4.8 Article

Nanomechanical clues from morphologically normal cervical squamous cells could improve cervical cancer screening

Journal

NANOSCALE
Volume 7, Issue 38, Pages 15589-15593

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr03662c

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Funding

  1. National Research Fund for Fundamental Key Projects [2007CB935602, 2012CB933804]
  2. National Natural Science Foundation of China [10772007, 11072006]
  3. National Basic Research Program of China (973 Program) [2013CB933702]

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Applying an atomic force microscope, we performed a nanomechanical analysis of morphologically normal cervical squamous cells (MNSCs) which are commonly used in cervical screening. Results showed that nanomechanical parameters of MNSCs correlate well with cervical malignancy, and may have potential in cancer screening to provide early diagnosis.

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