Review
Immunology
Lijia Xuan, Nan Zhang, Xiangdong Wang, Luo Zhang, Claus Bachert
Summary: The role of IL-10 family cytokines in CRSwNP is being reevaluated, as they have been found to not only affect epithelial function but also be involved in allergies and infections, and respond to glucocorticoid treatment. Utilizing these cytokines for treatment may be an effective strategy for treating CRSwNP.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Otorhinolaryngology
Yujie Cao, Xianting Hu, Chun Zhou, Keqing Zhao, Yaoming Zheng, Wenxiu Jiang, Dehui Wang, Huabin Li
Summary: The study found that IL-1 alpha is significantly increased in NP tissues of CRSwNP patients in China and is mainly located in epithelial cells and neutrophils. IL-1 alpha in polyp tissues is associated with the production of IL-8, IL-1 beta, IL-6, IL-4, and IL-13, as well as tissue neutrophil infiltration. In vitro experiments showed that several stimuli, including poly (I:C), lipopolysaccharides, Flagellin, R848, and cytokines (IL-4, IL-5, and IL-13), increase the expression of IL-1 alpha in cultured NECs, and recombinant IL-1 alpha promotes the production of IL-8 and CXCL1.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rong-San Jiang, I-Chieh Chen, Yi-Ming Chen, Tzu-Hung Hsiao, Yi-Chen Chen
Summary: This study found that polygenic risk scores developed from European populations can be applied to the Taiwanese population to predict the risk of chronic rhinosinusitis, especially for female patients with nasal polyps.
Review
Biochemistry & Molecular Biology
Jingyu Huang, Yu Xu
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) has been considered a benign, chronic inflammatory, and hyperplastic disease. Recent studies have shown that autoimmune-related mechanisms play a role in nasal polyp pathology. Innate and adaptive immune pathways are mobilized during polyp formation, involving activated plasma cells, eosinophils, basophils, innate type 2 lymphocytes, mast cells, and proinflammatory cytokines in polyp tissue. The discovery of autoantibodies further supports the autoimmune nature of nasal polyps. This study elaborates on the role of autoimmunity in the pathogenesis of CRSwNP, discussing microbiome-mediated mechanisms, abnormal host immunity, and genetic changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Min-Seok Rha, Young Hoon Yoon, June-Young Koh, Jae Hyung Jung, Ha Seok Lee, Soo Kyoung Park, Su-Hyung Park, Yong Min Kim, Ki-Sang Rha, Eui-Cheol Shin
Summary: Sinonasal MAIT cells exhibit an activated phenotype and produce higher levels of IL-17A in patients with CRSwNP. These alterations are associated with the extent of disease in patients with E-NP.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Athina Dritsoula, Laura Dowsett, Camilla Pilotti, Marie N. O'Connor, Stephen E. Moss, John Greenwood
Summary: This study investigates the role of IL-6 in defective angiogenesis mediated by LRG1. The results show that IL-6 activates LRG1 transcription through STAT3 phosphorylation, resulting in vascular destabilization. This finding is important for understanding the role of IL-6 in COVID-19 patients.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Sifei Yu, Chen Cao, Qianying Li, Xueyi Wen, Xuexue Guo, Qing Bao, Yutao Zhou, Liyue Li, Xiaoyan Ye, Tianying Li, Hexin Chen, Changyou Wu, Chunwei Li
Summary: The study reveals a significant increase of IL-17(+) cells and T cell subsets in polyp tissues of patients with chronic rhinosinusitis with nasal polyps (CRSwNP), with a positive correlation with neutrophil infiltration. Additionally, the homogenates from polyp tissues were found to promote neutrophil migration in vitro.
INFLAMMATION RESEARCH
(2021)
Article
Otorhinolaryngology
Lauren T. Roland, Alan Regenberg, Amber U. Luong, Sarah K. Wise, Elina Toskala, Kent K. Lam, Joshua M. Levy, Christine B. Franzese, Kristine Smith, Jean Kim
Summary: Biologics have been approved for use in chronic rhinosinusitis with nasal polyps patients, showing effectiveness in controlling the disease in both subjective and objective short-term outcomes. However, the high costs of biologics may pose a burden for the healthcare system with widespread and prolonged use. Cost-effectiveness analyses are needed to determine appropriate usage, along with addressing patient preferences, counseling on side effects, and healthcare economics.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Junhu Tai, Jae-Min Shin, Jaehyung Park, Munsoo Han, Tae Hoon Kim
Summary: Oxidative stress is caused by an imbalance between reactive oxygen species production and the body's antioxidant defense system. It plays a crucial role in regulating the immune response and can contribute to various diseases. Recent studies have found that oxidative stress is important in the pathogenesis and persistence of chronic rhinosinusitis (CRS), attracting the attention of researchers. The relationship between reactive oxygen species and nasal polyp pathology is a key topic of interest. This article reviews the role of oxidative stress in respiratory diseases, specifically CRS, and introduces potential antioxidant therapies for targeted treatment.
Article
Allergy
Julie A. Poposki, Aiko Klingler, Whitney W. Stevens, Lydia A. Suh, Bruce K. Tan, Anju T. Peters, Hiam Abdala-Valencia, Leslie C. Grammer, Kevin C. Welch, Stephanie S. Smith, David B. Conley, Robert C. Kern, Robert P. Schleimer, Atsushi Kato
Summary: This study found that neutrophils accumulate and are highly activated in CRSwNP in Western populations, playing a significant role in the inflammation. This finding has important implications for the pathogenesis and treatment of CRSwNP in Western countries.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Florent Carsuzaa, Emilie Bequignon, Xavier Dufour, Guillaume de Bonnecaze, Jean-Claude Lecron, Laure Favot
Summary: This review summarizes the current state of knowledge regarding the cytokine signature in CRSwNP, as well as the role of cytokines in the pathogenesis of the disease and in intercellular communication between epithelial cells, fibroblasts, and inflammatory cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Zaichuan Wang, Qiqi Wang, Su Duan, Yuling Zhang, Limin Zhao, Shujian Zhang, Liusiqi Hao, Yan Li, Xiangdong Wang, Chenshuo Wang, Nan Zhang, Claus Bachert, Luo Zhang, Feng Lan
Summary: This study established a diagnostic model using machine learning algorithms, based on biomarkers in nasal secretions and clinical features, which can accurately predict patients with type 2 chronic rhinosinusitis with nasal polyps (CRSwNP). This may be beneficial for patients in daily clinical practice in selecting appropriate treatment methods.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yanni Zhang, Kang Zhu, Jingguo Chen, Cui Xia, Chao Yu, Tianxi Gao, Jing Yan, Bingjie Zhao, Xiaoyong Ren
Summary: This study found that serum IL-33 and sST2 levels were upregulated in CRSwNP patients and were associated with the degree of mucosal eosinophil infiltration and postoperative recurrence. Serum IL-33 and sST2 may serve as objective biomarkers for distinguishing CRSwNP endotypes and predicting recurrence, with their combined use showing better effectiveness.
MEDIATORS OF INFLAMMATION
(2022)
Article
Allergy
Yan Zhao, Junru Chen, Yun Hao, Boqian Wang, Yue Wang, Qinghua Liu, Jinming Zhao, Ying Li, Ping Wang, Xiangdong Wang, Peng Zhang, Luo Zhang
Summary: The study found that altered nasal microbiota constituents can be used as biomarkers to predict CRSwNP recurrence, providing new insights for the prognosis of nasal polyp patients. The nasal microbiome is an understudied source of clinical variation in CRSwNP and represents a novel therapeutic target for future prevention and treatment.
Article
Allergy
Junqin Bai, Julia H. Huang, Caroline P. E. Price, Jacob M. Schauer, Lydia A. Suh, Regan Harmon, David B. Conley, Kevin C. Welch, Robert C. Kern, Stephanie Shintani-Smith, Anju T. Peters, Whitney W. Stevens, Atsushi Kato, Robert P. Schleimer, Bruce K. Tan
Summary: This study aimed to evaluate the impact of polyp recurrence (PR) on disease severity post-ESS and quantify the prognostic value of various clinical variables and biomarkers. The study found a significant association between PR and radiographic and sinonasal test scores post-ESS. A combined model incorporating clinical and biomarker factors accurately predicted PR.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Critical Care Medicine
Tara F. Carr, Amir A. Zeki, Monica Kraft
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Article
Allergy
Noriko Ogasawara, Julie A. Poposki, Aiko I. Klingler, Bruce K. Tan, Ava R. Weibman, Kathryn E. Hulse, Whitney W. Stevens, Anju T. Peters, Leslie C. Grammer, Robert P. Schleimer, Kevin C. Welch, Stephanie S. Smith, David B. Conley, Joseph R. Raviv, Pejman Soroosh, Omid Akbari, Tetsuo Himi, Robert C. Kern, Atsushi Kato
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Allergy
Hai Wang, Zhi-Yong Li, Wen-Xiu Jiang, Bo Liao, Guan-Ting Zhai, Nan Wang, Zhen Zhen, Jian-wen Ruan, Xiao-Bo Long, Heng Wang, Wei-Hong Liu, Geng-Tian Liang, Wei-Min Xu, Atsushi Kato, Zheng Liu
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Allergy
Tara F. Carr, Debra A. Stern, Marilyn Halonen, Anne L. Wright, Fernando D. Martinez
CLINICAL AND EXPERIMENTAL ALLERGY
(2019)
Letter
Allergy
Juan Carlos Cardet, Christopher D. Codispoti, Tonya S. King, Leonard Bacharier, Tara Carr, Mario Castro, Vernon Chinchilli, Ryan Dunn, Fernando Holquing, Linda Engle, Kyle Nelson, Victor E. Ortega, Michael Peters, Sima Ramratnam, Jerry A. Krishnan, Michael E. Wechsler, Elliot Israel
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2019)
Article
Respiratory System
Tara F. Carr, Rhonda Alkatib, Monica Kraft
CLINICS IN CHEST MEDICINE
(2019)
Editorial Material
Allergy
Atsushi Kato, Whitney W. Stevens, Bruce S. Bochner
Review
Allergy
Atsushi Kato, Anju T. Peters, Whitney W. Stevens, Robert P. Schleimer, Bruce K. Tan, Robert C. Kern
Summary: The study of chronic rhinosinusitis (CRS) has shifted from phenotype-based classification to endotype-based classification, identifying three main endotypes that orchestrate the expression of different gene sets. The development of improved methods for endotyping disease is expanding the use of biological therapies, targeting Type 2 inflammation and potentially other inflammatory endotypes in the future.
Review
Allergy
Atsushi Kato, Robert P. Schleimer, Benjamin S. Bleier
Summary: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by inflammation in the upper airways, which can be divided into two main types based on the presence of nasal polyps. The inflammation is characterized by three different endotypes based on the elevation of specific cytokines. The sinonasal epithelium plays a crucial role in the pathogenesis of CRS by acting as a barrier and participating in both innate and adaptive immunity. Further research is needed to fully understand the mechanisms of CRS pathogenesis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Masafumi Sakashita, Tetsuji Takabayashi, Yoshimasa Imoto, Tetsuya Homma, Kanako Yoshida, Kazuhiro Ogi, Yukihiro Kimura, Atsushi Kato, Whitney W. Stevens, Stephanie S. Smith, Kevin C. Welch, James E. Norton, Lydia A. Suh, Roderick G. Carter, Kathryn E. Hulse, Sudarshan Seshadri, Jin-Young Min, Kathryn L. Pothoven, David B. Conley, Bruce K. Tan, Kathleen E. Harris, Robert C. Kern, Shinichi Haruna, Yoshinori Matsuwaki, Ryosuke Ochiai, Shigeharu Fujieda, Robert P. Schleimer
Summary: This study found that patients with AERD have lower levels of retinoids, which may contribute to decreased tPA and fibrinolysis. In vitro experiments showed that retinoic acid can induce tPA production in epithelial cells and reverse the inhibitory effect of IL-13 on tPA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Respiratory System
Roy A. Pleasants, Khosrow Heidari, Jill Ohar, James F. Donohue, Njira L. Lugogo, Sarojini M. Kanotra, Monica Kraft, David M. Mannino, Charlie B. Strange
Summary: This study examines the relationship between respiratory symptoms, associated factors such as smoking, and health impairments among adults in the US. Among the findings, it is noteworthy that many individuals who do not have diagnosed asthma or COPD still experience moderate to severe symptoms. Age, smoking duration, and obesity were identified as significant risk factors for respiratory symptoms.
Review
Allergy
Tara F. Carr, Merritt L. Fajt, Monica Kraft, Wanda Phipatanakul, Stanley J. Szefler, Amir A. Zeki, David B. Peden, Steven R. White
Summary: The Precision Interventions for Severe and/or Exacerbation-Prone Asthma network is evaluating novel treatments for severe asthma and addressing clinical dilemmas caused by the COVID-19 pandemic. Drug interactions between established asthma therapies and COVID-19 interventions have emerged as a critical issue in asthma care. The network has considered available literature and product information to develop management strategies for potential interactions between asthma treatments and COVID-19 therapies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Brian S. Schwartz, Jonathan S. Pollak, Karen Bandeen-Roche, Annemarie G. Hirsch, Ashton E. Lehmann, Robert C. Kern, Bruce K. K. Tan, Atsushi Kato, Robert P. Schleimer, Anju T. Peters
Summary: This study investigates the association between chronic rhinosinusitis (CRS) and new onset asthma. By analyzing electronic health record data from Geisinger, it is found that prevalent CRS is associated with the diagnosis of new onset adult asthma in the following year. These findings have clinical implications for asthma prevention.
Article
Allergy
Marcus M. Soliai, Atsushi Kato, Katherine A. Naughton, James E. Norton, Aiko I. Klinger, Robert C. Kern, Bruce K. K. Tan, Dan L. Nicolae, Robert P. Schleimer, Carole Ober, Jayant M. Pinto
Summary: This study investigated the epigenetic and transcriptional responses in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) to rhinovirus (RV) using a primary sinonasal epithelial cell culture model. They found that RV activates specific epigenetic programs and correlated transcriptional networks in the sinonasal epithelium of individuals with CRSwNP, suggesting potential therapeutic targets for this condition.
Letter
Allergy
Brian S. Schwartz, Annemarie G. Hirsch, Karen Bandeen-Roche, Atsushi Kato, Robert Schleimer