Article
Allergy
Sen Hee Tay, Amelia Santosa, Eugene Chen Howe Goh, Chun Xiang Xu, Lik Hang Wu, Mei Bigliardi-Qi, Leroy Sivappiragasam S. O. Pakkiri, Bernett Teck Kwong Lee, Chester Lee Drum, Paul Lorenz Bigliardi
Summary: This study is the first to combine both transcriptomic and metabolomic approaches in patients with NIUA, contributing to a deeper understanding of the pathogenesis of NIUA and potentially paving the way for a molecular diagnosis of NSAID hypersensitivity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Stefan Woehrl, Christian Ostermayer, Gabriele Sesztak-Greinecker, Reinhart Jarisch, Wolfgang Hemmer, Felix Wantke
Summary: The study shows that a third of cases of questionable drug hypersensitivity reactions to betalactam antibiotics can be solved using drug-specific history, drug-specific IgE, and skin tests. Penicillin V in vitro tests and early readings of ampicillin skin tests showed the highest rates of positivity among the tests conducted.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Allergy
Nidhal Touati, Barbara Cardoso, Marie Delpuech, Raphaelle Bazire, Nathalie El Kara, Djamila Ouali, Pascal Demoly, Anca-Mirela Chiriac
Summary: This study explored cephalosporin drug hypersensitivity over a 26-year period in France, with about 22.3% of tested patients confirmed as hypersensitive. Immediate and anaphylactic reactions were common, with cross-reactivity mainly observed with aminopenicillins. Logistic regression analysis revealed risk factors associated with confirmed drug hypersensitivity, highlighting the need for further research in this area.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Karen M. Anstey, Lulu Tsao, Iris M. Otani
Summary: Drug allergy delabeling programs are important for antibiotic stewardship and involve patient selection, design, stakeholder engagement, team assembly, implementation, and outcome evaluation. Current programs focus on removing inaccurate antibiotic allergy labels for patients with beta-lactam allergies and high-risk populations likely to need beta-lactam antibiotics. Inpatients, pediatric patients, and telehealth programs have successfully implemented beta-lactam delabeling programs. This review also highlights delabeling programs for high-risk populations, such as perioperative, prenatal, and immunocompromised patients. Successful delabeling strategies and future innovation areas are discussed.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Microbiology
Wedad M. Nageeb, Nada AlHarbi, Amani A. Alrehaili, Shadi A. Zakai, Ahmed Elfadadny, Helal F. Hetta
Summary: This study provides a comprehensive analysis of potential membrane proteins and efflux-pump variants related to carbapenem susceptibility in A. baumannii. It sheds light on their clinical utility as diagnostic markers and treatment modification targets for more focused studies.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Primary Health Care
Estelle A. Green, Kelan Fogarty, Faoud T. Ishmael
Summary: Allergy to penicillin can occur in different types of Gel-Coombs hypersensitivity reactions, with varying severity and treatment options. Immediate discontinuation of penicillin is necessary for all reactions, and medications such as epinephrine, antihistamines, and glucocorticoids may be used depending on the reaction type. Most beta-lactams can be safely used in penicillin-allergic patients, except for first-generation and second-generation cephalosporins. Testing, such as skin testing, patch testing, and graded challenge, can be useful in determining allergies and desensitization may be used when penicillin treatment is essential.
Article
Allergy
Eric Macy, William W. Crawford, Myngoc T. Nguyen, John L. Adams, Elizabeth A. McGlynn, Thomas A. McCormick
Summary: This study aimed to investigate the association between the use of b-lactams sharing exact R1 side chains and allergic reactions. The research tracked all courses of ACC and trimethoprimsulfamethoxazole used by Kaiser Permanente California members in 2017 and 2018, comparing with sulfonamide antibiotic allergy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Allergy
Allison Ramsey
Summary: This review discusses the epidemiology of penicillin allergy and perioperative anaphylaxis separately and together, as well as considerations for penicillin allergy during pregnancy. It addresses the minimal cross reactivity between penicillins and cephalosporins and highlights the management of perioperative anaphylaxis and opportunities for education regarding pre-operative penicillin allergy evaluations.
FRONTIERS IN ALLERGY
(2022)
Article
Obstetrics & Gynecology
Jason H. Kwah, Martina S. Burn, Jane Liao, Jennifer Cate, Moeun Son
Summary: This study evaluated a hospital-wide multidisciplinary program to identify, refer, evaluate, and test pregnant women with unverified penicillin allergies and assessed its association with maternal and neonatal outcomes. The results showed that referred women were less likely to receive alternative antibiotics, but the associations with other maternal and neonatal adverse outcomes were not significant.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Obstetrics & Gynecology
Linda X. Li, Cyndy Oliver, Stefania Ronzoni, Arthur Zaltz, Jerome A. Leis, Marion Elligsen, Philip W. Lam
Summary: This study evaluated the impact of a standardized allergy-guided approach on Group B Streptococcus prophylaxis in pregnant women with reported penicillin or cephalosporin allergy. The results showed that implementing this approach improved antibiotic use safely and effectively, without any hypersensitivity reactions.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA
(2022)
Article
Allergy
D. Dubrall, M. Schulz, M. Schmid, B. Sachs
Summary: This study analyzed hypersensitivity reactions associated with beta-lactam antibiotics (BLA) in the European adverse drug reaction (ADR) database, and found differences between different generations of cephalosporins and penicillins. However, due to methodological limitations, no definite conclusions could be drawn.
Review
Otorhinolaryngology
Mohamad R. Chaaban, David Moffatt, Alex E. Wright, James A. Cowthran, En Shuo Hsu, Yong-Fang Kuo
Summary: A systematic review and meta-analysis found that aspirin desensitization can significantly improve FEV-1 and reduce asthma medication/steroid use. However, there was no significant improvement in sinonasal quality of life among patients undergoing aspirin desensitization. Further high-quality studies are needed to optimize personalized treatment protocols.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
