4.6 Article

Catalytic kinetics of single gold nanoparticles observed via optical microwell arrays

Journal

NANOTECHNOLOGY
Volume 26, Issue 5, Pages -

Publisher

IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/26/5/055704

Keywords

nanocatalysis; single particle studies; gold nanoparticles

Funding

  1. Harvard University's Center for Nanoscale Systems (CNS) through the NSF National Nanotechnology Infrastructure Network (NNIN)

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Catalytic activities and kinetics are measured at the single-particle level for gold nanoparticles catalyzing a fluorogenic oxidation reaction. This measurement is accomplished by confining the reactions in optically addressable microwell arrays. Citrate-capped gold nanoparticles are isolated in sealed similar to 70 fL microwells along with a substrate, and the accumulation of a fluorescent product over time is observed. Thousands of reactions are measured in parallel. Catalytic activities are calculated for each nanoparticle and the activity distribution is analyzed.

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