Article
Microscopy
Isabel S. Maggiano, Corey M. Maggiano, David M. L. Cooper
Summary: This study investigates the variability of osteon circularity in bone microstructure, finding differences in On.Cr. between individuals and significant dispersion along the length of the same osteon. The findings suggest a patterned deviation from circularity and emphasize the role of Haversian systems as integrated parts of a greater morphological complex.
Article
Chemistry, Multidisciplinary
Marco Zedda
Summary: This study found that the spatial distribution of osteons in bone tissue is related to geometrical order, with ordered arrangement in functional bone tissue and random arrangement in irregular Haversian tissue.
APPLIED SCIENCES-BASEL
(2023)
Article
Biophysics
Yanhua Li, Aihua Li
Summary: The current research on crack propagation resistance characteristics of osteons is based on the single osteon model, which cannot reflect the interaction among osteons and the influence of material-property changes on the crack propagation. Moreover, the Haversian canal and the cement line were not included in the model, which could not reflect the influence of the true structural characteristics of the cortical bone on the microcracks.
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Andre Gutierrez Marty, Paul E. Barbone, Elise F. Morgan
Summary: This study aims to understand how aging-related changes in cortical bone microstructure affect mechanical properties at the macroscale. By modeling cortical bone as a bundle of elastic-plastic fibers and simulating aging-related changes, the study found that changes to all three input parameters were needed to capture the decline in mechanical properties. Rupture of interstitial fibers led to initial strength loss, while plasticity and gradual rupture of osteons contributed to the remainder of the response.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Zhichao Ma, Zhenfeng Qiang, Kaiyang Zeng, Jianlin Xiao, Liming Zhou, Lihui Zu, Hongwei Zhao, Luquan Ren
Summary: The study utilized depth-sensing nanoindentation to obtain hardness distribution map of cortical bones, and successfully predicted the fracture path under compressive stress by analyzing the correlation between hardness distribution map and compressive fracture path. The feasibility of the prediction method was verified through experiments, and the relation between the fracture propagation path and distribution of Haversian canals was also analyzed.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Engineering, Biomedical
Marta Pena Fernandez, Jakob Schwiedrzik, Alexander Burki, Francoise Peyrin, Johann Michler, Philippe K. Zysset, Uwe Wolfram
Summary: The development of treatment strategies for skeletal diseases relies on the understanding of bone mechanical properties in relation to its structure at different length scales. In this study, the anisotropic crack propagation, deformation, and fracture of ovine cortical bone under different indenters were investigated using in situ high-resolution SR μCT indentation testing and digital volume correlation. The results revealed the significant dependence of the crack development on the anisotropy ahead of the tip, with lower strains and smaller crack systems developing in samples indented in the transverse material direction. The study sheds light on the importance of three-dimensional investigation of bone deformation and fracture behavior to explore the mechanisms of bone failure.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Manufacturing
Michael Conward, Johnson Samuel
Summary: This article investigates the failure mechanisms observed during the fracture cutting of age-varying bovine cortical bone based on characteristic microstructures. Orthogonal cutting experiments are conducted on different age groups of bovine bones, showing key differences in microstructural constituents. High-speed camera images reveal six dominant microstructure-specific failure mechanisms. The cutting responses are sensitive to age-related microstructural variations and the tool rake angle.
JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME
(2023)
Article
Anatomy & Morphology
Subok Kim, Sanghun Jang, Onseok Lee
Summary: This study aimed to objectively diagnose osteoporosis (OP) by visualizing micro-damage caused by OP using synchrotron radiation-based mu CT (SR-mu CT). The results showed that the OVX group had smaller cortical bone volume and thickness, as well as lower trabecular bone volume/total volume compared to the SHAM group. In addition, the SHAM group had larger canal volume and lacuna volume than the OVX group.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Oncology
Hao Xu, Marie-Helene Lafage-Proust, Lamia Bouazza, Sandra Geraci, Philippe Clezardin, Bernard Roche, Francoise Peyrin, Max Langer
Summary: This study used synchrotron radiation microcomputed tomography (SR-mu CT) to investigate the effect of anti-angiogenic drugs on bone metastasis. The results suggest that combined anti-angiogenic drug treatment can reduce bone resorption at an early stage and affect bone microvascular structure at a later stage.
Article
Mechanics
Federica Buccino, Sara Bagherifard, Lorenzo D'Amico, Luigi Zagra, Giuseppe Banfi, Giuliana Tromba, Laura Maria Vergani
Summary: This study proposes a fracture mechanics-based approach using synchrotron scans and micro-mechanical tests to quantify the critical stress intensification in healthy and osteoporotic human bones. A morphological and densitometric framework is also applied to capture the differences in lacunar network under pathological alterations. Convolutional neural network is implemented to detect the initiation and propagation of micro-scale damages. The results highlight the importance of the interaction between toughening and weakening phenomena at the micro-scale for fracture prevention.
ENGINEERING FRACTURE MECHANICS
(2022)
Article
Anatomy & Morphology
Susan E. Lad, Rebecca J. Anderson, Stephen A. Cortese, Carmen E. Alvarez, Andrew D. Danison, Hannah M. Morris, Matthew J. Ravosa
Summary: This study assessed the relationship between cyclical loading and remodeling in the rabbit maxilla, finding a significant difference in the alveolar region of the maxilla in the overuse group. The hypothesis that cyclical loading engenders Haversian remodeling in the developing maxilla is not supported, possibly due to the continuation of modeling throughout the experimental duration.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Jose A. Robles-Linares, Dragos Axinte, Zhirong Liao, Andres Gameros
Summary: The study reveals that damage induced by bone cutting extends beyond the necrotic region, with high cutting temperatures causing lower modulus, strength, and brittle behavior near the machined surface. In contrast, the bulk bone retains pristine properties and ductile behavior. This shows that drilling thermo-mechanical effects can impact bone both biologically and micromechanically, revealing previously neglected bone damage.
MATERIALS & DESIGN
(2021)
Article
Clinical Neurology
Hao Li, Nadine Schart-Moren, Gunesh Rajan, Jeremy Shaw, Seyed Alireza Rohani, Francesca Atturo, Hanif M. Ladak, Helge Rask-Andersen, Sumit Agrawal
Summary: The study analyzed the 3D anatomy of the basal region of the human cochlea, vestibular apparatus, and EDS to optimize surgical approaches following cochlear implantation. Results showed that drilling during the surgery may harm the vestibular organ function by disrupting fluid barriers and injuring the endolymphatic space. Round window insertion may be a less traumatic alternative but could still affect vestibular receptors.
FRONTIERS IN NEUROLOGY
(2021)
Article
Engineering, Mechanical
Sina Asadollahi, Mehdi Dehestani
Summary: This study employs two analytical approaches to provide models of an osteon, focusing on the lamella texture at the micro-scale. The effects of loading and geometrical parameters on the behavior of the osteon are explored through numerical evaluations. The results indicate that the diameter of the Haversian canal is the most important geometrical parameter influencing the elastic stresses in the osteon.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART C-JOURNAL OF MECHANICAL ENGINEERING SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Marissa Chatterjee, Fernanda Faot, Cassia Correa, Jente Kerckhofs, Katleen Vandamme
Summary: The study revealed that ovariectomy-induced osteoporosis only affects specific jaw bone regions, which can be prevented by bisphosphonate treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Madge Martin, Vittorio Sansalone, David M. L. Cooper, Mark R. Forwood, Peter Pivonka
Article
Microscopy
Isabel S. Maggiano, Corey M. Maggiano, David M. L. Cooper
Summary: This study investigates the variability of osteon circularity in bone microstructure, finding differences in On.Cr. between individuals and significant dispersion along the length of the same osteon. The findings suggest a patterned deviation from circularity and emphasize the role of Haversian systems as integrated parts of a greater morphological complex.
Review
Anthropology
Rachel Simpson, David M. L. Cooper, Treena Swanston, Ian Coulthard, Tamara L. Varney
Summary: Trace elements with a strong affinity for the skeleton are often stored in bones and teeth long term, providing insights into past human lifeways. Advances in techniques such as micro-sampling and non-traditional stable isotope analysis have helped overcome limitations faced by the discipline, with a surge in popularity in bioarchaeological trace element analysis over the past few decades.
ARCHAEOLOGICAL AND ANTHROPOLOGICAL SCIENCES
(2021)
Article
Paleontology
Maryann E. Scott, William N. Dust, David M. L. Cooper, Ernest G. Walker, Angela R. Lieverse
Summary: This research focused on studying osteoarthritis lesions in modern patients and identified some non-standard OA lesions not included in current paleopathological measures. These lesions showed correspondence with clinical OA diagnostic criteria, with the presence of lytic defects potentially indicating bone marrow lesions linked to pain, inflammation, and ligament pathology. Additionally, proliferative bone in the intercondylar region and other observed bone lesions may have implications for understanding OA pathogenesis and pain mechanisms.
INTERNATIONAL JOURNAL OF PALEOPATHOLOGY
(2021)
Article
Anatomy & Morphology
Amir M. Ashique, Oghenevwogaga J. Atake, Katie Ovens, Ruiyi Guo, Isaac Pratt, H. William Detrich, David M. L. Cooper, Thomas Desvignes, John H. Postlethwait, B. Frank Eames
Summary: The reduced bone in icefishes was not attributed to changes in bone microstructure or bone mineral density at a systemic level, but rather occured only at the gross anatomic level. Microstructural measures and bone mineral density were similar among icefish and non-icefish Antarctic notothenioids.
JOURNAL OF ANATOMY
(2022)
Article
Environmental Sciences
Rachel Simpson, Tamara L. Varney, Ian Coulthard, Treena Swanston, Vaughan Grimes, T. Jessica A. Munkittrick, Rimantas Jankauskas, David M. L. Cooper
Summary: Bones serve as a valuable archive for studying environmental lead exposure in modern and archaeological populations. Synchrotron radiation X-ray fluorescence imaging allows for mapping of lead distribution in bone at a microstructural level, offering insights into individuals' exposure history and the nature of lead uptake in bones. Researchers compared spatial patterns of lead in modern and archaeological bone samples, finding differences in distribution corresponding to biogenic vs. diagenetic uptake.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Biotechnology & Applied Microbiology
Zahra Yazdanpanah, James D. Johnston, David M. L. Cooper, Xiongbiao Chen
Summary: Treating large bone defects is challenging and bone tissue engineering using 3D bioprinted scaffolds has emerged as a promising approach. This review highlights the latest developments in the use of bioprinted scaffolds for critical-sized defect treatment, including the biomaterials, cells, and growth factors used in bioink formulation and bioprinting techniques. The review also discusses current limitations and emerging approaches in this field.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Anatomy & Morphology
Janna M. Andronowski, Mary E. Cole, Reed A. Davis, Gina R. Tubo, Joshua T. Taylor, David M. L. Cooper
Summary: Cellular communication in the mechanosensory osteocyte Lacuno-Canalicular Network (LCN) plays a critical role in bone remodeling. Age-related declines in LCN size and connectivity impair mechanosensitivity and compromise bone quality. Increased vascular porosity contributes to bone fragility with aging, while a reduced and disconnected LCN undermines the mechanosensitivity required for bone repair and reinforcement.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Kim D. Harrison, Erika Sales, Beverly D. Hiebert, Arash Panahifar, Ning Zhu, Terra Arnason, Kurtis J. Swekla, Peter Pivonka, L. Dean Chapman, David M. L. Cooper
Summary: In this study, a 4D in vivo method was used to directly measure the longitudinal erosion rate (LER) for studying the spatiotemporal coordination of bone remodeling and its role in diseases such as osteoporosis. The method involved synchrotron imaging of rabbit tibias in vivo and ex vivo, and the average LER was determined.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Food Science & Technology
Athira Mohanan, Kim Harrison, David M. L. Cooper, Michael T. Nickerson, Supratim Ghosh
Summary: This study explored the use of oleofoams obtained from pulse protein foam-templated oleogels for cake baking and found that oleogels containing high-melting monoglyceride (MAG) could form stable oleofoams. By improving rheology and increasing air incorporation in the batter, high-quality cakes can be obtained with MAG-containing oleofoams made from pulse protein foam-templated oleogels.
Article
Instruments & Instrumentation
Xiaoman Duan, Naitao Li, David M. L. Cooper, Xiao Fan Ding, Xiongbiao Chen, Ning Zhu
Summary: This study focuses on the integration of SR-PBI-CT and helical acquisition mode (SRPBI-HCT) to visualize hydrogel scaffolds. The imaging parameters, including helical pitch, photon energy, and acquisition projections per rotation/revolution, were optimized to improve image quality and reduce artifacts. The results demonstrate that SR-PBI-HCT imaging can effectively avoid ring artifacts and visualize hydrogel scaffolds with good contrast.
JOURNAL OF SYNCHROTRON RADIATION
(2023)
Article
Cell & Tissue Engineering
L. L. Loundagin, D. M. L. Cooper
Summary: Abnormal changes in BMU activity can lead to osteoporosis. This review examines the alterations in BMU activity in various conditions and the impact of pharmaceutical treatments. The regulation of BMU activity and the dynamics of remodelling, particularly in cortical bone, are still poorly understood. Recent advances in imaging technology provide opportunities for studying cortical bone remodelling in vivo.
EUROPEAN CELLS & MATERIALS
(2022)
Article
Endocrinology & Metabolism
Yunyun Di, Ellen K. Wasan, Jacqueline Cawthray, Jaweria Syeda, Munawar Ali, David M. L. Cooper, Ahmad Al-Dissi, Nima Ashjaee, Wubin Cheng, James Johnston, David M. Weekes, Thomas I. Kostelnik, Chris Orvig, Kishor M. Wasan
Summary: In this study, the efficacy and toxicity of a novel lanthanum compound, La (XT), in an ovariectomized rat model of osteoporosis were evaluated. The treatment did not show kidney or liver toxicities, and increased trabecular bone stiffness.
Article
Developmental Biology
Daisy (Jihyung) Ko, Tess Kelly, Lacey Thompson, Jasmene K. Uppal, Nasim Rostampour, Mark Adam Webb, Ning Zhu, George Belev, Prosanta Mondal, David M. L. Cooper, Julia C. Boughner
Summary: Research suggests that the initiation time and developmental duration of molars in the upper and lower jaws are comparable, despite differences in retromolar space and molar sizes. This indicates that the timing of molar formation may not be influenced by jaw length and space, but rather by conditions within the dental lamina. The physical reorganization of dental epithelium and its impact on underlying mesenchyme may play a crucial role in molar onset.
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Amanda Zimmerling, Zahra Yazdanpanah, David M. L. Cooper, James D. Johnston, Xiongbiao Chen
Summary: The study found that different techniques used to prepare materials can influence the printing process and post-printing scaffold properties. Melt-blended materials demonstrated good consistency and stability, while powder-blended materials performed better in terms of mechanical properties; liquid solvent materials had limited printability and minimal micro-porosity.
BIOMATERIALS RESEARCH
(2021)