Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 125, Issue 5, Pages 1061-1068Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2010.02.023
Keywords
Chinese patients; chronic rhinosinusitis; collagen; fork-head box P3 (FOXP3); matrix metalloproteinase; nasal polyposis; regulatory T cells; tissue remodeling; TGF-beta 1; tissue inhibitor of metalloproteinase
Categories
Funding
- Program of Science and Technology Foundation of Sichuan Province [2009HH0027]
- National Natural Science Foundation of China [30973291]
Ask authors/readers for more resources
Background: To date there is no information on the expression of mediators associated with tissue remodeling in Asian patients with chronic rhinitis with (CRSwNP) or without (CRSsNP) nasal polyps. Objectives: To study the expression of TGF-beta 1, matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), collagen, and regulatory T cells in Chinese patients with CRSwNP and CRSsNP. Methods: Thirty-six male and female subjects (12 patients with CRSwNP, 12 patients with CRSsNP, and 12 control subjects), age 17 to 60 years, were recruited into the study. Samples were collected from polyp and sinusoidal mucosal, ethmoidal mucosal, or inferior turbinate in the respective groups and assessed for TGF-beta 1, MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2, TIMP-3, and TIMP-4 by immunoassay; collagen by histochemistry; and forkhead box P3 (FOXP3) mRNA by real-time PCR. Results: Patients with CRSwNP showed significantly lower concentrations of TGF-beta 1, TIMP-1, TIMP-4, FOXP3, and collagen compared with patients with CRSsNP. Although there were no significant differences between the concentrations of MMP-7 and MMP-9 in patients with CRSwNP and CRSsNP, these were significantly increased compared with control patients. MMP-2 and TIMP-2 concentrations were not significantly different in any patient group, whereas TIMP-3 was not detectable. Conclusion: Chronic rhinosinusitis with nasal polyps is characterized by a relative lack of TGF-beta expression versus CRSsNP. This finding may be causal for decreased collagen, TIMP-1/4, and FOXP3 expression in CRSwNP versus CRSsNP. TGF-beta serves as a main switch for different remodeling patterns in sinus disease. (J Allergy Clin Immunol 2010;125:1061-8.)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available