Review
Pharmacology & Pharmacy
Lanchun Liu, Jun Hu, Qiyuan Mao, Chao Liu, Haoqiang He, Xiaoshan Hui, Guang Yang, Peirong Qu, Wenjing Lian, Lian Duan, Yan Dong, Juhua Pan, Yongmei Liu, Qingyong He, Jun Li, Jie Wang
Summary: This paper elaborates on the current pharmacological effects of ginseng functional components in treating cardiovascular diseases, summarizes the adverse reactions of ginseng, and provides a list of Chinese patent medicines containing ginseng formula for the treatment of cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoxue Fang, Manqi Wang, Xinteng Zhou, Huan Wang, Huaying Wang, Hongxing Xiao
Summary: This study investigated the effects of growth years on gene expression in cultivated ginseng and wild ginseng through transcriptome sequencing. The results showed that the growth years significantly affected gene expression in cultivated ginseng, especially in the MAPK signaling pathway and terpenoid backbone biosynthesis pathway. Moreover, the growth years had significant effects on genes related to ginsenoside synthesis in cultivated ginseng but had little influence on wild ginseng.
Review
Biochemistry & Molecular Biology
Xianmei Yin, Haoyu Hu, Xiaofeng Shen, Xiangyan Li, Jin Pei, Jiang Xu
Summary: Ginseng, known as the king of herbs, has been used as an important traditional medicine for thousands of years. Ginsenosides, bioactive compounds of ginseng, have posed challenges for research and development due to their complexity. In recent years, the emergence of new biological research tools, particularly omics and bioinformatic tools, has become a major trend in ginseng research.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Horticulture
Hong Chen, Xiangzhu Li, Yongjun Zheng, Mingming Liu, Kangyu Wang
Summary: Panax ginseng, an ancient and potent herb, contains ginsenosides which contribute to its medicinal effects. Wild and cultivated ginseng has insufficient saponin content to meet market demand, but ginseng adventitious root suspension culture can produce targeted ginsenosides. The length of culture time impacts plant growth, secondary metabolite accumulation, and gene expression. Extraction and analysis revealed increased total saponins, protopanaxadiol ginsenosides (specifically Rd and Rb1), and gene changes related to ginsenoside biosynthesis.
Article
Biotechnology & Applied Microbiology
Tao Zhang, Changbao Chen, Yuqiu Chen, Qinghe Zhang, Qiong Li, Weichen Qi
Summary: Short-term cold stress can reduce ginseng biomass and activate antioxidant mechanisms, leading to an increase in ginsenoside concentrations. Key enzyme genes involved in ginsenoside biosynthesis are positively correlated with ginsenoside accumulation trends. Manipulation of protopanaxadiol/protopanaxatriol ratios can be achieved through low-temperature storage or treatments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hui Wang, Shuai Zhang, Lu Zhai, Liwei Sun, Daqing Zhao, Zeyu Wang, Xiangyan Li
Summary: The study showed that total ginsenosides (TGS) can extend the lifespan of worms, improve mobility, have antioxidant and health benefits, and achieve these effects by activating signaling pathways related to antioxidant regulation and longevity.
Article
Biochemistry & Molecular Biology
Chang Liu, Kangyu Wang, Ziyi Yun, Wenbo Liu, Mingzhu Zhao, Yanfang Wang, Jian Hu, Tao Liu, Nan Wang, Yi Wang, Meiping Zhang
Summary: Ginseng, a well-known perennial herb, has been studied for the biosynthesis of ginsenosides. The involvement of GRAS transcription factors in ginsenoside biosynthesis was found, and the PgGRAS68-01 gene closely related to ginsenoside biosynthesis was identified and analyzed. The study revealed that the PgGRAS68-01 gene has spatio-temporal specific expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Zhaoqiang Chen, Zepeng Zhang, Jiaqi Liu, Hongyu Qi, Jing Li, Jinjin Chen, Qingxia Huang, Qing Liu, Jia Mi, Xiangyan Li
Summary: This review systematically summarizes the characteristics of ginseng in regulating gut microbiota diversity and the effects of gut microbiota on ginsenoside transformation. The findings suggest that ginseng treatment can modulate the composition of gut microbiota, promoting the growth of beneficial bacteria and inhibiting pathogenic bacteria. Key bacteria involved in the transformation of ginsenosides were also identified. The regulation of gut microbiota by ginseng has important implications for the prevention and treatment of metabolic diseases, colitis, neurological diseases, cancer, and other conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Plant Sciences
Lei Zhu, Jian Hu, Ruiqi Li, Chang Liu, Yang Jiang, Tao Liu, Mingming Liu, Mingzhu Zhao, Yi Wang, Kangyu Wang, Meiping Zhang
Summary: In this study, the PgGT25-04 gene was identified as a negative regulator of ginsenoside synthesis in ginseng. The gene was found to respond to ABA signals and exhibited spatiotemporally specific expression patterns in ginseng. The results suggest that PgGT25-04 plays a role in the secondary metabolism of ginseng and provide a theoretical basis for further study of Trihelix transcription factors in Panax ginseng.
Article
Biotechnology & Applied Microbiology
Li Li, Yanfang Wang, Mingzhu Zhao, Kangyu Wang, Chunyu Sun, Lei Zhu, Yilai Han, Ping Chen, Jun Lei, Yi Wang, Meiping Zhang
Summary: At least five PgOSC genes are involved in ginsenoside biosynthesis, including three newly identified genes and two published genes. These genes show significant correlations with ginsenoside contents and their mutations influence ginsenoside levels. The regulation analysis using MeJA further supports the role of these genes in ginsenoside biosynthesis.
Article
Biochemical Research Methods
Qinghai Dong, Yang An, Guangguang Du, Jia Wang, Jiayin Liu, Jun Su, Hongliu Xie, Chongyang Liang, Jihua Liu
Summary: In this study, the differential bioactivities of Panax notoginseng (PN) and Panax ginseng (PG) were investigated using a metabolomics approach. The results revealed the differences in metabolites and signaling pathways that contribute to the distinct bioactivities of PN and PG.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Review
Plant Sciences
Paul H. Goodwin, Madison A. Best
Summary: Ginsenosides have been widely studied for their medicinal benefits and their role in ginseng plant biology. They play a crucial role in ginseng's defense against biotic stresses, providing antimicrobial, antifeedant, and allelopathic activities. Ginsenosides also have roles in ginseng development and abiotic stress tolerance.
Article
Plant Sciences
Jaewook Kim, Yeongbae Yun, Jeonghoon Huh, Yurry Um, Donghwan Shim
Summary: Comparative transcriptome analysis between 7-year-old and 13-year-old wild-simulated ginseng identified differentially expressed genes involved in pentose-phosphate shunt, abscisic acid and defense responses. Up-regulated bacterial stimulation-induced gene expression in 13-year-old ginseng may contribute to minor ginsenoside biosynthesis.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Ping Di, Xiao Yang, Mingming Wan, Mei Han, Yonggang Zhang, Limin Yang
Summary: This study investigated the changes in physiology, metabolism, and gene expression in Panax ginseng leaves under different light intensities. The results showed that higher light intensity positively influenced the quality of P. ginseng leaves, leading to an increase in ginsenoside accumulation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Horticulture
Ga Oun Lee, Seong-Nam Jang, Min Ju Kim, Du Yong Cho, Kye Man Cho, Ji Hyun Lee, Ki-Ho Son
Summary: This study analyzed various factors such as growth patterns, biological compounds, antioxidant properties, ginsenoside contents, metabolites, and the annual net production to determine the optimal harvesting time for ginseng sprouts. Different cultivars showed variations in growth patterns, biological compounds, and antioxidant properties. `Yunpoong' and `K-1' exhibited the highest ginsenoside contents at 5 weeks after transplanting. The longer the growth period, the lower the yield and annual ginsenoside net production. Therefore, `Yunpoong' and `K-1' should be harvested as ginseng sprouts at approximately 3 and 4 weeks after transplanting, respectively.