Journal
NANOMEDICINE
Volume 10, Issue 23, Pages 3495-3512Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm.15.180
Keywords
biomarkers; circulating tumor cells; exosomes; nanoparticles; nanosensors; therapeutic drug monitoring
Funding
- AIRC 5xmille grant 'Application of Advanced Nanotechnology in the Development of Innovative Cancer Diagnostics Tools' [12214]
- Italian MUIR-FIRB grant 'Approcci nanotecnologici per la teragnostica dei tumori' [RBA-P11ETKA]
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The use of nanotechnology for drug delivery in cancer therapy has raised high expectations. Additionally, the use of nanomaterials in sensors to extract and detect tumor specific biomarkers, circulating tumor cells, or extracellular vesicles shed by the tumor holds the promise to detect cancer much earlier and hence improve long-term survival of the patients. Moreover, the monitoring of the anticancer drug concentration, which has a narrow therapeutic window, will allow for a personalized dosing of the drug and will lead to improved therapeutic outcome and life quality of the patient. This review will provide an overview on the use of nanosensors for the early diagnosis of cancer and for the therapeutic drug monitoring, giving some examples. We envision nanosensors to make significant improvements in the cancer management as easy-to-use point-of-care devices for a broad population of users.
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