Article
Chemistry, Multidisciplinary
Artem O. Denisov, Seong W. Oh, Gordian Fuchs, Adam R. Mills, Pengcheng Chen, Christopher R. Anderson, Mark F. Gyure, Arthur W. Barnard, Jason R. Petta
Summary: Researchers have successfully combined the spatial resolution of scanning probe microscopy with the speed of microwave measurements by coupling a metallic tip to a Si/SiGe double quantum dot. They were able to observe excited states with an energy of -65microelectronvolts, consistent with valley splittings in Si/SiGe.
Article
Chemistry, Multidisciplinary
Shantanu Mishra, Shadi Fatayer, Saleta Fernandez, Katharina Kaiser, Diego Pena, Leo Gross
Summary: We report the on-surface synthesis of a non-benzenoid triradical through dehydrogenation of truxene (C27H18) on coinage metal and insulator surfaces. The final product truxene-5,10,15-triyl (1) retains its open-shell quartet ground state on a two monolayer-thick NaCl layer on a Cu(111) surface, and its frontier orbital densities correspond to spin-split singly occupied molecular orbitals.
Article
Chemistry, Multidisciplinary
Nicolas Neel, Joerg Kroeger
Summary: The study revealed that the formation of a chemical bond between a CO molecule and a Cu(111) surface is accompanied by bending of the molecular probe due to van der Waals attraction and Pauli repulsion, resulting in characteristic changes in the vertical force between CO and Cu(111) as a function of molecule-surface distance. Experimental data were successfully reproduced by model calculations, shedding new light on vertical-force extrema in scanning probe experiments.
Article
Chemistry, Multidisciplinary
Yuan Zhang, Daniel J. Trainer, Badri Narayanan, Yang Li, Anh T. Ngo, Sushila Khadka, Arnab Neogi, Brandon Fisher, Larry A. Curtiss, Subramanian K. R. S. Sankaranarayanan, Saw Wai Hla
Summary: By using a q+ atomic force microscopy at low temperature, researchers observed lateral force anisotropy of a sexiphenyl molecule moving on an atomically flat Ag(111) surface. The one-dimensional shape of the molecule was identified as the origin of this phenomenon, which was confirmed through molecular dynamics simulations. This finding may have significant implications for atomic scale frictional phenomena on materials surfaces.
Article
Chemistry, Multidisciplinary
Donglin Li, Luye Sun, Yuanqi Ding, Mengxi Liu, Lei Xie, Yinfu Liu, Lina Shang, Yangfan Wu, Hui-Jun Jiang, Lifeng Chi, Xiaohui Qiu, Wei Xu
Summary: This study focuses on the role of water molecules in driving chiral separation on the surface when RNA base uracil selfassembles into homochiral structures upon water exposure. The findings provide insights into the general role of water molecules in the origin of homochirality in living systems, with implications for other biologically relevant molecules such as amino acids and sugars.
Review
Chemistry, Physical
Chunlei Yang, Tianhui Su, Yanbo Hua, Liming Zhang
Summary: This review summarizes the latest results of electrochemical scanning probe microscopy techniques in studying the interfacial properties of electrocatalysts and photoelectrodes, and offers some perspectives on future research directions.
Article
Chemistry, Multidisciplinary
Leonard-Alexander Lieske, Mario Commodo, Jacob W. W. Martin, Katharina Kaiser, Vasiliki Benekou, Patrizia Minutolo, Andrea D'Anna, Leo Gross
Summary: This study used high-resolution atomic force microscopy and scanning tunneling microscopy to investigate the initial formation of soot in flames. The research revealed the atomic structure and orbital densities of single soot molecules, as well as the formation mechanisms of aromatic compounds through cross-linking and cyclodehydrogenation reactions. The findings also detected the presence of nonhexagonal rings in flame aromatics, indicating simultaneous growth through aromatic cross-linking/cyclodehydrogenation and hydrogen abstraction acetylene addition. Furthermore, the study identified three classes of open-shell π-radical species and their implications for soot formation and cleaner combustion.
Article
Chemistry, Multidisciplinary
Wenze Gao, Faming Kang, Xia Qiu, Zewei Yi, Lina Shang, Mengxi Liu, Xiaohui Qiu, Yi Luo, Wei Xu
Summary: The configuration of carbon allotropes in condensed phases, whether linear or cyclic, has long been a mystery. In this study, a molecule with a C-6 skeleton was designed to address this issue. The C-6 ring intermediate resulting from complete debromination was found to be energetically unstable at room temperature. It subsequently underwent a ring-opening process and polymerized into an organometallic polyyne.
Article
Chemistry, Multidisciplinary
Xunshan Liu, Adam Matej, Tim Kratky, Jesus Mendieta-Moreno, Sebastian Guenther, Pingo Mutombo, Silvio Decurtins, Ulrich Aschauer, Jascha Repp, Pavel Jelinek, Shi-Xia Liu, Laerte L. Patera
Summary: In this study, selective C-H activation of hexaazatriphenylene by Scholl reaction was reported for the first time, achieving dehydrogenative C-C couplings. The formation of one-dimensional polymers with a double-chain structure was revealed using low-temperature scanning tunneling microscopy and atomic force microscopy. Density functional theory calculations rationalized the growth process, highlighting the cooperative catalytic action of Na and Ag adatoms in steering the C-H selectivity for polymerization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Euihwan Do, Jae Whan Park, Oleksandr Stetsovych, Pavel Jelinek, Han Woong Yeom
Summary: In this study, the low-temperature structural distortion of a one-dimensional electronic system formed on Au-decorated vicinal silicon surfaces is unambiguously identified using high-resolution atomic force microscopy and scanning tunneling microscopy. The buckling of the step-edge Si chains, forming trimer unit cells, is found to be the most important structural element of this surface. This observation supports the recent model of rehybridized dangling bonds and contradicts the previously proposed antiferromagnetic spin ordering.
Article
Chemistry, Multidisciplinary
Dingxin Fan, James R. Chelikowsky
Summary: Significant progress has been made in increasing the resolution of scanning probe microscopy, with noncontact atomic force microscopy now able to characterize and visualize single molecules with subatomic resolution. Real-space pseudopotentials constructed within density functional theory are used to accurately simulate nc-AFM images of molecules containing heteroatoms, enabling the easy identification of S and I atoms and proposing a method to discriminate N atoms from C atoms using tip functionalization.
Article
Chemistry, Physical
Xin Tan, Jinliang Pan, Yangfan Wu, Peng Xu, Luye Sun, Kui Hu, Xia Qiu, Menglei Li, Mengxi Liu, Donglin Ma, Xiaohui Qiu
Summary: In this study, the formation of stable Na3Cl nanoclusters and a Na3Cl4 monolayer was directly observed using scanning tunneling microscopy and non-contact atomic force microscopy. The stability of these structures was confirmed through density functional theory calculations. The study also found that charge transfer between the nanoclusters and the metal substrate stabilized NaCl of non-1:1 stoichiometry.
Article
Chemistry, Multidisciplinary
Vincent Notot, Willem Walravens, Maxime Berthe, Nemanja Peric, Ahmed Addad, Xavier Wallart, Christophe Delerue, Zeger Hens, Bruno Grandidier, Louis Biadala
Summary: The doping in square and epitaxially fused PbSe quantum dot superlattices was explored using low-temperature scanning tunneling microscopy and spectroscopy. The study found that the electronic coupling between quantum dots leads to the release and capture of free holes.
Article
Chemistry, Multidisciplinary
Ana Barragan, Tomas Nicolas-Garcia, Koen Lauwaet, Ana Sanchez-Grande, Jose Urgel, Jonas Bjork, Emilio M. Perez, David Ecija
Summary: Nanocars are carbon-based single-molecules that can be precisely controlled on a surface at the atomic scale. The design of these molecules plays a crucial role in advancing the development of molecular machines and understanding self-assembly and other processes. In this study, we present the design and construction of a collection of minimalistic nanocars featuring an anthracene chassis and benzene derivatives as wheels. By using a scanning tunneling microscope (STM) tip to induce a dipole in the nanocar, we were able to manipulate it along the surface, achieving controlled and rapid displacement. The use of carbon monoxide functionalized tips prevented decomposition and accidental picking up of the nanocars during manipulation, leading to our success in the Nanocar Race II championship.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Peng Fan, Hui Chen, Xingtai Zhou, Lu Cao, Geng Li, Meng Li, Guojian Qian, Yuqing Xing, Chengmin Shen, Xiancheng Wang, Changqing Jin, Genda Gu, Hong Ding, Hong-Jun Gao
Summary: We demonstrate the manipulation of Abrikosov vortices on the surfaces of Fe(Te,Se) and LiFeAs by utilizing one-dimensional wrinkles and low-temperature scanning tunneling microscopy/spectroscopy (STM/S). The wrinkles trap the Abrikosov vortices induced by the external magnetic field, and we are able to tailor and manipulate the wrinkles using an STM tip. Surprisingly, we show that the pinned vortices move together with these wrinkles even at high magnetic field up to 6 T. This work provides a universal and effective method for manipulating wrinkle-pinned vortices and simultaneously measuring the local density of states on the surfaces of iron-based superconductors.
Article
Nutrition & Dietetics
Junko Ueshima, Keisuke Maeda, Akio Shimizu, Ayano Nagano, Yuria Ishida, Tomoko Takeuchi, Tomoyuki Nonogaki, Remi Matsuyama, Yosuke Yamanaka, Kenta Murotani, Naoharu Mori
Summary: This study aimed to validate the cachexia staging score (CSS) as a diagnostic method for measuring cachexia severity in patients with advanced cancer receiving palliative care. The results showed that as the severity of cachexia increased, patients had shorter survival and experienced changes in symptoms and biomarkers associated with cachexia.
Article
Oncology
Masako Nakamura, Ming Zhu, Keisuke Maeda, Misako Toda, Naoharu Mori
Summary: This small-sample pilot study aimed to uncover the role of palliative care education for general nurses providing care to patients with intractable cancer. A questionnaire was developed and a lecture and free study session on Integrating Oncology and Palliative Care (IOP) were delivered using information and communication technology (ICT). The study found that continued education using ICT may improve the practical skills of general nurses caring for patients with intractable cancer.
JOURNAL OF CANCER EDUCATION
(2023)
Article
Nanoscience & Nanotechnology
Jaime Carracedo-Cosme, Carlos Romero-Muniz, Pablo Pou, Ruben Perez
Summary: We propose a chemical characterization approach based on noncontact atomic force microscopy with metal tips functionalized with a CO molecule (HR-AFM) to resolve the internal structure of individual molecules. Our work demonstrates that a stack of constant-height HR-AFM images provides enough chemical information for the identification of quasiplanar organic molecules, and this information can be retrieved using machine learning techniques. The algorithm, trained with a large dataset, can generate the IUPAC name of the imaged molecule as the final output. Our findings highlight the potential of deep learning algorithms in the automatic identification of molecular compounds by AFM.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Editorial Material
Emergency Medicine
Keisuke Maeda, Yuji Okazaki, Toshihisa Ichiba
ANNALS OF EMERGENCY MEDICINE
(2023)
Article
Nutrition & Dietetics
Sayaka Abe, Yoji Kokura, Keisuke Maeda, Shinta Nishioka, Ryo Momosaki, Hiroki Matsuoka, Yasuomi Tomii, Shinnosuke Sugita, Kenta Shimizu, Nanami Esashi, Hidetaka Wakabayashi
Summary: This retrospective cohort study examines the impact of undernutrition on swallowing function and activities of daily living in hospitalized patients. Using data from the Japanese Sarcopenic Dysphagia Database, the study includes hospitalized patients over 20 years old with dysphagia. Results show that undernutrition is associated with decreased improvement in swallowing function and ability to perform daily activities, as measured by the Food Intake Level Scale and Barthel Index.
Correction
Multidisciplinary Sciences
Akino Saiki, Kanako Yoshimi, Kazuharu Nakagawa, Yuki Nagasawa, Akira Yoshizawa, Ryosuke Yanagida, Kohei Yamaguchi, Ayako Nakane, Keisuke Maeda, Haruka Tohara
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Emiliano Ventura-Macias, Carlos Romero-Muniz, Pablo Gonzalez-Sanchez, Pablo Pou, Ruben Perez
Summary: Functionalized tips with carbon monoxide (CO) in frequency modulation atomic force microscopy (AFM) can achieve high resolution imaging of molecules and reveal their internal structure on frequency shift maps. Traditionally, frequency shift measurements at low amplitudes have been interpreted as the force gradient between the probe and the sample, but our study shows that this interpretation fails for CO-terminated tips even at amplitudes as small as 0.2-0.3 Å. This is due to the rapid variation in tip-sample interaction caused by the mobility of the CO probe, which deflects to reduce the Pauli repulsion with the sample. In addition, we propose a new and simple approach to the frequency shift based on the force at the closest tip-sample separation, independent of CO deflection. This force approximation accurately reproduces the real frequency maps for amplitudes larger than ~0.3 Å.
APPLIED SURFACE SCIENCE
(2023)
Review
Nutrition & Dietetics
Yoko Saino, Fumiya Kawase, Ayano Nagano, Junko Ueshima, Haruko Kobayashi, Kenta Murotani, Tatsuro Inoue, Shinsuke Nagami, Mizue Suzuki, Keisuke Maeda
Summary: This scoping review investigated the diagnosis, associated problems, and prevalence of sarcopenic obesity (SO) in colorectal cancer (CRC) patients. The diagnosis of SO mainly relied on the combination of skeletal muscle mass index (SMI) and body mass index (BMI), with little evaluation of muscle strength and body composition. The overall prevalence of SO in CRC patients was approximately 15%. Further research on diagnostic methods and clinical outcomes of SO in CRC patients is needed due to its association with poor prognosis.
CLINICAL NUTRITION
(2023)
Article
Chemistry, Analytical
Yusuke Akamatsu, Keisuke Maeda, Takahiro Ogawa, Miki Haseyama
Summary: In this paper, a semi-supervised multi-view embedding approach is proposed to address the problem of zero-shot neural decoding. Additional images related to the target categories are utilized to exploit complementary information, and fMRI activity patterns are projected into a multi-view embedding space to rectify the projection domain shift problem. Experimental results demonstrate that the proposed approach outperforms existing methods.
Article
Nutrition & Dietetics
Ayano Nagano, Masami Onaka, Keisuke Maeda, Junko Ueshima, Akio Shimizu, Yuria Ishida, Shinsuke Nagami, Shuzo Miyahara, Keiji Nishihara, Akiyuki Yasuda, Shosuke Satake, Naoharu Mori
Summary: This study aimed to investigate the prevalence, progression, and distinct attributes of sarcopenic dysphagia (SD) in geriatric medicine. The study found that SD was common among older patients and those with SD showed a better recovery rate compared to other types of dysphagia. Patients with SD had compromised nutritional profiles, diminished energy and protein consumption, and extended fasting durations. Thus, an integrated approach in geriatric medicine is crucial for addressing SD.
Review
Nutrition & Dietetics
Keisuke Maeda, Motoomi Nagasaka, Ayano Nagano, Shinsuke Nagami, Kakeru Hashimoto, Masaki Kamiya, Yuto Masuda, Kenichi Ozaki, Koki Kawamura
Summary: Dysphagia, a syndrome of abnormal eating function associated with malnutrition, has traditionally been difficult to assess without invasive and expensive methods. However, recent advancements in ultrasound technology have made it possible to noninvasively evaluate swallowing-related muscles and propose a protocol for diagnosing sarcopenic dysphagia in elderly patients.
Editorial Material
Cell Biology
Akio Shimizu, Tatsuro Inoue, Keisuke Maeda
Article
Dentistry, Oral Surgery & Medicine
Sahoko Takagi, Keisuke Maeda, Akio Shimizu, Hidemichi Yuasa, Keita Yamauchi, Hideki Sakai
Summary: Poor oral health status in elderly patients with acute ischemic stroke is associated with worse short-term functional outcomes, including higher disability rates, dysphagia, and longer hospital stays.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Geriatrics & Gerontology
Akio Shimizu, Keisuke Maeda, Tatsuro Inoue, Naoharu Mori, Ryo Momosaki
Summary: This study found that early physical rehabilitation intervention can effectively reduce adverse outcomes, including 30-day mortality and readmission rates, in frail older patients with community-acquired pneumonia.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
