Article
Biochemistry & Molecular Biology
Nana Bie, Xiaojuan Feng, Chenjing Li, Meng Meng, Chunling Wang
Summary: DHA protects PC12 cells from oxidative damage induced by H2O2 by increasing antioxidant capacity, mitochondrial function, and phosphorylation levels of signaling proteins; it also promotes neurite outgrowth and regulates neurotransmitter levels.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Valdemar B. I. Johansen, Elizabeth Hampson, Elpida Tsonou, Chiara Pantarelli, Julia Y. Chu, Laraine Crossland, Hanneke Okkenhaug, Andrew J. Massey, David C. Hornigold, Heidi C. E. Welch, Stephen A. Chetwynd
Summary: Norbin is an adaptor protein that plays important roles in neuronal function and GPCR trafficking. This study provides new insights into the cellular functions of Norbin, showing that it regulates cell size, growth, and viability in PC12 cells. Additionally, Norbin controls the steady-state surface levels and agonist-induced internalisation of the GPCR S1PR1, suggesting it has a broader role in GPCR trafficking than previously thought. Furthermore, Norbin is involved in the activation of signaling pathways in PC12 cells. These findings enhance our understanding of the cellular functions of Norbin and its role in GPCR trafficking.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ramon Martinez-Marmol, YeJin Chai, Jacinta N. Conroy, Zahra Khan, Seong-Min Hong, Seon Beom Kim, Rachel S. Gormal, Dae Hee Lee, Jae Kang Lee, Elizabeth J. Coulson, Mi Kyeong Lee, Sun Yeou Kim, Frederic A. Meunier
Summary: The traditional medicinal mushroom Hericium erinaceus enhances peripheral nerve regeneration through neurotrophic activity. We identified N-de phenylethyl isohericerin (NDPIH) and hericene A as biologically active compounds from this mushroom that promote neurite outgrowth in hippocampal neurons. NDPIH acts through a neurotrophic pathway independent of TrkB with ERK1/2 activation, while hericene A acts through a novel pan-neurotrophic signaling pathway, leading to improved cognitive performance in mice.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Juliane Meissner, Maryam Rezaei, Isabel Siepe, Doreen Ackermann, Simone Koenig, Johannes A. Eble
Summary: Proteomics studies have shown that adhesomes are made up of a variety of proteins at cellular contact sites with the extracellular matrix. The redox state of individual adhesome proteins in response to environmental signals adds a new aspect to adhesome complexity. This redox proteomic analysis revealed that sulfenylation and protein location at adhesomes mutually influence each other.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Takeru Koga, Hideyuki Ito, Yuji Iwaoka, Toshiro Noshita, Akihiro Tai
Summary: Isorhamnetin-3-O-glucoside and astragalin, found in the petals of Paeonia lactiflora, were identified as compounds that promote neurite outgrowth. They showed strong activity and could potentially be used as functional food ingredients to prevent cognitive decline.
Article
Endocrinology & Metabolism
Congying Chen, Lingling Bu, Huan Liu, Yifeng Rang, Huiying Huang, Xueman Xiao, Genghua Ou, Chunhong Liu
Summary: This study found that 1,4-butanediol induces oxidative stress and inflammation in PC12 cells, leading to reduced levels of Glutathione and Acetylcholine, and ultimately resulting in learning and memory impairment. Furthermore, 1,4-butanediol affects synaptic plasticity via the ERK1/2-CREB-BDNF pathway.
METABOLIC BRAIN DISEASE
(2022)
Article
Cell Biology
Nessma Sultan, Laila E. Amin, Ahmed R. Zaher, Mohammed E. Grawish, Ben A. Scheven
Summary: Dental pulp stem cells secrete neurotrophic factors that significantly promote cell survival and neurite outgrowth in PC12 cells, with NGF, BDNF, and GDNF playing important roles. These factors may have potential therapeutic applications for peripheral nerve repair.
NEURAL REGENERATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yu-pu Liu, Ming-yue Tian, Yi-duo Yang, Han Li, Tian-tian Zhao, Jin Zhu, Fang-fang Mou, Guo-hong Cui, Hai-dong Guo, Shui-jin Shao
Summary: This study found that the level of miR-21 was decreased in serum exosomes from DPN rats. Under high glucose conditions, Schwann cells (SC) proliferation was inhibited and cell apoptosis was increased. The expression of miR-21 in cells and exosomes was downregulated. miR-21 expression and SC-derived exosomes could affect neurite outgrowth through the AKT signaling pathway. This suggests the importance of SC-derived exosomal miR-21 in the regulation of neurite outgrowth under high glucose conditions.
Article
Biochemistry & Molecular Biology
Benhong Xu, Chuanyue Gao, Huan Zhang, Xinfeng Huang, Xifei Yang, Chen Yang, Wei Liu, Desheng Wu, Jianjun Liu
Summary: The study revealed the important roles of PRDX3 in neurite outgrowth and Alzheimer's disease (AD) development. Knockdown of PRDX3 expression promoted retinoic acid-induced neurite outgrowth and led to dysregulation of multiple proteins.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Hayley D. D. Ackerman, Glenn S. S. Gerhard
Summary: Increasing evidence supports the neuroprotective role of bile acids in major neurodegenerative disorders. The study focused on the two cellular receptors, FXR and TGR5, and their potential as neurotrophic agents. The results showed that DCA and TGR5 agonism could stimulate neurite outgrowth, suggesting a targetable pathway for promoting neurite growth.
Article
Behavioral Sciences
Yutaka Gomita, Satoru Esumi, Soichiro Ushio, Yoshihisa Kitamura, Toshiaki Sendo, Hirotoshi Motoda, Shigeki Inoue, Hiroaki Araki, Yoshio Kano
Summary: This study found that plasma from rats subjected to ICSS and IMM treatments promoted neurite outgrowth in PC12m12 cells, with different neuronal signal transduction pathways involved. By using neurotransmitter-sensitive cells, it may be possible to elucidate the pathogenesis of mental diseases and search for therapeutic drugs.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Gabrielle Edwards, Taaliah Campbell, Veronica Henderson, Alira Danaher, Daqing Wu, Rekha Srinivasan, Khosrow Rezvani, Valerie A. Odero-Marah
Summary: The study demonstrates that prostate cancer cells promote migration and adhesion to nerve cells through Snail expression, as well as neurite outgrowth via secretion of soluble factors. Targeting cancer cell interaction with nerves may be a potential strategy to halt prostate cancer progression/metastasis.
Article
Biochemistry & Molecular Biology
Wenting You, Tos T. J. M. Berendschot, Kevin Knoops, Marc A. M. J. van Zandvoort, Carroll A. B. Webers, Chris P. M. Reutelingsperger, Theo G. M. F. Gorgels
Summary: Neurodegenerative diseases are characterized by the loss of certain neurons and a slow progressive course. Our study indicates that damaged neurons in the process of cell death can be recovered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Monica Stanwick, Courtney Barkley, Rosa Serra, Andrew Kruggel, Amy Webb, Yue Zhao, Maciej Pietrzak, Chandler Ashman, Allie Staats, Shifa Shahid, Sarah B. Peters
Summary: Transforming growth factor beta (TGF beta) plays an important role in tooth morphogenesis and mineralization. Deletion of Tgfbr2 in dental pulp mesenchyme leads to significant defects in bone and teeth, including reduced mineralization and short roots. Tgfbr2 deletion disrupts axon-like structures and reduces innervation in teeth. Downregulation of mineralization-related and neuronal genes is observed in Tgfbr2-deleted dental pulp. Tgfbr2 in the dental pulp mesenchyme regulates differentiation and the ability to guide neurite outgrowth during tooth mineralization and innervation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Hyo-Jeong Yong, Jong-Ik Hwang, Jae-Young Seong
Summary: This study highlights the critical role of FAM19A1 in neuronal maturation and function by affecting dendritic spine development and neurite arborization, demonstrating its involvement in maintaining neural integrity and connectivity.
Article
Agriculture, Multidisciplinary
Shih-Fen Chen, Pei-Yi Chen, Hao-Jen Hsu, Ming-Jiuan Wu, Jui-Hung Yen
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Pei-Yi Chen, Hsin-Jung Tien, Shih-Fen Chen, Chi-Ting Horng, Huei-Lin Tang, Hui-Ling Jung, Ming-Jiuan Wu, Jui-Hung Yen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Agriculture, Multidisciplinary
Pei-Shan Wu, Hsiou-Yu Ding, Jui-Hung Yen, Shu-Fen Chen, Kuan-Han Lee, Ming-Jiuan Wu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Agriculture, Multidisciplinary
Wan-Yun Gao, Pei-Yi Chen, Shih-Fen Chen, Ming-Jiuan Wu, Heng-Yuan Chang, Jui-Hung Yen
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Biotechnology & Applied Microbiology
Lisu Wang, Shu-Yuan Chiou, Yi-Ting Shen, Fu-Tsun Yen, Hsiou-Yu Ding, Ming-Jiuan Wu
BIOMED RESEARCH INTERNATIONAL
(2014)
Article
Agriculture, Multidisciplinary
Pei-Yi Chen, Yu-Ting Chen, Wan-Yun Gao, Ming-Jiuan Wu, Jui-Hung Yen
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Agriculture, Multidisciplinary
Sang Kim Thang, Pei-Yi Chen, Wan-Yun Gao, Ming-Jiuan Wu, Min-Hsiung Pan, Jui-Hung Yen
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Cell Biology
Jui-Hung Yen, Ching-Yen Lin, Chin-Hsien Chuang, Hsien-Kuo Chin, Ming-Jiuan Wu, Pei-Yi Chen
Article
Biochemistry & Molecular Biology
Pei-Shan Wu, Jui-Hung Yen, Chih-Yang Wang, Pei-Yi Chen, Jui-Hsiang Hung, Ming-Jiuan Wu
Article
Biochemistry & Molecular Biology
Wan-Yun Gao, Pei-Yi Chen, Hao-Jen Hsu, Ching-Yen Lin, Ming-Jiuan Wu, Jui-Hung Yen
Summary: Tanshinone IIA exhibits lipid-lowering effects by inhibiting genes related to lipogenesis, increasing phosphorylation of ACC1 protein, and regulating the expression of SREBP1, potentially through modulating the LXR alpha/SREBP1 pathway in hepatic cells.
Review
Biochemistry & Molecular Biology
Pei-Yi Chen, Wan-Yun Gao, Je-Wen Liou, Ching-Yen Lin, Ming-Jiuan Wu, Jui-Hung Yen
Summary: Dyslipidemia, characterized by elevated levels of LDL-C, TGs, and TGRLs, is a major risk factor for ASCVDs. ANGPTL3, synthesized exclusively in the liver, plays a critical role in regulating lipoprotein metabolism and its downregulation is associated with reduced risk of cardiovascular events. Therapies targeting ANGPTL3 show promise for managing dyslipidemia and ASCVDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pei-Shan Wu, Chih-Yang Wang, Pin-Shern Chen, Jui-Hsiang Hung, Jui-Hung Yen, Ming-Jiuan Wu
Summary: 8-OHD exerts anti-CML effects by downregulating JAK/STAT, PI3K/AKT, MMP, and OXPHOS pathways, as well as MYC expression. These findings shed new light on the development of 8-OHD for CML therapy.
Article
Biochemistry & Molecular Biology
Pei-Yi Chen, Chih-Yang Wang, En-Ci Tsao, Yu-Ting Chen, Ming-Jiuan Wu, Chi-Tang Ho, Jui-Hung Yen
Summary: In this study, we found that 5-demethyl NOB significantly suppressed the proliferation of human leukemia cells by modulating the expression of related genes, inducing cell cycle arrest, promoting apoptosis and differentiation. Moreover, 5-demethyl NOB exerted cytotoxic effects by inhibiting genes associated with cell proliferation and controlling the activity of relevant signaling pathways. Additionally, 5-demethyl NOB exhibited synergistic effects with common leukemia chemotherapy drugs, enhancing their effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ching-Yen Lin, Pei-Yi Chen, Hao-Jen Hsu, Wan-Yun Gao, Ming-Jiuan Wu, Jui-Hung Yen
Summary: This study investigated the lipid-lowering effects of nobiletin and its underlying molecular mechanisms. The results showed that nobiletin can regulate lipid metabolism by targeting the LXR alpha-ANGPTL3-LPL axis. Animal studies also showed that nobiletin can reduce plasma triglycerides and cholesterol levels. These findings suggest that nobiletin may be a potential inhibitor for dyslipidemia and atherosclerotic cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Pei-Rong Chang, Je-Wen Liou, Pei-Yi Chen, Wan-Yun Gao, Chia-Ling Wu, Ming-Jiuan Wu, Jui-Hung Yen
Summary: This study investigates the potential neuroprotective properties of fisetin against corticosterone-induced cell death and explores the underlying molecular mechanism. The results demonstrate that fisetin effectively protects PC12 cells against corticosterone-induced neurotoxicity by reducing reactive oxygen species generation and inhibiting apoptosis. Fisetin exerts its neuroprotective effect through the modulation of MAPK/ERK, p38, and the PI3K/Akt/FOXO3a-dependent pathways.