Article
Pharmacology & Pharmacy
Brandon W. Lewis, Maria L. Ford, Aiman Q. Khan, Joshua Walum, Rodney D. Britt
Summary: Type 2-high severe asthma is a distinct subtype characterized by Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. Acute and chronic allergen models induce type 2 inflammation, but the differences in corticosteroid sensitivity remain unclear. This study found that chronic allergen exposure is associated with more persistent type 2 immune responses and corticosteroid insensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Respiratory System
Gail M. Gauvreau, Jens M. Hohlfeld, J. Mark FitzGerald, Louis-Philippe Boulet, Donald W. Cockcroft, Beth E. Davis, Stephanie Korn, Oliver Kornmann, Richard Leigh, Irvin Mayers, Henrik Watz, Sarah S. Grant, Monish Jain, Maciej Cabanski, Peter E. Pertel, Ieuan Jones, Jean R. Lecot, Hui Cao, Paul M. O'Byrne
Summary: The study evaluated the efficacy and safety of ecleralimab, an inhaled neutralizing antibody fragment against TSLP, in subjects with mild atopic asthma. The results showed that ecleralimab significantly reduced allergen-induced bronchoconstriction and airway inflammation, and it was safe in subjects with mild atopic asthma.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Immunology
Timothy C. Borbet, Miranda B. Pawline, Xiaozhou Zhang, Matthew F. Wipperman, Sebastian Reuter, Timothy Maher, Jackie Li, Tadasu Iizumi, Zhan Gao, Megan Daniele, Christian Taube, Sergei B. Koralov, Anne Mueller, Martin J. Blaser
Summary: Antibiotics, commonly used in children, can alter gut microbiome communities and metabolic functions, which in turn affects host immunity. This study shows that early-life microbiome alterations due to antibiotic exposure can lead to increased susceptibility to allergy and asthma.
MUCOSAL IMMUNOLOGY
(2022)
Article
Immunology
Guojun Qian, Wenxia Jiang, Donglin Sun, Zhun Sun, Anning Chen, Hongwei Fang, Jingyao Wang, Yongzhong Liu, Zhinan Yin, Haiming Wei, Hao Fang, Xiaoren Zhang
Summary: This study reveals that IL-10 derived from B cells, regulated by Bcl-3, promotes the development of allergic asthma. Inhibition of the Bcl-3/IL-10 axis may serve as a potential therapeutic approach for treating allergic asthma.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Respiratory System
Maria Weitoft, Mans Kadefors, Henning Stenberg, Ellen Tufvesson, Zuzana Diamant, Sara Rolandsson Enes, Leif Bjermer, Oskar Rosmark, Gunilla Westergren-Thorsson
Summary: This study aimed to investigate the changes in plasma proteome and circulating hematopoietic progenitor cells associated with the late phase response (LPR) to inhaled allergens in asthmatic individuals. The results showed that LPR was associated with significant changes in a large proportion of plasma proteome, especially in protease inhibitors, which may influence the inflammatory response. Additionally, alterations in multiple coagulation-related proteins were found to be associated with LPR.
RESPIRATORY RESEARCH
(2022)
Article
Endocrinology & Metabolism
Andries Heida, Nanda Gruben, Leen Catrysse, Martijn Koehorst, Mirjam Koster, Niels J. Kloosterhuis, Albert Gerding, Rick Havinga, Vincent W. Bloks, Laura Bongiovanni, Justina C. Wolters, Theo van Dijk, Geert van Loo, Alain de Bruin, Folkert Kuipers, Debby P. Y. Koonen, Bart van de Sluis
Summary: This study investigated the role of the hepatocytic NF-kB signaling pathway as a metabolic regulator in promoting the development of hepatic steatosis. The activation of hepatic NF-kB led to hepatic steatosis without inflammation, while the ablation of A20 in hepatocytes exacerbated hepatic steatosis and increased plasma cholesterol levels. These findings suggest that chronic NF-kB activation may contribute to the initiation of hepatic steatosis and cardiovascular disease risk in MAFLD patients.
MOLECULAR METABOLISM
(2021)
Article
Medicine, Research & Experimental
Xiang He, Jie Liu, Xiaojun Xiao, Shuang Zhang, Xinxin Wang, Jiangqi Liu, Zhiqiang Liu, Junyi Wang, Xiaoyu Liu, Guoping Li, Pingchang Yang
Summary: The study found that psychological stress significantly affects the efficacy of SIT in mice with allergic airway disorder, reducing the induction of immune regulatory cells and impairing immune tolerance. Blocking MARCH1 can counteract the impact of psychological stress on SIT efficacy.
Article
Multidisciplinary Sciences
Koji Iijima, Takao Kobayashi, Koji Matsumoto, Kenzo Ohara, Hirohito Kita, Li Y. Drake
Summary: Early life respiratory insults can increase asthma susceptibility later in life, with IL-33 playing a critical role in allergic airway diseases. Transiently increasing IL-33 expression during the neonatal period in a mouse model resulted in enhanced allergic airway responses to IL-33 or allergen exposure in adulthood, but had differential effects on multiple exposures to allergens.
Article
Chemistry, Multidisciplinary
Jianhuan Qi, Fan Mo, Ni A. An, Tingwei Mi, Jiaxin Wang, Jun-Tian Qi, Xiangshang Li, Boya Zhang, Longkuo Xia, Yingfei Lu, Gaoying Sun, Xinyue Wang, Chuan-Yun Li, Baoyang Hu
Summary: The study identified a human-specific de novo gene, SP0535, which is preferentially expressed in the ventricular zone of the human fetal brain and plays an important role in cortical development and function. Knockout of SP0535 in human embryonic stem cell-derived cortical organoids compromises their growth and neurogenesis. In SP0535 transgenic mice, expression of SP0535 induces fetal cortex expansion and formation of sulci and gyri-like structures. SP0535 also promotes unique proliferation and differentiation of progenitors and neurons in the mouse cortex. SP0535 TG adult mice exhibit improved cognitive ability and working memory. Mechanistically, SP0535 interacts with the membrane protein Na+/K+ ATPase subunit alpha-1 (ATP1A1) and releases Src from the ATP1A1-Src complex, promoting cell proliferation.
Article
Biochemistry & Molecular Biology
Shaymaviswanathan Karnaneedi, Roger Huerlimann, Elecia B. Johnston, Roni Nugraha, Thimo Ruethers, Aya C. Taki, Sandip D. Kamath, Nicholas M. Wade, Dean R. Jerry, Andreas L. Lopata
Summary: This study successfully identified seven known crustacean allergens and up to 39 unreported allergens in different shrimp species through mining complete transcriptomes. Multiple sequence alignment revealed high homology of these shrimp allergens with allergens from other invertebrates such as mites and cockroaches. This first transcriptomic analyses of allergens in a major food source provides a valuable resource for investigating shellfish allergens, comparing invertebrate allergens and future development of improved diagnostics for food allergy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Kazuki Motomura, Naoya Sugi, Atsushi Takeda, Shohei Yamaoka, Daisuke Maruyama
Summary: The nucleus of the vegetative cell in pollen tubes plays a key role in their directional growth and fertilization. However, mutant plants with immotile vegetative and sperm nuclei show female-targeting behavior in their pollen tubes. Our study further explores the mechanism by which pollen tubes can grow without transcription from the vegetative nucleus.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Melodie Boute, Saliha Ait Yahia, Ying Fan, Daniel Alvarez-Simon, Han Vorng, Joanne Balsamelli, Julie Nanou, Patricia de Nadai, Cecile Chenivesse, Anne Tsicopoulos
Summary: This study aimed to evaluate the impact of MDP as an adjuvant on the development of Th2/Th17 responses. The results showed that MDP did not affect lung inflammation in a mouse model and induced a Th2/Th17 profile in asthma patients. These findings suggest that NOD2 may not be involved in infection-related asthma development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Litty Johnson, Lorenz Aglas, Benjamin Punz, Hieu-Hoa Dang, Constantin Christ, Lisa Pointner, Mario Wenger, Norbert Hofstaetter, Sabine Hofer, Mark Geppert, Ancuela Andosch, Fatima Ferreira, Jutta Horejs-Hoeck, Albert Duschl, Martin Himly
Summary: The incorporation of nanomaterials into consumer products has raised safety concerns due to their ability to cross epithelial barriers and interact with allergens, potentially affecting immune responses. This study investigates the impact of silica nanoparticle-allergen interactions on allergic sensitization by studying molecular mechanisms affecting allergic responses. The results suggest that the interaction of birch pollen allergen with silica nanoparticles skews the immune response towards a Th1-dominated profile, indicating a potential decrease in allergic sensitization.
Article
Multidisciplinary Sciences
Yang Zhang, Yi Xu, Wenyun Lu, Jinyang Li, Sixiang Yu, Eric J. Brown, Ben Z. Stanger, Joshua D. Rabinowitz, Xiaolu Yang
Summary: Metastasizing cancer cells can withstand oxidative stress by expanding their NADPH and NADP(+) pools. This expansion is achieved through up-regulation of G6PD and activation of the NADK1 pathway. The transcription factor TAp73 plays a role in activating G6PD, which is regulated by multiple pathways. Elevated levels of G6PD and its activators are found in metastatic pancreatic cancer.
Article
Pharmacology & Pharmacy
Petra Luschnig, Melanie Kienzl, David Roula, Johannes Pilic, Reham Atallah, Akos Heinemann, Eva M. Sturm
Summary: Baricitinib, a JAK1/2 inhibitor, was found to be more potent in suppressing eosinophil effector function compared to the JAK3 inhibitor tofacitinib.
BIOCHEMICAL PHARMACOLOGY
(2021)
