Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 25, Issue 1, Pages 43-46Publisher
IOS PRESS
DOI: 10.3233/JAD-2011-110071
Keywords
Alzheimer's disease; amyloid-beta; Congo red; human brain; senile plaque; spherulites; thioflavin T
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Funding
- Somerset County Council
- Nuffield Bursary
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Recent evidence showed that amyloid-beta, A beta(42), formed spherulites in vitro and, possibly, in vivo in Alzheimer's disease brain tissue. We now confirm the presence of spherulites in human brains and that they are composed of beta sheets of amyloid. The spherulites were identical in appearance to spherulites of A beta(42) formed in vitro which suggested that they may too be composed of A beta. The physiological significance of this finding may be in its support of previous speculation that spherulites in human brain tissue are the 3-dimensional manifestations of what are otherwise identified as senile or neuritic plaques.
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