Journal
NANOMEDICINE
Volume 10, Issue 7, Pages 1203-1218Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.206
Keywords
Alzheimer's disease; amyloid-beta peptide; blood-brain barrier; nanomedicine; nanoparticles
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Alzheimer's disease affects more than 35 million people worldwide and this number is presumed to double by the year 2050. Currently, there is no efficient therapy for this disorder but a promising approach is represented by nanotechnology, easily multifunctionalizable devices with size in the order of billionth of meter. This review provides a concise survey on the nano-based strategies for Alzheimer's disease treatment, aiming at carrying drugs across the blood-brain barrier, in particular to target the metabolism of beta-amyloid peptide, a pivotal player in this pathology.
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