Article
Neurosciences
Joshua G. Jackson, Elizabeth Krizman, Hajime Takano, Meredith Lee, Grace H. Choi, Mary E. Putt, Michael B. Robinson
Summary: Neurovascular coupling is the coordinated increase in local blood flow in response to neuronal signaling. Glutamate transporter activation is sufficient to increase arteriole diameter, providing direct evidence for the control of blood flow. Understanding these mechanisms is important for studying neurodegenerative disorders and measuring neuronal activity.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Adrien Paumier, Sylvie Boisseau, Muriel Jacquier-Sarlin, Karin Pernet-Gallay, Alain Buisson, Mireille Albrieux
Summary: Understanding the sequence of cellular dysfunctions in preclinical Alzheimer's disease is crucial for developing new therapeutic strategies. The hyperactivity of hippocampal neurons is an early event in both humans and mouse models. This study shows that chronic inhibition of the TRPA1 channel can protect against Alzheimer's disease progression by normalizing astrocytic activity, preventing neuronal dysfunction, and preserving synaptic integrity.
Article
Biology
Pratish Thakore, Michael G. Alvarado, Sher Ali, Amreen Mughal, Paulo W. Pires, Evan Yamasaki, Harry A. T. Pritchard, Brant E. Isakson, Cam Ha T. Tran, Scott Earley
Summary: Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the brain's metabolic demands. TRPA1 channels in capillary endothelial cells act as neural activity sensors, initiating microvascular vasodilatory responses to redirect blood flow to regions of metabolic demand.
Article
Biochemistry & Molecular Biology
Soren Grubb, Martin Lauritzen, Christian Aalkjaer
Summary: Neurovascular coupling is essential for matching cerebral activity with relevant blood flow, controlled by capillaries and precapillary arterioles. Mural cells, such as pericytes and smooth muscle cells, play a crucial role in determining blood vessel diameter and flow through their tone. The structure of these blood vessels and excitation-contraction coupling of mural cells are important factors to consider.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Physiology
Lin Li, Xin-Kang Tong, Mohammadamin Hosseini Kahnouei, Diane Vallerand, Edith Hamel, Helene Girouard
Summary: Alzheimer's disease, characterized by neuronal degeneration and cerebrovascular dysfunction, may have cerebrovascular dysfunction as a key factor in its pathogenesis. This study aimed to investigate neurovascular coupling in a mouse model of AD and found that NVC is altered at multiple levels in APP mice, partly due to oxidative stress.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Ajay Vikram Singh, Vaisali Chandrasekar, Peter Laux, Andreas Luch, Sarada Prasad Dakua, Paolo Zamboni, Amruta Shelar, Yin Yang, Vaibhav Pandit, Veronica Tisato, Donato Gemmati
Summary: This study proposes a hybrid blood-brain barrier (BBB)-on-chip cell culture device that integrates microcontact printing and perfusion co-culture to facilitate the study of BBB function. The research reveals the biochemical regulation of BBB function by astrocytes and the geometry-force control of astrocyte-endothelial cell interactions in the BBB model.
Article
Biochemistry & Molecular Biology
Reka Toth, Attila E. Farkas, Istvan A. Krizbai, Peter Makra, Ferenc Bari, Eszter Farkas, Akos Menyhart
Summary: This study reveals the presence of post-SD astrocyte Ca2+ oscillations in the mouse somatosensory cortex, occurring minutes after the Ca2+ wave of SD and involving fewer astrocytes compared to the Ca2+ waves. Additionally, the data confirms the correlation between astrocyte Ca2+ waves and arteriolar constriction, while post-SD Ca2+ oscillations coincide with the peak of the SD-related vasodilation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Mathematics
Osman Taylan, Mona Abusurrah, Ehsan Eftekhari-Zadeh, Ehsan Nazemi, Farheen Bano, Ali Roshani
Summary: This paper investigates the regulatory role of astrocyte cells in neuronal activity and presents a model to describe their interactions. Simulation results demonstrate that by adjusting the coupling coefficients of astrocytes, the spiking frequency of neurons can be reduced and the activity of neuronal cells can be modulated.
Article
Multidisciplinary Sciences
Zhiwen Zhou, Kazuki Okamoto, Junya Onodera, Toshimitsu Hiragi, Megumi Andoh, Masahito Ikawa, Kenji F. Tanaka, Yuji Ikegaya, Ryuta Koyama
Summary: The study demonstrates that increasing cAMP levels in astrocytes can induce synaptic plasticity and affect memory formation and retention, mediated through the astrocyte-neuron lactate shuttle. This provides a tool to modulate astrocytic cAMP in vivo and sheds light on the role of astrocytic cAMP in brain function.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Marianela Evelyn Traetta, Nonthue Alejandra Uccelli, Sandra Cristina Zarate, Dante Gomez Cuautle, Alberto Javier Ramos, Analia Reines
Summary: This study reveals the reactive changes in cortical microglia and astroglia, as well as synaptic alterations in a rat model prenatally exposed to valproic acid. Additionally, it highlights the importance of communication between microglia and astroglia in neuroinflammation associated with autism spectrum disorder, suggesting it as a potential target for interventions.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Neurosciences
Kazuo Yamagata
Summary: Astrocytes play a crucial role in regulating synapse formation and function, protecting the brain from damage and restoring synaptic function after injury. They release various molecules to induce synaptic structure and function, providing a protective effect against synaptic damage.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Michael Boily, Lin Li, Diane Vallerand, Helene Girouard
Summary: The study revealed that Angiotensin II impairs neurovascular coupling by enhancing astrocytic calcium responses, promoting vasoconstriction over vasodilation and altering cerebral blood flow increases in response to neuronal activity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Ana M. Fernandez, Laura Martinez-Rachadell, Marta Navarrete, Julia Pose-Utrilla, Jose Carlos Davila, Jaime Pignatelli, Sonia Diaz-Pacheco, Santiago Guerra-Cantera, Emilia Viedma-Moreno, Rocio Palenzuela, Samuel Ruiz de Martin Esteban, Ricardo Mostany, Cristina Garcia-Caceres, Matthias Tschop, Teresa Iglesias, Maria L. de Ceballos, Antonia Gutierrez, Ignacio Torres Aleman
Summary: Insulin receptors in astrocytes play a role in neurovascular coupling by modulating glucose uptake and angiogenesis. Lack of insulin receptors in astrocytes leads to uncoupling of brain blood flow with glucose uptake, disturbed mitochondrial function, and abnormal angiogenesis. Treatment with the antioxidant N-acetylcysteine can normalize these effects.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Neurosciences
Patrick J. Drew
Summary: In the brain, increases in neural activity lead to changes in local blood flow through neurovascular coupling. However, the traditional explanation that increased blood flow supplies the metabolic needs of active neurons is inconsistent with a large body of evidence. Neurovascular coupling is irregular or absent in many brain regions and states, and increased respiration can improve brain oxygenation without changes in blood flow. Simulation studies suggest that low blood flow areas are inevitable due to the brain's vascular architecture and cannot be eliminated by functional hyperemia. This article discusses potential alternative functions of neurovascular coupling such as supplying oxygen for neuromodulator synthesis, regulating brain temperature, signaling to neurons, optimizing cerebral vascular structure, accommodating non-Newtonian blood flow, and driving cerebrospinal fluid circulation.
TRENDS IN NEUROSCIENCES
(2022)
Review
Clinical Neurology
Winston M. Zhu, Ain Neuhaus, Daniel J. Beard, Brad A. Sutherland, Gabriele C. DeLuca
Summary: To meet the metabolic demands of the brain, mechanisms have evolved to couple neuronal activity to vasodilation, increasing cerebral blood flow. The release of vasoactive molecules by neurons and astrocytes plays a key role in signaling pathways that induce vasodilation. Understanding neurovascular coupling is especially important in Alzheimer's disease, where disrupted cerebral blood flow regulation is a prominent feature.
Article
Cardiac & Cardiovascular Systems
Hao-Liang Xu, Lizhen Mao, Shuhua Ye, Chanannait Paisansathan, Francesco Vetri, Dale A. Pelligrino
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2008)
Article
Cardiac & Cardiovascular Systems
Hao-Liang Xu, Francesco Vetri, Hae-Kyung Lee, Shuhua Ye, Chanannait Paisansathan, Lizhen Mao, Fulong Tan, Dale A. Pelligrino
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2009)
Article
Cardiac & Cardiovascular Systems
Chanannait Paisansathan, Haoliang Xu, Francesco Vetri, Moises Hernandez, Dale A. Pelligrino
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2010)
Article
Cardiac & Cardiovascular Systems
Francesco Vetri, Haoliang Xu, Lizhen Mao, Chanannait Paisansathan, Dale A. Pelligrino
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2011)
Article
Cardiac & Cardiovascular Systems
Francesco Vetri, Haoliang Xu, Chanannait Paisansathan, Dale A. Pelligrino
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2012)
Article
Neurosciences
Bin Shen, Francesco Vetri, Lizhen Mao, Hao-Liang Xu, Chanannait Paisansathan, Dale A. Pelligrino
Article
Neurosciences
Francesco Vetri, Rafael Chavez, Hao-Liang Xu, Chanannait Paisansathan, Dale A. Pelligrino
Article
Neurosciences
Hao-Liang Xu, Maggie Garcia, Fernando Testai, Francesco Vetri, Alexandra Barabanova, Dale A. Pelligrino, Chanannait Paisansathan
Article
Biochemistry & Molecular Biology
Jittiya Watcharotayangul, Lizhen Mao, Haoliang Xu, Francesco Vetri, Verna L. Baughman, Chanannait Paisansathan, Dale A. Pelligrino
JOURNAL OF NEUROCHEMISTRY
(2012)
Review
Cell Biology
Dale A. Pelligrino, Francesco Vetri, Hao-Liang Xu
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Marta Gomez-Gonzalo, Gabriele Losi, Angela Chiavegato, Micaela Zonta, Mario Cammarota, Marco Brondi, Francesco Vetri, Laura Uva, Tullio Pozzan, Marco de Curtis, Gian Michele Ratto, Giorgio Carmignoto
Article
Neurosciences
William J. Smith, David L. Cedeno, Samuel M. Thomas, Courtney A. Kelley, Francesco Vetri, Ricardo Vallejo
Summary: Numerous studies have shown the effectiveness of spinal cord stimulation in treating chronic neuropathic pain, but the exact mechanism remains uncertain. Recent research focuses on the role of microglial cells in chronic pain, highlighting differences between DTMP, HRP, and LRP in modulating microglial transcriptomes. The data suggests that DTMP may be more effective than traditional programming methods in modulating microglial activation transcriptomes and relieving pain.
Article
Neurosciences
Francesco Vetri, Danilo Menicucci, Dominga Lapi, Angelo Gemignani, Antonio Colantuoni