Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 65, Issue 2, Pages 597-605Publisher
IOS PRESS
DOI: 10.3233/JAD-180394
Keywords
Depression; network; small vessel disease
Categories
Funding
- National Research Foundation of Korea(NRF) - Ministry of Science, ICT & Future Planning [2016M3C7A1913844]
- National Research Foundation of Korea(NRF) - Korea government(MSIP) [NRF-2017R1A2B2005081]
Ask authors/readers for more resources
Late life depression is related to pathologic burdens, such as cerebral small vascular disease (CSVD) and amyloid, which are associated with brain network changes and cortical thinning. To examine the associations of various CSVD imaging markers, amyloid, and network changes with depression in cognitively impaired patients, we prospectively recruited 228 cognitively impaired patients having various degrees of amyloid and CSVD who underwent diffuse tensor image and PiB PET. Greater CSVD burden was associated with greater Geriatric Depression Scale (GDS) (white matter hyperintensities, WMH: p = 0.025, lacunes: p < 0.001) but not with amyloid (p = 0.095), and cortical thinning (p = 0.630) was not associated with greater GDS. The changes in white matter networks were related to GDS with decreasing integration (global efficiency: p < 0.001) and increasing segregation (clustering coefficient: p = 0.009). The network changes mediated the relationships of WMH and lacunes with GDS. Our findings provide insight to better understand how CSVD burdens contribute to depression in cognitively impaired patients having varying degrees of amyloid and vascular burdens.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available