Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 19, Issue 2, Pages 423-428Publisher
IOS PRESS
DOI: 10.3233/JAD-2010-1241
Keywords
Amyloid; brain imaging; Familial British Dementia; PiB; positron emission tomography; Worster-Drought syndrome
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Funding
- Austin Hospital Medical Research Foundation, Neurosciences Victoria
- University of Melbourne
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Brain amyloid imaging is becoming an essential tool for the pre-mortem evaluation of Alzheimer's disease (AD). This study explores the pattern of C-11-PiB retention in a subject with Worster-Drought syndrome (WDS). A 55 year-old male carrier of the WDS gene mutation with mild signs of ataxia and subtle cognitive impairment underwent MRI and C-11-PiB-PET studies. Brain PiB regional distribution was compared to those from cohorts of healthy controls and AD patients. While no significant cortical C-11-PiB retention was present, a high degree of cerebellar C-11-PiB retention was observed in a genetically confirmed carrier of the WDS gene. We speculate that the sparsity of A(Bri) plaques in the neocortex together with its high deposition in the cerebellum, might explain the observed pattern of C-11-PiB retention.
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