Review
Allergy
Leonard B. Bacharier, Theresa W. Guilbert, Tuomas Jartti, Sejal Saglani
Summary: This review discusses the practical approach to deciding which children under 5 years with asthma should be treated, based on the severity, duration of symptoms, and evaluation of objective biomarkers. The optimal management of nonallergic preschool wheezing and asthma still presents numerous unanswered questions, highlighting the need for future research.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Pediatrics
Ramin Beheshti, E. Scott Halstead, Daniel McKeone, Steven D. Hicks
Summary: This study suggests that host-microbiome interactions in saliva may provide pathophysiological clues about the origins of wheezing and aid in identifying infants at risk for wheezing. The findings highlight the importance of understanding the relative contributions of infant traits, environment, and underlying biology in wheezing.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Jose A. Castro-Rodriguez, Erick Forno, Oslando Padilla, Paola Casanello, Bernardo J. Krause, Arturo Borzutzky
Summary: This study suggests that the asthma predictive index (API) can be used as a diagnostic tool for asthma in toddlers and preschoolers with high accuracy. Factors such as maternal body mass index, maternal education, birth weight, placenta weight, age of daycare, gastroesophageal reflux disease, acute otitis media, and respiratory infections were associated with API positivity. Using API for asthma diagnosis showed a sensitivity of 48% and specificity of 92%, with an adjusted odds for asthma of 11.4, indicating its potential as a diagnostic tool for respiratory illnesses in young children.
PEDIATRIC PULMONOLOGY
(2021)
Article
Pediatrics
Ying-Lun Hsu, Hsin-Chun Huang, Ting-Yu Su, I-Lun Chen
Summary: This study aimed to determine early life factors associated with preschool wheezing in premature neonates, finding that allergic rhinitis and re-hospitalization for respiratory tract infections were significant risk factors for preschool wheezing/asthma in premature neonates. Close follow-up of premature infants at high risk for asthma susceptibility is recommended.
Article
Multidisciplinary Sciences
Lu Li, Fan Zhang, Ping Sun, Jiangzhen Zheng, Tingting Chen, Tao Huang, Fang Wang, Ke Li
Summary: This study explored and compared the clinical control of three atomized inhalation budesonide regimens for Chinese preschool children with recurrent wheezing. The researchers found that the three regimens had similar efficacy in controlling symptoms, suggesting that treatment can be tailored to individual cases.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Ana Maria Herrera Gana, Gabriel Cavada Chacon, Maria Jesus Clavero Herrera
Summary: This study aimed to determine the hospitalization and mortality rates in children under 5 years of age in Chile with acute bronchitis and asthma. The study found a decrease in hospitalization rates for acute bronchitis and an increase in hospitalization rates for asthma. No deaths from asthma were observed.
Review
Chemistry, Multidisciplinary
Marco Maglione, Antonietta Giannattasio, Antonia Pascarella, Vincenzo Tipo
Summary: Montelukast is not a revolutionary drug for pediatric asthma management, but rather a second-line medication used when inhaled steroids are ineffective. However, concerns about its safety have arisen due to increasing side effects. This review summarizes the literature published since 2010 on the role of Montelukast in pediatric asthma, highlighting the controversial results and unanswered questions regarding its use.
APPLIED SCIENCES-BASEL
(2023)
Article
Pediatrics
Yibing Zhu, Lumin Chen, Yecheng Miao, Jinying Chen, Meng Bai, Haiyan Gao, Zhirong Zhu, Yuxuan Zhang, Jianzhong Zhang, Hafiz Khuram Raza, Guanghua Liu
Summary: This retrospective study collected data from 24,737 patients, among whom 8,572 infants were diagnosed with pneumonia with wheezing. The study found that male gender, past history of respiratory and cardiovascular diseases, low birth weight, severe pneumonia, and PICU admission were significantly associated with recurrent wheezing in infants.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Article
Allergy
Nannan Jiang, Wei Xu, Huijie Huang, Xiaoling Hou, Li Xiang
Summary: This retrospective observational study found that children with a history of asthma or recurrent wheezing have different clinical profiles of anaphylaxis compared to children without such history.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Pediatrics
Marzia Duse, Francesca Santamaria, Maria Carmen Verga, Marcello Bergamini, Giovanni Simeone, Lucia Leonardi, Giovanna Tezza, Annamaria Bianchi, Annalisa Capuano, Fabio Cardinale, Giovanni Cerimoniale, Massimo Landi, Monica Malventano, Mariangela Tosca, Attilio Varricchio, Anna Maria Zicari, Carlo Alfaro, Salvatore Barberi, Paolo Becherucci, Roberto Bernardini, Paolo Biasci, Carlo Caffarelli, Valeria Caldarelli, Carlo Capristo, Serenella Castronuovo, Elena Chiappini, Renato Cutrera, Giovanna De Castro, Luca De Franciscis, Fabio Decimo, Iride Dello Iacono, Lucia Diaferio, Maria Elisa Di Cicco, Caterina Di Mauro, Cristina Di Mauro, Dora Di Mauro, Francesco Di Mauro, Gabriella Di Mauro, Mattia Doria, Raffaele Falsaperla, Valentina Ferraro, Vassilios Fanos, Elena Galli, Daniele Giovanni Ghiglioni, Luciana Indinnimeo, Ahmad Kantar, Adima Lamborghini, Amelia Licari, Riccardo Lubrano, Stefano Luciani, Francesco Macri, Gianluigi Marseglia, Alberto Giuseppe Martelli, Luigi Masini, Fabio Midulla, Domenico Minasi, Vito Leonardo Miniello, Michele Miraglia del Giudice, Sergio Renzo Morandini, Germana Nardini, Agostino Nocerino, Elio Novembre, Giovanni Battista Pajno, Francesco Paravati, Giorgio Piacentini, Cristina Piersantelli, Gabriella Pozzobon, Giampaolo Ricci, Valter Spanevello, Renato Turra, Stefania Zanconato, Melissa Borrelli, Alberto Villani, Giovanni Corsello, Giuseppe Di Mauro, Diego Peroni
Summary: A multidisciplinary panel of experts from Italy developed a consensus document on the use of inhaled corticosteroids in common pediatric airway disorders, aiming to provide healthcare providers with guidance and drive future research.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Masahiko Kato, Hiroyuki Mochizuki, Yuichi Kama, Satoshi Kusuda, Kenji Okada, Shigemi Yoshihara, Hiroyuki Furuya, Eric A. F. Simoes
Summary: This study investigated whether prophylaxis with the anti-RSV monoclonal antibody palivizumab given to preterm infants reduced the incidence of subsequent recurrent wheezing and/or development of asthma. The results showed that at 10 years of age, there was no significant difference in recurrent wheezing or asthma development between the treated and untreated groups. However, there was a significant correlation between maternal passive smoking with aeroallergen sensitization and development of asthma.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Brooke Gustafson, Rodney D. Britt Jr, Mariah Eisner, Deepika Narayanan, Mitchell H. Grayson
Summary: This retrospective study identified risk factors associated with the development of wheezing in late preterm infants. Positive family history of asthma, receiving antibiotics during the neonatal period, requiring continuous positive airway pressure for less than 24 hours, and receiving supplemental oxygen during the newborn period were associated with the development of wheezing.
PEDIATRIC PULMONOLOGY
(2023)
Article
Immunology
Joseph P. McGinley, Gu Lung Lin, Deniz Oner, Tanya Golubchik, Daniel O'Connor, Matthew D. Snape, Olivier Gruselle, Annefleur C. Langedijk, Joanne Wildenbeest, Peter Openshaw, Harish Nair, Jeroen Aerssens, Louis Bont, Federico Martinon-Torres, Simon B. Drysdale, Andrew J. Pollard
Summary: The study evaluated the association between the severity of RSV disease and host age, viral load, and RSV subtypes. Younger infants were more likely to have severe RSV disease, while older infants, higher viral load, and RSV-A were associated with fever. RSV-A and RSV-B caused similar disease severity.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Eli Rhoads, Gregory S. Montgomery, Clement L. Ren
Summary: Wheezing is a common symptom in preterm children, whether or not they have a history of bronchopulmonary dysplasia. This article will review the mechanisms, epidemiology, and treatment of wheezing in preterm children with and without a history of bronchopulmonary dysplasia.
PEDIATRIC PULMONOLOGY
(2021)
Article
Allergy
Javier Mallol, Dirceu Sole, Carolina Aranda, Eliana C. Toledo, Viviana Aguirre, Marilyn Urrutia-Pereira, Gabriela A. Szulman, Nelson Rosario, Herberto Chong, Lillian Sanchez-Lacerda, Jurg Niederbacher, Catalina Pinchak, Patricia Polles de Olivera, Erika Arruda-Chavez, Luis Garcia-Marcos
Summary: The study showed that infants with recurrent asthma-like symptoms have a high rate of wheezing exacerbation admissions, which are significantly associated with severe wheezing episodes, physician-diagnosed asthma, and the use of inhaled corticosteroids. In terms of preventive measures for admissions, prolonging breastfeeding, avoiding smoking during pregnancy, and increasing household income may have a protective role.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2021)
Article
Dermatology
Geovanna V. Cardenas, Carolina Iturriaga, Caroll D. Hernandez, Macarena Tejos-Bravo, Guillermo Perez-Mateluna, Carolina Cabalin, Marcela Urzua, Luis F. Venegas-Salas, Juan P. Fraga, Boris Rebolledo, Maria C. Poli, Gabriela M. Repetto, Paola Casanello, Jose A. Castro-Rodriguez, Arturo Borzutzky
Summary: This study is the first to evaluate FLG loss-of-function variants R501X and 2282del4 in a Latin American population, revealing a similar prevalence of these FLG variant carriers to that of European populations. Among Chileans, FLG variants were significantly associated with asthma but not AD.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Allergy
Ramiro Gonzalez Vera, Alberto Vidal Grell, Alejandra Mendez Yarur, Constanza Olivares Meneses, Jose A. Castro-Rodriguez
Summary: The study found that reactance inversion and CX5 are common in asthmatic children, decrease with age, and correlate more closely than X5 with other IOS-spirometry parameters for evaluating small airway dysfunction (SAD).
Article
Pediatrics
Carlos E. Rodriguez-Martinez, Monica P. Sossa-Briceno, Jose A. Castro-Rodriguez
Summary: Cost-utility analysis in Colombia suggests that adding omalizumab to standard treatment for pediatric patients with uncontrolled severe allergic asthma is not a cost-effective strategy in this middle-income country. The study found that although omalizumab led to greater improvement in quality-adjusted life-years, it also involved significantly higher costs when compared to standard treatment.
PEDIATRIC PULMONOLOGY
(2021)
Article
Pediatrics
Laura Petrarca, Raffaella Nenna, Greta Di Mattia, Antonella Frassanito, Jose A. Castro-Rodriguez, Carlos E. Rodriguez Martinez, Enrica Mancino, Serena Arima, Carolina Scagnolari, Alessandra Pierangeli, Fabio Midulla
Summary: This study investigates the association between different clinical profiles extracted by latent class analysis (LCA) and the risk of wheezing among infants hospitalized with bronchiolitis. The results show that severe bronchiolitis has a higher risk of wheezing during the first 4 years after the illness, while infants with high eosinophils blood count have a higher risk after 7 years.
PEDIATRIC PULMONOLOGY
(2022)
Review
Allergy
Heidi Makrinioti, Kohei Hasegawa, John Lakoumentas, Paraskevi Xepapadaki, Maria Tsolia, Jose A. Castro-Rodriguez, Wojciech Feleszko, Tuomas Jartti, Sebastian L. Johnston, Andrew Bush, Vasiliki Papaevangelou, Carlos A. Camargo, Nikolaos G. Papadopoulos
Summary: This study compares the associations of RSV-induced bronchiolitis and RV-induced bronchiolitis with the development of preschool wheeze and childhood asthma through a meta-analysis. The results show that the RV-bronchiolitis group is more likely to develop recurrent wheeze and asthma. This study is clinically significant for understanding the relationship between viruses and asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Pediatrics
Santiago Ucros, Javier A. Castro-Guevara, Catherine M. Hill, Jose A. Castro-Rodriguez
Summary: This review examines sleep studies in healthy children living at high altitude. The results suggest that there is a lack of research on sleep physiology in children at high altitude, and the normal sleep parameters used at low altitude may not be applicable in high altitude settings.
FRONTIERS IN PEDIATRICS
(2022)
Review
Immunology
Dominika Ambrozej, Heidi Makrinioti, Abigail Whitehouse, Nikolas Papadopoulos, Marek Ruszczynski, Aleksander Adamiec, Jose A. Castro-Rodriguez, Khalid Alansari, Tuomas Jartti, Wojciech Feleszko
Summary: Severe bronchiolitis is a heterogeneous disease and requires personalized treatment. Molecular markers can guide more effective pharmacological management and prevent chronic respiratory sequelae.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Alberto Vidal Grell, Ramiro Gonzalez Vera, Alejandra Mendez Yarur, Jose A. Castro-Rodriguez, Maria Angelica Palomino Montenegro, Oscar Fielbaum Colodro, Selim Abara Elias, Monica Saavedra Bentjerodt, Jorge Mackenney Poblete
Summary: This study aimed to investigate the relationship between some impulse oscillometry (IOS) parameters during preschool age and spirometry alterations at school age. The results showed that R5, R20, Fres, AX, and D5-20 during preschool age were associated with abnormal spirometry at school age. These parameters could be useful for predicting abnormal spirometry in schoolchildren.
PEDIATRIC PULMONOLOGY
(2023)
Review
Pediatrics
Santiago Ucros, Camila Aparicio, Jose A. Castro-Rodriguez, Dunbar Ivy
Summary: This systematic review focuses on high altitude pulmonary edema (HAPE) occurring in children and adolescents. The study found that HAPE is most commonly seen in children between 6 and 10 years old, with a higher incidence in males and rare occurrence in children under 2 years old. HAPE can be classified into re-entry HAPE (R-HAPE) and classic HAPE (C-HAPE), with a higher prevalence of structural cardiac/pulmonary abnormalities in C-HAPE cases compared to R-HAPE cases.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Jose A. Castro-Rodriguez, Fiorella Biancardi, Oslando Padilla, Andrea A. Beckhaus, Ignacio E. Tapia
Summary: This study analyzed the effects of adenotonsillectomy (AT) on asthma/wheezing and found that AT decreased the risk of wheezing.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pharmacology & Pharmacy
Diego Garcia-Huidobro, Carolina Iturriaga, Guillermo Perez-Mateluna, Paula Fajuri, Nicolas Severino, Marcela Urzua, Juan Pablo Fraga, Javiera de la Cruz, Cecilia Poli, Jose A. Castro-Rodriguez, Eleanor Fish, Arturo Borzutzky
Summary: This study evaluated the safety, tolerability, bioavailability, and biological activity of inhaled interferon α-2b in healthy adults. The results showed that inhaled interferon α-2b at 2.5-MIU or 5-MIU doses did not cause significant physiological changes or new symptoms, and its tolerability and biological activity were confirmed.
CLINICAL DRUG INVESTIGATION
(2023)
Review
Medicine, General & Internal
Sergio de Jesus Romero-Tapia, Jose Raul Becerril-Negrete, Jose A. Castro-Rodriguez, Blanca E. Del-Rio-Navarro
Summary: The clinical manifestations of asthma in children are diverse and associated with different molecular and cellular mechanisms. Early identification of high-risk patients and prediction models are essential. This review summarizes predictive factors, including lung function, allergic comorbidity, and relevant data from patient's medical history. It also highlights epigenetic factors such as DNA methylation, microRNA expression, and histone modification.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
J. A. Castro-Rodriguez, O. Padilla, P. Casanello, E. Forno
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Pediatrics
Jose A. Castro-Rodriguez, Oslando Padilla, Paola Casanello, Erick Forno
Summary: Higher insulin-like growth factor-1 in cord blood is associated with asthma risk in the preschool years.
PEDIATRIC PULMONOLOGY
(2023)
Review
Respiratory System
Erick Forno, Diego D. Brandenburg, Jose A. Castro-Rodriguez, Carlos A. Celis-Preciado, Fernando Holguin, Christopher Licskai, Stephanie Lovinsky-Desir, Marcia Pizzichini, Alejandro Teper, Connie Yang, Juan C. Celedon
Summary: Asthma in the Americas has different prevalence, morbidity, and mortality rates across the region. There is a need for research and health policies to improve the prevention, diagnosis, and management of pediatric and adult asthma. Attention should be given to regional differences in resources and risk factors, including indoor pollutants, tobacco use, and psychosocial stress.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
