Article
Multidisciplinary Sciences
Ken Arae, Masashi Ikutani, Kotaro Horiguchi, Sachiko Yamaguchi, Youji Okada, Hiroki Sugiyama, Keisuke Orimo, Hideaki Morita, Hajime Suto, Ko Okumura, Haruhiko Taguchi, Kenji Matsumoto, Hirohisa Saito, Katsuko Sudo, Susumu Nakae
Summary: Our study demonstrates that chitin induces the production of IL-33 and TSLP by alveolar and bronchial epithelial cells in mice. These cytokines play a crucial role in activating resident lung Th2 cells and ILC2s, leading to the development of chitin-induced airway eosinophilia.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Si-Hang Wang, Ya-Gang Zuo
Summary: TSLP, particularly the long form, plays a crucial role in immune-mediated skin diseases, driving Th2 and Th17 immune responses, inducing itch, and being associated with skin fibrosis and epidermal hyperplasia. Targeting TSLP may have significant implications for the treatment of these diseases in the future.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Respiratory System
Changhui Yu, Wufeng Huang, Zicong Zhou, Shixiu Liang, Zili Zhou, Jieyi Liu, Haijing Zhao, Laiyu Liu, Hangming Dong, Fei Zou, Shaoxi Cai
Summary: The short isoform of TSLP (sTSLP) inhibits airway inflammation in asthma by occupying the binding site of the long isoform of TSLP (lTSLP) in the TSLPR and IL-7R receptor complex, thereby reducing aerobic glycolysis and inflammatory cytokine production.
RESPIRATORY RESEARCH
(2022)
Article
Oncology
Ranya Guennoun, Jennet Hojanazarova, Kathryn E. Trerice, Marjan Azin, Matthew T. McGoldrick, Erik B. Schiferle, Michael P. Stover, Shadmehr Demehri
Summary: This study demonstrates the potential of immunotherapy for lung cancer by examining the impact of Thymic Stromal Lymphopoietin (TSLP) cytokine induction on early lung cancer development. TSLP induction suppresses the development of invasive lung tumors, dependent on CD4(+) T cells. This highlights the importance of adaptive immune response in protecting against lung cancer progression.
Article
Allergy
Thomas J. A. Maguire, Stephanie Yung, Elena Ortiz-Zapater, O. Stephanie Kayode, Stephen Till, Chris Corrigan, Leonard Q. C. Siew, Gregory A. Knock, Grzegorz Woszczek
Summary: S1P plays an important role in regulating airway smooth muscle reactivity and hyperplasia, potentially serving as a novel therapeutic target for asthma and other lung diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sylwia Smolinska, Dario Antolin-Amerigo, Florin-Dan Popescu, Marek Jutel
Summary: TSLP is a critical cytokine in allergy and asthma development, primarily produced by epithelial cells. It functions as a potent immune system activator through interaction with its receptor complex. Understanding the interplay between TSLP and dysfunctional epithelium provides insights into allergy and asthma pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ruth Choa, Junichiro Tohyama, Shogo Wada, Hu Meng, Jian Hu, Mariko Okumura, Rebecca M. May, Tanner F. Robertson, Ruth-Anne Langan Pai, Arben Nace, Christian Hopkins, Elizabeth A. Jacobsen, Malay Haldar, Garret A. FitzGerald, Edward M. Behrens, Andy J. Minn, Patrick Seale, George Cotsarelis, Brian Kim, John T. Seykora, Mingyao Li, Zoltan Arany, Taku Kambayashi
Summary: The study reveals a new mechanism in which the immune system regulates systemic metabolism, with T cells inducing white adipose loss through excessive sebum secretion. This adipose loss protects against obesity, improves glucose metabolism, and is not caused by alterations in food intake, absorption, or energy expenditure. The findings highlight the role of adaptive immunity in skin barrier function through sebum secretion.
Article
Cell Biology
Santosh K. Yadav, Pawan Sharma, Sushrut D. Shah, Reynold A. Panettieri, Taku Kambayashi, Raymond B. Penn, Deepak A. Deshpande
Summary: Inhibition of DGK activates PKA signaling pathway and induces COX expression and PGE(2) production in ASM cells, leading to attenuation of ASM contraction. This novel mechanism suggests DGK as a potential therapeutic target for effective bronchoprotection in asthma.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Miguel Angel Hernandez-Lara, Santosh K. Yadav, Sushrut D. Shah, Mariko Okumura, Yuichi Yokoyama, Raymond B. Penn, Taku Kambayashi, Deepak A. Deshpande
Summary: Airway remodeling in asthma involves the hyperproliferation of airway smooth muscle (ASM) cells. The inhibition of diacylglycerol kinase (DGK) reduces the conversion of diacylglycerol (DAG) into phosphatidic acid (PA) and inhibits ASM cell proliferation. These findings suggest that DGK may serve as a potential drug target for mitigating airway remodeling in asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Wanlin Li, Chenghui Liao, Jing Du, Jing Hu, Lu Wang, Xun Song, Zhendan He, Xiaohua Xiao, Liang Ye
Summary: Two isoforms of TSLP, lTSLP and sTSLP, exist in rheumatoid arthritis (RA), with lTSLP being predominant in active RA and sTSLP in inactive RA and healthy controls. lTSLP expression is associated with disease activity and proinflammatory cytokine expression. lTSLP promotes the expression of proinflammatory cytokines in PBMCs of RA, while inhibiting the expression of anti-inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Na-Ra Han, Seong-Gyu Ko, Phil-Dong Moon, Hi-Joon Park
Summary: Chloroquine (CQ) exhibits anti-inflammatory effects by modulating TSLP levels in mast cells and reducing ear edema thickness, as well as TSLP levels in ear tissue and serum. The down-regulation of CASP1, NF-kappa B, and other signaling cascades by CQ contributes to its protective role against TSLP-mediated inflammatory disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Yuhao Zhao, Yeping Zhang, Zongsheng Guo, Zheng Ma, Ye Liu, Chunming Han, Xinchun Yang, Lei Zhao
Summary: Plasma TSLP levels were higher in AMI patients compared to UA patients, and lower TSLP levels were associated with MACE after AMI. Follow-up analysis showed that TSLP was a negative predictor of MACE in AMI patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Simone Marcella, Angelica Petraroli, Luisa Cane, Anne Lise Ferrara, Remo Poto, Roberta Parente, Francesco Palestra, Leonardo Cristinziano, Luca Modestino, Maria Rosaria Galdiero, Maria Monti, Gianni Marone, Massimo Triggiani, Gilda Varricchi, Stefania Loffredo
Summary: Mastocytosis is a heterogeneous disease characterized by uncontrolled proliferation and increased density of mast cells. In this study, it was found that serum concentrations of Thymic stromal lymphopoietin (TSLP) were lower in patients with mastocytosis compared to healthy donors. TSLP was found to be a substrate for human mast cell tryptase, indicating a novel connection between these mediators in mastocytosis.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Respiratory System
Cassandra Spector, Camden M. De Sanctis, Reynold A. Panettieri Jr, Cynthia J. Koziol-White
Summary: Rhinovirus infections can lead to airway remodeling, which is characterized by irreversible airway obstruction and diminished responsiveness to bronchodilators. Structural cells of the airways, including epithelial cells, smooth muscles, fibroblasts, myofibroblasts, and lung vascular endothelial cells, play a role in this process by producing various mediators and components that contribute to airway remodeling. Rhinovirus exposure can induce airway hyperresponsiveness and remodeling phenotypes such as mucus hypersecretion, epithelial-mesenchymal transition, and fibroblast-myofibroblast transdifferentiation. Different cellular responses to rhinovirus infection can lead to persistent airway remodeling in asthmatic individuals, including exaggerated type 2 inflammation, increased extracellular matrix deposition, and enhanced production of pro-angiogenic mediators.
RESPIRATORY RESEARCH
(2023)
Article
Physiology
Philippe Delmotte, Natalia Marin Mathieu, Gary C. Sieck
Summary: In hASM of asthmatic patients, mitochondrial volume density is higher and fragmentation is more common, likely influenced by proinflammatory cytokines. TNF alpha exposure leads to increased mitochondrial biogenesis, volume density, and fragmentation, ultimately reducing O-2 consumption rate per mitochondrion. These changes are associated with alterations in expression of key mitochondrial proteins and increased cell proliferation in hASM.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Thomas H. Mahood, Christopher D. Pascoe, Tobias K. Karakach, Aruni Jha, Sujata Basu, Peyman Ezzati, Victor Spicer, Neeloffer Mookherjee, Andrew J. Halayko
Summary: Analysis of proteomes from lung tissues and BALF of allergen-challenged mice revealed greater diversity in proteins between lung tissues and BALF compared to changes induced by allergen challenge. Biological pathways enriched after allergen exposure were compartment-dependent, with lung tissues showing innate immune responses and oxidative stress, and BALF showing changes in metabolism. Integration of proteomes from different compartments highlighted redox pathways and new proteins that may mediate interactions between lung tissue and BALF after allergen challenge.
Article
Chemistry, Medicinal
Hadeesha Piyadasa, Mahadevappa Hemshekhar, Natasha Osawa, Dylan Lloyd, Anthony Altieri, Sujata Basu, Oleg Krokhin, Andrew J. Halayko, Neeloffer Mookherjee
Summary: Research demonstrates the importance of the tryptophan (W8) in the central hydrophobic region of IDR-1002 for its immunomodulatory activities in both murine and human models. This study provides insights for the design of targeted IDR peptides with specific impact on immunomodulation and respiratory diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Editorial Material
Critical Care Medicine
Andrew J. Halayko, Christopher D. Pascoe, Jessica D. Gereige, Michael C. Peters, Robyn T. Cohen, Prescott G. Woodruff
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Immunology
Jyoti Balhara, Latifa Koussih, Ashfaque Mohammed, Lianyu Shan, Bouchaib Lamkhioued, Abdelilah S. Gounni
Summary: This study revealed that deficiency of PTX3 results in an increase in lung CD11c(+)CD11b(+) DC numbers and function, exacerbating airway inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Pawan Sharma, Javad Alizadeh, Maya Juarez, Afshin Samali, Andrew J. Halayko, Nicholas J. Kenyon, Saeid Ghavami, Amir A. Zeki
Summary: The study found that cell stress markers in lung tissue of IPF patients are associated with lung function deficits, with co-localization of UPR and autophagy markers positively correlated with increased lung function.
Article
Physiology
Christopher D. Pascoe, Sujata Basu, Jacquie Schwartz, Mario Fonseca, Shana Kahnamoui, Aruni Jha, Vernon Dolinsky, Andrew J. Halayko
Summary: Exposure to maternal diabetes may have different effects on lung health and airway inflammation in children, with female offspring being more susceptible to inflammatory lung conditions such as asthma, while male offspring display changes more characteristic of chronic obstructive pulmonary disease models.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Physiology
Jeffrey D. Ritzenthaler, Edilson Torres-Gonzalez, Yuxuan Zheng, Igor N. Zelko, Victor van Berkel, David R. Nunley, Biniam Kidane, Andrew J. Halayko, Ross Summer, Walter H. Watson, Jesse Roman
Summary: Old lung fibroblasts exhibit a profibrotic and senescence phenotype, which can be modulated by manipulating the Slc7a11 gene.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Immunology
Amena Aktar, Lianyu Shan, Latifa Koussih, Mohamed S. Almiski, Sujata Basu, Andrew Halayko, Ifeoma Okwor, Jude E. Uzonna, Abdelilah S. Gounni
Summary: The Sema3E/plexinD1 signaling pathway in interstitial macrophages regulates airway inflammation, airway resistance, and tissue remodeling in house dust mite-induced allergic asthma. Reduced IL-10 expression by plexinD1-deficient macrophages may contribute to the exacerbation of these allergic asthma features.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Vincent Wellemans, Hassan Ait Benhassou, Eloise Fuselier, Fabienne Bellesort, Sandra Dury, Francois Lebargy, Valerian Dormoy, Caroline Fichel, Richard Le Naour, Abdelilah S. Gounni, Bouchaib Lamkhioued
Summary: RSV infection may enhance virus replication by interacting with CCR3 and increasing airway responsiveness; lack of CCR3 is beneficial for resistance against RSV infection and reduction of airway inflammation.
Editorial Material
Biochemistry & Molecular Biology
Abdelilah S. Gounni, Latifa Koussih
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Julia Frankenberg Garcia, Andrew Rogers, Judith C. W. Mak, Andrew J. Halayko, Christopher K. M. Hui, Bingling Xu, Kian Fan Chung, Tristan Rodriguez, Charalambos Michaeloudes, Pankaj K. Bhavsar
Summary: Mitochondrial transfer from mesenchymal stem cells to airway smooth muscle cells can attenuate oxidative stress-induced damage in COPD. However, it is not known whether structural cells in the lungs can also exchange mitochondria and what role this plays in modulating bioenergetics and cellular function. Here, researchers found that airway smooth muscle cells in both healthy ex-smokers and COPD patients can exchange mitochondria, partially through extracellular vesicles. Exposure to cigarette smoke induces mitochondrial dysfunction and increases mitochondrial donation by the smooth muscle cells, suggesting it may be a stress response mechanism. Moreover, the study showed that the received mitochondria enhance mitochondrial biogenesis and respiration while reducing cell proliferation in healthy ex-smoker airway smooth muscle cells.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Immunology
Rony Thomas, Shuhe Wang, Rasheduzzaman Rashu, Ying Peng, Abdelilah S. Gounni, Xi Yang
Summary: Recent studies have shown that semaphorins, particularly Sema3E, play a significant role in immune responses and have therapeutic potential against bacterial infection. Exogenous Sema3E treatment can protect mice from chlamydial infection by enhancing Th1/Th17 response, reducing Treg response, and promoting the recruitment of dendritic cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Critical Care Medicine
Bouchaib Lamkioued, Abdelilah S. Gounni
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
