Article
Chemistry, Medicinal
Taylor Russell Ewell, Kieran Shay Struebin Abbotts, Natasha N. Bondareva Williams, Hannah Michelle Butterklee, Matthew Charles Bomar, Kole Jerel Harms, Jordan Douglas Rebik, Sarah Margaret Mast, Natalie Akagi, Gregory P. Dooley, Christopher Bell
Summary: The study aimed to describe and compare the pharmacokinetics of five commercial edible marijuana products, determine the influence of body composition on pharmacokinetics, and explore the influence of edible marijuana on glucose tolerance. Differences were found in plasma THC concentrations shortly after ingestion of different products. Body composition was related to pharmacokinetic parameters for some products, but not consistently across all five products. Overall, edible marijuana had no effect on oral glucose tolerance.
Article
Chemistry, Organic
Benedetta Bassetti, Christopher A. Hone, Oliver Kappe
Summary: This paper presents the development of two continuous flow protocols for the preparation of (-)-trans-Delta 9-tetrahydrocannabinol and (-)-trans-Delta 8-tetrahydrocannabinol, eliminating the need for extensive purification of the mixture of products obtained from the precursor reaction.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemical Research Methods
Cristina Sempio, Marilyn A. Huestis, Bruce Kaplan, Jost Klawitter, Uwe Christians, Thomas K. Henthorn
Summary: Urine is commonly used for cannabis use screening. An analysis of urinary clearance of THCCOOH showed that urine flow rate and urine creatinine concentrations significantly influence THCCOOH clearance. Only 2%-3% of bioavailable THC is excreted through urine.
DRUG TESTING AND ANALYSIS
(2022)
Article
Neurosciences
Vanessa A. Mitchell, Juliette Harley, Sherelle L. Casey, Arabella C. Vaughan, Bryony L. Winters, Christopher W. Vaughan
Summary: The study found that oral THC and CBD, either alone or in combination, have analgesic effects in an animal neuropathic pain model. However, unlike injection studies, the combination of THC:CBD lacks analgesic synergy when delivered orally. Furthermore, both oral THC and THC:CBD combination display a relatively poor therapeutic window, suggesting that CBD may provide a safer but less effective oral treatment for nerve injury-induced neuropathic pain than THC.
Article
Chemistry, Analytical
Cecilia L. Bergeria, Tory R. Spindle, Edward J. Cone, Dennis Sholler, Ella Goffi, John M. Mitchell, Ruth E. Winecke, George E. Bigelow, Ronald Flegel, Ryan Vandrey
Summary: Limited data is available on the pharmacokinetics of cannabidiol (CBD) in different formulations. This study compared the pharmacokinetic profiles of CBD, Delta 9-tetrahydrocannabinol (9-THC), and related metabolites in blood and oral fluid after participants took 100mg of CBD in oral and vaporized forms. The results showed that oral and vaporized formulations produce significant variability in the pharmacokinetics of CBD, and CBD alone is unlikely to convert to Delta 9-THC or produce positive drug tests for Delta 9-THC or its metabolite.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2022)
Article
Medicine, General & Internal
C. Austin Zamarripa, Tory R. Spindle, Renuka Surujunarain, Elise M. Weerts, Sumit Bansal, Jashvant D. Unadkat, Mary F. Paine, Ryan Vandrey
Summary: This study compared the pharmacokinetics and pharmacodynamics of orally administered ?9-THC-dominant and CBD-dominant cannabis extracts at the same dose of ?9-THC (20 mg). The results showed that the use of CBD-dominant extract resulted in stronger adverse effects, contradicting the common claim that CBD attenuates the adverse effects of ?9-THC. These differences are likely due to the inhibition of ?9-THC and 11-OH-?9-THC metabolism by CBD. This study is important for understanding the clinical and regulatory decisions regarding the use of cannabis products and the interactions between cannabinoid compounds and drugs.
Article
Psychology, Biological
Elisa Pabon, Frederica Rockwood, Greg J. Norman, Harriet de Wit
Summary: This study investigated the effects of oral THC on autonomic nervous system function in healthy adult women, finding that THC dose-dependently increased heart rate, decreased parasympathetic activity, and increased feelings of cannabis-like intoxication and anxiety. These results provide valuable insight into the relationship between autonomic effects of THC and subjective drug experience.
Article
Pharmacology & Pharmacy
Samantha L. Penman, Erin C. Berthold, Abrianna Mihalkovic, Nikki Hammond, Christopher R. Mccurdy, Kenneth Blum, Rina D. Eiden, Abhisheak Sharma, Panayotis K. Thanos
Summary: This study examined the pharmacokinetic and phenotypic profile of acutely inhaled THC in female rats compared to intraperitoneal injection, revealing differences in THC exposure between routes of administration.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Anesthesiology
Johannes Mueller, Walter Ploechl, Birgit Reiter, Thomas Stimpfl, Alexandra Graf, Joanna Baron-Stefaniak, Lukas Infanger, Thomas Hamp
Summary: This study aimed to investigate the effect of THC on the MAC of sevoflurane in rats. The results showed that gastric administration of THC 10mg/kg significantly reduced the MAC of sevoflurane.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2021)
Article
Neurosciences
Guy Shapira, Ifat Israel-Elgali, Meitar Grad, Eden Avnat, Lital Rachmany, Yosef Sarne, Noam Shomron
Summary: A microdose of THC can improve cognitive function and cause changes in brain morphology and biochemistry in old mice, possibly by affecting gene expression related to neurogenesis and brain development.
FRONTIERS IN NEUROSCIENCE
(2023)
Letter
Hematology
Aline Hatem, Sofia Esperti, Nicoletta Murciano, Min Qiao, Maria Giustina Rotordam, Nadine Becker, Elie Nader, Felix Maurer, Laurent Peres, Guillaume Bouyer, Lars Kaestner, Philippe Connes, Stephane Egee
Summary: THC activates the TRPV2 channel, resulting in a significant influx of calcium ions into sickle cell red blood cells, which may have harmful effects.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Environmental Sciences
Torki A. Zughaibi, Hassan Alharbi, Adel Al-Saadi, Abdulnasser E. Alzahrani, Ahmed I. Al-Asmari
Summary: This study investigated the presence of THC-COOH in postmortem fluid obtained from the chest cavity, and evaluated its suitability as a complementary specimen when bodily fluids are not available or suitable for analysis. The study found a relationship between THC-COOH concentration in the FCC samples and age, BMI, polydrug intoxication, manner, and cause of death.
Article
Chemistry, Physical
Edyta Rekiel, Anna Zdziennicka, Bronis Law Ja
Summary: This study examined the contact angle of ethanol and surfactin mixture on PTFE, PMMA and quartz surfaces at various ethanol concentrations, as well as determined the Gibbs adsorption isotherm and standard free energy of adsorption. The research also compared the isotherms of ethanol and surfactin adsorption at different interfaces and explained the linear relationship between adhesion and surface tension. Additionally, the study explored the formation of mixed layer of ethanol and surfactin beyond the solution drop settled on the PMMA and quartz surfaces.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Biochemistry & Molecular Biology
Thomas Murphy, Justin Matheson, Robert E. Mann, Bruna Brands, Christine M. Wickens, Arun K. Tiwari, Clement C. Zai, James Kennedy, Bernard Le Foll
Summary: This pilot study investigated the association between specific genetic variations within the CNR1 gene and the subjective effects of smoked cannabis. It found that carriers of the rs1049353 and rs2023239 minor alleles experience augmented subjective effects during acute cannabis intoxication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Jason C. Hedges, Carol B. Hanna, Lyndsey E. Shorey-Kendrick, Emily R. Boniface, Jasper C. Bash, Travis L. Rice-Stitt, Fernanda C. Burch, Rahul D'Mello, Terry K. Morgan, Ana Cristina Lima, Juanito Jose D. Terrobias, Jason A. Graham, Emily C. Mishler, Jared V. Jensen, Olivia L. Hagen, J. Wes Urian, Eliot R. Spindel, Charles A. Easley, Susan K. Murphy, Jamie O. Lo
Summary: This study used rhesus macaques as the animal model to investigate the effects of THC on male reproductive health and whether discontinuation of THC use can mitigate these effects. The results showed that chronic THC use caused testicular atrophy, decreased sex hormone levels, and changes in semen parameters, while these effects were partially restored after discontinuation of THC use.
FERTILITY AND STERILITY
(2023)