Review
Chemistry, Analytical
A. Fernez Asensio, E. Alvarez-Gonzalez, A. Rodriguez, L. M. Sierra, E. Blanco-Gonzalez
Summary: Dysregulation of TCA cycle enzymes leads to abnormal accumulation of oncometabolites, which contribute to cancer formation and progression. GC-MS and LC-MS are powerful analytical tools for accurate identification and determination of these metabolites.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Shahed Hassanpoor, Elham Tamri, Mostafa Hasanpour
Summary: In this study, FeS2/SRGO nanocomposite was synthesized and characterized, and successfully applied for the electrochemical determination of digoxin. The accuracy and precision of the method for digoxin determination in real samples were confirmed.
Article
Biochemical Research Methods
Martin Meyer, Lidia Montero, Sven W. Meckelmann, Oliver J. Schmitz
Summary: This study compared the analysis of carbohydrates using four common chromatographic methods coupled to mass spectrometry. It was found that gas chromatography and reversed-phase liquid chromatography, after derivatisation, showed superior separation performance compared to the other methods. Targeted analysis using different working modes of the mass spectrometer improved sensitivity and repeatability, with RP-LC-MS in MRM mode after derivatisation being the most suitable method for monosaccharide analysis.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Irena Y. Brozyna-Heredia, Mayar Luis Ganoza-Yupanqui, Luis Moreno-Exebio, Jean Leandro Dos Santos
Summary: This review paper describes the bioanalytical methods based on Liquid Chromatography that are utilized to quantify antitubercular drugs and their metabolites in different biological samples. These methods are crucial for determining bioequivalence and conducting pharmacokinetic studies.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Jayshil A. Bhatt, Hui Wei, Armita Azarpanah, Kenneth R. Morris, Qing Cai
Summary: The aim of this study was to develop and validate sensitive and efficient analytical methods for estimating systemic drug exposure and residual drug in topical delivery systems. Lidocaine was successfully analyzed using liquid-liquid extraction and ultra high-performance liquid chromatography. A separate LC-MS/MS method was developed for analyzing lidocaine in human serum samples. The developed methods are recommended for quantifying systemic exposure and residual drug analysis of topical systems.
Article
Biochemistry & Molecular Biology
Anna A. Druzina, Nadezhda V. Dudarova, Ivan V. Ananyev, Anastasia A. Antonets, Dmitry N. Kaluzhny, Alexey A. Nazarov, Igor B. Sivaev, Vladimir I. Bregadze
Summary: The synthesis of the first conjugates of acridine with cobalt bis(dicarbollide) was reported. A novel 9-azido derivative of acridine was prepared and its solid-state molecular structure was determined. The obtained conjugates showed weak binding with DNA, but demonstrated potential for the development of new agents for boron neutron capture therapy (BNCT).
Article
Biochemical Research Methods
Sara R. Fernandes, Andreia N. Meireles, Sara S. Marques, Luis Silva, Luisa Barreiros, Benedita Sampaio-Maia, Manuel Miro, Marcela A. Segundo
Summary: This review addresses the monitoring and evaluation of protein-bound uremic retention solutes in biological fluids, such as indole-3-acetic acid, indoxyl sulfate, p-cresol, and p-cresol sulfate, which have been associated with the development of kidney, cardiovascular, and bone toxicities. The review discusses conventional and advanced sample treatment procedures and chromatographic analytical methods for quantification of these compounds, with a particular focus on plasma, serum, and urine samples. There is a trend towards using liquid chromatography-tandem mass spectrometry for analysis, requiring protein precipitation, solid-phase extraction, and/or dilution prior to sample analysis. Miniaturized methods using microplate devices are recommended for sustainability.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Review
Engineering, Biomedical
Peng Wang, Yonghui Yuan, Ke Xu, Hongshan Zhong, Yinghui Yang, Shiyu Jin, Ke Yang, Xun Qi
Summary: Copper is an essential trace element in the human body, impacting health through enzyme and protein functions. Researchers are increasingly focusing on developing novel copper-containing biomaterials with unique properties for cardiovascular protection, bone healing, and antibacterial effects. These materials also show potential in wound healing, cancer treatment, PET imaging, and radiotherapy applications.
BIOACTIVE MATERIALS
(2021)
Article
Environmental Sciences
Pei Li, Caijiao He, Daohui Lin
Summary: A new method for extracting and quantifying nanoplastics from biological samples was developed in this study. The method involved alkaline digestion, cloud point extraction, and gold nanoparticles formation for quantification using single particle inductively coupled plasma mass spectrometry. The method was proven to be efficient and sensitive, allowing for accurate quantification of different sizes and surface functionalities of polystyrene nanoparticles. The method was validated using representative organism samples and showed good recovery rates and low limits of detection, making it a useful approach for studying the environmental behavior and toxicity of nanoparticles.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Amorn Slosse, Filip Van Durme, Nele Samyn, Debby Mangelings, Yvan Vander Heyden
Summary: The study aimed to evaluate the variability of illicit Cannabis samples using GC-FID and GC-MS herbal fingerprints, and establish thresholds for linking seized samples. By optimizing fingerprint-alignment parameters and using different data pre-treatments, improvements in discrimination between seized Cannabis samples were achieved. The study also highlighted the importance of accurate data pre-processing and calibration in enhancing the reliability of the results.
Review
Instruments & Instrumentation
Kai Shi, Xiaoyan Tu, Yan Hu, Xinfeng Zhang
Summary: Thallium (Tl) pollution has become a major concern due to its high toxicity and increasing release into the environment by human activities. Accurate determination of Tl in biological and environmental samples is crucial as its bioaccumulation can lead to various diseases and even death. This review article provides an overview of different analytical methods for Tl detection, including atomic emission spectrometry, atomic absorption spectrometry, inductively coupled plasma mass spectrometry, and molecular spectroscopy. It also summarizes the current trends in sample pretreatment techniques for Tl detection in environmental and biological samples, as well as briefly discussing the speciation analysis of different Tl species.
APPLIED SPECTROSCOPY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Shirley Kholofelo Selahle, Anele Mpupa, Philiswa Nosizo Nomngongo
Summary: Contaminants of emerging concern, such as PFAS, have attracted significant interest due to their impact on the environment. A study utilized dispersive magnetic solid-phase extraction for the enrichment of PFAS in water samples, achieving wide linear range, low limits of detection, and good precision. This method showed practicality for analyzing ultra-trace PFAS in water samples.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Mona A. Alamri, Mutlaq Al-Jahdali, Najlaa S. Al-Radadi, Mostafa A. Hussien
Summary: Three new triazene compounds with different substituents were synthesized and characterized, showing good DNA binding and cytotoxic activities, especially one compound exhibiting strong inhibition against both cell lines. Molecular docking studies indicated good correlations between compound binding and experimental cytotoxicity findings.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Agriculture, Multidisciplinary
Liu Xu, Xiaocao Quan, Zhong Li, Peter Maienfisch
Summary: We conducted a research program to discover novel ethylsulfonylpyridines as insecticides with a broader spectrum, wider range of uses, and/or improved properties by introducing silicon motifs and studying their biological effects. We designed a series of Oxazosulfyl analogues in which the hydrogen atom at the 5-position of the pyridyl moiety is replaced by a trialkylsilyl group and prepared these compounds using denovo synthetic methodology. Our novel ethylsulfonylpyridines exhibited excellent insecticidal activities, with the best compound, A18, reaching the activity level of the commercial standard Oxazosulfyl against Plutella xylostella.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Optics
Bijie Bai, Xilin Yang, Yuzhu Li, Yijie Zhang, Nir Pillar, Aydogan Ozcan
Summary: Histological staining is an important technique in clinical pathology and research, but it is expensive, time-consuming, and limited in resource-limited settings. Deep learning techniques have provided a solution by digitally generating histological stains, which are rapid, cost-effective, and accurate alternatives to chemical staining methods. This review provides an overview of recent advances in deep learning-enabled virtual histological staining and discusses its future potential.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Chemistry, Medicinal
E. S. Stepanova, M. V. Ovcharov, S. S. Barsegyan, V. V. Chistyakov
PHARMACEUTICAL CHEMISTRY JOURNAL
(2016)
Article
Chemistry, Medicinal
S. S. Barsegyan, T. V. Maksimova, M. A. Morozova, E. M. Salomatin, T. E. Elizarova, A. V. Syroeshkin, T. V. Pleteneva
PHARMACEUTICAL CHEMISTRY JOURNAL
(2013)
Article
Chemistry, Medicinal
Yu. A. Obidchenko, N. S. Khuchua, R. A. Abramovich, A. Yu. Savochkina, A. S. Karamyan, S. S. Barsegyan, Yu. Yu. Khomyakov, M. V. Ovcharov, V. V. Chistyakov
PHARMACEUTICAL CHEMISTRY JOURNAL
(2013)
