Article
Clinical Neurology
Anna Pink, Janina Krell-Roesch, Jeremy A. Syrjanen, Maria Vassilaki, Val J. Lowe, Prashanthi Vemuri, Gorazd B. Stokin, Teresa J. Christianson, Walter K. Kremers, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, Yonas E. Geda
Summary: This study found that cortical amyloid deposition, anxiety, and depression independently increased the risk of incident mild cognitive impairment. Additionally, anxiety modified the association between cortical amyloid deposition and incident mild cognitive impairment.
ALZHEIMERS & DEMENTIA
(2022)
Review
Neurosciences
Qing Zhao, Xinxin Du, Wenhong Chen, Ting Zhang, Zhuo Xu
Summary: Alzheimer's disease is a global health issue with significant negative impacts. PET/CT and neuropsychological scales are useful for early identification and diagnosis, as well as offering early therapies. There is a lack of large-scale investigations focusing on the pathology of AD and MCI, hence further research is needed to understand the interaction between neuropsychological test scales and PET/CT measurements of disease progression.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Shiloh L. Echevarria-Cooper, Emily H. Ho, Richard C. Gershon, Sandra Weintraub, Thorsten Kahnt
Summary: Olfactory decline is associated with aging, amnestic mild cognitive impairment (aMCI), and Alzheimer's disease dementia. The National Institutes of Health Toolbox Odor Identification Test (NIHTB-OIT) can distinguish between these clinical categories. The scores of NIHTB-OIT decrease with age and are lower for aMCI and ADd participants compared to NC participants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Egle Audronyte, Vaiva Sutnikiene, Gyte Pakulaite-Kazliene, Gintaras Kaubrys
Summary: This study investigated olfactory memory and its relationship with verbal memory and other clinical features in patients with early-stage Alzheimer's disease (AD). The results showed that olfactory memory was significantly impaired in patients with AD compared to individuals with mild cognitive impairment due to AD and cognitively normal older participants. Furthermore, the duration of AD symptoms was a strong predictor of olfactory recognition memory scores.
FRONTIERS IN NEUROLOGY
(2023)
Review
Immunology
Jie Huang
Summary: This review discusses the current status and applications of molecule-based positron emission tomography (PET) imaging in neuroinflammation. Despite certain limitations, neuroinflammation PET imaging is considered a promising approach to understanding the pathophysiological process of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Emmanuelle Belanger, Eric Jutkowitz, Peter Shewmaker, Courtney H. Van Houtven, James R. Burke, Brenda L. Plassman, Megan Shepherd-Banigan, Elyse Couch, Caroline Mills, Terrie T. Wetle
Summary: This study found that in individuals with cognitive impairment, those without elevated beta-amyloid levels were more likely to be diagnosed with depression. However, there was no significant association between different beta-amyloid levels and the incidence of depressive symptoms or diagnosed depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Fang Liu, Yudi Shi, Qiuyan Wu, Huifeng Chen, Ying Wang, Li Cai, Nan Zhang
Summary: The study aimed to analyze the value of F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with amyloid PET in cognitive impairment diagnosis. The results showed that hypometabolism in the temporoparietal and posterior cingulate/precuneus cortex on FDG PET suggested amyloid pathology in patients with cognitive impairment. This combined approach is helpful in diagnostic decision-making and predicting the conversion from MCI to AD dementia.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Yorito Hattori, Satoshi Saito, Yuriko Nakaoku, Soshiro Ogata, Masashi Hattori, Mio Nakatsuji, Kunihiro Nishimura, Masafumi Ihara
Summary: This retrospective study investigated the association between TAX intake and cognitive changes. The results showed that TAX intake was significantly associated with changes in visuospatial/executive function, verbal fluency, and total score of MoCA, but not with ADAS-Cog. These findings provide a basis for TAX as a novel strategy for maintaining brain health.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Computer Science, Artificial Intelligence
Ashik Mostafa Alvi, Siuly Siuly, Hua Wang, Kate Wang, Frank Whittaker
Summary: This study aims to design a deep learning-based framework for effective detection of MCI participants and compares it with other classifiers to improve the successful application of early identification and treatment strategies.
KNOWLEDGE-BASED SYSTEMS
(2022)
Article
Clinical Neurology
Jung-Min Pyun, Nayoung Ryoo, Young Ho Park, SangYun Kim
Summary: The study found that ChEIs had no impact on cognitive change and disease progression to CDR 1 in patients with MCI at a 1-year follow-up visit. The presence or absence of amyloid PET positivity did not alter this result. Progression to CDR 1 at the 1-year follow-up visit was associated with a low baseline MMSE score, but not with ChEI use or amyloid PET result.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Sheng-Min Wang, Dong Woo Kang, Yoo Hyun Um, Sunghwan Kim, Chang Uk Lee, Hyun Kook Lim
Summary: This study found that olfactory dysfunction is associated with beta-amyloid deposition in the brain and is related to cognitive impairments in the trajectory of Alzheimer's disease. Olfactory deficits may serve as an additional marker for disease progression and contribute to understanding the underlying mechanisms of AD.
Article
Endocrinology & Metabolism
Esen Saka, Lutfiye Ozlem Atay, Umit Ozgur Akdemir, Ezgi Yetim, Erdem Balci, Ethem Murat Arsava, Mehmet Akif Topcuoglu
Summary: This study investigates the relationship between amyloid load and vasomotor reactivity in Alzheimer's disease. The results show a significant negative association between amyloid load and vasomotor reactivity. Additionally, vasomotor reactivity is positively correlated with metabolic activity and cerebral blood flow, and negatively correlated with age and white matter lesion volume.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aleksandar Jovalekic, Nuria Roe-Vellve, Norman Koglin, Mariana Lagos Quintana, Aaron Nelson, Markus Diemling, Johan Lilja, Juan Pablo Gomez-Gonzalez, Vincent Dore, Pierrick Bourgeat, Alex Whittington, Roger Gunn, Andrew W. Stephens, Santiago Bullich
Summary: The purpose of this study was to demonstrate the robustness of FBB PET quantification. The results showed that quantitative methods provided comparable results to visual assessments, indicating their potential in early detection, disease monitoring, and treatment evaluation for amyloid deposition.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Clinical Neurology
Pavel Katsel, Peter Fam, Weilun Tan, Sonia Khan, Miguel Gama-Sosa, Rita De Gasperi, Panos Roussos, Ari Robinson, Itzik Cooper, Michal Schnaider-Beeri, Vahram Haroutunian
Summary: The study found that subsets of vascular genes related to early response to hypoxia were upregulated in MCI patients before the accumulation of AD neuropathology, suggesting that cerebrovascular remodeling is an important antecedent to the development of dementia and a component of the homeostatic response to reduced oxygen tension in aging prior to the onset of AD. The early activation of pro-angiogenic hypoxia-inducible factor signaling in response to mild hypoxia was also detected in mouse brains similar to those that were altered in MCI. Protracted responses to hypoxia were characterized by activation of phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt)-the mammalian target of rapamycin (mTOR) pathways in brain microvessel isolates.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Pratishtha Chatterjee, Steve Pedrini, Nicholas J. Ashton, Michelle Tegg, Kathryn Goozee, Abhay K. Singh, Thomas K. Karikari, Joel Simren, Eugeen Vanmechelen, Nicola J. Armstrong, Eugene Hone, Prita R. Asih, Kevin Taddei, Vincent Dore, Victor L. Villemagne, Hamid R. Sohrabi, Henrik Zetterberg, Colin L. Masters, Kaj Blennow, Ralph N. Martins
Summary: This study found that GFAP and p-tau have good diagnostic and longitudinal monitoring potential in preclinical Alzheimer's disease. Combining GFAP with other proteins can improve diagnostic accuracy.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Tingting Wang, Kevin Huynh, Corey Giles, Natalie A. Mellett, Thy Duong, Anh Nguyen, Wei Ling Florence Lim, Alex A. T. Smith, Gavriel Olshansky, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F. Watts, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Ashley Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Kevin Taddei, Vincent Dore, Juergen Fripp, Matthias Arnold, Gabi Kastenmueller, Kwangsik Nho, Andrew J. Saykin, Rebecca Baillie, Xianlin Han, Ralph N. Martins, Eric K. Moses, Rima Kaddurah-Daouk, Peter J. Meikle
Summary: The APOE genotype is strongly associated with late-onset Alzheimer's disease, with specific lipid species mediating up to 30% and 10% of the treatment effect of APOE epsilon 2 and epsilon 4, respectively. Plasma lipid species represent a potential therapeutic target for Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2022)
Review
Psychology, Clinical
Kerryn E. Pike, Marina G. Cavuoto, Lily Li, Bradley J. Wright, Glynda J. Kinsella
Summary: Subjective Cognitive Decline (SCD) is associated with an increased risk of developing dementia and mild cognitive impairment (MCI). Factors such as worry in the SCD definition, younger age, and recruitment source impact the risk of developing MCI, while they have little influence on the risk of developing dementia. Further research is needed to identify effective interventions for risk reduction and cognitive management in individuals with SCD.
NEUROPSYCHOLOGY REVIEW
(2022)
Article
Geriatrics & Gerontology
Kerryn E. Pike, Bradley J. Wright, Glynda J. Kinsella
Summary: The study found no significant differences in strategy use between individuals with amnestic mild cognitive impairment (aMCI) and healthy older adults, but strategy use varied depending on the task. Some strategies were more effective, while others were detrimental to performance. Therefore, in addition to teaching more beneficial approaches, it is important to identify and correct ineffective memory strategies.
EXPERIMENTAL AGING RESEARCH
(2023)
Article
Multidisciplinary Sciences
Nicholas W. G. Murray, Petra L. L. Graham, Paul F. F. Sowman, Greg Savage
Summary: Episodic memory deficits are common in aging and neurodegenerative disorders. Transcranial electrical stimulation (TES) is a promising tool for memory enhancement, but the optimal stimulation parameters are not yet determined. In a double-blind, randomized, sham-controlled study, applying TES over the left temporal lobe resulted in a decrease in word recall and an increase in memory errors compared to sham stimulation.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Clinical
Florence Requier, Anne Sophia Hendy, Marco Schlosser, Harriet Demnitz-King, Tim Whitfield, Gael Chetelat, Olga Klimecki, Antoine Lutz, Natalie L. Marchant, Fabienne Collette
Summary: This study aimed to assess the association between dispositional mindfulness (or more generally trait meditation capacities) and cognition in older adults. The results showed a positive relationship between the "deconstructive capacity" associated with self-inquiry and downregulation of maladaptive affective schemes, and global cognition in healthy aging. However, it remains unclear to what extent explicit training in meditation positively influences these capacities and whether these changes contribute to better cognition in aging.
Article
Clinical Neurology
Antoine Garnier-Crussard, Francois Cotton, Pierre Krolak-Salmon, Gael Chetelat
Summary: White matter hyperintensities (WMH) are vascular lesions frequently seen in older adults, but recent evidence suggests that non-vascular mechanisms, particularly in Alzheimer's disease (AD), may also contribute to WMH. This alternative hypothesis is supported by arguments from neuropathology, neuroimaging, fluid biomarkers, and genetics. The underlying mechanisms of AD-related WMH, such as neurodegeneration or neuroinflammation, are discussed, as well as the implications for AD diagnosis and management. Testing this hypothesis and addressing remaining challenges can improve personalized care for patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Health Care Sciences & Services
Kerryn Pike, Carl Moller, Christina Bryant, Maree Farrow, Duy P. Dao, Kathryn A. Ellis
Summary: This study evaluated the feasibility, acceptability, and efficacy of the Online Personalised Training in Memory Strategies for Everyday (OPTIMiSE) program, a web-based intervention for older adults with cognitive decline. The results showed that OPTIMiSE was feasible, acceptable, and efficacious, with improvements in memory, strategy knowledge and use, and mood. The participants reported significant changes in strategy use, daily life improvements, reduced concern about memory, and increased confidence and self-efficacy, which were consistent with previous in-person interventions. This web-based program has the potential to provide evidence-based memory interventions for older adults worldwide.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Clinical Neurology
Elizabeth Kuhn, Audrey Perrotin, Renaud La Joie, Edelweiss Touron, Sophie Dautricourt, Matthieu Vanhoutte, Denis Vivien, Vincent de La Sayette, Gael Chetelat
Summary: This study aimed to assess the association between informant-reported subjective memory decline and Alzheimer disease biomarkers. The results showed a strong correlation between the informant report and higher amyloid deposition as well as lower cognitive performance in patients with mild cognitive impairment.
Article
Oncology
Katarzyna M. Lion, Kerryn E. Pike, Haryana M. Dhillon, Eng-Siew Koh, Mark B. Pinkham, Joanne Shaw, Georgia K. B. Halkett, Tamara Ownsworth, BRAINS Program Invest
Summary: This qualitative study aimed to understand the specific psychosocial support pathways for people with brain tumors and their families from the perspectives of Australian healthcare professionals. The study found that there are challenges in fitting people into the existing care system, benefits of longer-term care coordination and interdisciplinary connections, and the impact of brain tumors on the whole family. Despite established psychosocial care pathways, service access varied and lacked continuity for individuals with lower-grade glioma and benign tumors. As a result, healthcare professionals recognize the need for improved access to care coordination and multidisciplinary psychosocial care tailored to the varying needs of people with brain tumors and their families.
Letter
Clinical Neurology
Antoine Garnier-Crussard, Gael Chetelat
ALZHEIMERS & DEMENTIA
(2023)
Review
Behavioral Sciences
Andrea Brown, Sarah K. Salo, Greg Savage
Summary: This narrative synthesis summarizes the cognitive profiles of frontal variant Alzheimer's disease (fvAD) and highlights the need for further investigation into differential diagnostic markers, such as executive dysfunction and behavioral symptoms. It also reveals some similarities between fvAD and typical AD, which may guide future research in disease diagnosis.
Article
Cell Biology
Sebastian Baez-Lugo, Yacila Deza-Araujo, Christel Maradan, Fabienne Collette, Antoine Lutz, Natalie L. Marchant, Gael Chetelat, Patrik Vuilleumier, Olga Klimecki
Summary: Basic emotional functions appear intact in older adults, but their response to and recovery from negative social events are not well understood. The researchers used a 'task-rest' paradigm and functional MRI to investigate the neural dynamics of empathy-related functions in older adults. They found that emotional elicitation during the task enhanced resting-state connectivity between the default mode network and amygdala in older adults, and this connectivity was associated with higher anxiety, rumination, and negative thoughts.
Review
Psychology, Clinical
Dana Wong, Kerryn Pike, Rene Stolwyk, Kelly Allott, Jennie Ponsford, Adam Mckay, Wendy Longley, Pascalle Bosboom, Antoinette Hodge, Glynda Kinsella, Loren Mowszowski
Summary: Delivery of neuropsychological interventions is a crucial skill for clinical neuropsychologists, with the potential to greatly impact clinical settings. This guidance paper provides considerations and recommendations for the selection, delivery, and implementation of interventions for adults and older adults, based on evidence and expert consensus. It aims to be a valuable resource for clinicians, managers, policymakers, educators, and researchers worldwide.
NEUROPSYCHOLOGY REVIEW
(2023)
Article
Cell Biology
Valentin Ourry, Stephane Rehel, Claire Andre, Alison Mary, Leo Paly, Marion Delarue, Florence Requier, Anne Hendy, Fabienne Collette, Natalie L. Marchant, Francesca Felisatti, Cassandre Palix, Denis Vivien, Vincent de la Sayette, Gael Chetelat, Julie Gonneaud, Geraldine Rauchs
Summary: Sleep, especially slow wave sleep, plays a crucial role in cognitive functioning, but it is reduced in older adults. Cognitive reserve (CR) may modulate the impact of sleep on cognition. This study found that individuals with higher CR were able to maintain cognitive performance despite lower amounts of slow wave sleep, suggesting that CR may protect against age-related sleep changes on cognition.
