Article
Immunology
Syed-Rehan A. Hussain, Michelle Rohlfing, Jenny Resiliac, Jennifer Santoro, Mark E. Peeples, Dominique Garcin, Mitchell H. Grayson
Summary: Research has shown that RSV infection in infancy is associated with an increased risk of asthma, except in cases where allergic disease is present at the time of infection. In a mouse model, pre-existing atopy has been found to protect against postviral airway disease, a protection that is dependent on neutrophils. Development of atopy leads to an increase in neutrophil response, potentially interacting with IL-4 to prevent the development of postviral airway disease.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Sergio de Jesus Romero-Tapia, Crystell Guadalupe Guzman Priego, Blanca E. Del-Rio-Navarro, Manuel Sanchez-Solis
Summary: This review summarizes the close association between viral infection and the onset, progression, and exacerbation of asthma, discussing related protective and risk factors, as well as treatment options. It also presents recent research on the innate immunological pathways and changes in the epithelial barrier. The review emphasizes the importance of genetics and epigenetics in asthma and virus susceptibility, and describes the involvement of viral etiology in bronchiolitis, childhood wheezing, and asthma. The most frequently related respiratory viruses and their mechanisms of action are mentioned.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Sheila F. Lumley, Nicholas Richens, Emily Lees, Jack Cregan, Elizabeth Kalimeris, Sarah Oakley, Marcus Morgan, Shelley Segal, Moya Dawson, A. Sarah Walker, David W. Eyre, Derrick W. Crook, Sally Beer, Alex Novak, Nicole E. Stoesser, Philippa C. Matthews
Summary: The SARS-CoV-2 pandemic had a significant impact on the incidence of paediatric viral respiratory tract infection in Oxfordshire, UK. The findings have implications for clinical service demand, testing strategies, timing of palivizumab RSV prophylaxis, and the effectiveness of public health interventions in preventing respiratory virus infections.
JOURNAL OF INFECTION
(2022)
Review
Allergy
Niek B. Achten, Annemarie M. C. van Rossum, Leonard B. Bacharier, Anne M. Fitzpatrick, Tina Hartert
Summary: This article examines the impact of early-life viral infections on the lung and immune systems and focuses on the causal relationship between early-life viral infections and asthma. The article calls for a shift in research focus towards improving patient outcomes in the spectrum of respiratory diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
Orianne Dumas, Riku Erkkola, Eija Bergroth, Kohei Hasegawa, Jonathan M. Mansbach, Pedro A. Piedra, Tuomas Jartti, Carlos A. Camargo
Summary: This study aimed to investigate the association between severe bronchiolitis profiles identified by clustering and childhood asthma. The results showed that children with a history of wheezing and/or eczema and rhinovirus infection had a higher risk of developing childhood asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Virology
Erwan Sallard, Frank Schult, Carolin Baehren, Eleni Buedding, Olivier Mboma, Parviz Ahmad-Nejad, Beniam Ghebremedhin, Anja Ehrhardt, Stefan Wirth, Malik Aydin
Summary: Respiratory viruses play a significant role in exacerbating asthma, and human rhinovirus (HRV) infection is a strong biomarker for exacerbation.
Article
Pediatrics
Julie Magnier, Valerie Julian, Aurelien Mulliez, Alexandra Usclade, Emmanuelle Rochette, Bertrand Evrard, Flore Amat, Carole Egron
Summary: The study revealed that male infants with a family history of allergies may be at higher risk for asthma at school age following their first episode of acute bronchiolitis. Additionally, rhinovirus infection and specific gene may have significant associations with asthma at age seven.
Review
Allergy
Heidi Makrinioti, Kohei Hasegawa, John Lakoumentas, Paraskevi Xepapadaki, Maria Tsolia, Jose A. Castro-Rodriguez, Wojciech Feleszko, Tuomas Jartti, Sebastian L. Johnston, Andrew Bush, Vasiliki Papaevangelou, Carlos A. Camargo, Nikolaos G. Papadopoulos
Summary: This study compares the associations of RSV-induced bronchiolitis and RV-induced bronchiolitis with the development of preschool wheeze and childhood asthma through a meta-analysis. The results show that the RV-bronchiolitis group is more likely to develop recurrent wheeze and asthma. This study is clinically significant for understanding the relationship between viruses and asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Pediatrics
Phanthila Sitthikarnkha, Rattapon Uppala, Sirapoom Niamsanit, Sumitr Sutra, Kaewjai Thepsuthammarat, Leelawadee Techasatian, Watit Niyomkarn, Jamaree Teeratakulpisarn
Summary: Among hospitalized children in Thailand, RSV LRTI was the leading cause of hospitalization, with the highest incidence occurring during the rainy season. The mortality rate of RSV LRTI was higher in infants under 1 year old and children with underlying illnesses; future preventive interventions should target these patient groups.
Article
Immunology
Natalie Mazur, Yvette N. Lowensteyn, Joukje E. Willemsen, Christopher J. Gill, Leah Forman, Lawrence M. Mwananyanda, Dianna M. Blau, Robert F. Breiman, Shabir A. Madhi, Sana Mahtab, Emily S. Gurley, Shams El Arifeen, Nega Assefa, J. Anthony G. Scott, Dickens Onyango, Beth A. Tippet Barr, Karen L. Kotloff, Samba O. Sow, Inacio Mandomando, Ikechukwu Ogbuanu, Amara Jambai, Quique Bassat, Mauricio T. Caballero, Fernando P. Polack, Saad Omer, Abdul Momin Kazi, Eric A. F. Simoes, Ashish Satav, Louis J. Bont
Summary: The study investigated 829 RSV-related deaths in children under 1 year old from 38 developing countries, including 166 community deaths from 12 countries. It was found that infants who died in the community were younger at the time of death compared to those who died in the hospital. Neonatal deaths were also higher in the community than in hospitals.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Pharmacology & Pharmacy
Farah Elawar, Ahmed K. Oraby, Quinten Kieser, Lionel D. Jensen, Tyce Culp, Frederick G. West, David J. Marchant
Summary: RSV infection is a major cause of pediatric hospitalizations and deaths, with limited treatment options. The development of effective antivirals and vaccines is crucial in combating RSV, despite challenges in therapeutics so far. This review provides insight into current research progress and future considerations in RSV treatment.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Immunology
Pekka Hurme, Miisa Komulainen, Marleena Tulkki, Annamari Leino, Beate Ruckert, Riitta Turunen, Tytti Vuorinen, Mubeccel Akdis, Cezmi A. Akdis, Tuomas Jartti
Summary: The cytokine profiles of Rhinovirus (RV) and respiratory syncytial virus (RSV)-induced first wheezing episode differ, with higher cytokine expression and longer hospitalization time in the RSV group. In the RV group, increased expression of I-309 (CCL1) and TARC is associated with fewer relapses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Hans Bisgaard, Marianne Mikkelsen, Morten Arendt Rasmussen, Astrid Sevelsted, Ann-Marie Malby Schoos, Nicklas Brustad, Anders U. Eliasen, Jonathan Thorsen, Bo Chawes, Goezde Guerdeniz, Andreanne Morin, Ken Stark, Jakob Stokholm, Carole Ober, Casper Emil Tingskov Pedersen, Klaus Bonnelykke
Summary: Fish-oil supplementation during pregnancy reduces the risk of persistent wheeze or asthma in the child. It has protective effects on non-atopic asthma and infections, but the effects on atopic asthma depend on maternal genotype and n-3 LCPUFA levels.
Review
Pediatrics
Etienne Bizot, Anais Bousquet, Maelle Charpie, Florence Coquelin, Servane Lefevre, Justin Le Lorier, Margaux Patin, Perrine See, Eytan Sarfati, Servane Walle, Benoit Visseaux, Romain Basmaci
Summary: Human rhinoviruses (HRVs) are a main cause of common colds in children and are increasingly involved in severe clinical infections. They can cause upper and lower respiratory tract infections, with HRV bronchiolitis posing a higher risk of asthma. Although HRVs can be detected in stools, blood, or cerebrospinal fluid, their high rate of asymptomatic carriage and prolonged excretion post-symptoms complicate interpretation.
FRONTIERS IN PEDIATRICS
(2021)
Article
Immunology
Jonathan M. Mansbach, Ruth J. Geller, Kohei Hasegawa, Pedro A. Piedra, Vasanthi Avadhanula, James E. Gern, Yury A. Bochkov, Janice A. Espinola, Ashley F. Sullivan, Carlos A. Camargo
Summary: This study found that infants with respiratory syncytial virus (RSV) at hospitalization followed by a new rhinovirus (RV) infection had the highest risk of recurrent wheezing among severe bronchiolitis cases.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Brendan Flannery, Jessie R. Chung, Arnold S. Monto, Emily T. Martin, Edward A. Belongia, Huong Q. McLean, Manjusha Gaglani, Kempapura Murthy, Richard K. Zimmerman, Mary Patricia Nowalk, Michael L. Jackson, Lisa A. Jackson, Melissa A. Rolfes, Sarah Spencer, Alicia M. Fry, Joshua G. Petrie, Ryan E. Malosh, E. J. McSpadden, Hannah E. Segaloff, Caroline K. Cheng, Rachel Truscon, Emileigh Johnson, Lois E. Lamerato, Lynn C. Ivacic, Jennifer P. King, Jennifer K. Meece, Madalyn M. Palmquist, Sherri A. Guzinski, Anne Robertson, Ashley Kossie, Michael Smith, Vanessa Hoelscher, Lydia Clipper, Kimberley Walker, Marcus Volz, Arundhati Rao, Robert Fader, Yolanda Munoz-Maldonado, Michael Reis, John V. Williams, Goundappa K. Balasubramani, Evelyn C. Reis, Heather Eng, Samantha Ford, Todd M. Bear, Edmund M. Ricci, Robert W. Hickey, Krissy K. Moehling, Jonathan M. Raviotta, Theresa M. Sax, Michael Susick, Monika Johnson, Rose Azrak, LaShondra Berman, Angie Foust, Wendy Sessions, Juliana DaSilva, Thomas Stark, John Barnes
CLINICAL INFECTIOUS DISEASES
(2019)
Article
Virology
Piet Maes, Gaya K. Amarasinghe, Maria A. Ayllon, Christopher F. Basler, Sina Bavari, Kim R. Blasdell, Thomas Briese, Paul A. Brown, Alexander Bukreyev, Anne Balkema-Buschmann, Ursula J. Buchholz, Kartik Chandran, Ian Crozier, Rik L. de Swart, Ralf G. Dietzgen, Olga Dolnik, Leslie L. Domier, Jan F. Drexler, Ralf Duerrwald, William G. Dundon, W. Paul Duprex, John M. Dye, Andrew J. Easton, Anthony R. Fooks, Pierre B. H. Formenty, Ron A. M. Fouchier, Juliana Freitas-Astua, Elodie Ghedin, Anthony Griffiths, Roger Hewson, Masayuki Horie, Julia L. Hurwitz, Timothy H. Hyndman, Daohong Jiang, Gary P. Kobinger, Hideki Kondo, Gael Kurath, Ivan V. Kuzmin, Robert A. Lamb, Benhur Lee, Eric M. Leroy, Jianrong Li, Shin-Yi L. Marzano, Elke Muhlberger, Sergey V. Netesov, Norbert Nowotny, Gustavo Palacios, Bernadett Palyi, Janusz T. Paweska, Susan L. Payne, Bertus K. Rima, Paul Rota, Dennis Rubbenstroth, Peter Simmonds, Sophie J. Smither, Qisheng Song, Timothy Song, Kirsten Spann, Mark D. Stenglein, David M. Stone, Ayato Takada, Robert B. Tesh, Keizo Tomonaga, Noel Tordo, Jonathan S. Towner, Bernadette van den Hoogen, Nikos Vasilakis, Victoria Wahl, Peter J. Walker, David Wang, Lin-Fa Wang, Anna E. Whitfield, John V. Williams, Gongyin Ye, F. Murilo Zerbini, Yong-Zhen Zhang, Jens H. Kuhn
ARCHIVES OF VIROLOGY
(2019)
Review
Pediatrics
Megan Culler Freeman, Carolyn B. Coyne, Michael Green, John V. Williams, Laurie A. Silva
PEDIATRIC TRANSPLANTATION
(2019)
Article
Emergency Medicine
Natan Cramer, Neil Munjal, Danielle Ware, Sriram Ramgopal, Dennis Simon, Megan C. Freeman, Marian G. Michaels, Christopher Stem, Kavita Thakkar, John V. Williams, Ashok Panigrahy, Desiree N. W. Neville, Sylvia Owusu-Ansah
ANNALS OF EMERGENCY MEDICINE
(2019)
Article
Immunology
Melissa A. Rolfes, Brendan Flannery, Jessie R. Chung, Alissa O'Halloran, Shikha Garg, Edward A. Belongia, Manjusha Gaglani, Richard K. Zimmerman, Michael L. Jackson, Arnold S. Monto, Nisha B. Alden, Evan Anderson, Nancy M. Bennett, Laurie Billing, Seth Eckel, Pam Daily Kirley, Ruth Lynfield, Maya L. Monroe, Melanie Spencer, Nancy Spina, H. Keipp Talbot, Ann Thomas, Salina M. Torres, Kimberly Yousey-Hindes, James A. Singleton, Manish Patel, Carrie Reed, Alicia M. Fry, Huong Q. McLean, Jennifer P. King, Mary Patricia Nowalk, G. K. Balasubramani, Todd M. Bear, Robert Hickey, John V. Williams, Evelyn C. Reis, Krissy K. Moehling, Heather Eng, Lisa A. Jackson, Michael Smith, Chandni Raiyani, Lydia Clipper, Kempapura Murthy, Wencong Chen, Michael Reis, Joshua G. Petrie, Ryan E. Malosh, E. J. McSpadden, Hannah E. Segaloff, Caroline K. Cheng, Rachel Truscon, Emileigh Johnson, Lois E. Lamerato
CLINICAL INFECTIOUS DISEASES
(2019)
Article
Virology
J. Tyler Kinder, Edita M. Klimyte, Andres Chang, John Williams, Rebecca Ellis Dutch
Article
Public, Environmental & Occupational Health
Stephanie A. Kujawski, Claire M. Midgley, Brian Rha, Joana Y. Lively, W. Allan Nix, Aaron T. Curns, Daniel C. Payne, Janet A. Englund, Julie A. Boom, John Williams, Geoffrey A. Weinberg, Mary A. Staat, Rangaraj Selvarangan, Natasha B. Halasa, Eileen J. Klein, Leila C. Sahni, Marian G. Michaels, Lynne Shelley, Monica McNeal, Christopher J. Harrison, Laura S. Stewart, Adriana S. Lopez, Janell A. Routh, Manisha Patel, M. Steven Oberste, John T. Watson, Susan Gerber
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2019)
Article
Virology
Gaya K. Amarasinghe, Maria A. Ayllon, Yiming Bao, Christopher F. Basler, Sina Bavari, Kim R. Blasdell, Thomas Briese, Paul A. Brown, Alexander Bukreyev, Anne Balkema-Buschmann, Ursula J. Buchholz, Camila Chabi-Jesus, Kartik Chandran, Chiara Chiapponi, Ian Crozier, Rik L. de Swart, Ralf G. Dietzgen, Olga Dolnik, Jan F. Drexler, Ralf Duerrwald, William G. Dundon, W. Paul Duprex, John M. Dye, Andrew J. Easton, Anthony R. Fooks, Pierre B. H. Formenty, Ron A. M. Fouchier, Juliana Freitas-Astua, Anthony Griffiths, Roger Hewson, Masayuki Horie, Timothy H. Hyndman, Daohong Jiang, Elliott W. Kitajima, Gary P. Kobinger, Hideki Kondo, Gael Kurath, Ivan V. Kuzmin, Robert A. Lamb, Antonio Lavazza, Benhur Lee, Davide Lelli, Eric M. Leroy, Jianrong Li, Piet Maes, Shin-Yi L. Marzano, Ana Moreno, Elke Muhlberger, Sergey V. Netesov, Norbert Nowotny, Are Nylund, Arnfinn L. Okland, Gustavo Palacios, Bernadett Palyi, Janusz T. Paweska, Susan L. Payne, Alice Prosperi, Pedro Luis Ramos-Gonzalez, Bertus K. Rima, Paul Rota, Dennis Rubbenstroth, Mang Shi, Peter Simmonds, Sophie J. Smither, Enrica Sozzi, Kirsten Spann, Mark D. Stenglein, David M. Stone, Ayato Takada, Robert B. Tesh, Keizo Tomonaga, Noel Tordo, Jonathan S. Towner, Bernadette van den Hoogen, Nikos Vasilakis, Victoria Wahl, Peter J. Walker, Lin-Fa Wang, Anna E. Whitfield, John V. Williams, F. Murilo Zerbini, Tao Zhang, Yong-Zhen Zhang, Jens H. Kuhn
ARCHIVES OF VIROLOGY
(2019)
Article
Pediatrics
Alicia M. Alcamo, Michael S. Wolf, Lauren J. Alessi, Hey J. Chong, Michael Green, John V. Williams, Dennis W. Simon
Review
Virology
Bethany K. Sederdahl, John Williams
Article
Multidisciplinary Sciences
Thomas Klink, Danielle A. Rankin, Bhinnata Piya, Andrew J. Spieker, Samir Faouri, Asem Shehabi, John V. Williams, Najwa Khuri-Bulos, Natasha B. Halasa
Article
Pediatrics
Brian Rha, Aaron T. Curns, Joana Y. Lively, Angela P. Campbell, Janet A. Englund, Julie A. Boom, Parvin H. Azimi, Geoffrey A. Weinberg, Mary A. Staat, Rangaraj Selvarangan, Natasha B. Halasa, Monica M. McNeal, Eileen J. Klein, Christopher J. Harrison, John V. Williams, Peter G. Szilagyi, Monica N. Singer, Leila C. Sahni, Daniella Figueroa-Downing, Darius McDaniel, Mila M. Prill, Brett L. Whitaker, Laura S. Stewart, Jennifer E. Schuster, Barbara A. Pahud, Gina Weddle, Vasanthi Avadhanula, Flor M. Munoz, Pedro A. Piedra, Daniel C. Payne, Gayle Langley, Susan I. Gerber
Article
Virology
Meredith C. Rogers, Margot Miranda-Katz, Yu Zhang, Tim D. Oury, Melissa B. Uccellini, Adolfo Garcia-Sastre, John Williams
Article
Virology
Jens H. Kuhn, Scott Adkins, Daniela Alioto, Sergey V. Alkhovsky, Gaya K. Amarasinghe, Simon J. Anthony, Tatjana Avsic-Zupanc, Maria A. Ayllon, Justin Bahl, Anne Balkema-Buschmann, Matthew J. Ballinger, Tomas Bartonicka, Christopher Basler, Sina Bavari, Martin Beer, Dennis A. Bente, Eric Bergeron, Brian H. Bird, Carol Blair, Kim R. Blasdell, Steven B. Bradfute, Rachel Breyta, Thomas Briese, Paul A. Brown, Ursula J. Buchholz, Michael J. Buchmeier, Alexander Bukreyev, Felicity Burt, Nihal Buzkan, Charles H. Calisher, Mengji Cao, Inmaculada Casas, John Chamberlain, Kartik Chandran, Remi N. Charrel, Biao Chen, Michela Chiumenti, Il-Ryong Choi, J. Christopher S. Clegg, Ian Crozier, John V. da Graca, Elena Dal Bo, Alberto M. R. Davila, Juan Carlos de la Torre, Xavier de Lamballerie, Rik L. de Swart, Patrick L. Di Bello, Nicholas Di Paola, Francesco Di Serio, Ralf G. Dietzgen, Michele Digiaro, Valerian V. Dolja, Olga Dolnik, Michael A. Drebot, Jan Felix Drexler, Ralf Duerrwald, Lucie Dufkova, William G. Dundon, W. Paul Duprex, John M. Dye, Andrew J. Easton, Hideki Ebihara, Toufic Elbeaino, Koray Ergunay, Jorlan Fernandes, Anthony R. Fooks, Pierre B. H. Formenty, Leonie F. Forth, Ron A. M. Fouchier, Juliana Freitas-Astua, Selma Gago-Zachert, George Fu Gao, Maria Laura Garcia, Adolfo Garcia-Sastre, Aura R. Garrison, Aiah Gbakima, Tracey Goldstein, Jean-Paul J. Gonzalez, Anthony Griffiths, Martin H. Groschup, Stephan Guenther, Alexandro Guterres, Roy A. Hall, John Hammond, Mohamed Hassan, Jussi Hepojoki, Satu Hepojoki, Udo Hetzel, Roger Hewson, Bernd Hoffmann, Seiji Hongo, Dirk Hoeper, Masayuki Horie, Holly R. Hughes, Timothy H. Hyndman, Amara Jambai, Rodrigo Jardim, Daohong Jiang, Qi Jin, Gilda B. Jonson, Sandra Junglen, Serpil Karadag, Karen E. Keller, Boris Klempa, Jonas Klingstrom, Gary Kobinger, Hideki Kondo, Eugene V. Koonin, Mart Krupovic, Gael Kurath, Ivan V. Kuzmin, Lies Laenen, Robert A. Lamb, Amy J. Lambert, Stanley L. Langevin, Benhur Lee, Elba R. S. Lemos, Eric M. Leroy, Dexin Li, Jianrong Li, Mifang Liang, Wenwen Liu, Yan Liu, Igor S. Lukashevich, Piet Maes, William Marciel de Souza, Marco Marklewitz, Sergio H. Marshall, Giovanni P. Martelli, Robert R. Martin, Shin-Yi L. Marzano, Sebastien Massart, John W. McCauley, Nicole Mielke-Ehret, Angelantonio Minafra, Maria Minutolo, Ali Mirazimi, Hans-Peter Muehlbach, Elke Muhlberger, Rayapati Naidu, Tomohide Natsuaki, Beatriz Navarro, Jose A. Navarro, Sergey V. Netesov, Gabriele Neumann, Norbert Nowotny, Marcio R. T. Nunes, Are Nylund, Arnfinn L. Okland, Renata C. Oliveira, Gustavo Palacios, Vicente Pallas, Bernadett Palyi, Anna Papa, Colin R. Parrish, Alex Pauvolid-Correa, Janusz T. Paweska, Susan Payne, Daniel R. Perez, Florian Pfaff, Sheli R. Radoshitzky, Aziz-ul Rahman, Pedro L. Ramos-Gonzalez, Renato O. Resende, Carina A. Reyes, Bertus K. Rima, Victor Romanowski, Gabriel Robles Luna, Paul Rota, Dennis Rubbenstroth, Jonathan A. Runstadler, Daniel Ruzek, Sead Sabanadzovic, Jiri Salat, Amadou Alpha Sall, Maria S. Salvato, Kamil Sarpkaya, Takahide Sasaya, Martin Schwemmle, Muhammad Z. Shabbir, Xiaohong Shi, Zhengli Shi, Yukio Shirako, Peter Simmonds, Jana Sirmarova, Manuela Sironi, Sophie Smither, Teemu Smura, Jin-Won Song, Kirsten M. Spann, Jessica R. Spengler, Mark D. Stenglein, David M. Stone, Petra Strakova, Ayato Takada, Robert B. Tesh, Natalie J. Thornburg, Keizo Tomonaga, Noel Tordo, Jonathan S. Towner, Massimo Turina, Ioannis Tzanetakis, Rainer G. Ulrich, Anna Maria Vaira, Bernadette van den Hoogen, Arvind Varsani, Nikos Vasilakis, Martin Verbeek, Victoria Wahl, Peter J. Walker, Hui Wang, Jianwei Wang, Xifeng Wang, Lin-Fa Wang, Taiyun Wei, Heather Wells, Anna E. Whitfield, John V. Williams, Yuri I. Wolf, Zhiqiang Wu, Xin Yang, Xinglou Yang, Xuejie Yu, Natalya Yutin, F. Murilo Zerbini, Tong Zhang, Yong-Zhen Zhang, Guohui Zhou, Xueping Zhou
ARCHIVES OF VIROLOGY
(2020)
Article
Microbiology
Krista G. Freeman, Katherine S. Wetzel, Yu Zhang, Kira M. Zack, Deborah Jacobs-Sera, Sara M. Walters, Dominique J. Barbeau, Anita K. McElroy, John V. Williams, Graham F. Hatfull
Summary: Researchers explored the potential of using mycobacteriophages as a vaccine platform, citing advantages such as a large variety of characterized phages and the ability to display multiple antigen copies on a single particle. They found that mycobacteriophage Bxb1 and its recombinants displaying SARS-CoV-2 antigens exhibit strong immunogenicity.