Review
Chemistry, Multidisciplinary
Wei Liu, Xin Li, Ting Wang, Fei Xiong, Changrui Sun, Xikuang Yao, Wei Huang
Summary: Platinum (Pt) drugs are widely used in cancer therapy, but their efficacy is compromised by side effects and drug resistance. Precise delivery and release of Pt drugs have become important with the development of immunotherapy and imaging-guided therapy. Targeted delivery of Pt drugs increases accumulation at tumor sites and enhances antitumor efficacy. Combining Pt drugs with other theranostic agents in nanosystems achieves synergistic therapy and real-time monitoring.
Review
Chemistry, Multidisciplinary
Zhichu Xiang, Mouquan Liu, Jun Song
Summary: Biocompatible nanosystems based on polymeric materials show promise as drug delivery nanocarriers for antitumor therapy, but their efficacy is hindered by nonspecific accumulation and drug release in normal tissues. Stimuli-responsive nanosystems triggered by tumor-specific stimuli have recently garnered interest for their controllable drug release properties. This review discusses various polymers and external stimuli for developing stimuli-responsive polymeric nanosystems, and outlines the challenges in designing such Nanomedicine to enhance therapeutic efficacy.
APPLIED SCIENCES-BASEL
(2021)
Review
Pharmacology & Pharmacy
Mayank Handa, Ajit Singh, Swaran Jeet Singh Flora, Rahul Shukla
Summary: This study reviews the potential and behavior of stimuli-responsive drug delivery systems. Stimuli-responsive nanocarriers have the ability to efficiently deliver drugs to specific sites or targeted cells without drug leakage. These systems are effective for both hydrophilic and hydrophobic drugs and can release the drugs upon applied stimulus.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Pharmacology & Pharmacy
Kele Cristina Ferreira Dantas, Jania Dos Santos Rosario, Priscila Pereira Silva-Caldeira
Summary: Nanotechnology-based approaches for targeted delivery of metal-based therapeutic agents have shown significant potential in enhancing their therapeutic effect and reducing systemic toxicities. Polymer-based nanosized systems have been employed to physically load or covalently conjugate metal-based agents, improving their bioavailability and anticancer efficacy. While initially used for platinum-based chemotherapeutic agents, these nanocarriers are now being explored for nonplatinum-containing agents. Furthermore, they have been extensively studied as polymeric nanocarrier-assisted metal-based photosensitizers in photodynamic therapy for almost three decades. This review focuses on non-platinum systems and highlights recent advances in polymeric nanosystems coupled with metal-based compounds, which hold promise for successful clinical applications.
Article
Biophysics
Xiao Ma, Caihong Yang, Ruirui Zhang, Jie Yang, Yan Zu, Xin Shou, Yongxiang Zhao
Summary: A novel natural biomass-based hydrogel microparticle was developed using microfluidic electrospray technology. The microparticles showed enhanced chemotherapy effect, inhibited tumor growth, and exhibited good biocompatibility and sustained drug release.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Aharon Azagury, Cameron Baptista, Kosta Milovanovic, Hyeseon Shin, Peter Morello, James Perez-Rogers, Victoria Goldenshtein, Travis Nguyen, Arianna Markel, Soham Rege, Stephanie Hojsak, Alexander Perl, Carder Jones, Megan Fife, Stacia Furtado, Edith Mathiowitz
Summary: Decades of research have not reached a consensus on the properties that produce effective oral drug delivery systems using nanoparticles. This study proposes a mechanism involving biocoating to explain the behavior of nanoparticles in vivo, which can alter their surface properties and affect their systemic uptake. Coating nanoparticles with mucus is found to increase their mucosal diffusion rate and promote high systemic uptake.
Article
Engineering, Environmental
Zun Fan, Chengyang Zhu, Jun Yin, Lei Qin, Xin Zhao
Summary: Inspired by the structure of a pitaya, a microcarrier-embedded hydrogel-based construct is designed via one-pot microfluidic emulsification. It possesses tailorable structures and versatile functionalization. In vitro and in vivo experiments demonstrate that it can prevent bacteria invasion, promote cell function, and accelerate wound healing with enhanced epidermis regeneration, collagen deposition, blood vessel formation, and skin function recovery.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Physical
Yue Jiang, Xueting Pan, Tao Yu, Hai Wang
Summary: The existence of the blood-brain barrier (BBB) poses challenges for drug delivery to the central nervous system (CNS). Intranasal administration has emerged as an alternative method for delivering drugs to the brain by bypassing the BBB. This review focuses on the mechanisms, properties, and strategies of intranasal nanosystems for brain-targeted drug delivery. Despite promising results in animal models and clinical applications, significant challenges need to be overcome for the translation of these nanosystems into clinics. The future prospects of intranasal drug delivery nanosystems are discussed, aiming to provide insights and guidance for effective neurological disease treatment.
Review
Biochemistry & Molecular Biology
Siavash Iravani, Rajender S. Varma
Summary: Advanced drug delivery micro- and nanosystems with appealing specificity, biocompatibility, and low toxicity have the potential for targeted therapy of cardiovascular diseases. However, the number of drug delivery systems currently approved for clinical use is limited.
Review
Biotechnology & Applied Microbiology
Xianchao Jiang, Zhen Du, Xinran Zhang, Fakhar Zaman, Zihao Song, Yuepeng Guan, Tengfei Yu, Yaqin Huang
Summary: Drug delivery nanosystems (DDnS) using gelatin as a biomaterial have been widely developed. Gelatin, with its hydrophilic and amphoteric properties, can effectively enhance the utilization of anticancer drugs and minimize side effects. The versatility of gelatin allows for crosslinking and further modifications, making it suitable for various requirements of DDnS. This review focuses on the properties of gelatin and their correlation with anticancer DDnS, as well as the applications of gelatin-based DDnS in cancer treatments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Hossein Omidian, Niloofar Babanejad, Luigi X. Cubeddu
Summary: Cardiovascular diseases continue to be a major cause of illness and death worldwide. While there have been significant advancements in pharmacological therapies, targeted drug delivery to the cardiovascular system remains challenging. This review examines various drug delivery strategies, including polymeric nanoparticles, liposomes, microparticles, and dendrimers, and discusses specific strategies such as magnetic nanoparticles and porous stent surfaces. The review highlights the potential of innovative drug delivery systems as effective strategies for the treatment of cardiovascular diseases.
Review
Materials Science, Multidisciplinary
Jingchao Li, Xiangrong Yu, Xiangyang Shi, Mingwu Shen
Summary: PEI plays a significant role in constructing multifunctional nanosystems for versatile biomedical applications, especially in cancer nanomedicine. These systems can be utilized for molecular imaging, drug delivery, and other functions.
PROGRESS IN MATERIALS SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Margarida Ferreira-Silva, Catarina Faria-Silva, Pedro Viana Baptista, Eduarda Fernandes, Alexandra Ramos Fernandes, Maria Luisa Corvo
Summary: Rheumatoid arthritis is an autoimmune disease with available therapies, but there is a need for more effective treatments. Drug delivery systems like liposomes play a crucial role in treatment, but obstacles to successful clinical translation need to be addressed.
Article
Nanoscience & Nanotechnology
Jiali Wang, Chong Wang, Qiao Wang, Zhuohao Zhang, Hui Wang, Shengyi Wang, Zhangcai Chi, Luoran Shang, Wuqing Wang, Yilai Shu
Summary: Local drug delivery has become an effective method for disease therapy in fine organs. However, the anatomical and physiological barriers and unique clearance pathways in these organs have resulted in suboptimal drug delivery efficiency. In this study, dexamethasone sodium phosphate-encapsulated gelatin methacryloyl (Dexsp@GelMA) microgel particles were developed as drug delivery vehicles for hearing loss therapy. The microgels showed strong adhesion to the round window membrane and improved therapeutic effects compared to bulk hydrogels.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Agata Noelia Traverso, David Jose Fragale, Diego Luis Viale, Octavio Garate, Pablo Torres, Gaston Valverde, Alejandro Berra, Ana Vanesa Torbidoni, Juan Sebastian Yakisich, Mariano Grasselli, Martin Radrizzani
Summary: In this study, a two-step procedure for preparing biohybrid nanoparticles with a hydrophobic quantum dot core and a multilayer coating of human serum albumin is reported. These nanoparticles, decorated with proteins like human serum albumin or human transferrin, retained their fluorescent properties and showed no corona effect in the presence of serum. They were selectively taken up by lung cancer and neuroblastoma cells but not by non-cancerous cells or differentiated neurons. Moreover, digitoxin-loaded transferrin-decorated nanoparticles specifically reduced the number of lung cancer cells. Finally, the in vivo uptake of these biohybrid nanoparticles by retinal cells in mice demonstrated their excellent targeting and traceability.
Article
Nanoscience & Nanotechnology
Nassim Rousset, Ruben Lopez Sandoval, Mario Matteo Modena, Andreas Hierlemann, Patrick M. Misun
Summary: As 3D in vitro tissue models become more prevalent, analyzing the gradients and heterogeneity of nutrient and metabolite concentrations becomes more challenging. In this study, the researchers used electrochemical biosensors to measure glucose concentrations around tissue models, allowing them to study size-dependent metabolism data.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Engineering, Biomedical
Alessio Paolo Buccino, Xinyue Yuan, Vishalini Emmenegger, Xiaohan Xue, Tobias Ganswein, Andreas Hierlemann
Summary: This article proposes a fully automated approach to reconstruct axons from extracellular electrical-potential landscapes. The method first constructs a graph based on the voltage signal amplitudes and latencies, and then interrogates the graph to extract possible axonal branches. After pruning the axonal branches, the velocities of axonal action-potential propagation are computed.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Violetta Sessi, Bergoi Ibarlucea, Florent Seichepine, Stephanie Klinghammer, Imad Ibrahim, Andre Heinzig, Nadine Szabo, Thomas Mikolajick, Andreas Hierlemann, Urs Frey, Walter M. Weber, Larysa Baraban, Gianaurelio Cuniberti
Summary: This study introduces a hybrid integration technique that combines bottom-up silicon-nanowire Schottky-junction FETs with complementary-metal-oxide-semiconductor (CMOS) readout and amplification electronics to establish a stable biosensing platform. It enables selective detection of biomarkers at high dilution levels and shows great potential for various applications.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Paolo S. Ravaynia, Stefan Biendl, Francesco Grassi, Jennifer Keiser, Andreas Hierlemann, Mario M. Modena
Summary: Schistosomiasis is a neglected tropical disease that affects a significant number of people annually. Due to the lack of effective drugs, repurposing compound libraries has become a viable option for accelerating drug development. A study using a high-throughput screening platform identified several potential drug candidates for the treatment of schistosomiasis.
Article
Engineering, Biomedical
Xiaohan Xue, Alessio Paolo Buccino, Sreedhar Saseendran Kumar, Andreas Hierlemann, Julian Bartram
Summary: This article introduces a novel approach to identify and monitor monosynaptic connections between neurons. The method combines high-resolution imaging and large-scale recording of electrical activity. The proposed approach offers unique advantages in accurately localizing synapses, providing precise information of presynaptic spiking, measuring postsynaptic spine Ca2+ signals, and allowing for long-term measurements.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Manuel Schroter, Congwei Wang, Marco Terrigno, Philipp Hornauer, Ziqiang Huang, Ravi Jagasia, Andreas Hierlemann
Summary: This study utilizes high-density microelectrode arrays to perform large-scale electrophysiological recordings on human cerebral organoids, providing insights into their functionality and potential functional connectivity, leading to a better understanding of developing neuronal networks in brain organoids.
Article
Multidisciplinary Sciences
Tal Sharf, Tjitse van der Molen, Stella M. K. Glasauer, Elmer Guzman, Alessio P. Buccino, Gabriel Luna, Zhuowei Cheng, Morgane Audouard, Kamalini G. Ranasinghe, Kiwamu Kudo, Srikantan S. Nagarajan, Kenneth R. Tovar, Linda R. Petzold, Andreas Hierlemann, Paul K. Hansma, Kenneth S. Kosik
Summary: Brain organoids can replicate the cellular organization found in the developing human brain, and by utilizing microelectronics, functional circuits can be assembled to mirror the complexity of brain networks. This study explores the physiology of neuronal circuits within brain organoids and how they can be influenced by external stimuli. The results suggest that brain organoids have the potential to be used in studying neuropsychiatric diseases, drug action, and the effects of external stimuli on neuronal networks.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Analytical
Nassim Rousset, Christian Lohasz, Julia Alicia Boos, Patrick M. Misun, Fernando Cardes, Andreas Hierlemann
Summary: Microfluidic-drop networks, consisting of stable drops connected through microfluidic channels, provide a versatile configuration for long-term organ model culturing. Mathematical modeling, such as computational fluid dynamics (CFD), is useful for designing and optimizing drop-based microfluidic devices, but lacks computational efficiency. Alternatively, the hydraulic-electric analogy is an efficient method to explore design and operation parameters of microfluidic-drop networks. A circuit-based model of hanging- and standing-drop compartments is presented, along with a phase diagram describing the nonlinearity of the capillary pressure of a hanging drop. The methodology for finding flow rates and pressures within drop networks is also discussed. This paper reviews several applications where the method outlined has been instrumental in optimizing design and operation.
Article
Immunology
Burcak Yesildag, Joan Mir-Coll, Aparna Neelakandhan, Claire B. Gibson, Nikole R. Perdue, Chantal Rufer, Maria Karsai, Adelinn Biernath, Felix Forschler, Patricia Wu Jin, Patrick M. Misun, Alexandra Title, Andreas Hierlemann, Frederik F. Kreiner, Johnna D. Wesley, Matthias G. von Herrath
Summary: In this study, three in-vitro islet-immune injury models were established to investigate the immunopathogenesis of type 1 diabetes. The results showed that liraglutide protected pancreatic cells from immune attack.
CLINICAL IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Furkan Gokce, Alicia Kaestli, Christian Lohasz, Martina de Geus, Hans-Michael Kaltenbach, Kasper Renggli, Beat Bornhauser, Andreas Hierlemann, Mario Modena
Summary: Despite improving survival rates in pediatric leukemia patients, the outcome for certain subtypes remains poor. A microphysiological drug-testing platform has been developed to address the limitations of current screening methods, allowing for the co-culture of patient-derived leukemia cells, bone marrow cells, and liver tissues. By testing the activation of the prodrug ifosfamide in this platform, sample-specific sensitivities to ifosfamide in primary leukemia samples can be identified, providing potential for precision chemotherapy selection.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Mathematical & Computational Biology
Taehoon Kim, Dexiong Chen, Philipp Hornauer, Vishalini Emmenegger, Julian Bartram, Silvia Ronchi, Andreas Hierlemann, Manuel Schroter, Damian Roqueiro
Summary: In this study, modern Graph Neural Networks (GNNs) were applied to analyze a large-scale electrophysiological dataset of rodent neuronal networks. The results demonstrate that the joint representation of node features and functional connectivity, extracted from baseline recordings, is informative for predicting changes in firing rate of individual neurons after a pharmacological perturbation.
FRONTIERS IN NEUROINFORMATICS
(2023)
Article
Chemistry, Multidisciplinary
Wei Wei, Fernando Cardes, Andreas Hierlemann, Mario M. M. Modena
Summary: This study presents a human-cell-based platform for monitoring the tightness of the blood-brain barrier in real time. The results demonstrate that oxygen-glucose deprivation induces cellular actin remodeling and morphological changes in endothelial cells, leading to barrier breakage. The platform recapitulates the main barrier functions and can be used to investigate the reorganization of the blood-brain barrier.
Article
Engineering, Biomedical
Fernando Cardes, Ebrahim Azizi, Andreas Hierlemann
Summary: CMOS neural interfaces are used to study neuronal electrical activity and have the potential to restore lost functions of the nervous system. This article introduces a novel readout technique for neural interfaces based on a voltage-controlled oscillator (VCO) that uses digital timestamps for postprocessing the VCO output. The proposed method offers advantages in scalability and efficiency for multi-channel architectures, and a prototype fabricated in 0.18-μm CMOS technology successfully detected extracellular action potentials with low noise.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2023)
Article
Biochemical Research Methods
Nassim Rousset, Martina de Geus, Vittoria Chimisso, Alicia J. Kaestli, Andreas Hierlemann, Christian Lohasz
Summary: This paper presents an optimized pneumatic-pump system integrated with hanging-drop networks for closed-loop recirculation of particles. Experimental results suggest that the aggregation of submicron-scale cell-culture-medium components is the cause of the pseudo-no-slip boundary condition. By adjusting the height of hanging drops, the flow or stagnation of particles can be controlled, providing a foundation for controlling the residence time of single cells around 3D organ models.
Meeting Abstract
Developmental Biology
Manon Murdeu, Andreas Hierlemann, Julia Boos, Tina Buerki-Thurnherr
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.
