Article
Chemistry, Multidisciplinary
Kinam Park, Andrew Otte, Farrokh Sharifi, John Garner, Sarah Skidmore, Haesun Park, Young Kuk Jhon, Bin Qin, Yan Wang
Summary: Injectable long-acting formulations, particularly those based on poly(lactide-co-glycolide) (PLGA), have been utilized for systemic drug delivery for up to 6 months, but the development of clinical products and generics has been slow. The limited understanding of PLGA polymers and the complex variables involved in composition and manufacturing processes hinder the control over formulation properties and drug efficacy. Factors such as formulation composition, manufacturing processes, and surface morphology play crucial roles in determining the pharmacokinetic profile of the formulations, highlighting the importance of proper characterization and control of these parameters for desired drug release kinetics and efficacy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Guiying Li, Yanping He, Wanqing Han, Yang Yu, Linhua Zhu, Tian Si, Yanlin Sun
Summary: This research aimed to prepare high encapsulation efficiency poly(lactic acid) microspheres via an improved solvent evaporation method with foam-transfer. The critical process of foam transfer was studied, and factors affecting it were investigated. Results showed that appropriate oil/water ratio, stirring rate, and concentrations of PVA and EtOH could aid in producing enough foam for effective foam-transfer, leading to enhanced delivery efficiency of microspheres.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Antonios Vlachopoulos, Georgia Karlioti, Evangelia Balla, Vasileios Daniilidis, Theocharis Kalamas, Myrika Stefanidou, Nikolaos D. Bikiaris, Evi Christodoulou, Ioanna Koumentakou, Evangelos Karavas, Dimitrios N. Bikiaris
Summary: The sustained release of pharmaceutical substances through polymeric microparticles is a convenient and widely-used drug delivery system. Poly(lactic acid) and poly(lactic-co-glycolic acid) microparticles are frequently used biodegradable carriers for drug encapsulation.
Article
Chemistry, Multidisciplinary
Yihua Pei, Jianping Wang, Nisar Ul Khaliq, Fanfei Meng, Kaoutar A. Oucherif, Jie Xue, Sarena D. Horava, Amy L. Cox, Coralie A. Richard, Monica R. Swinney, Kinam Park, Yoon Yeo
Summary: Poly(lactide-co-glycolide) (PLGA) polymers are commonly used for drug delivery due to their biodegradability and biocompatibility. This study focused on achieving sustained drug release from PLGA microparticles (MPs) for two weeks using meloxicam. By encapsulating meloxicam as a solid and incorporating magnesium hydroxide (Mg(OH)2), the researchers were able to control the drug release kinetics of the MPs. The study demonstrated the feasibility of controlling drug release from PLGA MPs over weeks based on the physical state of the drug and the inclusion of Mg(OH)2 to neutralize the microenvironmental pH of the MPs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Polymer Science
Iouliana Chrysafi, Stavroula Nanaki, Alexandra Zamboulis, Margaritis Kostoglou, Eleni Pavlidou, Dimitrios N. Bikiaris
Summary: The study investigated the formulation of Risperidone microparticles from poly(lactic acid)/poly(hexylene succinate) (PLA-b-PHSu) block copolymers in different ratios, demonstrating their biocompatibility and drug release properties. The microparticles showed controlled drug release, with higher content of PHSu leading to increased release of Risperidone.
Article
Pharmacology & Pharmacy
Vasiliki Karava, Aggeliki Siamidi, Marilena Vlachou, Evi Christodoulou, Nikolaos D. Bikiaris, Alexandra Zamboulis, Margaritis Kostoglou, Eleni Gounari, Panagiotis Barmpalexis
Summary: The study evaluates the use of synthesized block copolymers as microcarriers for drug delivery, with different ratios affecting the erosion and dissolution rates of the copolymers. SEM images show well-shaped particles with smooth surfaces, while FTIR spectroscopy reveals the formation of new ester bonds within the copolymers. In vitro dissolution studies indicate a highly tunable extended release for up to 30 days, suggesting potential for long-acting injectable formulations.
Article
Polymer Science
Shih-Jyun Shen, Ying-Chao Chou, Shih-Chieh Hsu, Yu-Ting Lin, Chia-Jung Lu, Shih-Jung Liu
Summary: In this study, drug-loaded microparticles were successfully prepared using electrospraying technique, and their release behavior was investigated. The results showed that the drugs were sustainably released at the target region in vivo and maintained low concentrations in the blood. This technique has the potential for postoperative pain control.
Article
Pharmacology & Pharmacy
Chenghao Zhang, Roland Bodmeier
Summary: The study aimed to prepare poly(lactide-co-glycolide) (PLGA) microparticles loaded with nanosized drugs by combining non-aqueous wet bead milling and microencapsulation. Nanosized dexamethasone, hydrocortisone, and dexamethasone sodium phosphate were successfully prepared using PLGA as a stabilizer. The microparticles loaded with nanosized drugs were prepared using solvent evaporation or organic phase separation methods.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Mengyao Xu, Zuyue Liao, Yang Liu, Shiwei Guo, Haiyang Hu, Tao Chen, Yuesong Wu, Shengli Wan, Meiling Zhou, Muhe Lu, Shiluo Jiluo, Lan Yao, Xiaofeng Pu, Shurong Wang, Qingze Fan
Summary: The study presents a modified emulsion solvent evaporation (ESE) technique to prepare small-sized poly(lactic-co-glycolic acid) (PLGA) nanorods for targeted cancer therapy. The technique was optimized through single-factor and multi-factor experiments. The results showed that the nanorods had a yield of 99% and an aspect ratio of 5.35±2.05, with a minor axis of 135.49±72.66 nm and a major axis of 657.77±307.63 nm. Additionally, the anti-cancer drug paclitaxel was successfully encapsulated in the PLGA nanorods. This research enriches the ESE technique for preparing small-sized PLGA nanorods and demonstrates the potential application for targeted cancer therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Matthew J. Owen, Jasper H. N. Yik, Congwang Ye, Brianca Netto, Dominik R. Haudenschild, Gang-yu Liu
Summary: This study introduces a green method for drug delivery by using dimethyl carbonate as an organic phase solvent instead of dichloromethane in the production of PLGA microparticles. The use of microfluidic flow focusing resulted in PLGA microparticles with desirable sustained release profiles, showcasing high biocompatibility and efficacy through cytotoxicity and activity testing. The lower health and environmental toxicities of dimethyl carbonate compared to dichloromethane were evidenced by higher LD50 values in rats, faster degradation rate, and a higher GSK combined greenness value.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2021)
Article
Polymer Science
Alexis Theodorou, Vasilios Raptis, Chrissie Isabella Maria Baltzaki, Thrassyvoulos Manios, Vagelis Harmandaris, Kelly Velonia
Summary: In this study, we performed synthetic experiments and kinetic modeling calculations to investigate the polycondensation process of lactic acid and the formation of poly(lactic acid) (PLA). The results showed that under optimized conditions, PLLA with a weight-average molecular weight of 161 kDa could be obtained. The kinetic parameters obtained from the optimization accurately reproduced the experimental data.
Article
Polymer Science
Jonghun Lim, Hyungtae Cho, Kwon-chan Son, Yup Yoo, Junghwan Kim
Summary: In this work, alternative evaporation processes for PLA production were designed and economically evaluated. The utilization of multiple-effect evaporation and thermal vapor recompression-assisted evaporation processes can efficiently recover waste heat and significantly reduce steam consumption. The simulation results show that these alternative processes can greatly reduce energy consumption, and the TVR process is the cost-optimal choice.
Article
Biochemistry & Molecular Biology
Roufaida Merir, Milad Baitiche, Zineb Elbahri, Riadh Bourzami, Ferhat Djerboua, Mokhtar Boutahala
Summary: Microspheres containing Mesalazine (5-ASA) were prepared using the emulsion solvent evaporation technique for colon targeting drug. The formulation included 5-ASA as the active agent, sodium Alginate (SA) and Ethylcellulose (EC) as encapsulating agents, and polyvinyl alcohol (PVA) as emulsifier. Various processing parameters were considered, and the resulting microspheres were characterized using different techniques. In vitro release of 5-ASA was tested in biologically simulated fluids, and the release kinetics were mathematically analyzed. DOE study and DFT analysis were performed to evaluate the effects of variables and optimize molecular chemical interactions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Chemical
I. D. Perez-Landa, I. Bonilla-Landa, J. L. Monribot-Villanueva, M. Ramirez-Vazquez, R. Lasa, W. Ramos-Torres, J. L. Olivares-Romero, F. Barrera-Mendez
Summary: This study developed a photoprotective system for intake administration using chitosan and sodium lignosulfonate as encapsulating materials for the photosensitive spinosad. In vitro release studies showed high stability to photodegradation and appropriate insecticide release rate for the developed bioinsecticide carrier system.
Article
Medicine, Research & Experimental
Marta Glinka, Katerina Filatova, Justyna Kucinska-Lipka, Eva Domincova Bergerova, Andrzej Wasik, Vladimir Sedlarik
Summary: The study fabricated novel microparticles for efficient and long-term delivery of amikacin. The microparticles demonstrated high loading efficiency and antimicrobial action against various bacterial strains. The comprehensive characterization of the materials contributes to new means for conducting targeted therapy with broad-spectrum antibiotics.
MOLECULAR PHARMACEUTICS
(2021)
Article
Nanoscience & Nanotechnology
Muhammad Yasir, Tomas Sopik, Lenka Lovecka, Dusan Kimmer, Vladimir Sedlarik
Summary: This study investigates the adsorption kinetics of four highly potent sex hormones in water reservoirs. The results show that polyurethane nanofibers have the highest adsorption capacity and removal efficiency for these hormones, even after multiple uses.
Article
Nanoscience & Nanotechnology
Martin Cvek, Uttam C. Paul, Jasim Zia, Giorgio Mancini, Vladimir Sedlarik, Athanassia Athanassiou
Summary: In this study, a bio-based and biodegradable material was developed for sustainable packaging and as a smart indicator for ammonia vapor and food spoilage. The material, a blend of poly(lactic acid) and poly(propylene carbonate) loaded with curcumin, exhibited good compatibility and thermal stability. By changing the ratio of the biopolymers, the properties of the material could be easily adjusted. The material showed efficient absorption of UV radiation and the ability to provide effective antioxidant action. It also demonstrated the potential to serve as a cost-effective, easy-to-use, nondestructive, smart indicator for food packaging and NH3 gas monitoring.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Silvie Durpekova, Eva Domincova Bergerova, Dominika Hanusova, Miroslava Dusankova, Vladimir Sedlarik
Summary: Renewable and biodegradable hydrogels based on acid whey and cellulose derivatives blended with poly(lactic acid) were developed for sustainable agricultural applications. The hydrogels showed improved mechanical properties and extended decomposition time. They also demonstrated enhanced water retention capacity of the soil and improved growth pattern of plants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Muhammad Yasir, Fahanwi Asabuwa Ngwabebhoh, Tomas Sopik, Lenka Lovecka, Dusan Kimmer, Vladimir Sedlarik
Summary: This study prepared electrospun polysulfone nanofibers for the adsorption removal of estrogenic hormones in water. The results showed that the spun PSU fibers exhibited high removal efficiency and adsorption capacity for the simultaneous removal of four estrogens. Additionally, optimization of the adsorption conditions was also successful.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2022)
Review
Green & Sustainable Science & Technology
Ahmad Fayyazbakhsh, Michelle L. Bell, Xingbao Zhu, Xueyi Mei, Marek Koutny, Nima Hajinajaf, Yexin Zhang
Summary: This article reviews the primary pollutants emitted from diesel and gasoline engines, their formation process, and the current technologies for controlling emissions. It also discusses the challenges posed by exhaust emissions and strategies for reducing them.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Marta Glinka, Katerina Filatova, Justyna Kucinska-Lipka, Tomas Sopik, Eva Domincova Bergerova, Veronika Mikulcova, Andrzej Wasik, Vladimir Sedlarik
Summary: Three porous matrices based on poly(lactic acid) are proposed for controlled release of amikacin. By using modifiers such as chitosan and silica nanocarriers, the release of amikacin can be extended and properties of the matrices can be improved. Experimental results show that the materials exhibit varying efficacy for drug loading and inhibiting bacterial growth, and they can conform to a mathematical model for extended release.
Article
Biochemistry & Molecular Biology
Jana Sera, Florence Huynh, Faith Ly, Stepan Vinter, Marketa Kadleckova, Vendula Kratka, Daniela Macalova, Marek Koutny, Christopher Wallis
Summary: This study investigates the interactions between different polymers and soil matrix and their influence on the soil environment. The results show that slowly degrading polyesters are associated with higher humic substances in the soil, while the addition of PHB polymer increases fungal biomass and PE wax increases bacterial biomass. Additionally, PHB and PBAT polymers may be covered by fungal biofilms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Daniela Macalova, Magda Janalikova, Jana Sedlarikova, Iveta Rektorikova, Marek Koutny, Pavel Pleva
Summary: PHA is widely used in medical and other applications due to its biocompatibility and biodegradability. This study aimed to find potential PHA bacterial producers by detecting PHA synthases and related genes in 64 bacterial strains. Pseudomonas genus was identified as capable of utilizing all tested carbon sources, making it a potential candidate for biotechnology applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Anita Bialkowska, Beata Krzykowska, Iwona Zarzyka, Mohamed Bakar, Vladimir Sedlarik, Miroslava Kovarova, Anna Czerniecka-Kubicka
Summary: This paper presents an attempt to improve the properties of poly(3-hydroxybutyrate) (P3HB) by adding linear aliphatic polyurethane (PU400) and organomodified montmorillonite (MMT)-(Cloisite((R))30B). The hybrid nanobiocomposites were analyzed for their nanostructure, morphology, mechanical properties, and thermal properties. The addition of Cloisite((R))30B and aliphatic polyurethane to the P3HB matrix resulted in a decrease in the degree of crystallinity, an increase in the amorphous phase contents, and improved thermal stability. The best mechanical properties were observed in hybrid nanobiocomposites containing 10 wt.% of aliphatic polyurethane and 1 wt.% of Cloisite((R))30B.
Article
Polymer Science
Jaroslav Cisar, Petra Drohsler, Martina Pummerova, Vladimir Sedlarik, David Skoda
Summary: This manuscript presents a comprehensive study on the application of composite materials based on PLA in various fields, especially in food packaging. The research focuses on the preparation of the composite with suitable thermal stability for hot food packaging under semi-industrial conditions. The effects of composition, annealing process, and post-production thermal annealing on the properties of the composite were investigated.
Article
Engineering, Environmental
Muhammad Yasir, Hassan Ali, Milan Masar, Fahanwi Asabuwa Ngwabebhoh, Mukarram Zubair, Tomas Sopik, Michal Machovsky, Ivo Kuritka, Vladimir Sedlarik
Summary: Novel PU nanofibers incorporating TiO2/Nd nanoparticles were fabricated by electrospinning for photocatalytic degradation of estriol hormone. These nanofibers showed high porosity and uniform mesh-like structure, with better performance under UV light compared to visible light, fitting well with the pseudo-first-order kinetic model.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Engineering, Environmental
Eva Domincova Bergerova, Dusan Kimmer, Miroslava Kovarova, Lenka Lovecka, Ivo Vincent, Petra Drohsler, Vladimir Adamec, Klaudia Kobolova, Vladimir Sedlarik
Summary: This study investigates the effect of nanofibrous polymeric structures modified with an immobilized inorganic sorbent on the removal of arsenic from contaminated water. The results show that certain polyurethane samples, especially PU918, have high efficiency in arsenic removal, and adding a small amount of ferrous sulphate adsorbent further increases the efficiency. The adsorption process is well described by kinetic and isotherm models.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Muhammad Yasir, Fahanwi Asabuwa Ngwabebhoh, Tomas Sopik, Hassan Ali, Vladimir Sedlarik
Summary: This study reports the fabrication of electrospun polyurethane nanofibers modified by coating with polyaniline/polyvinyl alcohol for the enhanced removal of ethinylestradiol (EE2) estrogenic hormone. The modified PU membranes showed a maximum adsorption capacity of 2.11 mg/g and high removal percentage efficiency of ~82.20% for EE2. The adsorption mechanism involved intraparticle diffusion and was exothermic in nature.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Polymer Science
Muhammad Yasir, Tomas Sopik, Rahul Patwa, Dusan Kimmer, Vladimir Sedlarik
Summary: This study focuses on the rapid and simultaneous adsorptive removal of four estrogenic hormones from wastewater using recycled waste cigarette electrospun fibers. The submicron fibers showed a strong affinity towards all hormones due to hydrogen bonding interactions. The WCENFs can be repeatedly used and are effective in removing multiple organic pollutants.
EXPRESS POLYMER LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Rocio Lopez-Cabeza, Melanie Kah, Renato Grillo, Marek Koutny, Jan Salac, Zuzana Bilkova, Mahleh Eghbalinejad, Jakub Hofman
Summary: In this study, the release kinetics of pesticide nanoformulations were evaluated using dialysis method. The results indicated that the interaction between nanocarrier materials and pesticides played a crucial role in the release of active ingredients, and the durability of the nanoformulations was influenced by dilution.
ENVIRONMENTAL SCIENCE-NANO
(2022)