Article
Clinical Neurology
Brandon Frank, Madeline Ally, Bailee Brekke, Henrik Zetterberg, Kaj Blennow, Michael A. Sugarman, Nicholas J. Ashton, Thomas K. Karikari, Yorghos Tripodis, Brett Martin, Joseph N. Palmisano, Eric G. Steinberg, Irene Simkina, Katherine W. Turk, Andrew E. Budson, Maureen K. O'Connor, Rhoda Au, Lee E. Goldstein, Gyungah R. Jun, Neil W. Kowall, Thor D. Stein, Ann C. McKee, Ronald Killiany, Wei Qiao Qiu, Robert A. Stern, Jesse Mez, Michael L. Alosco
Summary: The study found that plasma p-tau(181) is effective in detecting AD dementia and supports the use of blood-based biomarkers for optimal disease detection. Plasma NfL also showed potential in discriminating diagnostic groups, while p-tau(181) had a direct association with cognitive diagnosis.
ALZHEIMERS & DEMENTIA
(2022)
Review
Clinical Neurology
Monica Rosselli, Idaly Velez Uribe, Emily Ahne, Layaly Shihadeh
Summary: Alzheimer's disease is the most frequent cause of dementia, characterized by abnormal accumulation of beta-amyloid and tau proteins. This review explores cultural and racial differences in cognition, test performance, and biomarkers, emphasizing the need for diversity and inclusion in Alzheimer's research.
Review
Clinical Neurology
Scott Carlson, Hyun Kim, Davangere P. Devanand, Terry E. Goldberg
Summary: The article comprehensively examines recent advancements in developing novel cognitive measures that can significantly improve the detection of outcome changes in Alzheimer's disease clinical trials. These new measures aim to detect early cognitive declines by reducing practice effects and exhibiting stronger correlations with Alzheimer's disease biomarkers. The article also discusses efforts in developing remote testing measures protocols and digital phenotyping as solutions to the limitations and inconvenience of in-person testing. However, further validation of the psychometric properties and diagnostic accuracies of these novel measures is required before they can be reliably implemented in Alzheimer's disease clinical trials.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Giulio Papiri, Arianna Vignini, Luigi Capriotti, Paola Verdenelli, Sonila Alia, Alice Di Paolo, Chiara Fiori, Sara Baldinelli, Mauro Silvestrini, Simona Luzzi
Summary: Alzheimer's disease and Multiple Sclerosis are emerging health problems globally, contributing significantly to disability burden in Western countries. This study found higher levels of α-CGRP in cerebrospinal fluid in control subjects and MS patients compared to AD patients, suggesting a potential differential involvement of α-CGRP in these disabling diseases. Retrospective analysis also showed an association between higher CSF CGRP content and higher MRI lesion count in MS, as well as lower α-CGRP levels and worse attention and visuo-perceptual skills in AD.
Article
Biochemistry & Molecular Biology
Andrea Mastrangelo, Veria Vacchiano, Corrado Zenesini, Edoardo Ruggeri, Simone Baiardi, Arianna Cherici, Patrizia Avoni, Barbara Polischi, Francesca Santoro, Sabina Capellari, Rocco Liguori, Piero Parchi
Summary: Recent studies have shown that ALS patients have higher levels of plasma GFAP compared to controls, and this marker is associated with cognitive decline. Plasma GFAP is an accurate biomarker for identifying Alzheimer's disease co-pathology in ALS, which can influence the cognitive phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Clinical
Kevin Duff, Kayla R. Suhrie, Dustin B. Hammers, Ava M. Dixon, Jace B. King, Vincent Koppelmans, John M. Hoffman
Summary: This study examined the relationship between the Indexes and subtest scores of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and three biomarkers of Alzheimer's disease (AD). The results showed that the RBANS scores were significantly related to amyloid deposition, hippocampal volumes, and APOE status, with poorer performance on the RBANS being associated with biomarker positivity.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Biochemistry & Molecular Biology
Yan Liu, Jinzhou Tian
Summary: This review discusses the alteration of neuroprotective proteins in Alzheimer's disease (AD), including changes in their contents and variants, as well as single nucleotide polymorphism (SNP) and gene changes. Epigenetic changes in AD are also highlighted, providing insights into the characteristics of the disease and guiding research in this area.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Cendrine Foucard, Juliette Palisson, Catherine Belin, Chloe Bereaux, Julien Dumurgier, Claire Paquet, Bertrand Degos, Elodie Bouaziz-Amar, Didier Maillet, Marion Houot, Beatrice Garcin
Summary: The TNI-93 is a quick memory test designed for all patients, regardless of their education level. In this study, the diagnostic value of TNI-93 for patients with biologically confirmed amyloid status was assessed. The results showed that immediate, free, and total recalls of TNI-93 are valuable tools for the diagnosis of Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Haiyan Liu, Nicolas R. Barthelemy, Vitaliy Ovod, James G. Bollinger, Yingxin He, Samir L. Chahin, Brendan Androff, Randall J. Bateman, Brendan P. Lucey
Summary: Sleep deprivation increases cerebrospinal fluid (CSF) amyloid beta (Aβ) and tau levels, while decreasing plasma levels. These findings suggest that sleep loss affects plasma biomarkers of Alzheimer's disease and should be taken into account when interpreting individual plasma biomarkers.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Christina Rabe, Tobias Bittner, Alexander Jethwa, Ivonne Suridjan, Ekaterina Manuilova, Michel Friesenhahn, Erik Stomrud, Henrik Zetterberg, Kaj Blennow, Oskar Hansson
Summary: This study evaluated the clinical performance and robustness of plasma Aβ(42)/Aβ(40) as a prescreening tool for Alzheimer's disease. It found that there were misclassifications caused by measurement errors and pre-analytical errors, and suggested that other blood biomarkers may be easier to implement as robust prescreening tools.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Clifford R. Jack Jr, Heather J. Wiste, Alicia Algeciras-Schimnich, Dan J. Figdore, Christopher G. Schwarz, Val J. Lowe, Vijay K. Ramanan, Prashanthi Vemuri, Michelle M. Mielke, David S. Knopman, Jonathan Graff-Radford, Bradley F. Boeve, Kejal Kantarci, Petrice M. Cogswell, Matthew L. Senjem, Jeffrey L. Gunter, Terry M. Therneau, Ronald C. Petersen
Summary: Staging the severity of Alzheimer's disease pathology is important for therapeutic trials and clinical prognosis. Biomarkers such as amyloid and tau PET can be used for disease staging, but plasma biomarkers would be more practical.
Article
Clinical Neurology
Salvatore Mazzeo, Michael Lassi, Sonia Padiglioni, Alberto Arturo Vergani, Valentina Moschini, Maenia Scarpino, Giulia Giacomucci, Rachele Burali, Carmen Morinelli, Carlo Fabbiani, Giulia Galdo, Lorenzo Gaetano Amato, Silvia Bagnoli, Filippo Emiliani, Assunta Ingannato, Benedetta Nacmias, Sandro Sorbi, Antonello Grippo, Alberto Mazzoni, Valentina Bessi
Summary: This study aims to use machine learning to predict Alzheimer's disease (AD) in patients with Subjective Cognitive Decline (SCD). By using non-invasive and easily accessible assessment tools, the study aims to identify patients who will progress to AD dementia. Through long-term follow-up and training of a machine learning algorithm, the expected results may provide effective and cost-effective methods for the diagnosis and treatment of early-stage AD patients.
Article
Neurosciences
Xi Xiong, Haijun He, Qianqian Ye, Shuangjie Qian, Shuoting Zhou, Feifei Feng, Evandro F. Fang, Chenglong Xie
Summary: The study aims to determine the most accurate biomarkers within the ATN framework for diagnosing Alzheimer's disease (AD) and predicting longitudinal cognitive decline. Results show that CSF-A, neuroimaging-T, and neuroimaging-N have the highest potential for accurate diagnosis of AD. Neuroimaging-T and CSF-N also demonstrate excellent predictive ability for cognitive decline. Overall, plasma, CSF, and neuroimaging biomarkers differ significantly within the ATN framework, with CSF-A, neuroimaging-T, and neuroimaging-N being the most accurate target biomarkers for diagnosing AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Zhenrong Fu, Mingyan Zhao, Yuxia Li, Yirong He, Xuetong Wang, Zongkui Zhou, Ying Han, Shuyu Li
Summary: This study evaluated SCD subtypes in a Chinese cohort and examined associated neuroimaging markers, biomarkers, and clinical outcomes. Four subtypes were identified: dysexecutive/mixed SCD, neuropsychiatric SCD, amnestic SCD, and cluster-derived normal. Each subtype showed distinct patterns in gray matter volume and amplitude of low-frequency fluctuations.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Mohamad El Haj, Claire Boutoleau-Bretonniere, Guillaume Chapelet
Summary: The study assessed the interpretation ability of the artificial intelligence model ChatGPT in neuropsychological screening. The results showed that while ChatGPT accurately interpreted the scores of each test, it did not use standardized scores and could not specify the cognitive domain of impairment.
AGEING RESEARCH REVIEWS
(2023)
Review
Clinical Neurology
Sid E. O'Bryant, Veer Gupta, Kim Henriksen, Melissa Edwards, Andreas Jeromin, Simone Lista, Chantal Bazenet, Holly Soares, Simon Lovestone, Harald Hampel, Thomas Montine, Kaj Blennow, Tatiana Foroud, Maria Carrillo, Neill Graff-Radford, Christoph Laske, Monique Breteler, Leslie Shaw, John Q. Trojanowski, Nicole Schupf, Robert A. Rissman, Anne M. Fagan, Pankaj Oberoi, Robert Umek, Michael W. Weiner, Paula Grammas, Holly Posner, Ralph Martins
ALZHEIMERS & DEMENTIA
(2015)
Review
Clinical Neurology
Christoph Laske, Hamid R. Sohrabi, Shaun M. Frost, Karmele Lopez-de-Ipina, Peter Garrard, Massimo Buscema, Justin Dauwels, Surjo R. Soekadar, Stephan Mueller, Christoph Linnemann, Stephanie A. Bridenbaugh, Yogesan Kanagasingam, Ralph N. Martins, Sid E. O'Bryant
ALZHEIMERS & DEMENTIA
(2015)
Article
Psychology, Clinical
Nicole D. Torrence, Samantha E. John, Brandon E. Gavett, Sid E. O'Bryant
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2016)
Article
Psychology, Clinical
Danielle R. Jahn, Jeffrey A. Dressel, Brandon E. Gavett, Sid E. O'Bryant
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2015)
Article
Geriatrics & Gerontology
Harold M. Szerlip, Melissa L. Edwards, Benjamin J. Williams, Leigh A. Johnson, Raul M. Vintimilla, Sid E. O'Bryant
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2015)
Article
Clinical Neurology
James R. Hall, April R. Wiechmann, Rebecca L. Cunningham, Leigh A. Johnson, Melissa Edwards, Robert C. Barber, Meharvan Singh, Scott Winter, Sid E. O'Bryant
ALZHEIMERS RESEARCH & THERAPY
(2015)
Article
Clinical Neurology
Bruno Dubois, Harald Hampel, Howard H. Feldman, Philip Scheltens, Paul Aisen, Sandrine Andrieu, Hovagim Bakardjian, Habib Benali, Lars Bertram, Kaj Blennow, Karl Broich, Enrica Cavedo, Sebastian Crutch, Jean-Francois Dartigues, Charles Duyckaerts, Stephane Epelbaum, Giovanni B. Frisoni, Serge Gauthier, Remy Genthon, Alida A. Gouw, Marie-Odile Habert, David M. Holtzman, Miia Kivipelto, Simone Lista, Jose-Luis Molinuevo, Sid E. O'Bryant, Gil D. Rabinovici, Christopher Rowe, Stephen Salloway, Lon S. Schneider, Reisa Sperling, Marc Teichmann, Maria C. Carrillo, Jeffrey Cummings, Cliff R. Jack
ALZHEIMERS & DEMENTIA
(2016)
Article
Behavioral Sciences
James R. Hall, April Wiechmann, Melissa Edwards, Leigh A. Johnson, Sid E. O'Bryant
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Neurosciences
Leigh A. Johnson, Adriana Gamboa, Raul Vintimilla, Melissa Edwards, James Hall, Brent Weiser, Menaka Yadav, Tony Dickensheets, Sid E. O'Bryant
JOURNAL OF ALZHEIMERS DISEASE
(2016)
Article
Geriatrics & Gerontology
Leigh A. Johnson, Hamid R. Sohrabi, James R. Hall, Taddei Kevin, Melissa Edwards, Sid E. O'Bryant, Ralph N. Martins
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2015)
Article
Multidisciplinary Sciences
Robert C. Barber, Nicole R. Phillips, Jeffrey L. Tilson, Ryan M. Huebinger, Shantanu J. Shewale, Jessica L. Koenig, Jeffrey S. Mitchel, Sid E. O'Bryant, Stephen C. Waring, Ramon Diaz-Arrastia, Scott Chasse, Kirk C. Wilhelmsen
Article
Neurosciences
Melissa Edwards, James Hall, Benjamin Williams, Leigh Johnson, Sid O'Bryant
JOURNAL OF ALZHEIMERS DISEASE
(2016)
Review
Neurosciences
Simone Lista, Jose L. Molinuevo, Enrica Cavedo, Lorena Rami, Philippe Amouyel, Stefan J. Teipel, Francesco Garaci, Nicola Toschi, Marie-Odile Habert, Kaj Blennow, Henrik Zetterberg, Sid E. O'Bryant, Leigh Johnson, Samantha Galluzzi, Arun L. W. Bokde, Karl Broich, Karl Herholz, Hovagim Bakardjian, Bruno Dubois, Frank Jessen, Maria C. Carrillo, Paul S. Aisen, Harald Hampel
JOURNAL OF ALZHEIMERS DISEASE
(2015)
Article
Neurosciences
Leigh A. Johnson, Adriana Gamboa, Raul Vintimilla, Austin J. Cheatwood, Alyann Grant, Ashesh Trivedi, Melissa Edwards, James R. Hall, Sid E. O'Bryant
JOURNAL OF ALZHEIMERS DISEASE
(2015)
Review
Neurosciences
Simone Lista, Sid E. O'Bryant, Kaj Blennow, Bruno Dubois, Jacques Hugon, Henrik Zetterberg, Harald Hampel
JOURNAL OF ALZHEIMERS DISEASE
(2015)