Article
Biochemistry & Molecular Biology
Ching-Kun Chang, Wei-Chung Cheng, Wen-Lung Ma, Po-Ku Chen, Chu-Huang Chen, Pei-Chun Shen, Chia-Ching Chen, Shih-Hsin Chang, Yi-Hua Lai, Der-Yuan Chen
Summary: The study found that the most electronegative subfraction of HDL-c (H5%) was higher in patients with rheumatoid arthritis compared to healthy controls, and H5% was a significant predictor for subclinical atherosclerosis in RA. Additionally, H5 induced higher levels of proinflammatory cytokines in cells and promoted foam cell formation, suggesting its involvement in RA-related atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Qianyi Xiao, Jianxiong Xi, Ruru Wang, Qianhua Zhao, Xiaoniu Liang, Wanqing Wu, Li Zheng, Qihao Guo, Zhen Hong, Hua Fu, Ding Ding
Summary: This study found a significant association between a specific gene locus and incident AD, while LDL-C levels were also found to be associated with the progression from MCI to AD, especially for carriers of the AG/AA genotype, where each 1 mmol/L increase in LDL-C was associated with a significantly reduced risk of AD.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Peter Piko, Tibor Jenei, Zsigmond Kosa, Janos Sandor, Nora Kovacs, Ildiko Seres, Gyorgy Paragh, Roza Adany
Summary: This study investigates the association between HDL and its subfractions with insulin resistance (IR), and defines cut-off values for identifying an increased risk of IR. The results show a significant negative correlation between HDL-1 to -6 subfractions and HDL-L, HDL-I classes with the progression and existence of IR. HDL-2 and HDL-L exhibit the strongest correlation. Individuals with lower levels of HDL-L and HDL-2 have a higher risk of IR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jessica G. G. Woo, John T. T. Melchior, Debi K. K. Swertfeger, Alan T. T. Remaley, Ebrima A. A. Sise, Fatou Sosseh, Jeffrey A. A. Welge, Andrew M. M. Prentice, W. Sean Davidson, Sophie E. E. Moore, Laura A. A. Woollett
Summary: The study evaluated the impact of pregnancy on lipoprotein particle concentrations and compositions. It found that lipoprotein subfraction concentrations changed during gestation but were not associated with infant birth weights. Changes in the proteome of HDL were observed to support gestation.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Robertina Giacconi, Patrizia D'Aquila, Marta Balietti, Cinzia Giuli, Marco Malavolta, Francesco Piacenza, Laura Costarelli, Demetrio Postacchini, Giuseppe Passarino, Dina Bellizzi, Mauro Provinciali
Summary: Microbial dysbiosis leads to alterations in gut barrier and bacterial translocation, resulting in increased blood bacterial DNA that promotes peripheral and neuro inflammation and contributes to cognitive impairment. It also affects the production of brain-derived neurotrophic factor, which plays a role in the etiopathogenesis of Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Kym McNicholas, Maxime Francois, Jian-Wei Liu, James D. Doecke, Jane Hecker, Jeff Faunt, John Maddison, Sally Johns, Tara L. Pukala, Robert A. Rush, Wayne R. Leifert
Summary: This study identified biomarkers in saliva that can be used for early detection of cognitive impairment and Alzheimer's disease. The findings suggest that combinations of specific proteins can effectively distinguish patients with cognitive impairment and Alzheimer's disease from cognitively normal individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Health Care Sciences & Services
Ping-Song Chou, Sharon Chia-Ju Chen, Chung-Yao Hsu, Li-Min Liou, Chi-Hung Juan, Chiou-Lian Lai
Summary: L5, the most electronegative subfraction of LDL-C, may be associated with cognitive impairment through a disease stage-dependent mode that occurs during neurodegeneration. The study found a negative correlation between serum L5 levels and cognitive performance in patients with MCI, especially in the orientation and language subdomains. However, there was no significant correlation between serum L5 levels and cognitive performance in the control group.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Kyung-Hyun Cho
Summary: This article summarizes the changes in the quantity, quality, and functionality of high-density lipoproteins (HDL) in the context of health and disease, and discusses their potential role in the diagnosis and treatment of diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Paola Polverino, Milos Ajcevic, Mauro Catalan, Giulia Mazzon, Claudio Bertolotti, Paolo Manganotti
Summary: This study investigated changes in brain cortical activity using high-density EEG in patients with Alzheimer's and Parkinson's diseases who had mild cognitive impairment (MCI), and explored the correlations between quantitative spectral EEG parameters and global cognitive status. The results revealed significant alterations in EEG patterns between AD-MCI and PD-MCI patients, and highlighted the potential of EEG parameters as surrogate markers for cognitive status in both neurodegenerative diseases.
CLINICAL NEUROPHYSIOLOGY
(2022)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Geriatrics & Gerontology
Michal S. Beeri, Sue E. Leugrans, Osvaldo Delbono, David A. Bennett, Aron S. Buchman
Summary: In this study, poor muscle function, rather than reduced lean muscle mass, was found to be associated with late-life cognitive impairment, including incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Further research is needed to identify muscle structure features that may enhance the specificity of sarcopenia in identifying older adults at risk for late-life cognitive impairment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Review
Geriatrics & Gerontology
Shuai Xiang, Jin-Long Ji, Sha Li, Xi-Peng Cao, Wei Xu, Lan Tan, Chen-Chen Tan
Summary: This study conducted a systematic review and meta-analysis to evaluate the efficacy and safety of probiotic therapy on cognitive function, oxidative stress, and gastrointestinal function in patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and Parkinson's disease (PD). The results suggest that probiotics can improve cognitive and gastrointestinal symptoms in these patients, possibly through reducing inflammatory response and improving lipid metabolism.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yi-Long Huang, Chao-Hsiung Lin, Tsung-Hsien Tsai, Chen-Hua Huang, Jie-Ling Li, Liang-Kung Chen, Chun-Hsien Li, Ting-Fen Tsai, Pei-Ning Wang
Summary: This study utilized untargeted metabolomics analysis to characterize plasma metabolites in MCI patients progressing to AD and stable MCI patients. A 20-metabolite signature panel associated with the presence and progression of AD was identified using machine learning, offering predictive value for conversion from MCI to AD. Additionally, the bacteria-generated metabolite indole-3-propionic acid was identified as a predictor of AD progression, suggesting a role for gut microbiota in AD pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Marina Botello-Marabotto, M. Carmen Martinez-Bisbal, Miguel Calero, Andrea Bernardos, Ana B. Pastor, Miguel Medina, Ramon Martinez-Manez
Summary: This study employed 1H NMR spectroscopy to conduct a metabolomic study in serum samples from patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively healthy controls (HC). The aim was to search for potential metabolite biomarkers. The results highlight the potential of 1H NMR metabolomics to support the diagnosis of dementia in a less invasive way, and provide a starting point for the study of potential biomarkers to identify MCI or HC subjects at risk of developing AD in the future.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Ryo Ohtani, Michikazu Nakamura, Shinsuke Nirengi, Osamu Kawakami, Jumpei Togawa, Kento Doi, Makoto Sainouchi, Yasuhiro Kuwata, Masaki Takata, Yuichi Masuda, Ryota Matsunari, Kiyoaki Takeda, Tetsuya Tsukahara, Naoki Sakane
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2019)
Article
Biochemistry & Molecular Biology
Yingyue Zhou, Wilbur M. Song, Prabhakar S. Andhey, Amanda Swain, Tyler Levy, Kelly R. Miller, Pietro L. Poliani, Manuela Cominelli, Shikha Grover, Susan Gilfillan, Marina Cella, Tyler K. Ulland, Konstantin Zaitsev, Akinori Miyashita, Takeshi Ikeuchi, Makoto Sainouchi, Akiyoshi Kakita, David A. Bennett, Julie A. Schneider, Michael R. Nichols, Sean A. Beausoleil, Jason D. Ulrich, David M. Holtzman, Maxim N. Artyomov, Marco Colonna
Article
Psychiatry
Atsuko Nagaoka, Yasuto Kunii, Mizuki Hino, Ryuta Izumi, Chisato Nagashima, Akari Takeshima, Makoto Sainouchi, Hiroyuki Nawa, Akiyoshi Kakita, Hirooki Yabe
JOURNAL OF PSYCHIATRIC RESEARCH
(2020)
Correction
Biochemistry & Molecular Biology
Yingyue Zhou, Wilbur M. Song, Prabhakar S. Andhey, Amanda Swain, Tyler Levy, Kelly R. Miller, Pietro L. Poliani, Manuela Cominelli, Shikha Grover, Susan Gilfillan, Marina Cella, Tyler K. Ulland, Konstantin Zaitsev, Akinori Miyashita, Takeshi Ikeuchi, Makoto Sainouchi, Akiyoshi Kakita, David A. Bennett, Julie A. Schneider, Michael R. Nichols, Sean A. Beausoleil, Jason D. Ulrich, David M. Holtzman, Maxim N. Artyomov, Marco Colonna
Letter
Clinical Neurology
Makoto Sainouchi, Hidetomo Tanaka, Hiroshi Shimizu, Takuya Mashima, Takao Fukushima, Yuya Hatano, Tomohiko Ishihara, Kunihiko Makino, Osamu Onodera, Akiyoshi Kakita
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Psychiatry
Ryuta Izumi, Mizuki Hino, Akira Wada, Atsuko Nagaoka, Takashi Kawamura, Tsutomu Mori, Makoto Sainouchi, Akiyoshi Kakita, Kiyoto Kasai, Yasuto Kunii, Hirooki Yabe
Summary: Studies have shown that inflammation is associated with the pathology of schizophrenia, with elevated levels of inflammatory cytokines in the brain and blood of patients. Analysis revealed changes in IL-1 alpha, IP-10, and IFN-alpha expression, potentially regulated by a common upstream pathway, providing insight into post-inflammatory alteration in chronic schizophrenia.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yasuto Kunii, Junya Matsumoto, Ryuta Izumi, Atsuko Nagaoka, Mizuki Hino, Risa Shishido, Makoto Sainouchi, Hiroyasu Akatsu, Yoshio Hashizume, Akiyoshi Kakita, Hirooki Yabe
Summary: Phosphoinositides play crucial roles in the brain functioning, and their metabolic pathways have been shown to be associated with the pathophysiology of schizophrenia. This study investigated the expression levels of PI signaling-associated proteins in the postmortem brains of schizophrenia patients and found lower expression of PIK4CA and higher expression of Akt in the prefrontal cortex of these patients. These results suggest that PIK4CA may be involved in the mechanism underlying the pathogenesis of schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Neurosciences
Makoto Sainouchi, Yuya Hatano, Mari Tada, Tomohiko Ishihara, Shoichiro Ando, Taisuke Kato, Jun Tokunaga, Gaku Ito, Hiroaki Miyahara, Yasuko Toyoshima, Akio Yokoseki, Tetsutaro Ozawa, Kohei Akazawa, Osamu Onodera, Akiyoshi Kakita
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Correction
Neurosciences
Makoto Sainouchi, Yuya Hatano, Mari Tada, Tomohiko Ishihara, Shoichiro Ando, Taisuke Kato, Jun Tokunaga, Gaku Ito, Hiroaki Miyahara, Yasuko Toyoshima, Akio Yokoseki, Tetsutaro Ozawa, Kohei Akazawa, Osamu Onodera, Akiyoshi Kakita
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Clinical Neurology
Ken Yasuda, Takashi Ayaki, Fangzhou Li, Yasuhiro Kuwata, Takakuni Maki, Makoto Sainouchi, Koki Moriyoshi, Michikazu Nakamura, Ryosuke Takahashi
Summary: A 79-year-old man presented with subacute onset of dementia, and brain MRI revealed leukoencephalopathy and microbleeds. Autopsy findings showed advanced-stage Alzheimer's disease, with amyloid-beta immunohistochemistry indicating cerebral amyloid angiopathy primarily affecting arteries. The disruption of the blood-brain barrier was found to be the cause of leukoencephalopathy rather than ischemia.
Article
Clinical Neurology
Makoto Sainouchi, Mari Tada, Yusran Ady Fitrah, Norikazu Hara, Kou Tanaka, Jiro Idezuka, Izumi Aida, Takashi Nakajima, Akinori Miyashita, Kohei Akazawa, Takeshi Ikeuchi, Osamu Onodera, Akiyoshi Kakita
Summary: The presence of TDP-43 inclusions in the brains of CBD patients has been correlated with clinical phenotypes. This study investigated the relationship between TDP-43 inclusions and neuronal loss in CBD. The results suggest that TDP-43 alterations in neurons, independent of tau pathology, may contribute to neuronal degeneration in CBD.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Peripheral Vascular Disease
Ken Yasuda, Shunichi Fukuda, Michikazu Nakamura, Ryo Ohtani, Yasuhiro Kuwata, Masaki Takata, Makoto Sainouchi, Masahiro Gotou, Yuichi Masuda, Satoru Kawarazaki, Yasuhiro Kawabata, Nagako Murase, Tomokazu Aoki, Naohiro Yonemoto, Masaharu Akao, Tetsuya Tsukahara
CEREBROVASCULAR DISEASES EXTRA
(2018)