Article
Health Care Sciences & Services
Priyadarshini Kachroo, Joanne E. Sordillo, Sharon M. Lutz, Scott T. Weiss, Rachel S. Kelly, Michael J. McGeachie, Ann Chen Wu, Jessica A. Lasky-Su
Summary: Metabolomic profiles associated with asthma exacerbations during inhaled corticosteroid treatment were analyzed in this study, revealing potential biomarkers of treatment response variability. Sex differences were observed in the levels of fatty acid metabolites during exacerbations, while interactions between age and metabolites on exacerbation were also detected. These findings suggest that plasma metabolites may play a role in elucidating metabolic pathways underlying variability in asthma treatment responses.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Michiel A. G. E. Bannier, Sophie Kienhorst, Quirijn Jobsis, Kim D. G. van de Kant, Frederik-Jan Van Schooten, Agnieszka Smolinska, Edward Dompeling
Summary: Exhaled breath analysis has the potential to diagnose various respiratory and non-respiratory diseases. This study found that inhaled corticosteroids can influence the volatile organic compounds in the exhaled breath of wheezing preschool children. Furthermore, the exhaled volatile organic compounds can predict the response to corticosteroid treatment in these children.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Antonius Schneider, Benjamin Brunn, Alexander Hapfelmeier, Konrad Schultz, Christina Kellerer, Rudolf A. Jorres
Summary: This study validates the diagnostic accuracy of fractional exhaled nitric oxide (FeNO) for diagnosing asthma, and finds that higher FeNO values are associated with increased responsiveness to inhaled corticosteroids (ICS).
Article
Allergy
Fahad H. Alahmadi, Brian Keevil, Lynn Elsey, Kate George, Robert Niven, Stephen J. Fowler
Summary: LC-MS/MS can reliably detect commonly used ICSs in the blood at least 8 hours after dosing, providing a measure of adherence in severe asthma patients. Lower blood levels were associated with higher exacerbation rates and poorer lung function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Chemistry, Multidisciplinary
Elzbieta Dembowska, Aleksandra Jaron, Karolina Skoczek-Szlosser, Ewa Gabrysz-Trybek, Joanna Bladowska, Grzegorz Trybek
Summary: Asthma, a common allergic disease, affects both general health and oral health. This study observed the oral health status of 120 adult patients aged 18 to 71, finding significantly deeper pockets in the lateral segments of the dentition in all study groups, especially in the bronchial-only group. However, there was no significant worsening of periodontal status in asthma patients treated with inhalation, regardless of baseline periodontal status. The history of asthma and the use of inhaled corticosteroids (ICS) have an impact on patients' periodontal status.
APPLIED SCIENCES-BASEL
(2022)
Article
Pediatrics
Bing Wei, Yan-Hong Dang, Xiang-Ping Liu, Miao Li
Summary: This study aimed to investigate the differences in characteristics of Mycoplasma pneumoniae pneumonia (MPP) among children with and without asthma, as well as among children with asthma with and without inhaled corticosteroid (ICS) therapy. The study found that children with asthma had higher chances of wheezing compared to those without asthma. Furthermore, children with asthma who received ICS therapy had fewer and less severe exacerbations of MPP compared to those without ICS therapy. ICS therapy was identified as an independent protective factor against exacerbation.
FRONTIERS IN PEDIATRICS
(2022)
Article
Allergy
Javier Perez-Garcia, Mario Gonzalez-Carracedo, Antonio Espuela-Ortiz, Jose M. Hernandez-Perez, Ruperto Gonzalez-Perez, Olaia Sardon-Prado, Elena Martin-Gonzalez, Elena Mederos-Luis, Paloma Poza-Guedes, Paula Corcuera-Elosegui, Ariel Callero, Inmaculada Sanchez-Machin, Javier Korta-Murua, Jose A. Perez-Perez, Jesus Villar, Maria Pino-Yanes, Fabian Lorenzo-Diaz
Summary: This study investigated the association between the upper-airway microbiome and asthma exacerbations despite treatment with inhaled corticosteroids (ICS) in 250 asthma patients. The results showed that case subjects had lower bacterial diversity in nasal and saliva samples compared to control subjects. Additionally, the salivary microbiome was identified as a potential biomarker for asthma exacerbations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Pontus Mertsch, Jeremias Goetschke, Julia Walter, Carlo Muemmler, Alessandro Ghiani, Ulrike Schuermann, Rosemarie Kiefl, Rudolf Maria Huber, Juergen Behr, Nikolaus Kneidinger, Katrin Milger
Summary: The study analyzed the impact of high altitude environment on lung function in mild seasonal asthmatics, finding that using inhaled corticosteroid treatment can prevent the decrease in FEV1 caused by high altitude factors, while untreated asthmatics experience a reduction in FEV1 in such conditions.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Brandon W. Lewis, Maria L. Ford, Lynette K. Rogers, Rodney D. Britt
Summary: The paragraph discusses how oxidative stress contributes to corticosteroid insensitivity in patients with severe asthma and COPD, emphasizing the importance of optimizing endogenous antioxidant responses to enhance corticosteroid sensitivity. Future studies should explore how antioxidant-based therapies can complement corticosteroids to reduce the need for prolonged high dose regimens in these patients.
Article
Allergy
Scott P. Ginebaugh, Matthias Hagner, Anuradha Ray, Serpil C. Erzurum, Suzy A. A. Comhair, Loren C. Denlinger, Nizar N. Jarjour, Mario Castro, Prescott G. Woodruff, Stephanie A. Christenson, Eugene R. Bleecker, Deborah A. Meyers, Annette T. Hastie, Wendy C. Moore, David T. Mauger, Elliot Israel, Bruce D. Levy, Sally E. Wenzel, Matthew J. Camiolo
Summary: This study investigated the transcriptional response of bronchial epithelial cells to inhaled corticosteroids. It was found that a subset of asthma patients with poor hormone treatment response had worse lung function and quality of life. Furthermore, the response to hormone treatment could be predicted using blood samples.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Freda Yang, John Busby, Liam G. Heaney, Ian D. Pavord, Chris E. Brightling, Katie Borg, Jane P. McDowell, Sarah E. Diver, Rahul Shrimanker, Peter Bradding, Malcolm Shepherd, Rekha Chaudhuri
Summary: In patients with severe eosinophilic asthma (SEA) receiving treatment with mepolizumab, the use of oral cortico-steroids (OCS) did not significantly improve symptoms or quality of life. However, it did improve small-airway obstruction and reduce biomarkers of type 2 inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Respiratory System
Alberta L. Wang, Lies Lahousse, Amber Dahlin, Ahmed Edris, Michael McGeachie, Sharon M. Lutz, Joanne E. Sordillo, Guy Brusselle, Jessica Lasky-Su, Scott T. Weiss, Carlos Iribarren, Meng X. Lu, Kelan G. Tantisira, Ann C. Wu
Summary: This study identified multiple novel SNPs associated with ICS response in older adult asthmatics. Some of these SNPs were annotated to genes previously associated with asthma and other airway or allergic diseases, such as PTCHD4.
Article
Health Care Sciences & Services
Natalia Hernandez-Pacheco, Mario Gorenjak, Jiang Li, Katja Repnik, Susanne J. Vijverberg, Vojko Berce, Andrea Jorgensen, Leila Karimi, Maximilian Schieck, Lesly-Anne Samedy-Bates, Roger Tavendale, Jesus Villar, Somnath Mukhopadhyay, Munir Pirmohamed, Katia M. C. Verhamme, Michael Kabesch, Daniel B. Hawcutt, Steve Turner, Colin N. Palmer, Kelan G. Tantisira, Esteban G. Burchard, Anke H. Maitland-van der Zee, Carlos Flores, Uros Potocnik, Maria Pino-Yanes
Summary: This study aimed to identify novel genetic markers involved in ICS response in asthma through a GWAS, and found suggestive association of the SNP rs1166980 in the ROBO2 gene with the change in lung function. It also validated the association of PDE10A-T with ICS response as described in a previous study. These results suggest that ROBO2 could be a potential novel locus for ICS response in Europeans.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Allergy
Joe G. Zein, Ronald Strauss, Amy H. Attaway, Bo Hu, Alex Milinovich, Nesreen Jawhari, Soulaima S. Chamat, Victor E. Ortega
Summary: This study investigates the associations between preexisting blood eosinophil counts, inhaled corticosteroids (ICS), and COVID-19 outcomes. The results suggest that preexisting eosinophilia and ICS treatment are associated with reduced hospitalization, admission to the intensive care unit (ICU), and mortality among patients with COVID-19.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Pharmacology & Pharmacy
Su-Boon Yong, Shuo-Yan Gau, Chia-Jung Li, Chih-Wei Tseng, Shiow-Ing Wang, James Cheng-Chung Wei
Summary: Asthmatic patients using inhaled corticosteroid (ICS) have a higher risk of COVID-19 but a significantly lower risk of hospitalization, emergency department visits, and mortality.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Melissa L. Spear, Donglei Hu, Maria Pino-Yanes, Scott Huntsman, Celeste Eng, Albert M. Levin, Victor E. Ortega, Marquitta J. White, Meghan E. McGarry, Neeta Thakur, Joshua Galanter, Angel C. Y. Mak, Sam S. Oh, Elizabeth Ampleford, Stephen P. Peters, Adam Davis, Rajesh Kumar, Harold J. Farber, Kelley Meade, Pedro C. Avila, Denise Serebrisky, Michael A. Lenoir, Emerita Brigino-Buenaventura, William Rodriguez Cintron, Shannon M. Thyne, Jose R. Rodriguez-Santana, Jean G. Ford, Rocio Chapela, Andres Moreno Estrada, Karla Sandoval, Max A. Seibold, Cheryl A. Winkler, Eugene R. Bleecker, Deborah A. Myers, L. Keoki Williams, Ryan D. Hernandez, Dara G. Torgerson, Esteban G. Burchard
PHARMACOGENOMICS JOURNAL
(2019)
Article
Allergy
Theresa W. Guilbert, Leonard B. Bacharier, David T. Mauger, Wanda Phipatanakul, Stanley J. Szefler, Susan Boehmer, Avraham Beigelman, Anne M. Fitzpatrick, Daniel J. Jackson, Sachin N. Baxi, Mindy Benson, Carey-Ann D. Burnham, Michael D. Cabana, Mario Castro, James F. Chmiel, Ronina Covar, Michael Daines, Jonathan M. Gaffin, Deborah A. Gentile, Fernando Holguin, Elliot Israel, H. William Kelly, Stephen C. Lazarus, Robert F. Lemanske, Ngoc Ly, Kelley Meade, Wayne Morgan, James Moy, J. Tod Olin, Stephen P. Peters, Jacqueline A. Pongracic, Hengameh H. Raissy, Kristie Ross, William J. Sheehan, Christine Sorkness, W. Gerald Teague, Shannon Thyne, Fernando D. Martinez
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Medicine, General & Internal
George R. Washko, Laura A. Colangelo, Raul San Jose Estepar, Samuel Y. Ash, Surya P. Bhatt, Yuka Okajima, Kiang Liu, David R. Jacobs, Carlos Iribarren, Bharat Thyagarajan, Cora E. Lewis, Rajesh Kumar, MeiLan K. Han, Mark T. Dransfield, Mercedes R. Carnethon, Ravi Kalhan
AMERICAN JOURNAL OF MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Lesly-Anne Samedy-Bates, Sam S. Oh, Thomas J. Nuckton, Jennifer R. Elhawary, Marquitta White, Tyronda Elliot, Andy M. Zeiger, Celeste Eng, Sandra Salazar, Michael A. LeNoir, Kelley Meade, Harold J. Farber, Denise Serebrisky, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Kirsten Bibbins-Domingo, Rajesh Ktunar, Shannon Thyne, Luisa N. Borre, Jose R. Rodriguez-Santana, Maria Pino-Yanes, Esteban G. Burchard
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2019)
Editorial Material
Allergy
Rajesh Kumar, Max A. Seibold, Esteban G. Burchard
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Correction
Multidisciplinary Sciences
Michelle Daya, Nicholas Rafaels, Tonya M. Brunetti, Sameer Chavan, Albert M. Levin, Aniket Shetty, Christopher R. Gignoux, Meher Preethi Boorgula, Genevieve Wojcik, Monica Campbell, Candelaria Vergara, Dara G. Torgerson, Victor E. Ortega, Ayo Doumatey, Henry Richard Johnston, Nathalie Acevedo, Maria Ilma Araujo, Pedro C. Avila, Gillian Belbin, Eugene Bleecker, Carlos Bustamante, Luis Caraballo, Alvaro Cruz, Georgia M. Dunston, Celeste Eng, Mezbah U. Faruque, Trevor S. Ferguson, Camila Figueiredo, Jean G. Ford, Weiniu Gan, Pierre-Antoine Gourraud, Nadia N. Hansel, Ryan D. Hernandez, Edwin Francisco Herrera-Paz, Silvia Jimenez, Eimear E. Kenny, Jennifer Knight-Madden, Rajesh Kumar, Leslie A. Lange, Ethan M. Lange, Antoine Lizee, Pissamai Maul, Trevor Maul, Alvaro Mayorga, Deborah Meyers, Dan L. Nicolae, Timothy D. O'Connor, Ricardo Riccio Oliveira, Christopher O. Olopade, Olufunmilayo Olopade, Zhaohui S. Qin, Charles Rotimi, Nicolas Vince, Harold Watson, Rainford J. Wilks, James G. Wilson, Steven Salzberg, Carole Ober, Esteban G. Burchard, L. Keoki Williams, Terri H. Beaty, Margaret A. Taub, Ingo Ruczinski, Rasika A. Mathias, Kathleen C. Barnes, Ayola Akim Adegnika, Ganiyu Arinola, Ulysse Ateba-Ngoa, Gerardo Ayestas, Hrafnhildur Bjarnadottir, Adolfo Correa, Said Omar Leiva Erazo, Marilyn G. Foreman, Cassandra Foster, Li Gao, Jingjing Gao, Leslie Grammer, Mark Hansen, Tina Hartert, Yijuan Hu, Iain Konigsberg, Kwang-Youn A. Kim, Pamela Landaverde-Torres, Javier Marrugo, Beatriz Martinez, Rosella Martinez, Luis F. Mayorga, Delmy-Aracely Mejia-Mejia, Catherine Meza, Solomon Musani, Shaila Musharoff, Oluwafemi Oluwole, Maria Pino-Yanes, Hector Ramos, Allan Saenz, Maureen Samms-Vaughan, Robert Schleimer, Alan F. Scott, Suyash S. Shringarpure, Wei Song, Zachary A. Szpiech, Raul Torres, Gloria Varela, Olga Marina Vasquez, Francisco M. De La Vega, Lorraine B. Ware, Maria Yazdanbakhsh
NATURE COMMUNICATIONS
(2019)
Article
Microbiology
Jeremy J. Lim, Anna C. Nilsson, Michael Silverman, Nimer Assy, Priya Kulkarni, Jacqueline M. McBride, Rong Deng, Chloe Li, Xiaoying Yang, Allen Nguyen, Priscilla Horn, Mauricio Maia, Aide Castro, Melicent C. Peck, Joshua Galanter, Tom Chu, Elizabeth M. Newton, Jorge A. Tavel
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Genetics & Heredity
Angel C. Y. Mak, Satria Sajuthi, Jaehyun Joo, Shujie Xiao, Patrick M. Sleiman, Marquitta J. White, Eunice Y. Lee, Benjamin Saef, Donglei Hu, Hongsheng Gui, Kevin L. Keys, Fred Lurmann, Deepti Jain, Goncalo Abecasis, Hyun Min Kang, Deborah A. Nickerson, Soren Germer, Michael C. Zody, Lara Winterkorn, Catherine Reeves, Scott Huntsman, Celeste Eng, Sandra Salazar, Sam S. Oh, Frank D. Gilliland, Zhanghua Chen, Rajesh Kumar, Fernando D. Martinez, Ann Chen Wu, Elad Ziv, Hakon Hakonarson, Blanca E. Himes, L. Keoki Williams, Max A. Seibold, Esteban G. Burchard
Article
Allergy
Rajesh Kumar, Ryan P. Ferrie, Lauren C. Balmert, Matthew Kienzl, Sheryl L. Rifas-Shiman, Diane R. Gold, Joanne E. Sordillo, Ken Kleinman, Carlos A. Camargo, Augusto A. Litonjua, Emily Oken, Joan M. Cook-Mills
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Eric M. Wohlford, Luisa N. Borrell, Jennifer R. Elhawary, Brian Plotkin, Sam S. Oh, Thomas J. Nuckton, Celeste Eng, Sandra Salazar, Michael A. LeNoir, Kelley Meade, Harold J. Farber, Denise Serebrisky, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Rajesh Kumar, Shannon Thyne, Max A. Seibold, Jose R. Rodriguez-Santana, Esteban G. Burchard
Article
Rheumatology
Daniel Keebler, Edmond Teng, Jenny Chia, Joshua Galanter, Jodie Peake, Katie Tuckwell
Article
Critical Care Medicine
Hongsheng Gui, Albert M. Levin, Donglei Hu, Patrick Sleiman, Shujie Xiao, Angel C. Y. Mak, Mao Yang, Andrea J. Barczak, Scott Huntsman, Celeste Eng, Samantha Hochstadt, Ellen Zhang, Kyle Whitehouse, Samantha Simons, Whitney Cabral, Sami Takriti, Goncalo Abecasis, Thomas W. Blackwell, Hyun Min Kang, Deborah A. Nickerson, Soren Germer, David E. Lanfear, Frank Gilliland, W. James Gauderman, Rajesh Kumar, David J. Erle, Fernando D. Martinez, Hakon Hakonarson, Esteban G. Burchard, L. Keoki Williams
Summary: This study identified a functional variant at the 17q12-21.1 locus associated with early-onset asthma in African American individuals. The lead signal, rs11078928, was found to be the top association for early-onset asthma after meta-analysis across cohorts. Additionally, a haplotype analysis suggested that the asthma association most closely with this variant.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Anastasia Ivanova, Elliot Israel, Lisa M. LaVange, Michael C. Peters, Loren C. Denlinger, Wendy C. Moore, Leonard B. Bacharier, M. Alison Marquis, Nathan M. Gotman, Michael R. Kosorok, Chalmer Tomlinson, David T. Mauger, Steve N. Georas, Rosalind J. Wright, Patricia Noel, Gary L. Rosner, Praveen Akuthota, Dean Billheimer, Eugene R. Bleecker, Juan Carlos Cardet, Mario Castro, Emily A. DiMango, Serpil C. Erzurum, John V. Fahy, Merritt L. Fajt, Benjamin M. Gaston, Fernando Holguin, Sonia Jain, Nicholas J. Kenyon, Jerry A. Krishnan, Monica Kraft, Rajesh Kumar, Mark C. Liu, Ngoc P. Ly, James N. Moy, Wanda Phipatanakul, Kristie Ross, Lewis J. Smith, Stanley J. Szefler, W. Gerald Teague, Michael E. Wechsler, Sally E. Wenzel, Steven R. White
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2020)
Article
Multidisciplinary Sciences
Satria P. Sajuthi, Peter DeFord, Yingchun Li, Nathan D. Jackson, Michael T. Montgomery, Jamie L. Everman, Cydney L. Rios, Elmar Pruesse, James D. Nolin, Elizabeth G. Plender, Michael E. Wechsler, Angel C. Y. Mak, Celeste Eng, Sandra Salazar, Vivian Medina, Eric M. Wohlford, Scott Huntsman, Deborah A. Nickerson, Soren Germer, Michael C. Zody, Goncalo Abecasis, Hyun Min Kang, Kenneth M. Rice, Rajesh Kumar, Sam Oh, Jose Rodriguez-Santana, Esteban G. Burchard, Max A. Seibold
NATURE COMMUNICATIONS
(2020)
Meeting Abstract
Allergy
Ryan Owen, Joshua Galanter, Rui Zhu, Fang Cai, Jennifer Tom, Chris Wynne, Matthew Durk, Liuxi Chen, Jane Kenny, Gao-hong She, Shweta Vadhavkar, Olivia Hwang, Hubert Chen
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)