Article
Multidisciplinary Sciences
Antony Gonzales, Deysi Choque, Pool Marcos-Carbajal, Guillermo Salvatierra
Summary: Diphtheria three-dose complete vaccination coverage in Peru has not reached the minimum recommended by the WHO. Factors such as maternal age, language, occupation, and accessibility are associated with completion of the vaccination scheme. These results can be used as a baseline to improve vaccination programs, reduce barriers, and increase DPT coverage in Peru.
Article
Microbiology
Eun Kim, Muhammad S. Khan, Alessandro Ferrari, Shaohua Huang, Jose C. Sammartino, Elena Percivalle, Thomas W. Kenniston, Irene Cassaniti, Fausto Baldanti, Andrea Gambotto
Summary: The study evaluates the booster effect of an S1 subunit vaccine in aged mice previously primed with adenoviral vaccines. It demonstrates that a booster dose of the rS1Beta subunit vaccine, given to mice, induces strong and long-lived S1-specific immune responses and significantly increases neutralizing antibodies against Wuhan, Beta, and Delta strains, including cross-reactive antibodies against Omicron variants. The findings suggest that the rS1Beta subunit vaccine can offer cross-neutralization against broad variants, providing important implications for controlling breakthrough SARS-CoV-2 variants in elderly individuals primed with adenovirus-based vaccines.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Annieck M. Diks, Pauline Versteegen, Cristina Teodosio, Rick J. Groenland, Bas de Mooij, Anne-Marie Buisman, Alba Torres-Valle, Martin Perez-Andres, Alberto Orfao, Guy A. M. Berbers, Jacques J. M. van Dongen, Magdalena A. Berkowska
Summary: This study used high-dimensional flow cytometry to investigate changes in B cells after administration of an acellular pertussis booster vaccine. The results showed that the expansion and maturation of plasma cells were the most significant cellular changes post-vaccination, and were more pronounced in individuals primed with whole-cell vaccine.
Article
Multidisciplinary Sciences
Caroline G. Atyeo, Lydia L. Shook, Sara Brigida, Rose M. De Guzman, Stepan Demidkin, Cordelia Muir, Babatunde Akinwunmi, Arantxa Medina Baez, Erin McSweeney, Madeleine Burns, Ruhi Nayak, Maya K. Kumar, Chinmay D. Patel, Allison Fialkowski, Dana Cvrk, Ilona T. Goldfarb, Lael M. Yonker, Alessio Fasano, Alejandro B. Balazs, Michal A. Elovitz, Kathryn J. Gray, Galit Alter, Andrea G. Edlow
Summary: Pregnant individuals infected with SARS-CoV-2 are at high risk of complications, but little is known about the immune response and antibody transfer from COVID-19 vaccines in different trimesters. This study characterizes the antibody response and transplacental transfer in pregnant individuals who received Ad26.COV2.S, mRNA-1273, or BNT162b2 vaccines. The findings show differences in vaccine-induced functions, receptor-binding, and efficacy against variants of concern. First and third trimester vaccination enhances maternal immune response and antibody transfer compared to the second trimester. These results provide valuable insights into the effect of vaccine platform and timing on maternal immune response and transplacental antibody transfer.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Annieck M. Diks, Indu Khatri, Liesbeth E. M. Oosten, Bas de Mooij, Rick J. Groenland, Cristina Teodosio, Martin Perez-Andres, Alberto Orfao, Guy A. M. Berbers, Jaap Jan Zwaginga, Jacques J. M. van Dongen, Magdalena A. Berkowska
Summary: This study used high-throughput multicolor flow cytometry to track changes in immune cells following pertussis booster vaccination, finding that while total IgG1 plasma cells peaked at day 7 post-vaccination, they did not correlate with the increase in antigen-specific Ig levels. Instead, a strong correlation was observed between antigen-specific IgGs and the expansion of total IgG1 and IgA1 memory B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Zhangkai J. Cheng, Huimin Huang, Peiyan Zheng, Mingshan Xue, Jing Ma, Zhiqing Zhan, Hui Gan, Yifeng Zeng, Runpei Lin, Shiyun Li, Ruifen Zhong, Siping Li, Hongman Wang, Baoqing Sun
Summary: This study reports on the kinetics, durability, and neutralizing ability of the Sinopharm/BBIBP COVID-19 vaccine-induced immunity, as well as the intensified antibody response elicited by the booster dose. The findings indicate that while antibody levels decline over time, the booster dose leads to a significant increase in antibody levels, indicating enhanced immune protection.
Article
Biochemistry & Molecular Biology
Koray Uetkuer, Sarina Schmidt, Klaus Mayer, Roland Klassen, Ulrich Brinkmann, Raffael Schaffrath
Summary: This study investigates the functional and structural aspects of the Dph1·Dph2 dimer in eukaryotes. The research reveals a specific SAM-binding pocket that is essential for the synthesis of diphthamide on EF2.
Article
Immunology
Elias Kowalski, Andreas Stengel, Axel Schneider, Miriam Goebel-Stengel, Stephan Zipfel, Johanna Graf
Summary: This study investigated the factors influencing vaccination willingness among individuals infected with SARS-CoV-2 and identified specific groups hesitant to get vaccinated. Factors associated with lower vaccination willingness included younger age, foreign nationality, low income, low trust in vaccination effectiveness, and fear of negative vaccination effects. The study suggests personalized vaccination campaigns and low-threshold vaccination education targeting different groups of infected individuals.
Article
Multidisciplinary Sciences
Gudmundur L. Norddahl, Pall Melsted, Kristbjorg Gunnarsdottir, Gisli H. Halldorsson, Thorunn A. Olafsdottir, Arnaldur Gylfason, Mar Kristjansson, Olafur T. Magnusson, Patrick Sulem, Daniel F. Gudbjartsson, Unnur Thorsteinsdottir, Ingileif Jonsdottir, Kari Stefansson
Summary: This study examines the immune responses elicited by different initial/booster vaccine combinations in Iceland and evaluates the effects of booster doses against Delta and Omicron infections. The findings suggest that mRNA boosters provide increased protection against both variants compared to other vaccine combinations.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Maarten Swart, Joan van der Lubbe, Sonja Schmit-Tillemans, Ella van Huizen, Johan Verspuij, Ana Izquierdo Gil, Ying Choi, Chenandly Daal, Aditya Perkasa, Adriaan de Wilde, Erwin Claassen, Rineke de Jong, Katrin E. Wiese, Lisette Cornelissen, Marieke van Es, Marjolein van Heerden, Eleni Kourkouta, Issam Tahiri, Michel Mulders, Jessica Vreugdenhil, Karin Feddes de Boer, Leacky Muchene, Jeroen Tolboom, Liesbeth Dekking, Jarek Juraszek, Jort Vellinga, Jerome Custers, Rinke Bos, Hanneke Schuitemaker, Frank Wegmann, Ramon Roozendaal, Harmjan Kuipers, Roland Zahn
Summary: Since the outbreak of SARS-CoV-2, several rapidly spreading variants of concern (VOC) have emerged. A single dose of Ad26.COV2.S has shown to protect against the Gamma and Delta variants in naive hamsters, supporting its efficacy in humans against these VOC. However, an Omicron BA.1-based booster does not improve immunogenicity and efficacy against Omicron BA.2 compared to an Ad26.COV2.S booster in hamsters with pre-existing immunity to SARS-CoV-2.
Review
Immunology
Zichun Wei, Jiarui He, Conghui Wang, Jiaqi Bao, Taiyang Leng, Fei Chen
Summary: Omicron variant, with high transmissibility and lower virulence, has rapidly become the dominant global variant. Vaccination remains a crucial public health priority, despite the underestimation of Omicron's pathogenicity and the increasing hospitalizations and deaths due to its high transmissibility. Mutations in the spike protein, especially in the receptor-binding domain and N-terminal domain, are associated with immune escape and vaccine hesitancy. Therefore, booster dose and third dose vaccination play a vital role in combating the emerging Omicron variant.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sabina Zurac, Cristian Vladan, Octavian Dinca, Carolina Constantin, Monica Neagu
Summary: This study aims to evaluate the waning of immune response after vaccination in SARS-CoV-2 infected individuals, particularly healthcare workers. The research found that the humoral response, measured by specific IgG and IgA antibodies, decreased 2.4 times for IgG and 2.7 times for IgA after 8 months post-vaccination. However, no documented infections were observed in the group. After the booster shot, the levels of IgG increased immediately, followed by an increase in specific IgA.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Nese Saltoglu, Harika Oyku Dinc, Ilker Inanc Balkan, Gunay Can, Dogukan Ozbey, Ayse Nur Beytur, Elif Keskin, Beyhan Budak, Okan Aydogan, Bilgul Mete, Ridvan Karaali, Sevgi Ergin, Bekir Kocazeybek
Summary: The objective of this study was to evaluate the antibody responses of healthcare workers who received a booster dose of BNT162b2 vaccine 6 months after two doses of the CoronaVac vaccine. The results showed that antibody titers increased 8-fold after the booster dose, indicating that the administration of mRNA vaccine as a booster can provide more effective protection against COVID-19.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2022)
Article
Immunology
Florian D. Hastert, Sascha Hein, Christine von Rhein, Nuka Ivalu Benz, Younes Husria, Doris Oberle, Thorsten J. Maier, Eberhard Hildt, Barbara S. Schnierle
Summary: This study analyzed the immune response to the Omicron variant in individuals vaccinated with different vaccines. The results showed that only individuals vaccinated with mRNA vaccines (such as Comirnaty) or heterologous vaccines (such as AZ/BNT) developed antibody levels with neutralizing capacity against Omicron. Additionally, a third booster vaccination significantly enhanced the immune response to all variants.
Article
Medicine, Research & Experimental
Prabhu S. Arunachalam, Lilin Lai, Hady Samaha, Yupeng Feng, Mengyun Hu, Harold Sai-yin Hui, Bushra Wali, Madison Ellis, Meredith E. Davis-Gardner, Christopher Huerta, Kareem Bechnak, Sarah Bechnak, Matthew Lee, Matthew B. Litvack, Cecilia Losada, Alba Grifoni, Alessandro Sette, Veronika I. Zarnitsyna, Nadine Rouphael, Mehul S. Suthar, Bali Pulendran
Summary: The durability of serum antibody responses only marginally improves after booster immunizations with the Pfizer-BioNTech or Moderna mRNA vaccines.
JOURNAL OF CLINICAL INVESTIGATION
(2023)