Article
Chemistry, Multidisciplinary
Suke Lan, Jiahao Zhang, Xin Li, Lejie Pan, Juncheng Li, Xian Wu, Sheng-Tao Yang
Summary: The study found that oral exposure to MOF-74(Co) NPs can lead to significant accumulation of Co in the liver and kidneys, but overall has low toxicity to mice. Cell viability is lost at 100 mg/L, while cell cycle arrest can occur even at 12.5 mg/L. Apart from slight inflammation, the histopathological images of the liver and kidneys after oral exposure to MOF-74(Co) NPs were normal compared to the control group.
Article
Environmental Sciences
Naresh K. Nirmal, Kumud K. Awasthi, Placheril J. John
Summary: The study found that graphene oxide (GO) has dose-dependent toxicity to the liver of male Wistar rats, with significantly elevated levels of liver enzymes and intermediary metabolites in high-dose treated animals, along with distinct histopathological changes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Tara Lyons-Darden, Jason L. L. Blum, Mark W. W. Schooley, Melissa Ellis, Jennifer Durando, Daniel Merrill, Adriana R. Oller
Summary: The acute toxicity of nickel oxide nanoparticles (NiO NPs) was evaluated in rats through oral and inhalation exposure. The LD50 for oral exposure and LC50 for inhalation exposure were determined to be >5000 mg/kg and >5.42 mg/L, respectively. These results suggest that NiO NPs do not exhibit serious acute toxicity and do not warrant an acute toxicity classification.
Article
Environmental Sciences
Zhuang Wang, Fan Zhang, Martina G. Vijver, Willie J. G. M. Peijnenburg
Summary: The study revealed enhanced cytotoxicity of a mixture of graphene-based carbon nanomaterials and nano-zirconium oxide to freshwater algae, attributed to intracellular oxidative stress and cellular membrane changes. Mitochondria-generated ROS played a significant role in the cellular response, indicating oxidative damage to algal cells. Additionally, reduced graphene oxide showed higher cytotoxicity and oxidative stress compared to graphene nanoplatelets.
Article
Environmental Sciences
Xiaolin Zhu, Liju Tan, Ting Zhao, Wenqiu Huang, Xin Guo, Jiayin Wang, Jiangtao Wang
Summary: The toxic effects of nano-ZnO and GQDs on dinoflagellate Gymnodinium were investigated. Nano-ZnO had slight effects on algal cell growth, while the growth inhibition of Gymnodinium increased with increasing GQDs concentration. Both nanoparticles induced accumulation of reactive oxygen species and activated intracellular antioxidant defense system. The combined exposure of nano-ZnO and GQDs showed decreased inhibitory effects compared to GQDs alone.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Materials Science, Biomaterials
Ilyas Ozcicek, Nese Aysit, Cagri Cakici, Asel Aydeger
Summary: Gold nanoparticles functionalized with PEI and PEG were synthesized and investigated for their neuronal toxicological effects and biodistribution in cells and suborgans; Surface coating with PEI and PEG enhanced both biocompatibility and biodistribution of the AuNPs; The study showed the presence of gold in various organs and tissues within a 30-day period.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Takuya Miyazaki, Shaoyi Chen, Stelios Florinas, Kazunori Igarashi, Yu Matsumoto, Tatsuya Yamasoba, Ze-Qi Xu, Herren Wu, Changshou Gao, Kazunori Kataoka, R. James Christie, Horacio Cabral
Summary: This study presents a Hoechst-based reporter system that can monitor the release and engagement of drugs from nanoparticle delivery systems. The system allows the visualization of drug distribution and binding to subcellular targets, providing insights into the effects of drug-linker and nanoparticle properties on target-bound drug distribution. The findings from this study were applied to develop highly potent, targeted anticancer nanoparticles with optimized drug-linker design, resulting in effective tumor growth inhibition without severe toxicity.
Article
Cell Biology
Johanna Simon, Gabor Kuhn, Michael Fichter, Stephan Gehring, Katharina Landfester, Volker Mailaender
Summary: The study highlights the different interactions between nanoparticles and blood proteins under in vivo and in vitro conditions, emphasizing the importance of in vivo protein corona studies. Additionally, the protein composition of the in vivo corona remains relatively stable over time. To mimic the in vivo scenario, an ex vivo approach using fresh whole blood from an animal was established.
Article
Pharmacology & Pharmacy
Sabrina Roussel, Philippe Grenier, Valerie Chenard, Nicolas Bertrand
Summary: Fluorescent labelling is commonly used to monitor the biodistribution of nanomedicines, but the stability of the labelling is crucial for meaningful interpretation of the results. This study investigates the stability of three fluorophores attached to polymeric hydrophobic biodegradable anchors. Results suggest that the more hydrophilic dye is released faster from the nanoparticles, leading to misinterpretation of in vivo data. These findings highlight the importance of stable labelling methods when studying the biological fate of nanomedicines.
Review
Engineering, Biomedical
Tao Huang, Xin Li, Michael Maier, Neil M. O'Brien-Simpson, Daniel E. Heath, Andrea J. O'Connor
Summary: Fungal infections pose a serious threat to human health and the limited number of clinically approved antifungal drugs, as well as the emergence of drug resistance, increase the impact of fungal infections. However, fungal infections receive less attention compared to bacterial infections.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Cassandra E. Callmann, Matthew K. Vasher, Anindita Das, Caroline D. Kusmierz, Chad A. Mirkin
Summary: The biological properties of spherical nucleic acids (SNAs) are primarily determined by the oligonucleotide surface density, rather than the nanoparticle core identity. Furthermore, the payload-to-carrier mass ratio of SNAs is inversely proportional to the core size. Ultrasmall nanoparticle constructs (<10 nm diameter) exhibit unique properties, including increased payload-to-carrier ratios, reduced liver accumulation, renal clearance, and enhanced tumor infiltration.
Article
Chemistry, Multidisciplinary
Nikolai Shirokii, Yevgeniya Din, Ilya Petrov, Yurii Seregin, Sofia Sirotenko, Julia Razlivina, Nikita Serov, Vladimir Vinogradov
Summary: Organic chemistry has made significant progress with the help of machine learning. However, applying artificial intelligence to materials science, particularly in predicting biological behavior, is challenging. Nanotoxicity is an important parameter in bio-related research, and pre-evaluating such properties can save time and resources. Existing machine learning models can predict whether a nanomaterial is toxic, but they often overlook the concentration dependence that experimental scientists care about. In this study, a machine learning-based approach is proposed to quantitatively predict the cytotoxicity of inorganic nanomaterials, achieving high precision and allowing for extrapolation on unseen samples. Feature importance analysis was conducted to find an interpretable model with optimal decision-making. These findings enable experimental scientists to perform initial candidate screening and reduce the need for excessive and labor-intensive experiments, thus facilitating the rapid development of nanomaterials for medicinal purposes.
Article
Pharmacology & Pharmacy
Eloy Pena-Rodriguez, Teresa Garcia-Berrocoso, Ezequiel Vazquez Fernandez, Francisco J. Otero-Espinar, Joaquin Abian, Francisco Fenandez-Campos
Summary: Confocal Raman microscopy and MALDI-TOF mass spectrometry imaging are two promising techniques for ex vivo skin imaging and quantification. The biodistribution of dexamethasone (DEX) loaded lipomers in the skin was compared using both techniques, with benzalkonium chloride (BAK) as a tracer. Confocal Raman microscopy showed higher DEX measurements, while MALDI-TOF MSI was more suitable for tracing BAK. Confocal Raman microscopy provided higher spatial resolution and observed specific skin structures, while MALDI-TOF MSI had a faster sampling rate and analyzed larger tissue areas.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Yadileiny Portilla, Yilian Fernandez-Afonso, Sonia Perez-Yague, Vladimir Mulens-Arias, M. Puerto Morales, Lucia Gutierrez, Domingo F. Barber
Summary: This study analyzed the biodistribution, organ accumulation and degradation of different coatings of iron oxide magnetic nanoparticles (MNPs) in vivo. The results showed that the coating influenced the proportion of MNPs in different organs, with faster degradation in the liver regardless of the coating. This information is important for choosing the optimal coating for specific biomedical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kuo Li, Dan Li, Cheng-Hsuan Li, Pengfei Zhuang, Chunmei Dai, Xiangka Hu, Dahao Wang, Yuanye Liu, Xifan Mei, Vincent M. Rotello
Summary: Studies have shown that ultra-small noble metal nanoclusters have comprehensive therapeutic effects for wound healing, promoting cell proliferation and migration while decreasing inflammation.
Article
Biochemistry & Molecular Biology
Saeed Ali Alsareii, Javed Ahmad, Ahmad Umar, Mohammad Zaki Ahmad, Ibrahim Ahmed Shaikh
Summary: Researchers are currently focused on exploring natural or herbal bioactive compounds for therapeutic intervention. This study investigated the wound healing potential of a piperine hydrogel formulation, which showed promising results in improving wound healing.
Article
Dermatology
Md. Shoaib Alam, Arif Ansari, Iftikhar Ahsan, Sheikh Shafiq-un-Nabi, Shadab Md, Rasheed A. A. Shaik, Basma G. G. Eid, Mohammad Zaki Ahmad, Javed Ahmad
Summary: This study investigates the beneficial effect of a silicone gel composition infused with hyaluronic acid and/or salts with polysiloxane derivatives on skin scar formation. The results show that this combination improves anti-scar activity compared to polysiloxanes alone.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Review
Engineering, Biomedical
Mohammad Zaki Ahmad, Abdul Aleem Mohammed, Mohammed. S. S. Algahtani, Awanish Mishra, Javed Ahmad
Summary: Psoriasis is a common skin condition that has a long history and was once mistaken for leprosy. It is an autoimmune disorder triggered by T-cell and/or B-cell activation. The pathophysiology of psoriasis is not fully understood, and research investigations are still ongoing. Nanoscale drug delivery systems show promising potential for improving the therapeutic efficacy of conventional anti-psoriatic drugs. This article discusses the pathophysiology, conventional pharmacotherapy, and current research in the area of nanoscale topical drug delivery systems for the management of psoriasis, including the significance of targeted pharmacotherapy.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Agronomy
M. M. Abdullah, Amir Khan, Hasan B. Albargi, Mohammad Zaki Ahmad, Javed Ahmad, Faheem Ahmad, Mohammad Shabib Akhtar, Nehal Mohsin, Fuzail Ahmad, Mohammad Azhar Kamal, Yaser E. Alqurashi, Hira Lal, Jari S. Algethami
Summary: This study evaluated the nematicidal effect of a plant extract on root-knot nematodes in carrots. Various concentrations of the extract showed mortality and inhibition of egg hatching in the nematodes, while promoting carrot growth and reducing nematode populations. Molecular docking analysis confirmed the interaction between the extract's compounds and a targeted protein in the nematodes, suggesting potential for the use of plant extracts as an alternative to chemical nematicides.
ACTA AGRICULTURAE SCANDINAVICA SECTION B-SOIL AND PLANT SCIENCE
(2023)
Article
Engineering, Multidisciplinary
Jawed Mustafa, M. M. Abdullah, Mohammad Zaki Ahmad, Basharat Jamil, Mohsen Sharifpur
Summary: This article presents a numerical study on entropy generation (ETG) of alumina/water nanofluid (NFD) flow in an aluminum heatsink (HSK). The results show that frictional ETG is larger than thermal ETG, and as a result, the effect of frictional ETG on total ETG is greater.
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
(2023)
Article
Engineering, Multidisciplinary
M. M. Abdullah, Hassan B. Albargi, Jawed Mustafa, Mohammad Zaki Ahmad, Mohammed Jalalah, Mohsen Sharifpur
Summary: This paper numerically studies the flow of a two-phase nanofluid in a circular heatsink for cooling LEDs. By varying the diameter of the circle, the side length of the heat sources, and the input velocity of the nanofluid, the values of thermal resistance, temperature uniformity, heat transfer coefficient, and pressure drop in the heatsink can be estimated. The study shows that the heat source placed in the middle has a lower temperature and the results are most influenced by the nanofluid velocity.
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
(2023)
Article
Engineering, Multidisciplinary
Jawed Mustafa, M. M. Abdullah, Mohammad Zaki Ahmad, Shahid Husain, Mohsen Sharifpur
Summary: This article presents a simulation of the turbulent flow of alumina/water nanofluid in a heatsink using the finite element method. The study focuses on the cooling of LEDs using a circular heatsink, with multiple LEDs placed under the heatsink. By varying the distance between the LEDs, the connection part dimensions, and the inlet velocity of the nanofluid, the heatsink temperature and the outlet temperature of the nanofluid are determined. The results show that changing the nanofluid velocity has the greatest impact on the heatsink's average temperature.
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
(2023)
Article
Polymer Science
Mohammad Zaki Ahmad, Kalyani Pathak, Ratna Jyoti Das, Riya Saikia, Himangshu Sarma, Neelutpal Gogoi, Urvashee Gogoi, Aparoop Das, Ali S. Alasiri, Basel A. Abdel-Wahab, M. M. Abdullah
Summary: This study aimed to design and develop a nanoformulation using isolated quercetin from Annona reticulata Linn leaves to improve therapeutic index, solubility, bioavailability, toxicity mitigation, pharmacological activity, and prevention of degradation of antidiabetic compounds. Quercetin has hypoglycemic effects but its poor solubility and low bioavailability limit its use. The polymeric nanoformulation of quercetin was found to enhance its antidiabetic activity. The optimized formulation demonstrated significant antidiabetic effects, making it an effective oral medicine for diabetes management. Rating: 9 out of 10.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
M. M. Abdullah, Rashid Nizam, Hasan B. Albargi, Mohammad Zaki Ahmad, Javed Ahmad, Mohd. Farhan Khan, Jawed Mustafa
Summary: This study investigates the behavior of two graphene models under different temperatures. The results show that the graphene exhibits significant changes in potential and energy with increasing temperature. The phonon spectral densities of both models also demonstrate leftward shifts and decreasing strengths with temperature increase.
JOURNAL OF NANOELECTRONICS AND OPTOELECTRONICS
(2023)
Review
Endocrinology & Metabolism
Mohammad Ahmed Khan, Nafis Haider, Tanveer Singh, Ritam Bandopadhyay, Mohammed M. Ghoneim, Sultan Alshehri, Murtada Taha, Javed Ahmad, Awanish Mishra
Summary: Parkinson's disease (PD) is a progressive neurological disease that affects approximately 10 million people worldwide. The manifestation of motor symptoms in PD patients occurs later, after the degeneration of most dopaminergic neurons. Therefore, the development of accurate biomarkers for early prognosis of PD is crucial for better management. This manuscript discusses potential biomarkers from various aspects, including biochemical, microRNA, and neuroimaging, for diagnosis, recent developments in PD management, and limitations of current anti-Parkinson therapy.
METABOLIC BRAIN DISEASE
(2023)
Review
Pharmacology & Pharmacy
Javed Ahmad, Anuj Garg, Gulam Mustafa, Abdul Aleem Mohammed, Mohammad Zaki Ahmad
Summary: 3D printing technology in medicine is gaining attention for its ability to fabricate various types of dosage forms. Nanomedicine-based solid dosage forms utilizing 3D printing technology have overcome challenges and allowed for personalized medicine. Extrusion-based 3D printing techniques have been used to produce tablets and suppositories for oral and rectal administration. The impact of process parameters on the performance of 3D-printed solid dosage forms is critically analyzed.
Review
Pharmacology & Pharmacy
Hassan A. Albarqi, Anuj Garg, Mohammad Zaki Ahmad, Abdulsalam A. Alqahtani, Ismail A. Walbi, Javed Ahmad
Summary: Glaucoma is a chronic degenerative eye disease that leads to irreversible vision loss due to high intraocular pressure. Traditional ocular drug delivery systems have low bioavailability, making glaucoma therapy challenging. Chitosan-based nanoparticulate systems have shown promise in overcoming these limitations. This manuscript reviews recent research on chitosan-based nanoparticulate systems for glaucoma treatment, discussing their significance in improving drug residence time and ocular bioavailability. It also analyzes the impact of chitosan-based nanomedicine on corneal permeability, ocular bioavailability, and therapeutic performance of loaded antiglaucoma agents.
Review
Computer Science, Information Systems
Javed Ahmad, Anuj Garg, Gulam Mustafa, Mohammad Zaki Ahmad, Mohammed Aslam, Awanish Mishra
Summary: Cancer remains a leading cause of death worldwide, and multidrug resistance is a major challenge in cancer treatment. Nanoparticulate systems offer promising approaches for accurate diagnosis and effective therapy, including theranostic strategies and targeted drug delivery using carbon-based and graphene-based quantum dots. This review highlights the use of hybrid quantum dots as a theranostic system in different cancers and discusses the role of biomolecule conjugation in enhancing their biopharmaceutical attributes and therapeutic outcomes in cancer.
Review
Endocrinology & Metabolism
Kalyani Pathak, Riya Saikia, Himangshu Sarma, Manash Pratim Pathak, Ratna Jyoti Das, Urvashee Gogoi, Mohammad Zaki Ahmad, Aparoop Das, Basel A. Abdel Wahab
Summary: The objective of this study is to discuss the use of nanomaterials like nanosensors for diagnosing Diabetes and highlight their applications in the treatment of Diabetes.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2023)
