Doxycycline-sensitized solid-phase fluorescence of europium on silica in the presence of surfactants

The effect of the second ligand and surfactant micelles on the solid-phase time-resolved fluorescence of europium sensitized by doxycycline on Silasorb 600 is studied. A procedure of the sorption-luminescence determination of doxycycline using micelles of Triton X-100 nonionic surfactant is developed; the detection limit is 1.1 x 10(-7). The analytical range for doxycycline is 3 x 10(-7) to 3 x 10(-5) M. The procedure is tested on a doxycycline pharmaceutical drug; RSD was no worse than 4%.