Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 127, Issue 2, Pages 406-411Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2010.11.038
Keywords
Asthma; medication adherence; electronic monitoring; outcome expectancy; behavioral intervention
Categories
Funding
- National Institutes of Health (National Heart, Lung, and Blood Institute) [R01HL073494]
- American Lung Association
- Centers for Disease Control and Prevention
- Merck
- Teva
- NIH
- Elsevier
- Asthmatx
- Amgen
- Ception
- GlaxoSmithKline
- Genentech
- MedImmune
- Novartis
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Background: Little is known about how drug presentation influences medication adherence. Objective: To examine the effect of an educational program aimed at increasing expectations of treatment benefit on medication adherence. Methods: Data are analyzed from 99 participants who underwent electronic drug monitoring during the Trial of Asthma Patient Education, a randomized, placebo-controlled, multicenter trial. Participants with suboptimally controlled asthma were randomized to placebo or montelukast in conjunction with a presentation mode that was either neutral or designed to increase outcome expectancy. Adherence was monitored electronically over 4 weeks and was defined as >= 80% use of prescribed doses. Outcome expectancy, peak expiratory flow, prebronchodilator FEV(1), asthma control (Juniper asthma control questionnaire), and asthma-related quality of life were assessed at baseline and at the 4-week follow-up. Results: Average electronic medication adherence was 69.9%. There was a significant interaction between presentation mode and drug assignment, with participants in the enhanced/montelukast group having a higher change in outcome expectancy (Delta 2.1 points; P < .001) and better medication adherence (odds ratio, 4.0; 95% CI, 1.1-14.3) compared with those in the neutral/placebo group. There was no difference in asthma symptoms, quality of life, or clinical outcomes on the basis of presentation mode. Rather, increased outcome expectancy was associated with modest improvements in asthma symptoms after adjusting for presentation mode, drug assignment, and medication adherence. Conclusion: The use of an enhanced presentation aimed at increasing outcome expectancy may lead to improved medication adherence. (J Allergy Clin Immunol 2011;127:406-11.)
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