Article
Pediatrics
Peter Csonka, Terhi Tapiainen, Mika J. Makela, Lauri Lehtimaki
Summary: Guidelines for treating preschool children with wheezing in emergency rooms are not well supported, highlighting the need for research to identify specific approaches for guideline implementation in primary care. Clinical research needs to focus on strengthening recommendations that are currently not embraced.
Article
Pediatrics
Alex Gileles-Hillel, Sharon Guttman, Oded Breuer, Joel Reiter, Regina Leshem, David Shoseyov, Eitan Kerem, Malena Cohen-Cymberknoh
Summary: The study compared the efficacy of betamethasone and dexamethasone in treating preschool children hospitalized for acute wheezing, finding that both achieved similar clinical responses but dexamethasone was used in higher cumulative doses. Further research is needed to explore additional benefits of betamethasone over other steroids or placebo.
PEDIATRIC PULMONOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Marco Maglione, Antonietta Giannattasio, Antonia Pascarella, Vincenzo Tipo
Summary: Montelukast is not a revolutionary drug for pediatric asthma management, but rather a second-line medication used when inhaled steroids are ineffective. However, concerns about its safety have arisen due to increasing side effects. This review summarizes the literature published since 2010 on the role of Montelukast in pediatric asthma, highlighting the controversial results and unanswered questions regarding its use.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Michiel A. G. E. Bannier, Sophie Kienhorst, Quirijn Jobsis, Kim D. G. van de Kant, Frederik-Jan Van Schooten, Agnieszka Smolinska, Edward Dompeling
Summary: Exhaled breath analysis has the potential to diagnose various respiratory and non-respiratory diseases. This study found that inhaled corticosteroids can influence the volatile organic compounds in the exhaled breath of wheezing preschool children. Furthermore, the exhaled volatile organic compounds can predict the response to corticosteroid treatment in these children.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Abby D. Mutic, David T. Mauger, Jocelyn R. Grunwell, Cydney Opolka, Anne M. Fitzpatrick
Summary: The study shows that social vulnerability may lead to more severe symptoms and exacerbations in preschool children with recurrent wheezing, despite receiving standardized and supervised care. These children experience more severe symptoms during upper respiratory infections and respiratory flare days, and their exacerbations result in significantly poorer caregiver quality of life. Social vulnerability is also associated with poorer housing conditions and other environmental factors.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Pediatrics
Yibing Zhu, Lumin Chen, Yecheng Miao, Jinying Chen, Meng Bai, Haiyan Gao, Zhirong Zhu, Yuxuan Zhang, Jianzhong Zhang, Hafiz Khuram Raza, Guanghua Liu
Summary: This retrospective study collected data from 24,737 patients, among whom 8,572 infants were diagnosed with pneumonia with wheezing. The study found that male gender, past history of respiratory and cardiovascular diseases, low birth weight, severe pneumonia, and PICU admission were significantly associated with recurrent wheezing in infants.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Review
Allergy
Varpu Elenius, Bo Chawes, Pekka L. Malmberg, Aleksander Adamiec, Marek Ruszczynski, Wojciech Feleszko, Tuomas Jartti
Summary: The review suggests that FEV1 measurement using spirometry is useful, and for those unable to perform spirometry, whole-body plethysmography and IOS may be helpful. Adding bronchial reversibility to beta2-agonist and hyperresponsiveness tests could improve the sensitivity of the tests. A lack of large randomized controlled trials makes it challenging to establish monitoring guidelines for asthma in preschool children.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Allergy
Marek Ruszczynski, Dominika Ambrozej, Aleksander Adamiec, Klaudia Ryczaj, Varpu Elenius, Ozlem Cavkaytar, Paraskevi Maggina, Heidi Makrinioti, Nikolaos Papadopoulos, Gunilla Hedlin, Jon R. Konradsen, Bianca Schaub, Hermelijn H. Smits, Tuomas Jartti, Wojciech Feleszko
Summary: The study found variations in the quality of guidelines for asthma management in children, and a significant gap in reliable recommendations for the management and treatment of non-asthmatic preschool wheeze.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Pediatrics
Nicola Ullmann, Annalisa Allegorico, Andrew Bush, Federica Porcaro, Valentina Negro, Alessandro Onofri, Claudio Cherchi, Simone De Santis, Lorenza Rosito, Renato Cutrera
Summary: Research showed that preschool wheezers experienced significant clinical improvement during the national lockdown, with reduced respiratory symptoms, medication use, and healthcare resource utilization. However, these positive outcomes reversed when lockdown restrictions were eased.
PEDIATRIC PULMONOLOGY
(2021)
Article
Respiratory System
Katie Bonner, Elizabeth Scotney, Sejal Saglani
Summary: Preschool wheezing is associated with early life exposures, such as early allergen sensitization, respiratory infections, and the impact of the environment on shaping the airway microbiome and immune responses. While there is abundant associative data showing factors influencing wheeze onset and persistence, mechanistic and stratified interventional studies are needed to confirm these associations.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2021)
Article
Virology
Katarzyna Niespodziana, Katarina Stenberg-Hammar, Nikolaos G. Papadopoulos, Margarete Focke-Tejkl, Peter Errhalt, Jon R. Konradsen, Cilla Soderhall, Marianne van Hage, Gunilla Hedlin, Rudolf Valenta
Summary: Allergen exposure and rhinovirus (RV) infections are common triggers of acute wheezing exacerbations in early childhood. Increases in VP1-specific IgG and in allergen-specific IgE may serve as biomarkers for RV infections or allergen exposure. Our results suggest that, in the majority of preschool children, RV infections trigger wheezing attacks, but, in addition, allergen exposure seems to play a role as a trigger factor.
Article
Allergy
Pailin Yooma, Wiparat Manuyakorn, Adithep Sawatchai, Wanlapa Jotikasthira, Potjanee Kiewngam, Watcharoot Kanchongkittiphon
Summary: This study found that preschool children with recurrent wheezing have significantly higher serum periostin levels compared to healthy controls, and serum periostin may be a valuable biomarker for predicting acute wheezing exacerbations in the following year.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Respiratory System
Matteo Bonato, Elisa Gallo, Erica Bazzan, Giovanna Marson, Luca Zagolin, Manuel G. Cosio, Angelo Barbato, Marina Saetta, Dario Gregori, Simonetta Baraldo
Summary: The study found that in children without wheezing, prolonged exposure to PM10 and NO2 was associated with reduced eosinophilic and neutrophilic inflammation. However, in children with wheezing, prolonged exposure to PM10 was linked to increased basement membrane thickness and eosinophilic inflammation, potentially contributing to asthma development by promoting airway remodeling and inflammation.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Multidisciplinary Sciences
Lu Li, Fan Zhang, Ping Sun, Jiangzhen Zheng, Tingting Chen, Tao Huang, Fang Wang, Ke Li
Summary: This study explored and compared the clinical control of three atomized inhalation budesonide regimens for Chinese preschool children with recurrent wheezing. The researchers found that the three regimens had similar efficacy in controlling symptoms, suggesting that treatment can be tailored to individual cases.
SCIENTIFIC REPORTS
(2022)
Article
Allergy
Carlos E. Rodriguez-Martinez, Monica P. Sossa-Briceno, Manuel E. Soto-Martinez
Summary: The study evaluated the cost-effectiveness of bacterial lysate therapy as an add-on treatment for preschool children with recurrent wheezing. Results showed that bacterial lysate therapy was associated with lower treatment costs and greater gains in quality-adjusted life years (QALYs) compared to standard care, making it a dominant strategy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Allergy
Tmirah Haselkorn, Stanley J. Szefler, Bradley E. Chipps, Eugene R. Bleecker, Michelle S. Harkins, Brandee Paknis, Farid Kianifard, Benjamin Ortiz, Robert S. Zeiger
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Article
Allergy
Mengdi Lu, Augusto A. Litonjua, George T. O'Connor, Robert S. Zeiger, Leonard Bacharier, Michael Schatz, Vincent J. Carey, Scott T. Weiss, Hooman Mirzakhani
Summary: Childhood asthma development is affected by a complex interplay of maternal asthma and prenatal vitamin D status. This study suggests that adequate vitamin D intake throughout pregnancy can help reduce the risk of childhood asthma exacerbated by maternal asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Hanna M. Knihtila, Benjamin J. Stubbs, Vincent J. Carey, Nancy Laranjo, Su H. Chu, Rachel S. Kelly, Robert S. Zeiger, Leonard B. Bacharier, George T. O'Connor, Jessica Lasky-Su, Scott T. Weiss, Augusto A. Litonjua
Summary: Low gestational 25(OH)D level and childhood asthma are important risk factors for decreased lung function in early childhood.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Patrick W. Sullivan, Vahram H. Ghushchyan, David P. Skoner, Jason LeCocq, Siyeon Park, Robert S. Zeiger
Summary: The study found that asthmatic children and adolescents treated with systemic corticosteroids had an increased risk of developing complications and higher healthcare resource utilization in the first year of follow-up compared to those not receiving corticosteroids.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Robert S. Zeiger, Michael Schatz, Benjamin Hong, Qiaowu Li, Julie A. Stern, Harpreet S. Takhar, Jessica P. Weaver, Vishal Bali, Jonathan Schelfhout, Wansu Chen
Summary: This study aimed to determine the severity, health status, and health care resource utilization among patients with chronic cough identified by electronic health records. Results showed that chronic cough is reported as a burdensome condition, especially in women and non-white minorities, with suboptimal treatment responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Eli O. Meltzer, Robert S. Zeiger, Peter Dicpinigaitis, Jonathan A. Bernstein, John J. Oppenheimer, Nate A. Way, Vicky W. Li, Robert Boggs, Michael J. Doane, Eduardo Urdaneta, Jessica P. Weaver, Jonathan Schelfhout, Eileen Fonseca
Summary: This study investigated the prevalence of chronic cough and its impact on individuals and the healthcare system in the United States. Findings showed that individuals with chronic cough had lower health-related quality of life, increased anxiety and depression, impaired work productivity, sleep quality, and higher healthcare utilization compared to matched controls.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Yih-Chieh S. Chen, Hooman Mirzakhani, Mengdi Lu, Robert S. Zeiger, George T. O'Connor, Megan T. Sande, Leonard B. Bacharier, Avraham Beigelman, Vincent J. Carey, Benjamin J. Hershfield, Nancy Laranjo, Augusto A. Litonjua, Scott T. Weiss, Kathleen A. Lee-Sarwar
Summary: This study found that third-trimester prenatal vitamin D sufficiency in mothers with first-trimester vitamin D insufficiency can reduce the risk of aeroallergen sensitization in children at ages 3 and 6. It also showed that high-dose prenatal vitamin D supplementation may decrease the development of clinical allergic rhinitis with sensitization in children. Associations between prenatal vitamin D and aeroallergen sensitization were stronger in children who also developed asthma or had a maternal history of atopy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Bradley E. Chipps, Kevin R. Murphy, Robert A. Wise, William A. McCann, David A. Beuther, Joan Reibman, Maureen George, Ileen Gilbert, James M. Eudicone, Hitesh N. Gandhi, Gale Harding, Melissa Ross, Robert S. Zeiger
Summary: The study aimed to evaluate the construct validity of the Asthma Impairment and Risk Questionnaire (AIRQ). The results showed that the AIRQ classified asthma control similarly to the Asthma Control Test (ACT) and exacerbation validation standard, and exhibited construct validity with a 3-month recall period for exacerbation-based risk questions. Worsening AIRQ control levels were associated with higher proportions of exacerbations and greater asthma morbidity according to patient global self-assessments.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Allergy
Kathleen Lee-Sarwar, Sandra Dedrick, Babak Momeni, Rachel S. Kelly, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Nancy Laranjo, Diane R. Gold, Jessica Lasky-Su, Augusto A. Litonjua, Yang-Yu Liu, Scott T. Weiss
Summary: This study analyzed the relationship between gut microbiome and metabolome and wheeze frequency in children with asthma. The results showed that specific microbial taxa and metabolites were associated with high wheeze proportion in children. This finding suggests the impact of the gut microbiome on asthma morbidity in children.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Robert S. Zeiger, Michael Schatz, Yichen Zhou, Fagen Xie, Vishal Bali, Jonathan Schelfhout, Amar Das, Julie A. Stern, Wansu Chen
Summary: This retrospective study analyzed the risk factors of persistent chronic cough (PCC) in patients diagnosed with chronic cough by specialists. The results showed that factors such as old age, female gender, low education level, comorbidities, specific medication use, and specialist care, particularly with pulmonologists, were associated with PCC.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
Kathleen A. Lee-Sarwar, Yih-Chieh Chen, Yuan Yao Chen, Anita L. Kozyrskyj, Piush J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Hans Bisgaard, Jakob Stokholm, Bo Chawes, Soren J. Sorensen, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Vincent J. Carey, Benjamin J. Harshfield, Nancy Laranjo, Diane R. Gold, Scott T. Weiss, Augusto A. Litonjua
Summary: This study found associations between prenatal and early-life fecal microbiomes and childhood asthma phenotypes. Cesarean section was found to increase the risk of early asthma.
Article
Pharmacology & Pharmacy
Greg E. Davis, Robert S. Zeiger, Benjamin Emmanuel, Yen Chung, Trung N. Tran, Kristin A. Evans, Stephanie Chen, Rohit Katial, James L. Kreindler, Joseph Tkacz
Summary: In patients with chronic rhinosinusitis with nasal polyposis (CRSwNP), the use of systemic corticosteroids (SCS) is associated with a higher risk of adverse outcomes and increased healthcare costs compared to controls without SCS exposure. Alternative treatment strategies that avoid or reduce SCS use may decrease healthcare costs.
CLINICAL THERAPEUTICS
(2022)
Article
Allergy
Yih-Chieh S. Chen, Kathleen A. Lee-Sarwar, Hooman Mirzakhani, George T. O'Connor, Leonard B. Bacharier, Robert S. Zeiger, Hanna M. Knihtila, Anjali Jha, Rachel S. Kelly, Nancy Laranjo, Raina N. Fichorova, Ngan Luu, Scott T. Weiss, Augusto A. Litonjua
Summary: Prenatal systemic inflammation, as measured by plasma CRP, is associated with childhood asthma, eczema, and allergic rhinitis. Elevated early and late prenatal CRP and an increase in CRP from early to late pregnancy are linked to the development of childhood asthma. This association is particularly strong for children with atopic asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
David A. Beuther, Kevin R. Murphy, Robert S. Zeiger, Robert A. Wise, William McCann, Joan Reibman, Maureen George, Ileen Gilbert, James M. Eudicone, Hitesh N. Gandhi, Melissa Ross, Karin S. Coyne, Bradley Chipps
Summary: The study evaluated the ability of the Asthma Impairment and Risk Questionnaire (AIRQ) to predict exacerbations reported by patients over a 12-month period. The results demonstrated that the control level assessed by AIRQ can predict exacerbation risk and the probability of time to first exacerbation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Health Care Sciences & Services
Kate Sully, Nicola Bonner, Helena Bradley, Robyn von Maltzahn, Rob Arbuckle, Louise Walker-Nthenda, Aoife Mahon, Brandon Becker, Louise O'Hara, Katherine B. Bevans, Mark Kosinski, Robert S. Zeiger, Ross Mackenzie, Linda Nelsen
Summary: This study developed alternative response option images for use in the C-ACT and provides qualitative evidence of the equivalency of these response options to the originals through interviews with children with asthma.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2021)