Biological reactivity of zinc oxide nanoparticles with mammalian test systems: an overview

Investigating the immunomodulatory nature of zinc oxide nanoparticles at sub-cytotoxic levels in vitro and after intranasal instillation in vivo

(2015) Shruti R Saptarshi et al.   JOURNAL OF NANOBIOTECHNOLOGY

Transcriptional and posttranscriptional regulation and endocytosis were involved in zinc oxide nanoparticle-induced interleukin-8 overexpression in human bronchial epithelial cells

(2014) Zhen Yan et al.   CELL BIOLOGY AND TOXICOLOGY

Toll-like receptor 6 mediated inflammatory and functional responses of zinc oxide nanoparticles primed macrophages

(2014) Ruchi Roy et al.   IMMUNOLOGY

Size-Dependent Effect of Zinc Oxide on Toxicity and Inflammatory Potential of Human Monocytes

(2014) Devashri Sahu et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Lack of genotoxic potential of ZnO nanoparticles in in vitro and in vivo tests

(2014) Jee Young Kwon et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Potential impact of metal oxide nanoparticles on the immune system: The role of integrins, L-selectin and the chemokine receptor CXCR4

(2014) Tamara Lozano-Fernández et al.   Nanomedicine-Nanotechnology Biology and Medicine

Reducing ZnO nanoparticle cytotoxicity by surface modification

(2014) Mingdeng Luo et al.   Nanoscale

Toxicology of ZnO and TiO2nanoparticles on hepatocytes: Impact on metabolism and bioenergetics

(2014) Celine Filippi et al.   Nanotoxicology

Particulate nature of inhaled zinc oxide nanoparticles determines systemic effects and mechanisms of pulmonary inflammation in mice

(2014) Jen-Kun Chen et al.   Nanotoxicology

Tracking translocation of industrially relevant engineered nanomaterials (ENMs) across alveolar epithelial monolayersin vitro

(2014) Joel M. Cohen et al.   Nanotoxicology

Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models

(2014) Andrea Adamcakova-Dodd et al.   Particle and Fibre Toxicology

Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles

(2014) Nagarjun V Konduru et al.   Particle and Fibre Toxicology

Comparison of UVA-induced ROS and sunscreen nanoparticle-generated ROS in human immune cells

(2014) Cenchao Shen et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Changes in protein expression in rat bronchoalveolar lavage fluid after exposure to zinc oxide nanoparticles: an iTRAQ proteomic approach

(2014) Yu-Min Juang et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Zinc oxide nanoparticles delay human neutrophil apoptosis by a de novo protein synthesis-dependent and reactive oxygen species-independent mechanism

(2014) David M. Goncalves et al.   TOXICOLOGY IN VITRO

ZnO nanoparticle-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes

(2014) Jieting Wang et al.   Nanoscale Research Letters

Quantification of ZnO Nanoparticle Uptake, Distribution, and Dissolution within Individual Human Macrophages

(2013) Simon A. James et al.   ACS Nano

Effects of sub-acute exposure to TiO2, ZnO and Al2O3nanoparticles on oxidative stress and histological changes in mouse liver and brain

(2013) Rupal Shrivastava et al.   DRUG AND CHEMICAL TOXICOLOGY

Involvement of MyD88 in zinc oxide nanoparticle-induced lung inflammation

(2013) Han Chang et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Zinc oxide nanoparticles provide an adjuvant effect to ovalbumin via a Th2 response in Balb/c mice

(2013) Ruchi Roy et al.   INTERNATIONAL IMMUNOLOGY

ZnO nanoparticles induce TNF-α expression via ROS-ERK-Egr-1 pathway in human keratinocytes

(2013) Sang Hoon Jeong et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Zinc oxide nanoparticles: Genotoxicity, interactions with UV-light and cell-transforming potential

(2013) Eşref Demir et al.   JOURNAL OF HAZARDOUS MATERIALS

Effects of serum on cytotoxicity of nano- and micro-sized ZnO particles

(2013) I-Lun Hsiao et al.   JOURNAL OF NANOPARTICLE RESEARCH

The Effect of the Binding of ZnO Nanoparticle on the Structure and Stability of α-Lactalbumin: A Comparative Study

(2013) Soumyananda Chakraborti et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Exposure to zinc oxide nanoparticles affects reproductive development and biodistribution in offspring rats

(2013) Eunhye Jo et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Challenge to assess the toxic contribution of metal cation released from nanomaterials for nanotoxicology – the case of ZnO nanoparticles

(2013) Mingsheng Xu et al.   Nanoscale

Intracellular accumulation dynamics and fate of zinc ions in alveolar epithelial cells exposed to airborne ZnO nanoparticles at the air–liquid interface

(2013) Cosmin Mihai et al.   Nanotoxicology

Cardiopulmonary toxicity of pulmonary exposure to occupationally relevant zinc oxide nanoparticles

(2013) Hsiao-Chi Chuang et al.   Nanotoxicology

Surface coatings of ZnO nanoparticles mitigate differentially a host of transcriptional, protein and signalling responses in primary human olfactory cells

(2013) Megan J Osmond-McLeod et al.   Particle and Fibre Toxicology

Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration

(2013) Wan-Seob Cho et al.   Particle and Fibre Toxicology

Zinc Oxide Nanoparticles Induce Necrosis and Apoptosis in Macrophages in a p47phox- and Nrf2-Independent Manner

(2013) Verena Wilhelmi et al.   PLoS One

Gene Expression Profiling of Immune-Competent Human Cells Exposed to Engineered Zinc Oxide or Titanium Dioxide Nanoparticles

(2013) Soile Tuomela et al.   PLoS One

Relating Cytotoxicity, Zinc Ions, and Reactive Oxygen in ZnO Nanoparticle–Exposed Human Immune Cells

(2013) Cenchao Shen et al.   TOXICOLOGICAL SCIENCES

Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation

(2013) Kyeong-Nam Yu et al.   TOXICOLOGY IN VITRO

Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling

(2013) Ruchi Roy et al.   TOXICOLOGY IN VITRO

Phosphate-enhanced cytotoxicity of zinc oxide nanoparticles and agglomerates

(2013) W. Neil Everett et al.   TOXICOLOGY LETTERS

An in vitroassessment of panel of engineered nanomaterials using a human renal cell line: cytotoxicity, pro-inflammatory response, oxidative stress and genotoxicity

(2013) Ali Kermanizadeh et al.   BMC Nephrology

Inflammatory and Oxidative Stress Responses of an Alveolar Epithelial Cell Line to Airborne Zinc Oxide Nanoparticles at the Air-Liquid Interface: A Comparison with Conventional, Submerged Cell-Culture Conditions

(2013) Anke-Gabriele Lenz et al.   Biomed Research International

A comprehensive in vitro and in vivo study of ZnO nanoparticles toxicity

(2013) Tae-Keun Hong et al.   Journal of Materials Chemistry B

Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle

(2013) Shruti R Saptarshi et al.   JOURNAL OF NANOBIOTECHNOLOGY

Microsomal Glutathione Transferase 1 Protects Against Toxicity Induced by Silica Nanoparticles but Not by Zinc Oxide Nanoparticles

(2012) Jingwen Shi et al.   ACS Nano

Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)

(2012) Vyom Sharma et al.   APOPTOSIS

Formation of Zinc-Containing Nanoparticles from Zn2+ Ions in Cell Culture Media: Implications for the Nanotoxicology of ZnO

(2012) Terence W. Turney et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Association of zinc ion release and oxidative stress induced by intratracheal instillation of ZnO nanoparticles to rat lung

(2012) Hiroko Fukui et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Toxicity of ZnO nanoparticles in healthy adult mice

(2012) Mohammad Esmaeillou et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Demonstration of an Olfactory Bulb–Brain Translocation Pathway for ZnO Nanoparticles in Rodent Cells In Vitro and In Vivo

(2012) Yi-Yun Kao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

In vitromechanistic study towards a better understanding of ZnO nanoparticle toxicity

(2012) Tina Buerki-Thurnherr et al.   Nanotoxicology

Effects of flame made zinc oxide particles in human lung cells - a comparison of aerosol and suspension exposures

(2012) David O Raemy et al.   Particle and Fibre Toxicology

Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

(2012) Stephan T Stern et al.   Particle and Fibre Toxicology

Effects of subtoxic concentrations of TiO2 and ZnO nanoparticles on human lymphocytes, dendritic cells and exosome production

(2012) Britta Andersson-Willman et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status

(2012) Morag Prach et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Reactive oxygen species-induced cytotoxic effects of zinc oxide nanoparticles in rat retinal ganglion cells

(2012) Dadong Guo et al.   TOXICOLOGY IN VITRO

Decreased Dissolution of ZnO by Iron Doping Yields Nanoparticles with Reduced Toxicity in the Rodent Lung and Zebrafish Embryos

(2011) Tian Xia et al.   ACS Nano

Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles

(2011) Boon Chin Heng et al.   ARCHIVES OF TOXICOLOGY

Titanium Oxide Shell Coatings Decrease the Cytotoxicity of ZnO Nanoparticles

(2011) I-Lun Hsiao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Responses of human cells to ZnO nanoparticles: a gene transcription study

(2011) Philip J. Moos et al.   Metallomics

Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles

(2011) Vyom Sharma et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Rapid dissolution of ZnO nanocrystals in acidic cancer microenvironment leading to preferential apoptosis

(2011) Abhilash Sasidharan et al.   Nanoscale

Independent cytotoxic and inflammatory responses to zinc oxide nanoparticles in human monocytes and macrophages

(2011) Bryce N. Feltis et al.   Nanotoxicology

Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice

(2011) Ching-Hao Li et al.   Nanotoxicology

Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ionsin vitroandin vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs

(2011) Wan-Seob Cho et al.   Nanotoxicology

Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

(2011) Wan-Seob Cho et al.   Particle and Fibre Toxicology

Cytotoxicity and oxidative stress induced by different metallic nanoparticles on human kidney cells

(2011) Igor Pujalté et al.   Particle and Fibre Toxicology

Aerosolized ZnO Nanoparticles Induce Toxicity in Alveolar Type II Epithelial Cells at the Air-Liquid Interface

(2011) Yumei Xie et al.   TOXICOLOGICAL SCIENCES

Zinc Oxide Nanoparticles Interfere With Zinc Ion Homeostasis to Cause Cytotoxicity

(2011) Yi-Yun Kao et al.   TOXICOLOGICAL SCIENCES

Toxicity of zinc oxide nanoparticles through oral route

(2011) Surekha Pasupuleti et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

ZnO nanoparticles induce apoptosis in human dermal fibroblasts via p53 and p38 pathways

(2011) Kyle Meyer et al.   TOXICOLOGY IN VITRO

ZnO Particulate Matter Requires Cell Contact for Toxicity in Human Colon Cancer Cells

(2010) Philip J. Moos et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Phosphorylation of p65 Is Required for Zinc Oxide Nanoparticle–Induced Interleukin 8 Expression in Human Bronchial Epithelial Cells

(2010) Weidong Wu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress

(2010) Boon Chin Heng et al.   FOOD AND CHEMICAL TOXICOLOGY

Zinc oxide particles induce inflammatory responses in vascular endothelial cells via NF-κB signaling

(2010) Tsui-Chun Tsou et al.   JOURNAL OF HAZARDOUS MATERIALS

Exposure to ZnO nanoparticles induces oxidative stress and cytotoxicity in human colon carcinoma cells

(2010) Barbara De Berardis et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of the dissolved zinc ion and reactive oxygen species in cytotoxicity of ZnO nanoparticles

(2010) Wenhua Song et al.   TOXICOLOGY LETTERS

Comparison of inhibitory activities of zinc oxide ultrafine and fine particulates on IgE-induced mast cell activation

(2009) Kouya Yamaki et al.   BIOMETALS

Steady state, time resolved, and circular dichroism spectroscopic studies to reveal the nature of interactions of zinc oxide nanoparticles with transport protein bovine serum albumin and to monitor the possible protein conformational changes

(2009) Munmun Bardhan et al.   JOURNAL OF APPLIED PHYSICS

DNA damaging potential of zinc oxide nanoparticles in human epidermal cells

(2009) Vyom Sharma et al.   TOXICOLOGY LETTERS

Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties

(2008) Tian Xia et al.   ACS Nano