Article
Plant Sciences
Xin Xu, Menghan Li, Ji-Xin Zou, Yu-Sheng Zheng, Dong-Dong Li
Summary: The study found that EgMYB108 in oil palm regulates the synthesis of VLCFAs and increases total lipid content. Experimental results show that EgMYB108 can bind to the promoters of EgKCS5 and EgLACS4, regulating their transcription.
PLANT CELL REPORTS
(2022)
Article
Plant Sciences
Yifei Wang, Jixin Zou, Jin Zhao, Yusheng Zheng, Dongdong Li
Summary: EgMADS16, a MADS-box transcription factor in oil palm, is highly expressed during late fruit development and is predicted to be targeted by EgmiR5179. Experimental results suggest that EgMADS16 expression is downregulated by EgmiR5179, impacting lipid metabolism in oil palm.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Horticulture
Yifei Wang, Jin Zhao, Hong Chen, Qing Zhang, Yusheng Zheng, Dongdong Li
Summary: In this study, a full-length cDNA encoding EgLACS9 was cloned from oil palm mesocarp and its subcellular localization in the endoplasmic reticulum (ER) was confirmed. Overexpression of EgLACS9 was shown to rescue LACS gene deficiency in S. cerevisiae and regulate fatty acid accumulation in oil palm, indicating its important role in lipid metabolic pathways.
SCIENTIA HORTICULTURAE
(2021)
Article
Energy & Fuels
Francisca Gleyciara Cavalcante Pinheiro, Renato Carrha Leitao, Elisabete Frollini
Summary: This study evaluated three methods for removing silica bodies from oil palm mesocarp fiber (OPMF) and found that alkali treatment was the most effective, removing approximately 91% of silica bodies and increasing the crystallinity index of the fibers.
BIOMASS CONVERSION AND BIOREFINERY
(2021)
Article
Plant Sciences
Yujiao Hua, Bingyi Dai, Yiyuan Luo, Yongjuan Ding
Summary: In this study, the different developmental stages of Rubus chingii fruit were analyzed to understand the molecular mechanism regulating flavonol biosynthesis. It was found that the contents of flavonoids varied at different stages. Through transcriptome analysis and functional analysis, the molecular regulation of flavonoid biosynthesis was revealed, and a potential regulator for molecular breeding of Rubus chingii was identified.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Thermodynamics
Chokchai Mueanmas, Nirattisai Rakmak
Summary: This study investigates the enhancement of the thermal properties of Oil Palm Mesocarp Fiber (OPMF) through the torrefaction process using a continuous screw conveyor reactor. The results show that temperature and residence time have an inverse relationship with mass yield, energy yield, and EMCI, while they have a direct correlation with torrefaction severity index, fuel ratio, degree of torrefaction, and heating value. Furthermore, the torrefied OPMF exhibited improved chemical and physical properties, with decreased moisture and volatile organic content and increased fixed carbon content. The pelletizing process further enhanced the thermal properties of torrefied OPMF and met the standards for solid biomass pellets fuel.
ENERGY CONVERSION AND MANAGEMENT
(2023)
Article
Multidisciplinary Sciences
Weida Lin, Huanwei Chen, Jianmei Wang, Yongli Zheng, Qiuwei Lu, Ziping Zhu, Na Li, Zexin Jin, Junmin Li, Hongfei Lu
Summary: Through RNA-seq technology, the biosynthesis pathway of polysaccharides in Cyclocarya paliurus leaves was investigated, revealing genes associated with glycosyltransferases. The changes in polysaccharide content and antioxidant activities in leaves at different developmental stages showed a positive correlation, suggesting potential applications based on leaf size.
Article
Agriculture, Multidisciplinary
Ruimin Huang, Ye Zhou, Junpei Zhang, Feiyang Ji, Feng Jin, Wei Fan, Dong Pei
Summary: This study focused on the oil biosynthesis in developing walnut embryos, revealing the high content of polyunsaturated fatty acids, especially linoleic acid and linolenic acid. Utilizing RNA sequencing and gene expression analysis, key genes involved in fatty acid biosynthesis were identified and shown to be upregulated during 63-119 DAP. Subcellular localization and gene coexpression network analysis provided insights into the mechanisms underlying lipid biosynthesis in walnut embryos.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Francisco Pereira Marques, Amanda Kelly Lima Soares, Diego Lomonaco, Lorena Mara Alexandre e Silva, Sandra Tedde Santaella, Morsyleide de Freitas Rosa, Renato Carrha Leitao
Summary: Steam explosion pretreatment combined with acetosolv can significantly increase lignin yield from oil palm mesocarp fibers and sugarcane bagasse.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Thonyaporn Saepoo, Sukanya Sarak, Jaruwan Mayakun, Theera Eksomtramage, Kaewta Kaewtatip
Summary: Thermoplastic starch composites with oil palm mesocarp fiber waste showed excellent mechanical properties and durability, while also being biodegradable and environmentally friendly. The biodegradable seeding pot made from this composite can support plant growth and has the potential to replace existing non-biodegradable products.
CARBOHYDRATE POLYMERS
(2023)
Article
Energy & Fuels
Victor Olugbenga Olumekun, Femi Francis Oloye, Mary Olajide, Oluwabunmi Peace Femi-Oloye, Oluwatosin Bamidele Oludaisi
Summary: The price of palm oil is rising due to its applications in industries and households. A study showed that ethanol and acetone performed better in recovering oil from pressed mesocarp fiber compared to dichloromethane and n-hexane, indicating the potential for more efficient oil recovery for industrial purposes.
BIOMASS CONVERSION AND BIOREFINERY
(2021)
Article
Plant Sciences
Suyan Yee, Vivien Rolland, Kyle B. Reynolds, Pushkar Shrestha, Lina Ma, Surinder P. Singh, Thomas Vanhercke, James R. Petrie, Anna El Tahchy
Summary: Plant oil production has been increasing with investments in high biomass plants and elevated oil content. The expression of specific genes and lipid droplet proteins can significantly increase leaf oil content.
Article
Plant Sciences
Anni Zhang, Longfei Jin, Rajesh Yarra, Hongxing Cao, Ping Chen, Jerome Jeyakumar John Martin
Summary: This study provides a transcriptomic analysis of zygotic embryo development in oil palm, revealing differentially expressed genes and pathways involved in hormone signaling, sucrose synthesis and degradation, and fatty acid synthesis. These findings offer new insights into the developmental and metabolic regulation of zygotic embryo development in oil palm at the transcriptional level.
Article
Chemistry, Applied
Soek Sin Teh, Harrison Lik Nang Lau
Summary: The quality assessment of refined red palm-pressed mesocarp olein (PPMO) showed that it has comparable physicochemical properties and oxidative stability with commercial cooking oil, palm olein (PO). Analyses on food safety parameters and contaminants proved that refined PPMO is safe to be consumed and it contains remarkably greater concentrations of phytonutrients. This indicates that refined PPMO is suitable for human consumption and may have protective health benefits.
Article
Multidisciplinary Sciences
Yajing Dou, Wei Xia, Annaliese S. Mason, Dongyi Huang, Xiwei Sun, Haikuo Fan, Yong Xiao
Summary: This study identified genetic variation and developed functional markers associated with vitamin E contents in 20 oil palm accessions. Thirty-seven homologous genes related to vitamin E biosynthesis pathway were identified and correlated with vitamin E traits. Functional markers, particularly the indel EgTMT-1-24, showed significant correlation with variation in vitamin E content, especially tocotrienol content, providing clues for further molecular breeding research in high vitamin E content oil palm.
Article
Respiratory System
Natalia Hernandez-Pacheco, Susanne J. Vijverberg, Esther Herrera-Luis, Jiang Li, Yang Yie Sio, Raquel Granell, Almudena Corrales, Cyrielle Maroteau, Ryan Lethem, Javier Perez-Garcia, Niloufar Farzan, Katja Repnik, Mario Gorenjak, Patricia Soares, Leila Karimi, Maximilian Schieck, Lina Perez-Mendez, Vojko Berce, Roger Tavendale, Celeste Eng, Olaia Sardon, Inger Kull, Somnath Mukhopadhyay, Munir Pirmohamed, Katia M. C. Verhamme, Esteban G. Burchard, Michael Kabesch, Daniel B. Hawcutt, Erik Melen, Uros Potocnik, Fook Tim Chew, Kelan G. Tantisira, Steve Turner, Colin N. Palmer, Carlos Flores, Maria Pino-Yanes, Anke H. Maitland-van der Zee
Summary: A genome-wide association study identified 10 independent variants associated with asthma exacerbations despite ICS treatment in European children. One variant at the CACNA2D3-WNT5A locus showed nominal replication in Europeans. Genes regulated by trichostatin A treatment were found to be enriched in associations.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Sze Lei Pang, Sri Anusha Matta, Yang Yie Sio, Yu Ting Ng, Yee-How Say, Chyan Leong Ng, Fook Tim Chew
Summary: The study identified K44 and E46 residues as major IgE-binding residues of the Der p 23 allergen for HDM-sensitized individuals. Individuals sensitized only to HDM have a higher number of IgE-binding residues compared to polysensitized individuals. Those with allergic multimorbidity and moderate-to-severe allergic rhinitis also exhibit a higher number of IgE-binding residues.
SCIENTIFIC REPORTS
(2021)
Article
Allergy
Elise M. A. Slob, Levi B. Richards, Susanne J. H. Vijverberg, Cristina Longo, Gerard H. Koppelman, Marielle W. H. Pijnenburg, Elisabeth H. D. Bel, Anne H. Neerincx, Esther Herrera Luis, Javier Perez-Garcia, Fook Tim Chew, Yang Yie Sio, Anand K. Andiappan, Steve W. Turner, Somnath Mukhopadhyay, Colin N. A. Palmer, Daniel Hawcutt, Andrea L. Jorgensen, Esteban G. Burchard, Natalia Hernandez-Pacheco, Maria Pino-Yanes, Anke H. Maitland-van der Zee
Summary: Despite no strong effects of single nucleotide polymorphisms (SNPs) on exacerbations during LABA use, two loci (TBX3 and EPHA7) previously implicated in the response to short-acting beta2-agonists (SABA) were identified for further investigation in response to LABA and SABA use.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Allergy
Yang Yie Sio, Ping Shi, Yee-How Say, Fook Tim Chew
Summary: This study identified significant associations between single nucleotide polymorphisms (SNPs) in the chromosome 4q21 region and NAAA gene expression levels at both gene and protein levels, confirming their functional role in allergic rhinitis (AR) susceptibility. The findings provide a better understanding of the genetic mechanisms contributing to the pathogenesis of AR.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Critical Care Medicine
Pei Yee Tiew, Albert Yick Hou Lim, Holly R. Keir, Alison J. Dicker, Micheal Mac Aogain, Sze Lei Pang, Teck Boon Low, Tidi Maharani Hassan, Mau Ern Poh, Huiying Xu, Thun How Ong, Mariko Siyue Koh, John Arputhan Abisheganaden, Augustine Tee, Fook Tim Chew, James D. Chalmers, Sanjay H. Chotirmall
Summary: Allergic bronchopulmonary aspergillosis (ABPA) is frequently observed in chronic respiratory diseases and is associated with poor outcomes. This study investigates the occurrence and clinical relevance of Aspergillus sensitization and ABPA in bronchiectasis-COPD overlap (BCO) compared with COPD or bronchiectasis without overlap. The results suggest that BCO is associated with a higher frequency and severity of ABPA, leading to worse clinical outcomes.
Article
Dermatology
Anna Hwee Sing Heng, Yee-How Say, Yang Yie Sio, Yu Ting Ng, Fook Tim Chew
Summary: This study found that parental acne was associated with acne presentation and severity, while sibling acne was associated with scarring grades. Additionally, gender, age, education level, number of siblings, weight status, atopic diseases, and dietary habits were all related to acne in different ways.
Letter
Allergy
Anand Kumar Andiappan, Kia Joo Puan, Yang Yie Sio, Fauziah Ally, Bernett Lee, Sri Anusha Matta, Nurhashikin Yusof, Anis Larbi, De Yun Wang, Fook Tim Chew, Olaf Rotzschke
Article
Dermatology
Yee-How Say, Yang Yie Sio, Anna Hwee Sing Heng, Yu Ting Ng, Sri Anusha Matta, Sze Lei Pang, Keng Foo Teh, Yi Ru Wong, Smyrna Moti Rawanan Shah, Kavita Reginald, Fook Tim Chew
Summary: The study identified the signaling pathways between high glycemic index/glycemic load diet and acne vulgaris. By analyzing the genomic and transcriptomic data of acne cases and controls, several genes related to acne and dietary quality were discovered. Additionally, an intronic SNP in the GOLGA7B gene was found to be associated with acne. These findings provide a new model for the pathogenesis of acne related to high glycemic index/glycemic load diet.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qing Xiong, Angel Tsz-Yau Wan, Xiaoyu Liu, Cathy Sin-Hang Fung, Xiaojun Xiao, Nat Malainual, Jinpao Hou, Lingyi Wang, Mingqiang Wang, Kevin Yi Yang, Yubao Cui, Elaine Lai-Han Leung, Wenyan Nong, Soo-Kyung Shin, Shannon Wing-Ngor Au, Kyoung Yong Jeong, Fook-Tim Chew, Jerome Ho-Lam Hui, Ting-Fan Leung, Anchalee Tungtrongchitr, Nanshan Zhong, Zhigang Liu, Stephen Kwok-Wing Tsui
Summary: This study examines the evolutionary origin, diverse lifestyles, and quick adaptation of astigmatic mites in human household environments using six high-quality assembled and annotated genomes. The research reveals that astigmatic mites evolved from Prostigmata, notorious plant pests, and rapidly diversified from soil oribatid mites. The study also highlights the rapid expansion of gene families via tandem gene duplications in astigmatic mites, providing genetic resources for adaptation to changing household environments. Additionally, massive horizontal gene transfer events occurred during the evolution of astigmatic mites, enabling detoxification and digestive functions and offering potential drug targets for pest control.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Allergy
Esther Herrera-Luis, Victor E. Ortega, Elizabeth J. Ampleford, Yang Yie Sio, Raquel Granell, Emmely de Roos, Natalie Terzikhan, Ernesto Elorduy Vergara, Natalia Hernandez-Pacheco, Javier Perez-Garcia, Elena Martin-Gonzalez, Fabian Lorenzo-Diaz, Simone Hashimoto, Paul Brinkman, Andrea L. Jorgensen, Qi Yan, Erick Forno, Susanne J. Vijverberg, Ryan Lethem, Antonio Espuela-Ortiz, Mario Gorenjak, Celeste Eng, Ruperto Gonzalez-Perez, Jose M. Hernandez-Perez, Paloma Poza-Guedes, Olaia Sardon, Paula Corcuera, Greg A. Hawkins, Annalisa Marsico, Thomas Bahmer, Klaus F. Rabe, Gesine Hansen, Matthias Volkmar Kopp, Raimon Rios, Maria Jesus Cruz, Francisco-Javier Gonzalez-Barcala, Jose Maria Olaguibel, Vicente Plaza, Santiago Quirce, Glorisa Canino, Michelle Cloutier, Victoria Del Pozo, Jose R. Rodriguez-Santana, Javier Korta-Murua, Jesus Villar, Uros Potocnik, Camila Figueiredo, Michael Kabesch, Somnath Mukhopadhyay, Munir Pirmohamed, Daniel B. Hawcutt, Erik Melen, Colin N. Palmer, Steve Turner, Anke H. Maitland-van der Zee, Erika von Mutius, Juan C. Celedon, Guy Brusselle, Fook Tim Chew, Eugene Bleecker, Deborah Meyers, Esteban G. Burchard, Maria Pino-Yanes
Summary: This multi-ancestry study identified novel suggestive regulatory loci for asthma exacerbations, located in genomic regions participating in inflammation and host defense, revealing the genetic basis of asthma exacerbations.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jun Yan Ng, Fook Tim Chew
Summary: Skin ageing is influenced by both genetic and lifestyle factors. This systematic review summarizes the current knowledge on skin ageing phenotypes and the associated genetic risk factors. The study identifies several promising SNPs and hub genes that are significantly associated with skin ageing. The findings suggest that pleiotropy plays a role in skin ageing and further research should focus on the contributions of genes on the chromosomal band 16q24.3.
SCIENTIFIC REPORTS
(2022)
Article
Respiratory System
Esther Herrera-Luis, Angel C. Y. Mak, Javier Perez-Garcia, Elena Martin-Gonzalez, Celeste Eng, Kenneth B. Beckman, Scott Huntsman, Donglei Hu, Ruperto Gonzalez-Perez, Jose M. Hernandez-Perez, Elena Mederos-Luis, Yang Yie Sio, Paloma Poza-Guedes, Olaia Sardon, Paula Corcuera, Inmaculada Sanchez-Machin, Javier Korta-Murua, Carlos Martinez-Rivera, Joaquim Mullol, Xavier Munoz, Antonio Valero, Joaquin Sastre, Judith Garcia-Aymerich, Sabrina Llop, Maties Torrent, Maribel Casas, Jose R. Rodriguez-Santana, Jesus Villar, Victoria del Pozo, Fabian Lorenzo-Diaz, L. Keoki Williams, Erik Melen, Fook Tim Chew, Luisa N. Borrell, Esteban G. Burchard, Maria Pino-Yanes
Summary: This study used admixture mapping analyses and fine mapping to identify genetic variants associated with severe asthma exacerbations in Hispanic/Latino subgroups. The results showed limited transferability of these variants to other populations and their potential regulation of DPYSL3 and SCGB3A2 genes.
Letter
Allergy
Elise M. A. Slob, Alen Faiz, Jos van Nijnatten, Susanne J. H. Vijverberg, Cristina Longo, Merve Kutlu, Fook Tim Chew, Yang Yie Sio, Esther Herrera-Luis, Antonio Espuela-Ortiz, Javier Perez-Garcia, Maria Pino-Yanes, Esteban G. Burchard, Uros Potocnik, Mario Gorenjak, Colin Palmer, Cyrielle Maroteau, Steve Turner, Katia Verhamme, Leila Karimi, Somnath Mukhopadhyay, Wim Timens, Pieter S. Hiemstra, Marielle W. Pijnenburg, Margaret Neighbors, Michele A. Grimbaldeston, Gaik W. Tew, Corry A. Brandsma, Vojko Berce, Hananeh Aliee, Fabian Theis, Don D. Sin, Xuan Li, Maarten van den Berge, Anke H. Maitland-van der Zee, Gerard H. Koppelman
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Review
Biochemistry & Molecular Biology
Wanlu Ouyang, Charlene E. Goh, Wei Bo Ng, Fook Tim Chew, Eric Peng Huat Yap, Chin-ying Stephen Hsu
Summary: Atopic dermatitis and tooth developmental abnormalities often occur together in some patients. It is suggested that there may be a common underlying mechanism involving gene mutations and protein interactions. This review explores the key gene mutations and signaling pathways associated with both diseases and identifies a possible association between the Wnt/beta-catenin signaling pathway and desmosomal proteins. Further research is needed to understand the mechanisms driving their co-occurrence and development of these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Qi Yi Ambrose Wong, Jun Jie Lim, Jun Yan Ng, Praneeth Malipeddi, Ying Eliza Lim, Yang Yie Sio, Fook Tim Chew
Summary: The study found that the lifetime asthma prevalence rate among young Chinese adults in Singapore was 19.1%, while the current asthma prevalence rate was 6.3%. Parental history of asthma was identified as the most important risk factor, and increased consumption of certain foods and television/computer usage were also associated with asthma risk. Future research should consider the interaction between various factors to better understand the impact of environment and lifestyle on asthma.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
