproductive organs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Ingrid Melnikovova, Daniela Russo, Tomas Fait, Michaela Kolarova, Jan Tauchen, Nataliya Kushniruk, Roberto Falabella, Luigi Milella, Eloy Fernandez Cusimamani
Summary: The study evaluated the effects of L. meyenii on infertile patients, and found that maca improved sperm concentration but the results were not statistically significant. Additionally, there was no significant change in hormone levels observed with maca treatment. Further research and trials are needed to draw conclusive results on the efficacy of maca on male fertility.
PHYTOTHERAPY RESEARCH
(2021)
Review
Endocrinology & Metabolism
Moses A. Hamed, Tunmise M. Akhigbe, Adetomiwa E. Adeogun, Oluwatosin B. Adesoye, Roland E. Akhigbe
Summary: This study provides a systematic review and meta-analysis on the impacts of OP pesticides on semen quality and male reproductive hormones, and finds that OP pesticides exposure reduced sperm count, concentration, total and progressive motility, and normal sperm morphology possibly via a testosterone-independent mechanism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Siddharth Pattnaik, Dipankar Das, Varun Akur Venkatesan
Summary: This study evaluated the accuracy of the home-based fertility monitor, Inito Fertility Monitor (IFM), in measuring urinary hormones and identified novel hormone trends in natural menstrual cycles. The IFM showed accurate recovery percentage and high correlation with ELISA in measuring E3G, PdG, and LH. It also introduced a novel criterion for earlier confirmation of ovulation and identified a new hormone trend associated with most menstrual cycles.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Claudia Omes, Veronica Tomasoni, Mara De Amici, Giorgia Testa, Cristina Torre, Rossella E. Nappi
Summary: Calprotectin concentration in seminal fluid may serve as a biological marker for preliminary screening in males at risk of infertility due to abnormalities in semen quality, such as morphology. Higher calprotectin concentration appears to be associated with better semen quality, and using calprotectin as a preliminary test can help differentiate individuals with abnormal semen parameters, particularly morphology.
Article
Urology & Nephrology
Kate Wiles, Ellen Anckaert, Francesca Holden, Jan Grace, Catherine Nelson-Piercy, Liz Lightstone, Lucy C. Chappell, Kate Bramham
Summary: The study showed that women with chronic kidney disease have lower serum AMH concentrations compared to healthy women, indicating a lower ovarian reserve and potentially reduced response to gonadotrophin stimulation.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Andrology
Ashok Agarwal, Rossella Cannarella, Ramadan Saleh, Florence Boitrelle, Murat Gul, Tuncay Toprak, Gianmaria Salvio, Mohamed Arafa, Giorgio I. Russo, Ahmed M. Harraz, Rajender Singh, Nicolas Garrido, Taha Abo-Almagd Abdel-Meguid Hamoda, Amarnath Rambhatla, Parviz Kavoussi, Shinnosuke Kuroda, Gokhan Calik, Pallavi Saini, Erman Ceyhan, Fotios Dimitriadis, Ralf Henkel, Andrea Crafa, Ayad Palani, Mesut Berkan Duran, Evangelos Maziotis, Emine Sais, Marion Bendayan, Mahsa Darbandi, Tan V. Le, Sezgin Gunes, Petroula Tsioulou, Pallav Sengupta, Berk Hazir, Gokhan Ceker, Sara Darbandi, Damayanthi Durairajanayagam, Azin Aghamajidi, Noora Alkhalidi, Emrullah Sogutdelen, Kristian Leisegang, Abdullah Alarbid, Christopher C. K. Ho, Vineet Malhotra, Federica Finocchi, Luis Crisostomo, Raghavender Kosgi, Haitham ElBardisi, Armand Zini, Ponco Birowo, Giovanni Colpi, Hyun Jun Park, Ege Can Serefoglu, Quang Nguyen, Edmund Ko, Jean de la Rosette, Germar M. Pinggera, Ho Vinh Phuoc Nguyen, Hussein Kandil, Rupin Shah
Summary: This study provides evidence for the positive effect of varicocele repair on conventional semen parameters in infertile men with clinical varicocele. There is significant improvement in sperm concentration, total motility, progressive motility, total sperm motility, and normal sperm morphology after varicocele repair. However, there is high inter-study heterogeneity.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Obstetrics & Gynecology
Tessa Copp, Rachel Thompson, Jenny Doust, Karin Hammarberg, Michelle Peate, Sarah Lensen, Erin Cvejic, Devora Lieberman, Ben W. Mol, Kirsten J. McCaffery
Summary: A survey in Australia finds that only 13% of women have heard of the anti-Mullerian hormone (AMH) test, and only 7% have undergone the test. The top reasons for testing include infertility investigations (51%), considering pregnancy and wanting to understand chances (19%), and finding out if a medical condition affected fertility (11%).
HUMAN REPRODUCTION
(2023)
Article
Andrology
Patience Castleton, Prabin Gyawali, Nicola Mathews, Shadrack Mulinge Mutuku, David James Sharkey, Nicole Olivia McPherson
Summary: This study found that the MiOXSYS(R) and OxiSperm(R) II systems for measuring sperm oxidative stress may have limited diagnostic potential. There were no significant associations between these systems and sperm function or oxidative stress. This may be due to limited understanding of their biochemistry and clinical application.
Review
Obstetrics & Gynecology
Edgardo Somigliana, Marco Reschini, Valentina Bonanni, Andrea Busnelli, Letizia Li Piani, Paolo Vercellini
Summary: Available evidence from IVF studies indicates a detrimental effect of submucosal and intramural fibroids on embryo implantation, but this should not be extrapolated to natural fertility. Current research on the impact of fibroids on natural fertility is inadequate, and further investigation is needed to understand the association between fibroids and infertility.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Review
Pharmacology & Pharmacy
Hye Won Lee, Myeong Soo Lee, Fan Qu, Je-Won Lee, Eunseop Kim
Summary: This study analyzed multiple studies and found that the use of maca for improving semen quality is still inconclusive, both for men experiencing infertility and healthy men. However, due to the limited number of studies and sample size, firm conclusions cannot be drawn.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Rohit R. Badia, Akshat Patel, Nathan Chertack, Jeffrey M. Howard, Aditya Bagrodia, Tolulope Bakare
Summary: This study aimed to investigate the impact of testicular cancer stage and histology on semen parameters in preorchiectomy cryopreservation samples. The results showed that semen parameters were similar across different stages of testicular cancer and did not significantly differ between different histology types. Therefore, regardless of the stage or histology, sperm banking should be recommended for patients with both localized and metastatic testicular cancer.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Review
Endocrinology & Metabolism
Andrea Garolla, Gabriel Cosmin Petre, Francesco Francini-Pesenti, Luca De Toni, Amerigo Vitagliano, Andrea Di Nisio, Giuseppe Grande, Carlo Foresta
Summary: A systematic review of dietary supplements for male infertility in Italy revealed that many supplements on the market contain a blend of ingredients with negligible doses or without any evidence of efficacy. However, some ingredients have been shown to be effective on specific sperm parameters. This study can assist in selecting supplements that are more likely to be effective on specific sperm alterations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Ido Feferkorn, Liat Azani, Einav Kadour-Peero, Ranit Hizkiyahu, Guy Shrem, Mali Salmon-Divon, Michael H. Dahan
Summary: Significant geographic variations in sperm parameters were found in this study, suggesting the importance of considering regional reference ranges based on local experience and treatment outcomes.
FERTILITY AND STERILITY
(2022)
Article
Genetics & Heredity
Iolanda Veneruso, Federica Cariati, Carlo Alviggi, Lucio Pastore, Rossella Tomaiuolo, Valeria D'Argenio
Summary: Infertility incidence is increasing globally, and male infertility accounts for about 50% of cases. This study analyzed the semen microbiota using NGS technology in 20 semen samples from men with and without semen alterations. The results showed reduced richness and evenness in the group with semen alterations, and specific genera such as Mannheimia, Escherichia_Shigella, and Varibaculum were significantly increased in this group. Moreover, a correlation between the microbial profile and semen hyperviscosity was identified. These findings suggest that semen microbiota could be a potential target for infertility management strategies.
Article
Medicine, General & Internal
Claudio Manna, Federica Barbagallo, Francesca Sagnella, Ashraf Farrag, Aldo E. E. Calogero
Summary: The commonly used protocols in assisted reproductive technology (ART) involve long-term embryo culture up to the blastocyst stage, freezing of all embryos, and subsequent transfer one by one. These practices have the potential risks of obstetric and perinatal complications, adverse epigenetic consequences, and ethical-legal concerns regarding frozen embryo storage. To minimize risks, the study suggests selecting a limited number of oocytes for insemination and transferring embryos at the cleaving stage. The results showed a comparable live birth rate to the commonly used protocols in older women with reduced ovarian reserve.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Andrology
Andrea Crafa, Rosita Angela Condorelli, Sandro La Vignera, Aldo Eugenio Calogero, Rossella Cannarella
Summary: This article presents a clinical case of a globozoospermic patient with a new mutation of the DPY19L2 gene and provides recommendations based on a systematic literature review on gene mutations, assisted reproductive techniques, and the risk of genetic abnormalities transmission. The study highlights the importance of genetic evaluation and specific assisted reproductive techniques in managing globozoospermia patients.
WORLD JOURNAL OF MENS HEALTH
(2023)
Review
Andrology
Aldo E. Calogero, Rossella Cannarella, Ashok Agarwal, Taha Abo-Almagd Abdel-Meguid Hamoda, Amarnath Rambhatla, Ramadan Saleh, Florence Boitrelle, Imad Ziouziou, Tuncay Toprak, Murat Gul, Tomer Avidor-Reiss, Parviz Kavoussi, Eric Chung, Ponco Birowo, Ramy Abou Ghayda, Edmund Ko, Giovanni Colpi, Fotios Dimitriadis, Giorgio Ivan Russo, Marlon Martinez, Gokhan Calik, Hussein Kandil, Gianmaria Salvio, Taymour Mostafa, Haocheng Lin, Hyun Jun Park, Nazim Gherabi, Nguyen Ho Vinh Phuoc, Nguyen Quang, Ricky Adriansjah, Sandro La Vignera, Sava Micic, Damayanthi Durairajanayagam, Ege Can Serefoglu, Vilvapathy Senguttuvan Karthikeyan, Priyank Kothari, Widi Atmoko, Rupin Shah
Summary: Infertility affects nearly 186 million people worldwide, with male infertility accounting for about half of the cases. There has been a decline in sperm concentration and total count over the past four decades, emphasizing the need for further research in Andrology.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Rossella Cannarella, Francesca Mancuso, Nunziata Barone, Iva Arato, Cinzia Lilli, Catia Bellucci, Marco Musmeci, Giovanni Luca, Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero
Summary: This study evaluated the expression of the follicle-stimulating hormone receptor (FSHR) in human spermatozoa and its effects on sperm function. The results showed that FSHR is expressed in the post-acrosomal segment, neck, midpiece, and tail of human spermatozoa, with no difference in localization between patients and controls. Incubation with FSH increased FSHR expression in patients. Furthermore, FSH incubation had a negative effect on sperm motility and mitochondrial function in both patients and controls, but more severely in controls. FSH also activated the AKT(473) signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rossella Cannarella, Carmelo Gusmano, Rosita A. Condorelli, Andrea Bernini, Jurgen Kaftalli, Paolo Enrico Maltese, Stefano Paolacci, Astrit Dautaj, Giuseppe Marceddu, Matteo Bertelli, Sandro La Vignera, Aldo E. Calogero
Summary: This study investigated five unrelated patients with cHH/KS and identified a new pathogenic variant in the CHD7 gene and three new variants of unknown significance in the IL17RD, FGF17, and DUSP6 genes. Further functional studies are needed to confirm their association with cHH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Rossella Cannarella, Andrea Crafa, Federica Barbagallo, Scott D. D. Lundy, Sandro La Vignera, Rosita A. A. Condorelli, Aldo E. E. Calogero
Summary: This systematic review and meta-analysis examine the differences in H19 gene methylation between patients with abnormal versus normal sperm parameters. The study also explores the impact of age and sperm concentration on H19 methylation using meta-regression analysis. The results indicate that H19 methylation levels are lower in infertile patients, particularly those with oligozoospermia or recurrent pregnancy loss, and are independent of age and sperm concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Livia Basile, Rosita A. Condorelli, Aldo E. Calogero, Rossella Cannarella, Federica Barbagallo, Andrea Crafa, Antonio Aversa, Sandro La Vignera
Summary: Red wine is rich in nutrients and has been the focus of numerous scientific studies. It has been reported that moderate consumption of red wine, with its phenolic and antioxidant properties, can have positive effects on various diseases. Additionally, the ethanol content in red wine has shown various biological properties. However, little is known about the correlation between red wine consumption and male sexual function. This review aimed to evaluate the effects of moderate red wine consumption on erectile function and found potential benefits in patients with erectile dysfunction as well as positive influences on reproductive function through vasorelaxant and antioxidant mechanisms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Francesca Privitera, Danilo Centonze, Sandro La Vignera, Rosita Angela Condorelli, Costanza Distefano, Rossella Gioco, Alba Ilari Civit, Giordana Riccioli, Ludovica Stella, Andrea Cavallaro, Matteo Angelo Cannizzaro, Massimiliano Veroux
Summary: This study evaluated the incidence and potential risk factors for postoperative hypoparathyroidism after thyroid surgical procedures in a single high-volume center. The results showed that young patients undergoing neck dissection and with incidental parathyroidectomy have the highest risk of postoperative hypoparathyroidism.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Andrea Crafa, Rossella Cannarella, Federica Barbagallo, Claudia Leanza, Roberto Palazzolo, Hunter Ausley Flores, Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero
Summary: Vitamin D deficiency and erectile dysfunction are common in males, especially in the elderly, suggesting a possible relationship between the two conditions. Studies indicate that vitamin D affects erectile function by regulating endothelial function and interfering with comorbidities associated with erectile dysfunction. Low levels of vitamin D may worsen erectile function through various mechanisms. However, the quality and heterogeneity of clinical trials evaluating the effects of vitamin D on erectile function and related comorbidities require further investigation.
Review
Biochemistry & Molecular Biology
Federica Barbagallo, Rossella Cannarella, Andrea Crafa, Sandro La Vignera, Rosita A. Condorelli, Claudio Manna, Aldo E. Calogero
Summary: This systematic review and meta-analysis found that a very short abstinence period (within 4 h) has a positive effect on assisted reproductive technique (ART) outcomes, significantly increasing the implantation rate, clinical pregnancy rate, and live birth rate. However, it does not have a significant impact on fertilization rate and miscarriage rate. It suggests that a second ejaculation shortly after the first one can be a simple strategy to improve ART outcomes, particularly in couples involving patients with abnormal sperm parameters.
Review
Pharmacology & Pharmacy
Rossella Cannarella, Cristina M. B. Petralia, Rosita A. Condorelli, Antonio Aversa, Aldo E. Calogero, Sandro La Vignera
Summary: This article provides an overview of the molecular mechanisms and usage of follicle-stimulating hormone (FSH) in the treatment of male infertility. It also evaluates the predictor factors of FSH administration response and the indications of the latest guidelines on the use of FSH in male infertility treatment.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Biochemistry & Molecular Biology
Alyssa J. J. Paganoni, Rossella Cannarella, Roberto Oleari, Federica Amoruso, Renata Antal, Marco Ruzza, Chiara Olivieri, Rosita A. Condorelli, Sandro La Vignera, Fationa Tolaj, Anna Cariboni, Aldo E. Calogero, Paolo Magni
Summary: Gonadotropin-releasing hormone (GnRH) neurons play a crucial role in regulating reproduction. AMH, GH, and IGF1 were found to enhance the migration and function of GnRH neurons in vitro. However, their involvement in the development and function of GnRH neurons in vivo remains unknown. This study evaluated the expression of AMHR2, GHR, and IGF1R during different developmental stages in mice, revealing differential protein expression patterns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sabrina Bossio, Anna Perri, Raffaella Gallo, Anna De Bartolo, Vittoria Rago, Daniele La Russa, Michele Di Dio, Sandro La Vignera, Aldo E. Calogero, Giovanni Vitale, Antonio Aversa
Summary: Alpha-lipoic acid (ALA) has been shown to inhibit cell growth and reduce viability in prostate cancer cells by inhibiting autophagy and affecting the redox balance system. ALA also reduces cell migration and invasion by regulating signaling pathways. These findings contribute to a better understanding of the potential therapeutic effects of ALA in prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Andrology
Rossella Cannarella, Claudia Leanza, Andrea Crafa, Federica Barbagallo, Sandro La Vignera, Rosita Angela Condorelli, Aldo Eugenio Calogero
Summary: This study examined the impact of MEST gene methylation pattern on sperm parameters in infertile patients and found that MEST gene methylation was higher in infertile patients compared to normal men.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Andrology
Rossella Cannarella, Matteo Bertelli, Rosita A. Condorelli, Marija Vilaj, Sandro La Vignera, Davor Jezek, Aldo E. Calogero
Summary: This study revealed that different mutations of the same gene can result in various testicular histological pictures. It suggests that it is the type of gene mutation/variation rather than the gene itself that determines the testicular histology. However, designing a genetic panel with prognostic value for testicular sperm extraction in patients with NOA remains challenging.
WORLD JOURNAL OF MENS HEALTH
(2023)
