Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 33, Issue 3, Pages 675-679Publisher
IOS PRESS
DOI: 10.3233/JAD-2012-121516
Keywords
Alzheimer's disease; amyloid-beta; cognitive decline; episodic memory; neuropsychological assessment
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Funding
- AstraZeneca Pharmaceuticals LP
- Australian Commonwealth Scientific Industrial and Research Organization
- Edith Cowan University
- Mental Health Research Institute
- Alzheimer's Australia
- National Ageing Research Institute
- Austin Health
- CogState Ltd.
- Hollywood Private Hospital
- Sir Charles Gardner Hospital
- National Health and Medical Research Council
- Dementia Collaborative Research Centres program
- McCusker Alzheimer's Research Foundation, Inc.
- Science and Industry Endowment Fund
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High levels of amyloid-beta (A beta) have been associated with greater rates of decline in episodic memory over 18 months in healthy older adults. Serial assessments over shorter time intervals may facilitate earlier detection of A beta-related memory decline in healthy older adults. In forty-four healthy older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Rate of Change Sub-Study, we compared rates of change in cognition over six months in healthy older adults with high and low levels of A beta. High A beta was associated with greater decline in episodic memory measures over 6 months in healthy older adults.
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